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Charles Michael Cotten, MD

Professor of Pediatrics
Chief, Division of Pediatric Neonatology
Campus mail: 2424 Erwin Rd Suite 504, Durham, NC 27710
Phone: (919) 681-4844
Email address: michael.cotten@duke.edu

I am involved in 4 major areas of research:
1) Neuroprotection. Working with colleagues from Cell Therapies and neuroradiology, we have initiated a pilot trial, funded by the DTRI, in providing autologous cord blood cells in the first 24 postnatal hours to infants with hypoxic ischemic encephalopathy. This follows our involvement with the two pivotal hypothermia studies, in which cooling decreased risk of death or disability, but among the treated groups in both trials, > 40% of infants either died or survived with impairments, strongly suggesting the need for further therapies.
2) Genomics. We led the NICHD Neonatal Research Network development of an Anonymized DNA bank of samples collected from 1,000 extremely low birthweight infants, with phenotype information linked to the samples. This resource will be the basis for multiple candidate gene, and genome wide scans to assess the genetic contributions to risk of morbidities of extremely preterm birth.
3) Newborn Screening and New Technologies: I have collaborated with Drs. David Millington from Duke and Vamsee Pamula, from Advanced Liquid Logic, on prototype new technology devices for use in newborn screening for lysosomal storage disease as well as prototypes for potential use for screening for severe combined immunodeficiency.
4)Microbiome in Micropreemies. Collaborating with Patrick Seed in Pediatric Infectious Diseases, we have initiated studies that will hopefully lead to an understanding of how the evolving microflora that inhabits the intestines of high risk, extremley preterm infants influences metabolism and developing immunologic function, and ultimately, health outcomes. I also conduct epidemiology research on Neonatal practice variation within our center, and within the Neonatal Research Network centers, to identify how variation in practice can influence outcomes.

Education and Training

  • Intern and Resident, Pediatrics, University of Miami, 1986 - 1989
  • M.D., University of Miami, 1986

Selected Grants and Awards

Publications

Laptook, AR, Bell, EF, Shankaran, S, Boghossian, NS, Wyckoff, MH, Kandefer, S, Walsh, M, Saha, S, Higgins, R, and Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research Network, . "Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants." The Journal of pediatrics 192 (January 2018): 53-59.e2.

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Pappas, A, Adams-Chapman, I, Shankaran, S, McDonald, SA, Stoll, BJ, Laptook, AR, Carlo, WA, Van Meurs, KP, Hintz, SR, Carlson, MD, Brumbaugh, JE, Walsh, MC, Wyckoff, MH, Das, A, and Higgins, RD. "Neurodevelopmental and Behavioral Outcomes in Extremely Premature Neonates With Ventriculomegaly in the Absence of Periventricular-Intraventricular Hemorrhage." JAMA Pediatrics 172, no. 1 (January 1, 2018): 32-32.

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Farkouh-Karoleski, C, Najaf, T, Wynn, J, Aspelund, G, Chung, WK, Stolar, CJ, Mychaliska, GB, Warner, BW, Wagner, AJ, Cusick, RA, Lim, F-Y, Schindel, DT, Potoka, D, Azarow, K, Cotten, CM, Hesketh, A, Soffer, S, Crombleholme, T, and Needelman, H. "A definition of gentle ventilation in congenital diaphragmatic hernia: a survey of neonatologists and pediatric surgeons." Journal of Perinatal Medicine 45, no. 9 (December 20, 2017).

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Watterberg, KL, Fernandez, E, Walsh, MC, Truog, WE, Stoll, BJ, Sokol, GM, Kennedy, KA, Fraga, MV, Beauman, SS, Carper, B, Das, A, Duncan, AF, Buss, WF, Gauldin, C, Lacy, CB, Sanchez, PJ, Chawla, S, Lakshminrusimha, S, Cotten, CM, Van Meurs, KP, Poindexter, BB, Bell, EF, Carlo, WA, Devaskar, U, Wyckoff, MH, and Higgins, RD. "Barriers to enrollment in a randomized controlled trial of hydrocortisone for cardiovascular insufficiency in term and late preterm newborn infants." Journal of perinatology : official journal of the California Perinatal Association 37, no. 11 (November 2017): 1220-1223.

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Puopolo, KM, Mukhopadhyay, S, Hansen, NI, Cotten, CM, Stoll, BJ, Sanchez, PJ, Bell, EF, Das, A, Hensman, AM, Van Meurs, KP, Wyckoff, MH, and NICHD Neonatal Research Network, . "Identification of Extremely Premature Infants at Low Risk for Early-Onset Sepsis." Pediatrics 140, no. 5 (November 2017).

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James, J, Munson, D, DeMauro, SB, Langer, JC, Dworetz, AR, Natarajan, G, Bidegain, M, Fortney, CA, Seabrook, R, Vohr, BR, Tyson, JE, Bell, EF, Poindexter, BB, Shankaran, S, Higgins, RD, Das, A, Stoll, BJ, Kirpalani, H, and Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, . "Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support." The Journal of pediatrics 190 (November 2017): 118-123.e4.

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Laptook, AR, Shankaran, S, Tyson, JE, Munoz, B, Bell, EF, Goldberg, RN, Parikh, NA, Ambalavanan, N, Pedroza, C, Pappas, A, Das, A, Chaudhary, AS, Ehrenkranz, RA, Hensman, AM, Van Meurs, KP, Chalak, LF, Khan, AM, Hamrick, SEG, Sokol, GM, Walsh, MC, Poindexter, BB, Faix, RG, Watterberg, KL, Frantz, ID, Guillet, R, Devaskar, U, Truog, WE, Chock, VY, Wyckoff, MH, McGowan, EC, Carlton, DP, Harmon, HM, Brumbaugh, JE, Cotten, CM, Sánchez, PJ, Hibbs, AM, and Higgins, RD et al. "Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial." JAMA 318, no. 16 (October 2017): 1550-1560.

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Chawla, S, Natarajan, G, Shankaran, S, Carper, B, Brion, LP, Keszler, M, Carlo, WA, Ambalavanan, N, Gantz, MG, Das, A, Finer, N, Goldberg, RN, Cotten, CM, Higgins, RD, and Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, . "Markers of Successful Extubation in Extremely Preterm Infants, and Morbidity After Failed Extubation." The Journal of pediatrics 189 (October 2017): 113-119.e2.

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Srinivasan, L, Page, G, Kirpalani, H, Murray, JC, Das, A, Higgins, RD, Carlo, WA, Bell, EF, Goldberg, RN, Schibler, K, Sood, BG, Stevenson, DK, Stoll, BJ, Van Meurs, KP, Johnson, KJ, Levy, J, McDonald, SA, Zaterka-Baxter, KM, Kennedy, KA, Sánchez, PJ, Duara, S, Walsh, MC, Shankaran, S, Wynn, JL, Cotten, CM, and Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, . "Genome-wide association study of sepsis in extremely premature infants." Archives of disease in childhood. Fetal and neonatal edition 102, no. 5 (September 2017): F439-F445.

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Morrow, LA, Wagner, BD, Ingram, DA, Poindexter, BB, Schibler, K, Cotten, CM, Dagle, J, Sontag, MK, Mourani, PM, and Abman, SH. "Antenatal Determinants of Bronchopulmonary Dysplasia and Late Respiratory Disease in Preterm Infants." American journal of respiratory and critical care medicine 196, no. 3 (August 2017): 364-374.

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