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William J. Steinbach, MD

Samuel L. Katz Professor of Pediatrics
Professor of Pediatrics
Chief, Division of Pediatric Infectious Diseases
Professor in Molecular Genetics and Microbiology
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: Box 3499 Med Ctr, Durham, NC 27710
Phone: (919) 681-1504
Email address: bill.steinbach@duke.edu

My overall clinical and research focus is to improve the diagnosis, treatment, and outcomes of immunocompromised patients, specifically those with invasive fungal infections.  My research enterprise is divided between my laboratory focusing on the molecular pathogenesis of Aspergillus fumigatus and development of novel antifungal drugs and diagnostic assays, and numerous translational and clinical studies centered on several diagnostic and therapeutic aspects of invasive fungal infections.  

My laboratory (www.steinbachlab.org) work is very translational in nature by design – all of it is performed with the specific goal of directly improving our fundamental understanding of how and why Aspergillus fumigatus, a leading killer in patients with cancer or following transplantation, is so deadly and how to best prevent and treat it. Our laboratory uses molecular genetic tools to knock-out or mutate pathogenesis genes and proteins to analyze their function and role in disease, including various genomic, proteomic, and biochemical approaches. We also perform extensive in vitro and in vivo testing of antifungal compounds . Since we are focused on the pathogenesis, we utilize numerous different animal models specifically designed to mimic the immune system of a cancer patient or transplant recipient.

I am also the Chief of Pediatric Infectious Diseases and my clinical research includes my founding and directing the International Pediatric Fungal Network (www.ipfn.org), a 55-site multinational NIH-funded consortium dedicated to the epidemiology, diagnosis, treatment, and outcomes of pediatric invasive fungal infections.  This Network is the largest of its kind in the world and is currently leading two global clinical studies that will allow us to generate the first ever pediatric-specific international guidelines for these diseases.

I am the co-founder and continuing co-chair of the past eight Advances Against Aspergillosis international conferences, the leading forum for this deadly disease and most recently at www.AAA2018.org.  I am the co-editor of the largest textbook in the field, Aspergillus fumigatus and Aspergillosis, and have co-edited eight other pediatric infectious diseases textbooks, including Feigin & Cherry's Textbook of Pediatric Infectious Diseases (nearly 4,000 pages), and the American Academy of Pediatrics Nelson's Pediatric Antimicrobial Therapy textbook.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 2001 - 2004
  • Resident, Pediatrics, Stanford University, 1998 - 2001
  • M.D., University of North Carolina at Chapel Hill, 1998

Selected Grants and Awards

Publications

Patterson, Thomas F., George R. Thompson, David W. Denning, Jay A. Fishman, Susan Hadley, Raoul Herbrecht, Dimitrios P. Kontoyiannis, et al. “Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America..” Clin Infect Dis 63, no. 4 (August 15, 2016): e1–60. https://doi.org/10.1093/cid/ciw326.

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Renshaw, Hilary, José M. Vargas-Muñiz, Amber D. Richards, Yohannes G. Asfaw, Praveen R. Juvvadi, and William J. Steinbach. “Distinct Roles of Myosins in Aspergillus fumigatus Hyphal Growth and Pathogenesis..” Infect Immun 84, no. 5 (May 2016): 1556–64. https://doi.org/10.1128/IAI.01190-15.

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Tonthat, Nam K., Praveen Rao Juvvadi, Hengshan Zhang, Soo Chan Lee, Ron Venters, Leonard Spicer, William J. Steinbach, Joseph Heitman, and Maria A. Schumacher. “Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function..” Mbio 7, no. 2 (April 26, 2016): e00492–e00416. https://doi.org/10.1128/mBio.00492-16.

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Juvvadi, Praveen R., Charles W. Pemble, Yan Ma, and William J. Steinbach. “Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus..” Febs Lett 590, no. 4 (February 2016): 501–8. https://doi.org/10.1002/1873-3468.12075.

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Steinbach, William J. “Pediatric Invasive Candidiasis: Epidemiology and Diagnosis in Children..” J Fungi (Basel) 2, no. 1 (January 8, 2016). https://doi.org/10.3390/jof2010005.

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Vargas-Muñiz, José M., Hilary Renshaw, Amber D. Richards, Greg Waitt, Erik J. Soderblom, Martin A. Moseley, Yohannes Asfaw, Praveen R. Juvvadi, and William J. Steinbach. “Dephosphorylation of the Core Septin, AspB, in a Protein Phosphatase 2A-Dependent Manner Impacts Its Localization and Function in the Fungal Pathogen Aspergillus fumigatus..” Front Microbiol 7 (2016). https://doi.org/10.3389/fmicb.2016.00997.

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Lamoth, Frédéric, Praveen R. Juvvadi, and William J. Steinbach. “Editorial: Advances in Aspergillus fumigatus Pathobiology..” Front Microbiol 7 (2016). https://doi.org/10.3389/fmicb.2016.00043.

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Lamoth, Frédéric, Praveen R. Juvvadi, and William J. Steinbach. “Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus..” Crit Rev Microbiol 42, no. 2 (2016): 310–21. https://doi.org/10.3109/1040841X.2014.947239.

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Juvvadi, Praveen R., and William J. Steinbach. “Calcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here?.” Pathogens 4, no. 4 (December 16, 2015): 883–93. https://doi.org/10.3390/pathogens4040883.

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Wattier, Rachel L., Christopher C. Dvorak, Jill A. Hoffman, Ava A. Brozovich, Ibrahim Bin-Hussain, Andreas H. Groll, Elio Castagnola, et al. “A Prospective, International Cohort Study of Invasive Mold Infections in Children..” J Pediatric Infect Dis Soc 4, no. 4 (December 2015): 313–22. https://doi.org/10.1093/jpids/piu074.

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