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Andrew Paul Landstrom, MD, PhD

Assistant Professor of Pediatrics
Assistant Professor in Cell Biology
Campus mail: Duke University Medical Center, Box 2652, Durham, NC 27710
Phone: (919) 684-3028
Email address: andrew.landstrom@duke.edu

I am a pediatric cardiologist and cardiovascular geneticist with both clinical and research interests in the genetic and molecular mechanisms of sudden cardiac arrest in children.  As a physician-scientist, I am trained at the confluence of pediatric cardiology, clinical electrophysiology, human genetics, and molecular biology which I apply towards the care for children with heritable arrhythmic disease of the heart.  I run a basic science research lab exploring the genetic and molecular causes of sudden cardiac death in children and young adults. These include cardiomyopathies (hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular dysplasia/cardiomyopathy) and channelopathies (long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome).  In our lab, we utilize human induced pluripotent stem cells, mouse models, and in vitro cellular models of disease.  Further, I have an active translational research interest in the interpretation of cardiovascular genetic testing and clarifying “variants of unknown significance”.   Overall, I hope to 1) utilize human genetics and functional genomics to more accurately diagnosis, risk stratify, and treat children and young adults at risk for these diseases and 2) determine the underlying molecular mechanisms of these complex and deadly diseases to identify novel patient-specific therapies.

Education and Training

  • Pediatric Cardiology Certification, American Board of Pediatrics, 2018 - 2099
  • Advanced Clinical Fellowship, Pediatrics/Electrophysiology, Baylor College of Medicine, 2017 - 2018
  • General Pediatrics Certification, American Board of Pediatrics, 2015 - 2099
  • Clinical Fellowship, Pediatrics/Cardiology, Baylor College of Medicine, 2014 - 2017
  • Post-Doctoral Research Fellowship, Molecular Physiology And Biophysics, Baylor College of Medicine, 2013 - 2018
  • Residency, Pediatrics, Baylor College of Medicine, 2013 - 2014
  • Internship, Pediatrics, Baylor College of Medicine, 2012 - 2013
  • Ph.D., Mayo School of Health Sciences, 2012
  • M.D., Mayo School of Health Sciences, 2012

Publications

Jones, Edward G., Neda Mazaheri, Reza Maroofian, Mina Zamani, Tahereh Seifi, Alireza Sedaghat, Gholamreza Shariati, et al. “Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy..” Sci Rep 9, no. 1 (June 21, 2019). https://doi.org/10.1038/s41598-019-44987-6.

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Headrick, Andrew T., Jill A. Rosenfeld, Yaping Yang, Hari Tunuguntla, Hugh D. Allen, Daniel J. Penny, Jeffrey J. Kim, and Andrew P. Landstrom. “Incidentally identified genetic variants in arrhythmogenic right ventricular cardiomyopathy-associated genes among children undergoing exome sequencing reflect healthy population variation..” Mol Genet Genomic Med 7, no. 6 (June 2019). https://doi.org/10.1002/mgg3.593.

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Jones, Edward G., and Andrew P. Landstrom. “Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation..” J Vis Exp, no. 143 (January 16, 2019). https://doi.org/10.3791/58907.

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Connell, Patrick S., Aamir Jeewa, Debra L. Kearney, Hari Tunuguntla, Susan W. Denfield, Hugh D. Allen, and Andrew P. Landstrom. “A 14-year-old in heart failure with multiple cardiomyopathy variants illustrates a role for signal-to-noise analysis in gene test re-interpretation..” Clinical Case Reports 7, no. 1 (January 2019): 211–17. https://doi.org/10.1002/ccr3.1920.

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Valdés, Santiago O., Christina Y. Miyake, Mary C. Niu, Caridad M. de la Uz, S Yukiko Asaki, Andrew P. Landstrom, Andrew E. Schneider, et al. “Early experience with intravenous sotalol in children with and without congenital heart disease..” Heart Rhythm 15, no. 12 (December 2018): 1862–69. https://doi.org/10.1016/j.hrthm.2018.07.010.

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Dailey-Schwartz, Andrew L., Hanna J. Tadros, Mahshid Sababi Azamian, Seema R. Lalani, Shaine A. Morris, Hugh D. Allen, Jeffrey J. Kim, and Andrew P. Landstrom. “Copy Number Variants of Undetermined Significance Are Not Associated with Worse Clinical Outcomes in Hypoplastic Left Heart Syndrome..” J Pediatr 202 (November 2018): 206-211.e2. https://doi.org/10.1016/j.jpeds.2018.07.022.

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Valdés, Santiago O., Andrew P. Landstrom, Andrew E. Schneider, Christina Y. Miyake, Caridad M. de la Uz, and Jeffrey J. Kim. “Intravenous sotalol for the management of postoperative junctional ectopic tachycardia..” Heartrhythm Case Rep 4, no. 8 (August 2018): 375–77. https://doi.org/10.1016/j.hrcr.2018.05.007.

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Landstrom, Andrew P., Ernesto Fernandez, Jill A. Rosenfeld, Yaping Yang, Andrew L. Dailey-Schwartz, Christina Y. Miyake, Hugh D. Allen, Daniel J. Penny, and Jeffrey J. Kim. “Amino acid-level signal-to-noise analysis of incidentally identified variants in genes associated with long QT syndrome during pediatric whole exome sequencing reflects background genetic noise..” Heart Rhythm 15, no. 7 (July 2018): 1042–50. https://doi.org/10.1016/j.hrthm.2018.02.031.

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Hildebrandt, Michelle A. T., Monica Reyes, Xifeng Wu, Xia Pu, Kara A. Thompson, Jianzhong Ma, Andrew P. Landstrom, Alanna C. Morrison, and Joann L. Ater. “Hypertension Susceptibility Loci are Associated with Anthracycline-related Cardiotoxicity in Long-term Childhood Cancer Survivors..” Sci Rep 7, no. 1 (August 29, 2017). https://doi.org/10.1038/s41598-017-09517-2.

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Landstrom, Andrew P., Dobromir Dobrev, and Xander H. T. Wehrens. “Calcium Signaling and Cardiac Arrhythmias..” Circ Res 120, no. 12 (June 9, 2017): 1969–93. https://doi.org/10.1161/CIRCRESAHA.117.310083.

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