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Charles Michael Cotten, MD

Professor of Pediatrics
Chief, Division of Pediatric Neonatology
Campus mail: 2424 Erwin Rd Suite 504, Durham, NC 27710
Phone: (919) 681-6035
Email address: michael.cotten@duke.edu

I am involved in 4 major areas of research:
1) Neuroprotection. Working with colleagues from Cell Therapies, we have added to Duke's experience participating in pivotal trials of hypothermia for term newborns with moderate to severe hypoxic-ischemic encephalopathy (HIE) by completing a phase I study of autologous cord blood cells for these infants, and developing and currently leading a multicenter, double-blind randomized clinical trial of autologous cord blood cells or placebo in term infants with moderate or severe HIE. We are currently initiating, w/ funding from Duke's CTSI support, the first phase I single center study of allogeneic cord tissue derived mesenchymal stromal cells for newborns with moderate or severe HIE who do not have autologous cells available.
2) Genomics. We at Duke have been in the NICHD Neonatal Research Network (NRN) since 2001. I led the NRN's development of an Anonymized DNA bank of samples collected from 1,000 extremely low birthweight infants, with phenotype information linked to the samples. This resource has been the basis for multiple candidate gene, and genome wide scan analysis, and has identified variants associated with severe retinopathy of prematurity and necrotizing enterocolitis.  
3) New Technologies: I have collaborated with Drs. David Millington from Duke and Vamsee Pamula (a Duke Pratt School graduate), from BAEBIES Inc, on prototype new technology devices for use in newborn screening for lysosomal storage disease as well as multiplex chips for screening for hyperbilirubinemia and related conditions, as well as working with Dr. Pamula and Dr. Michael Freemark (Peds Endocrinology) on screening panels for hypoglycemia and hypothyroidism, and with investigators from UAB on an Acute Kidney Injury panel. Also, I am collaborating with Dr. Cynthia Toth in pediatric ophthalmology, and Pratt School investigators to develop and apply use of optical coherence tomography for retinal imaging that will assess associations between retinal neurovascular development, brain development, and neurodevelopmental outcomes. I am also currently working with the Duke FORGE and multiple Pediatric subspecialists on machine-learning and deep informatics analysis of electronic health records to quantify risk for subsequent complications and on development of algorithms to identify neonatal seizures from neonatal EEG tracings. 
4)Microbiome in Micropreemies and health outcomes of periviable infants.  I have worked with multiple epidemiology researchers to assess practice variation within our center, and within the Neonatal Research Network centers, to identify how variation in practice can influence outcomes, with a particular focus on antibiotic use. This work demonstrated strong associations between high empirical antibiotic use in infants with sterile cultures and subsequent morbidities and mortality. This discovery has led to strong collaborations and new initiatives by young faculty leading studies of the evolving microbiome, leading to hypothesis generation re: the microbiome and optimal growth in extremely preterm infants.

Education and Training

  • Intern and Resident, Pediatrics, University of Miami, 1986 - 1989
  • M.H.S., Duke University School of Medicine, 2006
  • M.D., University of Miami, 1986

Selected Grants and Awards

Publications

Romaine, A, Clark, RH, Davis, BR, Hendershot, K, Kite, V, Laughon, M, Updike, I, Miranda, ML, Meier, PP, Patel, AL, Smith, PB, Cotten, CM, Benjamin, DK, and Greenberg, RG. "Predictors of Prolonged Breast Milk Provision to Very Low Birth Weight Infants." The Journal of Pediatrics 202 (November 2018): 23-30.e1.

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Hamvas, A, Feng, R, Bi, Y, Wang, F, Bhattacharya, S, Mereness, J, Kaushal, M, Cotten, CM, Ballard, PL, Mariani, TJ, and PROP Investigators, . "Exome sequencing identifies gene variants and networks associated with extreme respiratory outcomes following preterm birth." Bmc Genetics 19, no. 1 (October 20, 2018): 94-null.

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Shankaran, S, Bell, EF, Laptook, AR, Saha, S, Newman, NS, Kazzi, SNJ, Barks, J, Stoll, BJ, Bara, R, Gabrio, J, Childs, K, Das, A, Higgins, RD, Carlo, WA, Sánchez, PJ, Carlton, DP, Pavageau, L, Malcolm, WF, D'Angio, CT, Ohls, RK, Poindexter, BB, Sokol, GM, Van Meurs, KP, Colaizy, TT, Khmour, A, Puopolo, KM, Garg, M, Walsh, MC, Eunice Kennedy Shriver National Institute of Child Health, and and Human Development Neonatal Research Network, . "Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized Clinical Trial." The Journal of Pediatrics (October 15, 2018).

