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Daniel Kelly Benjamin, MD, PhD

Kiser-Arena Distinguished Professor
Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 7044 Duke Clinical Research Institute, 2400 Pratt St, Durham, NC 27710
Phone: (919) 668-7081

Dr. Danny Benjamin is the Principal Investigator and Chair of the National Institute of Child Health and Human Development’s Pediatric Trials Network. The Network is responsible for designing and leading clinical trials of off-patent medicines in children of all ages across all therapeutic areas. The team has established, or is actively studying, the correct dosing and safety of more than 70 of the most commonly used medicines in children. Each of these trials is conducted under an Investigational New Drug (IND) application with guidance from the Food and Drug Administration for labeling.

The Pediatric Trials Network has directly impacted the healthcare of over 90% of American children.

Signature programs of the Network include clinical trials in premature, term infants, breast feeding mothers, and obese children. Over the past 10 years, Danny’s group has enrolled more premature infants, at more sites, in more clinical trials of off-patent anti-infectives under an IND than all other academic medical centers, pharmaceutical companies, and government agencies in the world, combined.

Danny is recognized by the National Institutes of Health as a premiere mentor and educator. His research program serves as a platform to train students and early career investigators. Danny’s group has a clinical research summer program for high school and college students targeting under-represented minority students, and he is the primary mentor for medical students, residents, subspecialty fellows, and multiple junior faculty. He has been the primary or secondary mentor for 10 faculty who have received career development awards and who have then gone on to secure their own funding.

Danny's service to the community is expressed through his passion for coaching baseball. He has coached over 500 recreation league, travel league, and scholastic baseball games and he is the head coach of Smith Middle School, the 5-year reigning southern conference champions. Danny and his wife own a charitable non-profit that provides athletic and fitness opportunities for disadvantaged school-aged boys and girls.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 1998 - 2001
  • Resident, Pediatrics, Children's Hospital, 1995 - 1998
  • Ph.D., University of North Carolina - Chapel Hill, 2003
  • M.P.H., University of North Carolina - Chapel Hill, 2001
  • M.D., University of Virginia, 1995

Selected Grants and Awards

Publications

Puia-Dumitrescu, Mihai, Noelle Younge, Daniel K. Benjamin, Katie Lawson, Cordelia Hume, Kennedy Hill, Jonathan Mengistu, et al. “Medications and in-hospital outcomes in infants born at 22-24 weeks of gestation.” J Perinatol 40, no. 5 (May 2020): 781–89. https://doi.org/10.1038/s41372-020-0614-4.

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Ge, Shufan, Susan R. Mendley, Jacqueline G. Gerhart, Chiara Melloni, Christoph P. Hornik, Janice E. Sullivan, Andrew Atz, et al. “Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents.” Clin Transl Sci, April 23, 2020. https://doi.org/10.1111/cts.12803.

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Drolet, Beth A., Felix Boakye-Agyeman, Barrie Harper, Kristen Holland, Andrew Lewandowski, Nicole Stefanko, Chiara Melloni, and Chiara Pediatric Trials Network Steering Committee (See Acknowledgments for a listing of committee members.). “Systemic timolol exposure following topical application to infantile hemangiomas.” J Am Acad Dermatol 82, no. 3 (March 2020): 733–36. https://doi.org/10.1016/j.jaad.2019.02.029.

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Hornik, Christoph P., Amy A. Gelfand, Christina L. Szperka, Tara Pezzuto, Amanda Utevsky, Shirley Kessel, Susan McCune, John J. Alexander, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Development of a Prospective Real-World Data Clinical Registry of Children and Adolescents With Migraine.” Headache 60, no. 2 (February 2020): 405–15. https://doi.org/10.1111/head.13714.

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Puia-Dumitrescu, Mihai, Daniel K. Benjamin, P Brian Smith, Rachel G. Greenberg, Nada Abuzaid, Winsome Andrews, Kris Chellani, et al. “Impact of Gastrostomy Tube Placement on Short-Term Weight Gain in Hospitalized Premature Infants.” Jpen J Parenter Enteral Nutr 44, no. 2 (February 2020): 355–60. https://doi.org/10.1002/jpen.1539.

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Padula, Amy M., Catherine Monk, Patricia A. Brennan, Ann Borders, Emily S. Barrett, Cindy T. McEvoy, Sophie Foss, et al. “A review of maternal prenatal exposures to environmental chemicals and psychosocial stressors-implications for research on perinatal outcomes in the ECHO program.” J Perinatol 40, no. 1 (January 2020): 10–24. https://doi.org/10.1038/s41372-019-0510-y.

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Gonzalez, Daniel, Matthew M. Laughon, P Brian Smith, Shufan Ge, Namasivayam Ambalavanan, Andrew Atz, Gregory M. Sokol, et al. “Population pharmacokinetics of sildenafil in extremely premature infants.” Br J Clin Pharmacol 85, no. 12 (December 2019): 2824–37. https://doi.org/10.1111/bcp.14111.

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Petraitis, Vidmantas, Ruta Petraitiene, Jessica M. Valdez, Vasilios Pyrgos, Martin J. Lizak, Brenda A. Klaunberg, Darius Kalasauskas, et al. “Amphotericin B Penetrates into the Central Nervous System Through Focal Disruption of the Blood Brain Barrier in Experimental Hematogenous Candida Meningoencephalitis.” Antimicrob Agents Chemother, October 7, 2019. https://doi.org/10.1128/AAC.01626-19.

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Thompson, Elizabeth J., Huali Wu, Chiara Melloni, Stephen Balevic, Janice E. Sullivan, Matthew Laughon, Kira M. Clark, et al. “Population Pharmacokinetics of Doxycycline in Children.” Antimicrob Agents Chemother, September 23, 2019. https://doi.org/10.1128/AAC.01508-19.

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Balevic, Stephen J., P Brian Smith, Daniela Testoni, Huali Wu, Kim L. R. Brouwer, Kanecia O. Zimmerman, Nazario D. Rivera-Chaparro, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Cefazolin pharmacokinetics in premature infants.” J Perinatol 39, no. 9 (September 2019): 1213–18. https://doi.org/10.1038/s41372-019-0368-z.

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