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William J. Steinbach, MD

Samuel L. Katz Distinguished Professor of Pediatrics
Professor of Pediatrics
Chief, Division of Pediatric Infectious Diseases
Professor in Molecular Genetics and Microbiology
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: Box 3499 Med Ctr, Durham, NC 27710
Phone: (919) 681-1504
Email address: bill.steinbach@duke.edu

My overall clinical and research focus is to improve the diagnosis, treatment, and outcomes of immunocompromised patients, specifically those with invasive fungal infections.  My research enterprise is divided between my basic, translational, and clinical approaches.  My laboratory focuses on the molecular pathogenesis of Aspergillus fumigatus, a leading invasive fungal killer, and the development of novel antifungal drugs and diagnostic assays.  I also oversee numerous translational and clinical research studies centered on several diagnostic and therapeutic aspects of invasive fungal infections and other infections in immunocompromised patients.  

My laboratory (www.steinbachlab.org) work is very translational in nature by design – all of it is performed with the specific goal of directly improving our fundamental understanding of how and why Aspergillus fumigatus, a leading killer in patients with cancer or following transplantation, is so deadly and how to best prevent and treat it. Our laboratory uses molecular genetic tools to delete or mutate pathogenesis genes and proteins to analyze their function and role in disease, including various genomic, proteomic, structural biologic and biochemical approaches. We also perform extensive in vitro and in vivo testing of antifungal compounds . Since we are focused on the pathogenesis, we utilize numerous different animal models specifically designed to mimic the immune system of a cancer patient or transplant recipient.

I am also the Chief of Pediatric Infectious Diseases and my clinical research includes my founding and directing the International Pediatric Fungal Network (www.ipfn.org), a 55-site multinational NIH-funded consortium dedicated to the epidemiology, diagnosis, treatment, and outcomes of pediatric invasive fungal infections.  This Network is the largest of its kind in the world and is currently leading three NIH-funded global clinical studies that will allow us to generate the first ever pediatric-specific international guidelines for these diseases.

I am the co-founder and continuing co-chair of the past nine Advances Against Aspergillosis adn Mucormycosis international conferences, the leading forum for these deadly diseases and most recently at https://aaam2020.org.  I have co-edited 12 infectious diseases textbooks, including as co-editor of the largest textbook in the field, Aspergillus fumigatus and Aspergillosis, Feigin & Cherry's Textbook of Pediatric Infectious Diseases (approx. 4,000 pages), the American Academy of Pediatrics Nelson's Pediatric Antimicrobial Therapy textbook, and most recently as the lead editor of the only textbook in the subfield Pediatric Transplant and Oncology Infectious Diseases.

I am the Basic Science Research Director for the Duke Transplant Center, and Medical Director of the Duke Children’s Clinical Research Unit overseeing 813 studies.  I am a member of the American Academy of Pediatrics Red Book committee, and recently completed a Board of Directors tenure for the Pediatric Infectious Diseases Society, where I currently chair the Division Chief working group.  I am a fellow of the American Association for the Advancement of Science and have been elected into the American Society for Clinical Investigation and the Association of American Physicians, for which I currently serve on the Council. 

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 2001 - 2004
  • Resident, Pediatrics, Stanford University, 1998 - 2001
  • M.D., University of North Carolina - Chapel Hill, 1998

Selected Grants and Awards

Publications

Sugui, Janyce A., Kyung J. Kwon-Chung, Praveen R. Juvvadi, Jean-Paul Latgé, and William J. Steinbach. “Aspergillus fumigatus and related species.” Cold Spring Harb Perspect Med 5, no. 2 (November 6, 2014): a019786. https://doi.org/10.1101/cshperspect.a019786.

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Juvvadi, Praveen R., Frédéric Lamoth, and William J. Steinbach. “Calcineurin as a Multifunctional Regulator: Unraveling Novel Functions in Fungal Stress Responses, Hyphal Growth, Drug Resistance, and Pathogenesis.” Fungal Biol Rev 28, no. 2–3 (October 2014): 56–69. https://doi.org/10.1016/j.fbr.2014.02.004.

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Lamoth, Frédéric, Praveen R. Juvvadi, Christopher Gehrke, Yohannes G. Asfaw, and William J. Steinbach. “Transcriptional activation of heat shock protein 90 mediated via a proximal promoter region as trigger of caspofungin resistance in Aspergillus fumigatus.” J Infect Dis 209, no. 3 (February 1, 2014): 473–81. https://doi.org/10.1093/infdis/jit530.

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Lamoth, F., P. R. Juvvadi, and W. J. Steinbach. “Heat Shock Protein 90 (Hsp90) in Fungal Growth and Pathogenesis.” Current Fungal Infection Reports 8, no. 4 (January 1, 2014): 296–301. https://doi.org/10.1007/s12281-014-0195-9.

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Lamoth, Frédéric, Praveen R. Juvvadi, Erik J. Soderblom, M Arthur Moseley, Yohannes G. Asfaw, and William J. Steinbach. “Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus.” Antimicrob Agents Chemother 58, no. 4 (2014): 1889–96. https://doi.org/10.1128/AAC.02286-13.

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Siberry, G. K., M. J. Abzug, S. Nachman, W. J. Steinbach, M. B. Kleiman, A. Gaur, P. Flynn, et al. “Executive summary: Guidelines for the prevention and treatment of opportunistic infections in HIV-exposed and HIV-infected children: Recommendations from the national institutes of health, the centers for disease control and prevention, the HIV medicine association of the infectious diseases society of America, the pediatric infectious diseases society, and the American academy of pediatrics.” Journal of the Pediatric Infectious Diseases Society 2, no. 4 (December 1, 2013): 293–308. https://doi.org/10.1093/jpids/pit074.

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Muszkieta, L., W. J. Steinbach, and J. P. Latge. “Genetic, Genomic, and Molecular Approaches to Define Virulence of Aspergillus Fumigatus.” In Evolution of Virulence in Eukaryotic Microbes, 501–17, 2013. https://doi.org/10.1002/9781118308165.ch27.

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Steinbach, William J. “Are we there yet? Recent progress in the molecular diagnosis and novel antifungal targeting of Aspergillus fumigatus and invasive aspergillosis.” Plos Pathog 9, no. 10 (October 2013): e1003642. https://doi.org/10.1371/journal.ppat.1003642.

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Juvvadi, Praveen Rao, Detti Belina, Erik J. Soderblom, M Arthur Moseley, and William J. Steinbach. “Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus.” Biochem Biophys Res Commun 431, no. 3 (February 15, 2013): 547–53. https://doi.org/10.1016/j.bbrc.2013.01.020.

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Lamoth, Frédéric, Praveen R. Juvvadi, Christopher Gehrke, and William J. Steinbach. “In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains.” Antimicrob Agents Chemother 57, no. 2 (February 2013): 1035–39. https://doi.org/10.1128/AAC.01857-12.

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