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Phelps, DL, Watterberg, KL, Nolen, TL, Cole, CA, Cotten, CM, Oh, W, Poindexter, BB, Zaterka-Baxter, KM, Das, A, Lacy, CB, Scorsone, AM, Walsh, MC, Bell, EF, Kennedy, KA, Schibler, K, Sokol, GM, Laughon, MM, Lakshminrusimha, S, Truog, WE, Garg, M, Carlo, WA, Laptook, AR, Van Meurs, KP, Carlton, DP, Graf, A, DeMauro, SB, Brion, LP, Shankaran, S, Orge, FH, Olson, RJ, Mintz-Hittner, H, Yang, MB, Haider, KM, Wallace, DK, Chung, M, Hug, D, Tsui, I, Cogen, MS, Donahue, JP, Gaynon, M, Hutchinson, AK, Bremer, DL, Quinn, G, He, Y-G, Lucas, WR, Winter, TW, Kicklighter, SD, Kumar, K, Chess, PR, Colaizy, TT, Hibbs, AM, Ambalavanan, N, Harmon, HM, McGowan, EC, Higgins, RD, and Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, . "Effects of Myo-inositol on Type 1 Retinopathy of Prematurity Among Preterm Infants

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Herrera, TI, Edwards, L, Malcolm, WF, Smith, PB, Fisher, KA, Pizoli, C, Gustafson, KE, Goldstein, RF, Cotten, CM, Goldberg, RN, and Bidegain, M. "Outcomes of preterm infants treated with hypothermia for hypoxic-ischemic encephalopathy." Early Human Development 125 (October 2018): 1-7.

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Gray, KD, Dudash, K, Escobar, C, Freel, C, Harrison, T, McMillan, C, Puia-Dumitrescu, M, Cotten, CM, Benjamin, R, Clark, RH, Benjamin, DK, Greenberg, RG, and Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee, . "Prevalence and safety of diazoxide in the neonatal intensive care unit." Journal of Perinatology : Official Journal of the California Perinatal Association (September 11, 2018).

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Tran-Viet, D, Wong, BM, Mangalesh, S, Maldonado, R, Cotten, CM, and Toth, CA. "HANDHELD SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING THROUGH THE UNDILATED PUPIL IN INFANTS BORN PRETERM OR WITH HYPOXIC INJURY OR HYDROCEPHALUS." Retina (Philadelphia, Pa.) 38, no. 8 (August 2018): 1588-1594.

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Hintz, SR, Vohr, BR, Bann, CM, Taylor, HG, Das, A, Gustafson, KE, Yolton, K, Watson, VE, Lowe, J, DeAnda, ME, Ball, MB, Finer, NN, Van Meurs, KP, Shankaran, S, Pappas, A, Barnes, PD, Bulas, D, Newman, JE, Wilson-Costello, DE, Heyne, RJ, Harmon, HM, Peralta-Carcelen, M, Adams-Chapman, I, Duncan, AF, Fuller, J, Vaucher, YE, Colaizy, TT, Winter, S, McGowan, EC, Goldstein, RF, Higgins, RD, and SUPPORT study group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, . "Preterm Neuroimaging and School-Age Cognitive Outcomes." Pediatrics 142, no. 1 (July 2018).

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Blaisdell, CJ, Troendle, J, Zajicek, A, Chougnet, C, Greenberg, JM, Hardie, W, Jobe, AH, McDowell, K, Ferkol, T, Holland, MR, Kemp, J, Levy, PT, Tarr, P, Singh, GK, Warner, B, Hamvas, A, Ballard, PL, Ballard, RA, Keller, RL, Khan, AM, Lusk, L, Nielson, DW, Rogers, EE, Durand, DJ, Merrill, JD, Eichenwald, EC, Fike, C, Hartert, T, Moore, P, Aschner, J, Guthrie, S, Maitre, N, Summar, M, D'Angio, C, Kumar, V, Mariani, T, Pryhuber, G, Reynolds, AM, Scheible, K, Stevens, T, Ren, C, Ryan, RM, Cotten, CM, Fisher, K, Sharp, J, Voynow, JA, Davis, S, Poindexter, B, Ellenberg, J, Feng, R, Fernando, M, Panitch, H, Schmidt, B, Shaw, P, Bellamy, S, and Taussig, LM. "Acute Responses to Diuretic Therapy in Extremely Low Gestational Age Newborns: Results from the Prematurity and Respiratory Outcomes Program Cohort Study." The Journal of Pediatrics 197 (June 2018): 42-47.e1.

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Jilling, T, Ambalavanan, N, Cotten, CM, Martin, CA, Maheshwari, A, Schibler, K, Levy, J, and Page, GP. "Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8." Pediatric Research 83, no. 5 (May 16, 2018): 943-953.

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