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William J. Steinbach, MD

Samuel L. Katz Professor of Pediatrics
Professor of Pediatrics
Chief, Division of Pediatric Infectious Diseases
Professor in Molecular Genetics and Microbiology
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: Box 3499 Med Ctr, Durham, NC 27710
Phone: (919) 681-1504
Email address: bill.steinbach@duke.edu

My overall clinical and research focus is to improve the diagnosis, treatment, and outcomes of immunocompromised patients, specifically those with invasive fungal infections.  My research enterprise is divided between my laboratory focusing on the molecular pathogenesis of Aspergillus fumigatus and development of novel antifungal drugs and diagnostic assays, and numerous translational and clinical studies centered on several diagnostic and therapeutic aspects of invasive fungal infections.  

My laboratory (www.steinbachlab.org) work is very translational in nature by design – all of it is performed with the specific goal of directly improving our fundamental understanding of how and why Aspergillus fumigatus, a leading killer in patients with cancer or following transplantation, is so deadly and how to best prevent and treat it. Our laboratory uses molecular genetic tools to knock-out or mutate pathogenesis genes and proteins to analyze their function and role in disease, including various genomic, proteomic, and biochemical approaches. We also perform extensive in vitro and in vivo testing of antifungal compounds . Since we are focused on the pathogenesis, we utilize numerous different animal models specifically designed to mimic the immune system of a cancer patient or transplant recipient.

I am also the Chief of Pediatric Infectious Diseases and my clinical research includes my founding and directing the International Pediatric Fungal Network (www.ipfn.org), a 55-site multinational NIH-funded consortium dedicated to the epidemiology, diagnosis, treatment, and outcomes of pediatric invasive fungal infections.  This Network is the largest of its kind in the world and is currently leading two global clinical studies that will allow us to generate the first ever pediatric-specific international guidelines for these diseases.

I am the co-founder and continuing co-chair of the past eight Advances Against Aspergillosis international conferences, the leading forum for this deadly disease and most recently at www.AAA2018.org.  I am the co-editor of the largest textbook in the field, Aspergillus fumigatus and Aspergillosis, and have co-edited eight other pediatric infectious diseases textbooks, including Feigin & Cherry's Textbook of Pediatric Infectious Diseases (nearly 4,000 pages), and the American Academy of Pediatrics Nelson's Pediatric Antimicrobial Therapy textbook.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 2001 - 2004
  • Resident, Pediatrics, Stanford University, 1998 - 2001
  • M.D., University of North Carolina at Chapel Hill, 1998

Selected Grants and Awards

Publications

Lamoth, Frédéric, Praveen R. Juvvadi, and William J. Steinbach. “Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis..” Front Microbiol 6 (2015). https://doi.org/10.3389/fmicb.2015.00096.

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Juvvadi, Praveen R., Yan Ma, Amber D. Richards, Erik J. Soderblom, M Arthur Moseley, Frédéric Lamoth, and William J. Steinbach. “Identification and mutational analyses of phosphorylation sites of the calcineurin-binding protein CbpA and the identification of domains required for calcineurin binding in Aspergillus fumigatus..” Front Microbiol 6 (2015). https://doi.org/10.3389/fmicb.2015.00175.

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Chellapandian, Deepak, Thomas Lehrnbecher, Bob Phillips, Brian T. Fisher, Theoklis E. Zaoutis, William J. Steinbach, Joseph Beyene, and Lillian Sung. “Broncho-Alveolar Lavage and Lung Biopsy in Patients with Hematological Malignancy and Hematopoietic Stem Cell Transplantation Recipients: A Systematic Review and Meta-Analysis.” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.

Scholars@Duke

Juvvadi, Praveen R., Frédéric Lamoth, and William J. Steinbach. “Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus..” Mycopathologia 178, no. 5–6 (December 2014): 341–48. https://doi.org/10.1007/s11046-014-9794-9.

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Palazzi, Debra L., Antonio Arrieta, Elio Castagnola, Natasha Halasa, Sydney Hubbard, Ava A. Brozovich, Brian T. Fisher, and William J. Steinbach. “Candida speciation, antifungal treatment and adverse events in pediatric invasive candidiasis: results from 441 infections in a prospective, multi-national study..” Pediatr Infect Dis J 33, no. 12 (December 2014): 1294–96. https://doi.org/10.1097/INF.0000000000000431.

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Sugui, Janyce A., Kyung J. Kwon-Chung, Praveen R. Juvvadi, Jean-Paul Latgé, and William J. Steinbach. “Aspergillus fumigatus and related species..” Cold Spring Harb Perspect Med 5, no. 2 (November 6, 2014). https://doi.org/10.1101/cshperspect.a019786.

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Juvvadi, Praveen R., Frédéric Lamoth, and William J. Steinbach. “Calcineurin as a Multifunctional Regulator: Unraveling Novel Functions in Fungal Stress Responses, Hyphal Growth, Drug Resistance, and Pathogenesis..” Fungal Biol Rev 28, no. 2–3 (October 2014): 56–69. https://doi.org/10.1016/j.fbr.2014.02.004.

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Lamoth, Frédéric, Praveen R. Juvvadi, Christopher Gehrke, Yohannes G. Asfaw, and William J. Steinbach. “Transcriptional activation of heat shock protein 90 mediated via a proximal promoter region as trigger of caspofungin resistance in Aspergillus fumigatus..” J Infect Dis 209, no. 3 (February 1, 2014): 473–81. https://doi.org/10.1093/infdis/jit530.

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Lamoth, F., P. R. Juvvadi, and W. J. Steinbach. “Heat Shock Protein 90 (Hsp90) in Fungal Growth and Pathogenesis.” Current Fungal Infection Reports 8, no. 4 (January 1, 2014): 296–301. https://doi.org/10.1007/s12281-014-0195-9.

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Lamoth, Frédéric, Praveen R. Juvvadi, Erik J. Soderblom, M Arthur Moseley, Yohannes G. Asfaw, and William J. Steinbach. “Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus..” Antimicrob Agents Chemother 58, no. 4 (2014): 1889–96. https://doi.org/10.1128/AAC.02286-13.

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