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Ann Marie Reed, MD

Samuel L. Katz Professor of Pediatrics
Professor of Pediatrics
Chair of the Department of Pediatrics
Email address: ann.reed@duke.edu

I have spent my career caring for children with autoimmune disorders and immune dysfunction.  I have focused my work caring for children with juvenile dermatomyositis and auto inflammatory disorders.  I have overseen a research program for 24 years studying the  genetics and cause of human autoimmune disease, focused on dermatomyositis in children and adults. The long-term goal of my research team is to develop new biomarkers of diseases to identify those predisposed to develop disease, as well as monitor disease activity and response to treatment. My team makes extensive use of genomics, gene expression, protein expression and immunohistochemical techniques to study the inflammatory and non-inflammatory aspects of dermatomyositis diseases. Other autoimmune disease processes, including systemic lupus and vasculitis, have been focused on as well.

Education and Training

  • Fellowship, Molecular Genetics, University of Chicago, 1988 - 1990
  • Immunology/Rheumatology Fellowship, Department Of Pediatrics, Northwestern University Feinberg School of Medicine, 1987 - 1990
  • Residency, Department Of Pediatrics, Akron Children's Hospital, 1984 - 1987
  • M.D., Medical College of Ohio, 1984

Publications

Rothwell, Simon, Hector Chinoy, Janine A. Lamb, Frederick W. Miller, Lisa G. Rider, Lucy R. Wedderburn, Neil J. McHugh, et al. “Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups..” Ann Rheum Dis 78, no. 7 (July 2019): 996–1002. https://doi.org/10.1136/annrheumdis-2019-215046.

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Reed, Ann Marie, Cynthia S. Crowson, and Jeffrey Arthur Dvergsten. “A Path to Prediction of Outcomes in Juvenile Idiopathic Inflammatory Myopathy..” Front Immunol 10 (2019). https://doi.org/10.3389/fimmu.2019.00638.

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Stevens, Brandi E., Kathryn S. Torok, Suzanne C. Li, Nicole Hershey, Megan Curran, Gloria C. Higgins, Katharine F. Moore, et al. “Clinical Characteristics and Factors Associated With Disability and Impaired Quality of Life in Children With Juvenile Systemic Sclerosis: Results From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry..” Arthritis Care Res (Hoboken) 70, no. 12 (December 2018): 1806–13. https://doi.org/10.1002/acr.23547.

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Houtman, Miranda, Louise Ekholm, Espen Hesselberg, Karine Chemin, Vivianne Malmström, Ann M. Reed, Ingrid E. Lundberg, and Leonid Padyukov. “T-cell transcriptomics from peripheral blood highlights differences between polymyositis and dermatomyositis patients..” Arthritis Res Ther 20, no. 1 (August 29, 2018). https://doi.org/10.1186/s13075-018-1688-7.

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Hinks, Anne, Miranda C. Marion, Joanna Cobb, Mary E. Comeau, Marc Sudman, Hannah C. Ainsworth, John Bowes, et al. “Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis..” Arthritis Rheumatol 70, no. 6 (June 2018): 957–62. https://doi.org/10.1002/art.40443.

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Rider, Lisa G., Rohit Aggarwal, Pedro M. Machado, Jean-Yves Hogrel, Ann M. Reed, Lisa Christopher-Stine, and Nicolino Ruperto. “Update on outcome assessment in myositis..” Nat Rev Rheumatol 14, no. 5 (May 2018): 303–18. https://doi.org/10.1038/nrrheum.2018.33.

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Challa, Divya, Cynthia S. Crowson, Timothy B. Niewold, Ann M. Reed, and Ann M. CARRA Legacy Registry Investigators. “Predictors of changes in disease activity among children with juvenile dermatomyositis enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry..” Clin Rheumatol 37, no. 4 (April 2018): 1011–15. https://doi.org/10.1007/s10067-017-3901-5.

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Samad, A., M. L. Stoll, I. Lavi, J. J. Hsu, V. Strand, T. N. Robinson, E. D. Mellins, et al. “Adiposity in juvenile psoriatic arthritis.” Journal of Rheumatology 45, no. 3 (March 1, 2018): 411–18. https://doi.org/10.3899/jrheum.170598.

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Rubinstein, Tamar B., Wenzhu B. Mowrey, Norman T. Ilowite, Dawn M. Wahezi, and Dawn M. Childhood Arthritis and Rheumatology Research Alliance INVESTIGATORS. “Delays to Care in Pediatric Lupus Patients: Data From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry..” Arthritis Care Res (Hoboken) 70, no. 3 (March 2018): 420–27. https://doi.org/10.1002/acr.23285.

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McCann, Liza J., Clarissa A. Pilkington, Adam M. Huber, Angelo Ravelli, Duncan Appelbe, Jamie J. Kirkham, Paula R. Williamson, et al. “Development of a consensus core dataset in juvenile dermatomyositis for clinical use to inform research..” Ann Rheum Dis 77, no. 2 (February 2018): 241–50. https://doi.org/10.1136/annrheumdis-2017-212141.

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