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William J. Steinbach, MD

Samuel L. Katz Professor of Pediatrics
Professor of Pediatrics
Chief, Division of Pediatric Infectious Diseases
Professor in Molecular Genetics and Microbiology
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: Box 3499 Med Ctr, Durham, NC 27710
Phone: (919) 681-1504
Email address: bill.steinbach@duke.edu

My overall clinical and research focus is to improve the diagnosis, treatment, and outcomes of immunocompromised patients, specifically those with invasive fungal infections.  My research enterprise is divided between my laboratory focusing on the molecular pathogenesis of Aspergillus fumigatus and development of novel antifungal drugs and diagnostic assays, and numerous translational and clinical studies centered on several diagnostic and therapeutic aspects of invasive fungal infections.  

My laboratory (www.steinbachlab.org) work is very translational in nature by design – all of it is performed with the specific goal of directly improving our fundamental understanding of how and why Aspergillus fumigatus, a leading killer in patients with cancer or following transplantation, is so deadly and how to best prevent and treat it. Our laboratory uses molecular genetic tools to knock-out or mutate pathogenesis genes and proteins to analyze their function and role in disease, including various genomic, proteomic, and biochemical approaches. We also perform extensive in vitro and in vivo testing of antifungal compounds . Since we are focused on the pathogenesis, we utilize numerous different animal models specifically designed to mimic the immune system of a cancer patient or transplant recipient.

I am also the Chief of Pediatric Infectious Diseases and my clinical research includes my founding and directing the International Pediatric Fungal Network (www.ipfn.org), a 55-site multinational NIH-funded consortium dedicated to the epidemiology, diagnosis, treatment, and outcomes of pediatric invasive fungal infections.  This Network is the largest of its kind in the world and is currently leading two global clinical studies that will allow us to generate the first ever pediatric-specific international guidelines for these diseases.

I am the co-founder and continuing co-chair of the past eight Advances Against Aspergillosis international conferences, the leading forum for this deadly disease and most recently at www.AAA2018.org.  I am the co-editor of the largest textbook in the field, Aspergillus fumigatus and Aspergillosis, and have co-edited eight other pediatric infectious diseases textbooks, including Feigin & Cherry's Textbook of Pediatric Infectious Diseases (nearly 4,000 pages), and the American Academy of Pediatrics Nelson's Pediatric Antimicrobial Therapy textbook.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 2001 - 2004
  • Resident, Pediatrics, Stanford University, 1998 - 2001
  • M.D., University of North Carolina at Chapel Hill, 1998

Selected Grants and Awards

Publications

Steinbach, William J. “Special Issue "Aspergillus fumigatus: From Diagnosis to Therapy"..” J Fungi (Basel) 2, no. 4 (December 8, 2016). https://doi.org/10.3390/jof2040031.

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Fisher, Brian T., Rachael K. Ross, Emmanuel Roilides, Debra L. Palazzi, Mark J. Abzug, Jill A. Hoffman, David M. Berman, et al. “Failure to Validate a Multivariable Clinical Prediction Model to Identify Pediatric Intensive Care Unit Patients at High Risk for Candidemia..” J Pediatric Infect Dis Soc 5, no. 4 (December 2016): 458–61. https://doi.org/10.1093/jpids/piv024.

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Lehrnbecher, Thomas, Paula D. Robinson, Brian T. Fisher, Elio Castagnola, Andreas H. Groll, William J. Steinbach, Theoklis E. Zaoutis, et al. “Galactomannan, β-D-Glucan, and Polymerase Chain Reaction-Based Assays for the Diagnosis of Invasive Fungal Disease in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis..” Clin Infect Dis 63, no. 10 (November 15, 2016): 1340–48. https://doi.org/10.1093/cid/ciw592.

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Jackson, Mary Anne, Gordon E. Schutze, and Gordon E. COMMITTEE ON INFECTIOUS DISEASES. “The Use of Systemic and Topical Fluoroquinolones..” Pediatrics 138, no. 5 (November 2016). https://doi.org/10.1542/peds.2016-2706.

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Edwards, Kathryn M., Jesse M. Hackell, and Jesse M. COMMITTEE ON INFECTIOUS DISEASES, THE COMMITTEE ON PRACTICE AND AMBULATORY MEDICINE. “Countering Vaccine Hesitancy..” Pediatrics 138, no. 3 (September 2016). https://doi.org/10.1542/peds.2016-2146.

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Vargas-Muñiz, Jose M., Praveen R. Juvvadi, and William J. Steinbach. “Forging the ring: from fungal septins' divergent roles in morphology, septation and virulence to factors contributing to their assembly into higher order structures..” Microbiology 162, no. 9 (September 2016): 1527–34. https://doi.org/10.1099/mic.0.000359.

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Simon, G. R., C. Byington, C. Diasio, A. R. Edwards, B. Holmes, A. D. Arauz Boudreau, C. Baker, et al. “Medical versus nonmedical immunization exemptions for child care and school attendance.” Pediatrics 138, no. 3 (September 1, 2016). https://doi.org/10.1542/peds.2016-2145.

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Davies, H Dele, Carrie L. Byington, and Carrie L. COMMITTEE ON INFECTIOUS DISEASES. “Parental Presence During Treatment of Ebola or Other Highly Consequential Infection..” Pediatrics 138, no. 3 (September 2016). https://doi.org/10.1542/peds.2016-1891.

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Byington, C. L., Y. A. Maldonado, E. D. Barnett, H. D. Davies, K. M. Edwards, R. Lynfield, F. M. Munoz, et al. “Recommendations for serogroup B meningococcal vaccine for persons 10 years and older.” Pediatrics 138, no. 3 (September 1, 2016). https://doi.org/10.1542/peds.2016-1890.

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Patterson, Thomas F., George R. Thompson, David W. Denning, Jay A. Fishman, Susan Hadley, Raoul Herbrecht, Dimitrios P. Kontoyiannis, et al. “Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America..” Clin Infect Dis 63, no. 4 (August 15, 2016): 433–42. https://doi.org/10.1093/cid/ciw444.

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