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Ann Marie Reed, MD

William Cleland Professor of Pediatrics
Professor of Pediatrics
Chair of the Department of Pediatrics
Email address: ann.reed@duke.edu

I have spent my career caring for children with autoimmune disorders and immune dysfunction.  I have focused my work caring for children with juvenile dermatomyositis and auto inflammatory disorders.  I have overseen a research program for 24 years studying the  genetics and cause of human autoimmune disease, focused on dermatomyositis in children and adults. The long-term goal of my research team is to develop new biomarkers of diseases to identify those predisposed to develop disease, as well as monitor disease activity and response to treatment. My team makes extensive use of genomics, gene expression, protein expression and immunohistochemical techniques to study the inflammatory and non-inflammatory aspects of dermatomyositis diseases. Other autoimmune disease processes, including systemic lupus and vasculitis, have been focused on as well.

Education and Training

  • Fellowship, Molecular Genetics, University of Chicago, 1988 - 1990
  • Immunology/Rheumatology Fellowship, Department Of Pediatrics, Northwestern University Feinberg School of Medicine, 1987 - 1990
  • Residency, Department Of Pediatrics, Akron Children's Hospital, 1984 - 1987
  • M.D., Medical College of Ohio, 1984

Publications

McCann, LJ, Pilkington, CA, Huber, AM, Ravelli, A, Appelbe, D, Kirkham, JJ, Williamson, PR, Aggarwal, A, Christopher-Stine, L, Constantin, T, Feldman, BM, Lundberg, I, Maillard, S, Mathiesen, P, Murphy, R, Pachman, LM, Reed, AM, Rider, LG, van Royen-Kerkof, A, Russo, R, Spinty, S, Wedderburn, LR, and Beresford, MW. "Development of a consensus core dataset in juvenile dermatomyositis for clinical use to inform research. (Accepted)" Annals of the rheumatic diseases 77, no. 2 (February 2018): 241-250.

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Lundberg, IE, Tjärnlund, A, Bottai, M, Werth, VP, Pilkington, C, Visser, MD, Alfredsson, L, Amato, AA, Barohn, RJ, Liang, MH, Singh, JA, Aggarwal, R, Arnardottir, S, Chinoy, H, Cooper, RG, Dankó, K, Dimachkie, MM, Feldman, BM, Torre, IG-DL, Gordon, P, Hayashi, T, Katz, JD, Kohsaka, H, Lachenbruch, PA, Lang, BA, Li, Y, Oddis, CV, Olesinska, M, Reed, AM, Rutkowska-Sak, L, Sanner, H, Selva-O'Callaghan, A, Song, Y-W, Vencovsky, J, Ytterberg, SR, Miller, FW, and Rider, LG et al. "2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups." Annals of the rheumatic diseases 76, no. 12 (December 2017): 1955-1964.

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Lundberg, IE, Tjärnlund, A, Bottai, M, Werth, VP, Pilkington, C, de Visser, M, Alfredsson, L, Amato, AA, Barohn, RJ, Liang, MH, Singh, JA, Aggarwal, R, Arnardottir, S, Chinoy, H, Cooper, RG, Dankó, K, Dimachkie, MM, Feldman, BM, Garcia-De La Torre, I, Gordon, P, Hayashi, T, Katz, JD, Kohsaka, H, Lachenbruch, PA, Lang, BA, Li, Y, Oddis, CV, Olesinska, M, Reed, AM, Rutkowska-Sak, L, Sanner, H, Selva-O'Callaghan, A, Song, Y-W, Vencovsky, J, Ytterberg, SR, Miller, FW, and Rider, LG et al. "2017 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups." Arthritis & rheumatology (Hoboken, N.J.) 69, no. 12 (December 2017): 2271-2282.

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Challa, D, Crowson, CS, Niewold, TB, Reed, AM, and CARRA Legacy Registry Investigators, . "Predictors of changes in disease activity among children with juvenile dermatomyositis enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry." Clinical rheumatology (November 23, 2017).

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Rider, LG, Ruperto, N, Pistorio, A, Erman, B, Bayat, N, Lachenbruch, PA, Rockette, H, Feldman, BM, Huber, AM, Hansen, P, Oddis, CV, Lundberg, IE, Amato, AA, Chinoy, H, Cooper, RG, Chung, L, Danko, K, Fiorentino, D, García-De la Torre, I, Reed, AM, Wook Song, Y, Cimaz, R, Cuttica, RJ, Pilkington, CA, Martini, A, van der Net, J, Maillard, S, Miller, FW, Vencovsky, J, and Aggarwal, R et al. "2016 ACR-EULAR adult dermatomyositis and polymyositis and juvenile dermatomyositis response criteria-methodological aspects." Rheumatology (Oxford, England) 56, no. 11 (November 2017): 1884-1893.

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Moore, K, Fritzler, MJ, Klein-Gitelman, MS, Reed, AM, Lee, T, and Stevens, A. "Plasma CXCL4 As a Biomarker in Juvenile Systemic Sclerosis." October 2017.

Scholars@Duke

Deakin, C, Bowes, J, Marshall, L, Johnson, C, Mamyrova, G, Curiel, R, Rouster-Stevens, KA, Schmeling, H, Huber, A, Feldman, BM, Reed, AM, Pachman, LM, Raychaudhuri, S, Eyre, S, and Wedderburn, LR. "The Interaction between Genetic Risk Factors and Age of Disease Onset in Juvenile Dermatomyositis." October 2017.

Scholars@Duke

Aggarwal, R, Rider, LG, Ruperto, N, Bayat, N, Erman, B, Feldman, BM, Oddis, CV, Amato, AA, Chinoy, H, Cooper, RG, Dastmalchi, M, Fiorentino, D, Isenberg, D, Katz, JD, Mammen, A, de Visser, M, Ytterberg, SR, Lundberg, IE, Chung, L, Danko, K, García-De la Torre, I, Song, YW, Villa, L, Rinaldi, M, Rockette, H, Lachenbruch, PA, Miller, FW, Vencovsky, J, and International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation, . "2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative." Arthritis & rheumatology (Hoboken, N.J.) 69, no. 5 (May 2017): 898-910.

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Rider, LG, Aggarwal, R, Pistorio, A, Bayat, N, Erman, B, Feldman, BM, Huber, AM, Cimaz, R, Cuttica, RJ, de Oliveira, SK, Lindsley, CB, Pilkington, CA, Punaro, M, Ravelli, A, Reed, AM, Rouster-Stevens, K, van Royen-Kerkhof, A, Dressler, F, Magalhaes, CS, Constantin, T, Davidson, JE, Magnusson, B, Russo, R, Villa, L, Rinaldi, M, Rockette, H, Lachenbruch, PA, Miller, FW, Vencovsky, J, and Ruperto, N et al. "2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative." Arthritis & rheumatology (Hoboken, N.J.) 69, no. 5 (May 2017): 911-923.

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Rider, LG, Aggarwal, R, Pistorio, A, Bayat, N, Erman, B, Feldman, BM, Huber, AM, Cimaz, R, Cuttica, RJ, de Oliveira, SK, Lindsley, CB, Pilkington, CA, Punaro, M, Ravelli, A, Reed, AM, Rouster-Stevens, K, van Royen-Kerkhof, A, Dressler, F, Saad Magalhaes, C, Constantin, T, Davidson, JE, Magnusson, B, Russo, R, Villa, L, Rinaldi, M, Rockette, H, Lachenbruch, PA, Miller, FW, Vencovsky, J, and Ruperto, N et al. "2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative." Annals of the rheumatic diseases 76, no. 5 (May 2017): 782-791.

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