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William J. Steinbach, MD

Samuel L. Katz Distinguished Professor of Pediatrics
Professor of Pediatrics
Chief, Division of Pediatric Infectious Diseases
Professor in Molecular Genetics and Microbiology
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: Box 3499 Med Ctr, Durham, NC 27710
Phone: (919) 681-1504
Email address: bill.steinbach@duke.edu

My overall clinical and research focus is to improve the diagnosis, treatment, and outcomes of immunocompromised patients, specifically those with invasive fungal infections.  My research enterprise is divided between my basic, translational, and clinical approaches.  My laboratory focuses on the molecular pathogenesis of Aspergillus fumigatus, a leading invasive fungal killer, and the development of novel antifungal drugs and diagnostic assays.  I also oversee numerous translational and clinical research studies centered on several diagnostic and therapeutic aspects of invasive fungal infections and other infections in immunocompromised patients.  

My laboratory (www.steinbachlab.org) work is very translational in nature by design – all of it is performed with the specific goal of directly improving our fundamental understanding of how and why Aspergillus fumigatus, a leading killer in patients with cancer or following transplantation, is so deadly and how to best prevent and treat it. Our laboratory uses molecular genetic tools to delete or mutate pathogenesis genes and proteins to analyze their function and role in disease, including various genomic, proteomic, structural biologic and biochemical approaches. We also perform extensive in vitro and in vivo testing of antifungal compounds . Since we are focused on the pathogenesis, we utilize numerous different animal models specifically designed to mimic the immune system of a cancer patient or transplant recipient.

I am also the Chief of Pediatric Infectious Diseases and my clinical research includes my founding and directing the International Pediatric Fungal Network (www.ipfn.org), a 55-site multinational NIH-funded consortium dedicated to the epidemiology, diagnosis, treatment, and outcomes of pediatric invasive fungal infections.  This Network is the largest of its kind in the world and is currently leading three NIH-funded global clinical studies that will allow us to generate the first ever pediatric-specific international guidelines for these diseases.

I am the co-founder and continuing co-chair of the past nine Advances Against Aspergillosis adn Mucormycosis international conferences, the leading forum for these deadly diseases and most recently at https://aaam2020.org.  I have co-edited 12 infectious diseases textbooks, including as co-editor of the largest textbook in the field, Aspergillus fumigatus and Aspergillosis, Feigin & Cherry's Textbook of Pediatric Infectious Diseases (approx. 4,000 pages), the American Academy of Pediatrics Nelson's Pediatric Antimicrobial Therapy textbook, and most recently as the lead editor of the only textbook in the subfield Pediatric Transplant and Oncology Infectious Diseases.

I am the Basic Science Research Director for the Duke Transplant Center, and Medical Director of the Duke Children’s Clinical Research Unit overseeing 813 studies.  I am a member of the American Academy of Pediatrics Red Book committee, and recently completed a Board of Directors tenure for the Pediatric Infectious Diseases Society, where I currently chair the Division Chief working group.  I am a fellow of the American Association for the Advancement of Science and have been elected into the American Society for Clinical Investigation and the Association of American Physicians, for which I currently serve on the Council. 

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 2001 - 2004
  • Resident, Pediatrics, Stanford University, 1998 - 2001
  • M.D., University of North Carolina - Chapel Hill, 1998

Selected Grants and Awards

Publications

Vargas-Muñiz, Jose M., Praveen R. Juvvadi, and William J. Steinbach. “Forging the ring: from fungal septins' divergent roles in morphology, septation and virulence to factors contributing to their assembly into higher order structures.” Microbiology (Reading) 162, no. 9 (September 2016): 1527–34. https://doi.org/10.1099/mic.0.000359.

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COMMITTEE ON PRACTICE AND AMBULATORY MEDICINE, Joseph A., Joseph A. COMMITTEE ON INFECTIOUS DISEASES, Joseph A. COMMITTEE ON STATE GOVERNMENT AFFAIRS, Joseph A. COUNCIL ON SCHOOL HEALTH, and Joseph A. SECTION ON ADMINISTRATION AND PRACTICE MANAGEMENT. “Medical Versus Nonmedical Immunization Exemptions for Child Care and School Attendance.” Pediatrics 138, no. 3 (September 2016). https://doi.org/10.1542/peds.2016-2145.

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Davies, H Dele, Carrie L. Byington, and Carrie L. COMMITTEE ON INFECTIOUS DISEASES. “Parental Presence During Treatment of Ebola or Other Highly Consequential Infection.” Pediatrics 138, no. 3 (September 2016). https://doi.org/10.1542/peds.2016-1891.

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COMMITTEE ON INFECTIOUS DISEASES, J. M. “Recommendations for Serogroup B Meningococcal Vaccine for Persons 10 Years and Older.” Pediatrics 138, no. 3 (September 2016). https://doi.org/10.1542/peds.2016-1890.

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Patterson, Thomas F., George R. Thompson, David W. Denning, Jay A. Fishman, Susan Hadley, Raoul Herbrecht, Dimitrios P. Kontoyiannis, et al. “Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America.” Clin Infect Dis 63, no. 4 (August 15, 2016): 433–42. https://doi.org/10.1093/cid/ciw444.

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Patterson, Thomas F., George R. Thompson, David W. Denning, Jay A. Fishman, Susan Hadley, Raoul Herbrecht, Dimitrios P. Kontoyiannis, et al. “Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America.” Clin Infect Dis 63, no. 4 (August 15, 2016): e1–60. https://doi.org/10.1093/cid/ciw326.

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Renshaw, Hilary, José M. Vargas-Muñiz, Amber D. Richards, Yohannes G. Asfaw, Praveen R. Juvvadi, and William J. Steinbach. “Distinct Roles of Myosins in Aspergillus fumigatus Hyphal Growth and Pathogenesis.” Infect Immun 84, no. 5 (May 2016): 1556–64. https://doi.org/10.1128/IAI.01190-15.

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Tonthat, Nam K., Praveen Rao Juvvadi, Hengshan Zhang, Soo Chan Lee, Ron Venters, Leonard Spicer, William J. Steinbach, Joseph Heitman, and Maria A. Schumacher. “Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.” Mbio 7, no. 2 (April 26, 2016): e00492–e00416. https://doi.org/10.1128/mBio.00492-16.

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Juvvadi, Praveen R., Charles W. Pemble, Yan Ma, and William J. Steinbach. “Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus.” Febs Lett 590, no. 4 (February 2016): 501–8. https://doi.org/10.1002/1873-3468.12075.

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Steinbach, William J. “Pediatric Invasive Candidiasis: Epidemiology and Diagnosis in Children.” J Fungi (Basel) 2, no. 1 (January 8, 2016). https://doi.org/10.3390/jof2010005.

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