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William J. Steinbach, MD

Samuel L. Katz Distinguished Professor of Pediatrics
Professor of Pediatrics
Chief, Division of Pediatric Infectious Diseases
Professor in Molecular Genetics and Microbiology
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: Box 3499 Med Ctr, Durham, NC 27710
Phone: (919) 681-1504
Email address: bill.steinbach@duke.edu

My overall clinical and research focus is to improve the diagnosis, treatment, and outcomes of immunocompromised patients, specifically those with invasive fungal infections.  My research enterprise is divided between my basic, translational, and clinical approaches.  My laboratory focuses on the molecular pathogenesis of Aspergillus fumigatus, a leading invasive fungal killer, and the development of novel antifungal drugs and diagnostic assays.  I also oversee numerous translational and clinical research studies centered on several diagnostic and therapeutic aspects of invasive fungal infections and other infections in immunocompromised patients.  

My laboratory (www.steinbachlab.org) work is very translational in nature by design – all of it is performed with the specific goal of directly improving our fundamental understanding of how and why Aspergillus fumigatus, a leading killer in patients with cancer or following transplantation, is so deadly and how to best prevent and treat it. Our laboratory uses molecular genetic tools to delete or mutate pathogenesis genes and proteins to analyze their function and role in disease, including various genomic, proteomic, structural biologic and biochemical approaches. We also perform extensive in vitro and in vivo testing of antifungal compounds . Since we are focused on the pathogenesis, we utilize numerous different animal models specifically designed to mimic the immune system of a cancer patient or transplant recipient.

I am also the Chief of Pediatric Infectious Diseases and my clinical research includes my founding and directing the International Pediatric Fungal Network (www.ipfn.org), a 55-site multinational NIH-funded consortium dedicated to the epidemiology, diagnosis, treatment, and outcomes of pediatric invasive fungal infections.  This Network is the largest of its kind in the world and is currently leading three NIH-funded global clinical studies that will allow us to generate the first ever pediatric-specific international guidelines for these diseases.

I am the co-founder and continuing co-chair of the past nine Advances Against Aspergillosis adn Mucormycosis international conferences, the leading forum for these deadly diseases and most recently at https://aaam2020.org.  I have co-edited 12 infectious diseases textbooks, including as co-editor of the largest textbook in the field, Aspergillus fumigatus and Aspergillosis, Feigin & Cherry's Textbook of Pediatric Infectious Diseases (approx. 4,000 pages), the American Academy of Pediatrics Nelson's Pediatric Antimicrobial Therapy textbook, and most recently as the lead editor of the only textbook in the subfield Pediatric Transplant and Oncology Infectious Diseases.

I am the Basic Science Research Director for the Duke Transplant Center, and Medical Director of the Duke Children’s Clinical Research Unit overseeing 813 studies.  I am a member of the American Academy of Pediatrics Red Book committee, and recently completed a Board of Directors tenure for the Pediatric Infectious Diseases Society, where I currently chair the Division Chief working group.  I am a fellow of the American Association for the Advancement of Science and have been elected into the American Society for Clinical Investigation and the Association of American Physicians, for which I currently serve on the Council. 

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 2001 - 2004
  • Resident, Pediatrics, Stanford University, 1998 - 2001
  • M.D., University of North Carolina - Chapel Hill, 1998

Selected Grants and Awards

Publications

Donnelly, J Peter, Sharon C. Chen, Carol A. Kauffman, William J. Steinbach, John W. Baddley, Paul E. Verweij, Cornelius J. Clancy, et al. “Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium.” Clin Infect Dis, December 5, 2019. https://doi.org/10.1093/cid/ciz1008.

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Cornely, Oliver A., Ana Alastruey-Izquierdo, Dorothee Arenz, Sharon C. A. Chen, Eric Dannaoui, Bruno Hochhegger, Martin Hoenigl, et al. “Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium.” Lancet Infect Dis 19, no. 12 (December 2019): e405–21. https://doi.org/10.1016/S1473-3099(19)30312-3.

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COMMITTEE ON INFECTIOUS DISEASES, Michael T. “Recommendations for Prevention and Control of Influenza in Children, 2019-2020.” Pediatrics 144, no. 4 (October 2019). https://doi.org/10.1542/peds.2019-2478.

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Juvvadi, Praveen R., David Fox, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, et al. “Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.” Nat Commun 10, no. 1 (September 19, 2019): 4275. https://doi.org/10.1038/s41467-019-12199-1.

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Danziger-Isakov, Lara, William J. Steinbach, Grant Paulsen, Flor M. Munoz, Leigh R. Sweet, Michael Green, Marian G. Michaels, et al. “A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection.” J Pediatric Infect Dis Soc 8, no. 3 (July 1, 2019): 197–204. https://doi.org/10.1093/jpids/piy024.

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Shwab, E Keats, Praveen R. Juvvadi, Greg Waitt, Erik J. Soderblom, Blake C. Barrington, Yohannes G. Asfaw, M Arthur Moseley, and William J. Steinbach. “Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus.” Mol Microbiol 112, no. 1 (July 2019): 62–80. https://doi.org/10.1111/mmi.14254.

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Spees, Lisa P., Paul L. Martin, Joanne Kurtzberg, Andre Stokhuyzen, Lauren McGill, Vinod K. Prasad, Timothy A. Driscoll, et al. “Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014).” Biol Blood Marrow Transplant 25, no. 4 (April 2019): 756–63. https://doi.org/10.1016/j.bbmt.2018.11.018.

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COMMITTEE ON INFECTIOUS DISEASES, Gyan. “Recommended Childhood and Adolescent Immunization Schedules: United States, 2019.” Pediatrics 143, no. 3 (March 2019). https://doi.org/10.1542/peds.2019-0065.

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Fisher, Brian T., Lara Danziger-Isakov, Leigh R. Sweet, Flor M. Munoz, Gabriela Maron, Elaine Tuomanen, Alistair Murray, et al. “A Multicenter Consortium to Define the Epidemiology and Outcomes of Inpatient Respiratory Viral Infections in Pediatric Hematopoietic Stem Cell Transplant Recipients.” J Pediatric Infect Dis Soc 7, no. 4 (December 3, 2018): 275–82. https://doi.org/10.1093/jpids/pix051.

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Juvvadi, Praveen R., D Christopher Cole, Katie Falloon, Greg Waitt, Erik J. Soderblom, M Arthur Moseley, and William J. Steinbach. “Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus.” Biochem Biophys Res Commun 505, no. 3 (November 2, 2018): 740–46. https://doi.org/10.1016/j.bbrc.2018.09.186.

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