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William J. Steinbach, MD

Samuel L. Katz Professor of Pediatrics
Professor of Pediatrics
Chief, Division of Pediatric Infectious Diseases
Professor in Molecular Genetics and Microbiology
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: Box 3499 Med Ctr, Durham, NC 27710
Phone: (919) 681-1504
Email address: bill.steinbach@duke.edu

My overall clinical and research focus is to improve the diagnosis, treatment, and outcomes of immunocompromised patients, specifically those with invasive fungal infections.  My research enterprise is divided between my laboratory focusing on the molecular pathogenesis of Aspergillus fumigatus and development of novel antifungal drugs and diagnostic assays, and numerous translational and clinical studies centered on several diagnostic and therapeutic aspects of invasive fungal infections.  

My laboratory (www.steinbachlab.org) work is very translational in nature by design – all of it is performed with the specific goal of directly improving our fundamental understanding of how and why Aspergillus fumigatus, a leading killer in patients with cancer or following transplantation, is so deadly and how to best prevent and treat it. Our laboratory uses molecular genetic tools to knock-out or mutate pathogenesis genes and proteins to analyze their function and role in disease, including various genomic, proteomic, and biochemical approaches. We also perform extensive in vitro and in vivo testing of antifungal compounds . Since we are focused on the pathogenesis, we utilize numerous different animal models specifically designed to mimic the immune system of a cancer patient or transplant recipient.

I am also the Chief of Pediatric Infectious Diseases and my clinical research includes my founding and directing the International Pediatric Fungal Network (www.ipfn.org), a 55-site multinational NIH-funded consortium dedicated to the epidemiology, diagnosis, treatment, and outcomes of pediatric invasive fungal infections.  This Network is the largest of its kind in the world and is currently leading two global clinical studies that will allow us to generate the first ever pediatric-specific international guidelines for these diseases.

I am the co-founder and continuing co-chair of the past eight Advances Against Aspergillosis international conferences, the leading forum for this deadly disease and most recently at www.AAA2018.org.  I am the co-editor of the largest textbook in the field, Aspergillus fumigatus and Aspergillosis, and have co-edited eight other pediatric infectious diseases textbooks, including Feigin & Cherry's Textbook of Pediatric Infectious Diseases (nearly 4,000 pages), and the American Academy of Pediatrics Nelson's Pediatric Antimicrobial Therapy textbook.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 2001 - 2004
  • Resident, Pediatrics, Stanford University, 1998 - 2001
  • M.D., University of North Carolina at Chapel Hill, 1998

Selected Grants and Awards

Publications

Steinbach, William J., Frédéric Lamoth, and Praveen R. Juvvadi. “Potential Microbiological Effects of Higher Dosing of Echinocandins..” Clin Infect Dis 61 Suppl 6 (December 1, 2015): S669–77. https://doi.org/10.1093/cid/civ725.

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COMMITTEE ON INFECTIOUS DISEASES, Mark. “Influenza Immunization for All Health Care Personnel: Keep It Mandatory..” Pediatrics 136, no. 4 (October 2015): 809–18. https://doi.org/10.1542/peds.2015-2922.

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Committee on Infectious Diseases, American Academy of Pediatrics, T. E. “Recommendations for Prevention and Control of Influenza in Children, 2015-2016..” Pediatrics 136, no. 4 (October 2015): 792–808. https://doi.org/10.1542/peds.2015-2920.

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Steinbach, William J. “Blood-based Diagnosis of Invasive Fungal Infections in Immunocompromised/Oncology Patients..” Pediatr Infect Dis J 34, no. 9 (September 2015): 1020–22. https://doi.org/10.1097/INF.0000000000000797.

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Juvvadi, Praveen R., Alberto Muñoz, Frédéric Lamoth, Erik J. Soderblom, M Arthur Moseley, Nick D. Read, and William J. Steinbach. “Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus..” Antimicrob Agents Chemother 59, no. 8 (August 2015): 4946–55. https://doi.org/10.1128/AAC.00263-15.

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Lamoth, Frédéric, Praveen R. Juvvadi, Erik J. Soderblom, M Arthur Moseley, and William J. Steinbach. “Hsp70 and the Cochaperone StiA (Hop) Orchestrate Hsp90-Mediated Caspofungin Tolerance in Aspergillus fumigatus..” Antimicrob Agents Chemother 59, no. 8 (August 2015): 4727–33. https://doi.org/10.1128/AAC.00946-15.

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Vargas-Muñiz, José M., Hilary Renshaw, Amber D. Richards, Frédéric Lamoth, Erik J. Soderblom, M Arthur Moseley, Praveen R. Juvvadi, and William J. Steinbach. “The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence..” Fungal Genet Biol 81 (August 2015): 41–51. https://doi.org/10.1016/j.fgb.2015.05.014.

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Lamoth, Frédéric, Barbara D. Alexander, Praveen R. Juvvadi, and William J. Steinbach. “Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species..” J Antimicrob Chemother 70, no. 5 (May 2015): 1408–11. https://doi.org/10.1093/jac/dku549.

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Chellapandian, DeepakBabu, Thomas Lehrnbecher, Bob Phillips, Brian T. Fisher, Theoklis E. Zaoutis, William J. Steinbach, Joseph Beyene, and Lillian Sung. “Bronchoalveolar lavage and lung biopsy in patients with cancer and hematopoietic stem-cell transplantation recipients: a systematic review and meta-analysis..” Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 33, no. 5 (February 2015): 501–9. https://doi.org/10.1200/jco.2014.58.0480.

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Falloon, Katie, Praveen R. Juvvadi, Amber D. Richards, José M. Vargas-Muñiz, Hilary Renshaw, and William J. Steinbach. “Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus..” Plos One 10, no. 9 (2015). https://doi.org/10.1371/journal.pone.0137869.

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