Welcome to the Jiang Lab. We are part of the Division of Medical Genetics in the Department of Pediatrics as well as graduate programs in Neurobiology, Genetics and Genomics, and Cellular and Molecular Biology in the Duke University School of Medicine.
The research in the Jiang Lab is directed at understanding the genetic and epigenetic basis of human diseases with a focus on genomic imprinting disorders of Angelman and Prader-Willi syndrome as well as autism spectrum disorders. Angelman syndrome and Prader-Willi syndrome are two of the best examples of genomic imprinting disorders caused by the defect of an imprinting domain in the human chromosome 15q11-q13 region. Autism spectrum disorders are neurodevelopmental disorders that affect one out of 88 children. The core symptoms of autism spectrum disorders are impairment in communication and language development, social interaction, and stereotyped behaviors. Although the strong genetic etiology is implicated in autism spectrum disorders, the molecular basis for the majority of individuals with autism spectrum disorders remains unknown. From lessons learned from the genomic imprinting disorder of Angelman syndrome, we hypothesize that both genetic and epigenetic defects in genes encoding synaptic proteins contribute to the susceptibility of autism spectrum disorders.
Current areas of research focus on the genetics of autism spectrum disorders (ASD), autism mouse models, and epigenetics in brain function and neurodevelopmental disorders.
- Autism linked protein crucial for feeling pain
(Duke Today, 12.01.2016)