Skip to main content

Charles Michael Cotten, MD

Professor of Pediatrics
Chief, Division of Pediatric Neonatology
Campus mail: 2424 Erwin Rd Suite 504, Durham, NC 27710
Phone: (919) 681-6035
Email address: michael.cotten@duke.edu

I am involved in 4 major areas of research:
1) Neuroprotection. Working with colleagues from Cell Therapies, we have added to Duke's experience participating in pivotal trials of hypothermia for term newborns with moderate to severe hypoxic-ischemic encephalopathy (HIE) by completing a phase I study of autologous cord blood cells for these infants, and developing and currently leading a multicenter, double-blind randomized clinical trial of autologous cord blood cells or placebo in term infants with moderate or severe HIE. We are currently initiating, w/ funding from Duke's CTSI support, the first phase I single center study of allogeneic cord tissue derived mesenchymal stromal cells for newborns with moderate or severe HIE who do not have autologous cells available.
2) Genomics. We at Duke have been in the NICHD Neonatal Research Network (NRN) since 2001. I led the NRN's development of an Anonymized DNA bank of samples collected from 1,000 extremely low birthweight infants, with phenotype information linked to the samples. This resource has been the basis for multiple candidate gene, and genome wide scan analysis, and has identified variants associated with severe retinopathy of prematurity and necrotizing enterocolitis.  
3) New Technologies: I have collaborated with Drs. David Millington from Duke and Vamsee Pamula (a Duke Pratt School graduate), from BAEBIES Inc, on prototype new technology devices for use in newborn screening for lysosomal storage disease as well as multiplex chips for screening for hyperbilirubinemia and related conditions, as well as working with Dr. Pamula and Dr. Michael Freemark (Peds Endocrinology) on screening panels for hypoglycemia and hypothyroidism, and with investigators from UAB on an Acute Kidney Injury panel. Also, I am collaborating with Dr. Cynthia Toth in pediatric ophthalmology, and Pratt School investigators to develop and apply use of optical coherence tomography for retinal imaging that will assess associations between retinal neurovascular development, brain development, and neurodevelopmental outcomes. I am also currently working with the Duke FORGE and multiple Pediatric subspecialists on machine-learning and deep informatics analysis of electronic health records to quantify risk for subsequent complications and on development of algorithms to identify neonatal seizures from neonatal EEG tracings. 
4)Microbiome in Micropreemies and health outcomes of periviable infants.  I have worked with multiple epidemiology researchers to assess practice variation within our center, and within the Neonatal Research Network centers, to identify how variation in practice can influence outcomes, with a particular focus on antibiotic use. This work demonstrated strong associations between high empirical antibiotic use in infants with sterile cultures and subsequent morbidities and mortality. This discovery has led to strong collaborations and new initiatives by young faculty leading studies of the evolving microbiome, leading to hypothesis generation re: the microbiome and optimal growth in extremely preterm infants.

Education and Training

  • Intern and Resident, Pediatrics, University of Miami, 1986 - 1989
  • M.H.S., Duke University School of Medicine, 2006
  • M.D., University of Miami, 1986

Selected Grants and Awards

Publications

Worley, Gordon, Stephen W. Erickson, Kathryn E. Gustafson, Yuliya S. Nikolova, Allison E. Ashley-Koch, Daniel W. Belsky, Ricki F. Goldstein, Grier P. Page, C Michael Cotten, and C Michael Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. “Genetic variation in dopamine neurotransmission and motor development of infants born extremely-low-birthweight.” Dev Med Child Neurol 62, no. 6 (June 2020): 750–57. https://doi.org/10.1111/dmcn.14383.

Full Text

Mukhopadhyay, Sagori, Karen M. Puopolo, Nellie I. Hansen, Scott A. Lorch, Sara B. DeMauro, Rachel G. Greenberg, C Michael Cotten, et al. “Impact of Early-Onset Sepsis and Antibiotic Use on Death or Survival with Neurodevelopmental Impairment at 2 Years of Age among Extremely Preterm Infants.” J Pediatr 221 (June 2020): 39-46.e5. https://doi.org/10.1016/j.jpeds.2020.02.038.

Full Text

Stoll, Barbara J., Karen M. Puopolo, Nellie I. Hansen, Pablo J. Sánchez, Edward F. Bell, Waldemar A. Carlo, C Michael Cotten, et al. “Early-Onset Neonatal Sepsis 2015 to 2017, the Rise of Escherichia coli, and the Need for Novel Prevention Strategies.” Jama Pediatr, May 4, 2020, e200593. https://doi.org/10.1001/jamapediatrics.2020.0593.

Full Text

Benninger, Kristen L., Terrie E. Inder, Amy M. Goodman, C Michael Cotten, Douglas R. Nordli, Tushar A. Shah, James C. Slaughter, and Nathalie L. Maitre. “Perspectives from the Society for Pediatric Research. Neonatal encephalopathy clinical trials: developing the future.” Pediatr Res, March 27, 2020. https://doi.org/10.1038/s41390-020-0859-9.

Full Text

Puia-Dumitrescu, Mihai, Rachel G. Greenberg, Noelle Younge, Margarita Bidegain, C Michael Cotten, Martin McCaffrey, Amy Murtha, et al. “Disparities in the use of antenatal corticosteroids among women with hypertension in North Carolina.” J Perinatol 40, no. 3 (March 2020): 456–62. https://doi.org/10.1038/s41372-019-0555-y.

Full Text

Berube, Megan W., Monica E. Lemmon, Carolyn E. Pizoli, Margarita Bidegain, Veeral N. Tolia, C Michael Cotten, and Rachel G. Greenberg. “Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates.” J Perinatol 40, no. 1 (January 2020): 79–88. https://doi.org/10.1038/s41372-019-0533-4.

Full Text

McGowan, Elisabeth C., Abbot R. Laptook, Jean Lowe, Myriam Peralta-Carcelen, Dhuly Chowdhury, Rosemary D. Higgins, Susan R. Hintz, Betty R. Vohr, and Betty R. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. “Developmental Outcomes of Extremely Preterm Infants with a Need for Child Protective Services Supervision.” J Pediatr 215 (December 2019): 41-49.e4. https://doi.org/10.1016/j.jpeds.2019.07.063.

Full Text

Hansen, Adam W., Mullai Murugan, He Li, Michael M. Khayat, Liwen Wang, Jill Rosenfeld, B Kim Andrews, et al. “A Genocentric Approach to Discovery of Mendelian Disorders.” Am J Hum Genet 105, no. 5 (November 7, 2019): 974–86. https://doi.org/10.1016/j.ajhg.2019.09.027.

Full Text

Gonski, Samantha, Susan R. Hupp, C Michael Cotten, Reese H. Clark, Matthew Laughon, Kevin Watt, Christoph P. Hornik, Karan Kumar, P Brian Smith, and Rachel G. Greenberg. “Risk of development of treated retinopathy of prematurity in very low birth weight infants.” J Perinatol 39, no. 11 (November 2019): 1562–68. https://doi.org/10.1038/s41372-019-0487-6.

Full Text

Edwards, Laura, C Michael Cotten, P Brian Smith, Ronald Goldberg, Shampa Saha, Abhik Das, Abbot R. Laptook, et al. “Inadequate oral feeding as a barrier to discharge in moderately preterm infants.” J Perinatol 39, no. 9 (September 2019): 1219–28. https://doi.org/10.1038/s41372-019-0422-x.

Full Text

Pages