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William J. Steinbach, MD

Samuel L. Katz Distinguished Professor of Pediatrics
Professor of Pediatrics
Chief, Division of Pediatric Infectious Diseases
Professor in Molecular Genetics and Microbiology
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: Box 3499 Med Ctr, Durham, NC 27710
Phone: (919) 681-1504
Email address:

My overall clinical and research focus is to improve the diagnosis, treatment, and outcomes of immunocompromised patients, specifically those with invasive fungal infections.  My research enterprise is divided between my basic, translational, and clinical approaches.  My laboratory focuses on the molecular pathogenesis of Aspergillus fumigatus, a leading invasive fungal killer, and the development of novel antifungal drugs and diagnostic assays.  I also oversee numerous translational and clinical research studies centered on several diagnostic and therapeutic aspects of invasive fungal infections and other infections in immunocompromised patients.  

My laboratory ( work is very translational in nature by design – all of it is performed with the specific goal of directly improving our fundamental understanding of how and why Aspergillus fumigatus, a leading killer in patients with cancer or following transplantation, is so deadly and how to best prevent and treat it. Our laboratory uses molecular genetic tools to delete or mutate pathogenesis genes and proteins to analyze their function and role in disease, including various genomic, proteomic, structural biologic and biochemical approaches. We also perform extensive in vitro and in vivo testing of antifungal compounds . Since we are focused on the pathogenesis, we utilize numerous different animal models specifically designed to mimic the immune system of a cancer patient or transplant recipient.

I am also the Chief of Pediatric Infectious Diseases and my clinical research includes my founding and directing the International Pediatric Fungal Network (, a 55-site multinational NIH-funded consortium dedicated to the epidemiology, diagnosis, treatment, and outcomes of pediatric invasive fungal infections.  This Network is the largest of its kind in the world and is currently leading three NIH-funded global clinical studies that will allow us to generate the first ever pediatric-specific international guidelines for these diseases.

I am the co-founder and continuing co-chair of the past nine Advances Against Aspergillosis adn Mucormycosis international conferences, the leading forum for these deadly diseases and most recently at  I have co-edited 12 infectious diseases textbooks, including as co-editor of the largest textbook in the field, Aspergillus fumigatus and Aspergillosis, Feigin & Cherry's Textbook of Pediatric Infectious Diseases (approx. 4,000 pages), the American Academy of Pediatrics Nelson's Pediatric Antimicrobial Therapy textbook, and most recently as the lead editor of the only textbook in the subfield Pediatric Transplant and Oncology Infectious Diseases.

I am the Basic Science Research Director for the Duke Transplant Center, and Medical Director of the Duke Children’s Clinical Research Unit overseeing 813 studies.  I am a member of the American Academy of Pediatrics Red Book committee, and recently completed a Board of Directors tenure for the Pediatric Infectious Diseases Society, where I currently chair the Division Chief working group.  I am a fellow of the American Association for the Advancement of Science and have been elected into the American Society for Clinical Investigation and the Association of American Physicians, for which I currently serve on the Council. 

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 2001 - 2004
  • Resident, Pediatrics, Stanford University, 1998 - 2001
  • M.D., University of North Carolina - Chapel Hill, 1998

Selected Grants and Awards


Lamoth, Frédéric, Praveen R. Juvvadi, Erik J. Soderblom, M Arthur Moseley, and William J. Steinbach. “Hsp70 and the Cochaperone StiA (Hop) Orchestrate Hsp90-Mediated Caspofungin Tolerance in Aspergillus fumigatus.” Antimicrob Agents Chemother 59, no. 8 (August 2015): 4727–33.

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Vargas-Muñiz, José M., Hilary Renshaw, Amber D. Richards, Frédéric Lamoth, Erik J. Soderblom, M Arthur Moseley, Praveen R. Juvvadi, and William J. Steinbach. “The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence.” Fungal Genet Biol 81 (August 2015): 41–51.

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Lamoth, Frédéric, Barbara D. Alexander, Praveen R. Juvvadi, and William J. Steinbach. “Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species.” J Antimicrob Chemother 70, no. 5 (May 2015): 1408–11.

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Chellapandian, DeepakBabu, Thomas Lehrnbecher, Bob Phillips, Brian T. Fisher, Theoklis E. Zaoutis, William J. Steinbach, Joseph Beyene, and Lillian Sung. “Bronchoalveolar lavage and lung biopsy in patients with cancer and hematopoietic stem-cell transplantation recipients: a systematic review and meta-analysis.” J Clin Oncol 33, no. 5 (February 10, 2015): 501–9.

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Falloon, Katie, Praveen R. Juvvadi, Amber D. Richards, José M. Vargas-Muñiz, Hilary Renshaw, and William J. Steinbach. “Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus.” Plos One 10, no. 9 (2015): e0137869.

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Lamoth, Frédéric, Praveen R. Juvvadi, and William J. Steinbach. “Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis.” Front Microbiol 6 (2015): 96.

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Juvvadi, Praveen R., Yan Ma, Amber D. Richards, Erik J. Soderblom, M Arthur Moseley, Frédéric Lamoth, and William J. Steinbach. “Identification and mutational analyses of phosphorylation sites of the calcineurin-binding protein CbpA and the identification of domains required for calcineurin binding in Aspergillus fumigatus.” Front Microbiol 6 (2015): 175.

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Chellapandian, Deepak, Thomas Lehrnbecher, Bob Phillips, Brian T. Fisher, Theoklis E. Zaoutis, William J. Steinbach, Joseph Beyene, and Lillian Sung. “Broncho-Alveolar Lavage and Lung Biopsy in Patients with Hematological Malignancy and Hematopoietic Stem Cell Transplantation Recipients: A Systematic Review and Meta-Analysis.” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.


Juvvadi, Praveen R., Frédéric Lamoth, and William J. Steinbach. “Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus.” Mycopathologia 178, no. 5–6 (December 2014): 341–48.

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Palazzi, Debra L., Antonio Arrieta, Elio Castagnola, Natasha Halasa, Sydney Hubbard, Ava A. Brozovich, Brian T. Fisher, and William J. Steinbach. “Candida speciation, antifungal treatment and adverse events in pediatric invasive candidiasis: results from 441 infections in a prospective, multi-national study.” Pediatr Infect Dis J 33, no. 12 (December 2014): 1294–96.

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