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William J. Steinbach, MD

Samuel L. Katz Distinguished Professor of Pediatrics
Professor of Pediatrics
Chief, Division of Pediatric Infectious Diseases
Professor in Molecular Genetics and Microbiology
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: Box 3499 Med Ctr, Durham, NC 27710
Phone: (919) 681-1504
Email address: bill.steinbach@duke.edu

My overall clinical and research focus is to improve the diagnosis, treatment, and outcomes of immunocompromised patients, specifically those with invasive fungal infections.  My research enterprise is divided between my basic, translational, and clinical approaches.  My laboratory focuses on the molecular pathogenesis of Aspergillus fumigatus, a leading invasive fungal killer, and the development of novel antifungal drugs and diagnostic assays.  I also oversee numerous translational and clinical research studies centered on several diagnostic and therapeutic aspects of invasive fungal infections and other infections in immunocompromised patients.  

My laboratory (www.steinbachlab.org) work is very translational in nature by design – all of it is performed with the specific goal of directly improving our fundamental understanding of how and why Aspergillus fumigatus, a leading killer in patients with cancer or following transplantation, is so deadly and how to best prevent and treat it. Our laboratory uses molecular genetic tools to delete or mutate pathogenesis genes and proteins to analyze their function and role in disease, including various genomic, proteomic, structural biologic and biochemical approaches. We also perform extensive in vitro and in vivo testing of antifungal compounds . Since we are focused on the pathogenesis, we utilize numerous different animal models specifically designed to mimic the immune system of a cancer patient or transplant recipient.

I am also the Chief of Pediatric Infectious Diseases and my clinical research includes my founding and directing the International Pediatric Fungal Network (www.ipfn.org), a 55-site multinational NIH-funded consortium dedicated to the epidemiology, diagnosis, treatment, and outcomes of pediatric invasive fungal infections.  This Network is the largest of its kind in the world and is currently leading three NIH-funded global clinical studies that will allow us to generate the first ever pediatric-specific international guidelines for these diseases.

I am the co-founder and continuing co-chair of the past nine Advances Against Aspergillosis adn Mucormycosis international conferences, the leading forum for these deadly diseases and most recently at https://aaam2020.org.  I have co-edited 12 infectious diseases textbooks, including as co-editor of the largest textbook in the field, Aspergillus fumigatus and Aspergillosis, Feigin & Cherry's Textbook of Pediatric Infectious Diseases (approx. 4,000 pages), the American Academy of Pediatrics Nelson's Pediatric Antimicrobial Therapy textbook, and most recently as the lead editor of the only textbook in the subfield Pediatric Transplant and Oncology Infectious Diseases.

I am the Basic Science Research Director for the Duke Transplant Center, and Medical Director of the Duke Children’s Clinical Research Unit overseeing 813 studies.  I am a member of the American Academy of Pediatrics Red Book committee, and recently completed a Board of Directors tenure for the Pediatric Infectious Diseases Society, where I currently chair the Division Chief working group.  I am a fellow of the American Association for the Advancement of Science and have been elected into the American Society for Clinical Investigation and the Association of American Physicians, for which I currently serve on the Council. 

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 2001 - 2004
  • Resident, Pediatrics, Stanford University, 1998 - 2001
  • M.D., University of North Carolina - Chapel Hill, 1998

Selected Grants and Awards

Publications

Vargas-Muñiz, José M., Hilary Renshaw, Amber D. Richards, Greg Waitt, Erik J. Soderblom, Martin A. Moseley, Yohannes Asfaw, Praveen R. Juvvadi, and William J. Steinbach. “Dephosphorylation of the Core Septin, AspB, in a Protein Phosphatase 2A-Dependent Manner Impacts Its Localization and Function in the Fungal Pathogen Aspergillus fumigatus.” Front Microbiol 7 (2016): 997. https://doi.org/10.3389/fmicb.2016.00997.

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Lamoth, Frédéric, Praveen R. Juvvadi, and William J. Steinbach. “Editorial: Advances in Aspergillus fumigatus Pathobiology.” Front Microbiol 7 (2016): 43. https://doi.org/10.3389/fmicb.2016.00043.

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Lamoth, Frédéric, Praveen R. Juvvadi, and William J. Steinbach. “Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus.” Crit Rev Microbiol 42, no. 2 (2016): 310–21. https://doi.org/10.3109/1040841X.2014.947239.

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Juvvadi, Praveen R., and William J. Steinbach. “Calcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here?” Pathogens 4, no. 4 (December 16, 2015): 883–93. https://doi.org/10.3390/pathogens4040883.

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Wattier, Rachel L., Christopher C. Dvorak, Jill A. Hoffman, Ava A. Brozovich, Ibrahim Bin-Hussain, Andreas H. Groll, Elio Castagnola, et al. “A Prospective, International Cohort Study of Invasive Mold Infections in Children.” J Pediatric Infect Dis Soc 4, no. 4 (December 2015): 313–22. https://doi.org/10.1093/jpids/piu074.

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Steinbach, William J., Frédéric Lamoth, and Praveen R. Juvvadi. “Potential Microbiological Effects of Higher Dosing of Echinocandins.” Clin Infect Dis 61 Suppl 6 (December 1, 2015): S669–77. https://doi.org/10.1093/cid/civ725.

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COMMITTEE ON INFECTIOUS DISEASES, John C. “Influenza Immunization for All Health Care Personnel: Keep It Mandatory.” Pediatrics 136, no. 4 (October 2015): 809–18. https://doi.org/10.1542/peds.2015-2922.

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Committee on Infectious Diseases, American Academy of Pediatrics, T. E. “Recommendations for Prevention and Control of Influenza in Children, 2015-2016.” Pediatrics 136, no. 4 (October 2015): 792–808. https://doi.org/10.1542/peds.2015-2920.

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Steinbach, William J. “Blood-based Diagnosis of Invasive Fungal Infections in Immunocompromised/Oncology Patients.” Pediatr Infect Dis J 34, no. 9 (September 2015): 1020–22. https://doi.org/10.1097/INF.0000000000000797.

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Juvvadi, Praveen R., Alberto Muñoz, Frédéric Lamoth, Erik J. Soderblom, M Arthur Moseley, Nick D. Read, and William J. Steinbach. “Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus.” Antimicrob Agents Chemother 59, no. 8 (August 2015): 4946–55. https://doi.org/10.1128/AAC.00263-15.

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