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HOPE 1000: A mother-infant cohort study and biobanking initiative

Friday, October 19, 2018
Mother and infant

The first 1000 days of life profoundly influence later health and disease; however, there are few cohorts that have investigated maternal and fetal/infant exposures over that time period. The Children's Health & Discovery Initiative (CHDI) is preparing to launch a cohort study of 1000 mother-infant pairs, known as the HOPE 1000 study. Biospecimens will be collected each trimester of pregnancy, at delivery, 4-6 weeks postpartum, and at regular intervals over the first 2 years of a participating infant’s life. Data on health, socioeconomic factors, and environmental exposures will be collected beginning in pregnancy through the second year of life and beyond.

HOPE 1000 is designed as a backbone study - investigators may design additional protocols or develop studies that utilize the data and biospecimens collected as part of HOPE 1000. If you are interested in developing a related study, or would like to learn more about HOPE 1000, please email

Learn more about CHDI