Genes and Biology
Identification of Molecular Signatures of Disease in Umbilical Cord Blood
Many common chronic diseases originate with exposures in the prenatal period.
Identify molecular signatures in cord blood that predict the development of disease in childhood/early adulthood.
We will link Carolinas Cord Blood Bank (CCBB) donors with their electronic health records in order to identify donors with different disease states. We will then use ‘omics approaches to identify molecular signatures associated with these disease states.
- Gain new insights into fetal origins of disease
- Develop new early life diagnostics and therapeutics
- Do immune cell populations in cord blood predict development of asthma and/or allergy?
- Do cord blood molecular signatures of children with type 1 diabetes suggest potential therapeutic strategies?
- Do maternal infections or environmental exposures increase the risk of developing autism?
|Disease||Estimated number of affected CCBB donors|
|Congenital heart disease||400|
|Type 1 diabetes||142|