William J. Steinbach, MD

My overall clinical and research focus is to improve the diagnosis, treatment, and outcomes of immunocompromised patients, specifically those with invasive fungal infections. My research enterprise is divided between my basic, translational, and clinical approaches. My laboratory focuses on the molecular pathogenesis of Aspergillus fumigatus, a leading invasive fungal killer, and the development of novel antifungal drugs and diagnostic assays. I also oversee numerous translational and clinical research studies centered on several diagnostic and therapeutic aspects of invasive fungal infections and other infections in immunocompromised patients.
My laboratory (www.steinbachlab.org) work is very translational in nature by design – all of it is performed with the specific goal of directly improving our fundamental understanding of how and why Aspergillus fumigatus, a leading killer in patients with cancer or following transplantation, is so deadly and how to best prevent and treat it. Our laboratory uses molecular genetic tools to delete or mutate pathogenesis genes and proteins to analyze their function and role in disease, including various genomic, proteomic, structural biologic and biochemical approaches. We also perform extensive in vitro and in vivo testing of antifungal compounds . Since we are focused on the pathogenesis, we utilize numerous different animal models specifically designed to mimic the immune system of a cancer patient or transplant recipient.
I am also the Chief of Pediatric Infectious Diseases and my clinical research includes my founding and directing the International Pediatric Fungal Network (www.ipfn.org), a 55-site multinational NIH-funded consortium dedicated to the epidemiology, diagnosis, treatment, and outcomes of pediatric invasive fungal infections. This Network is the largest of its kind in the world and is currently leading three NIH-funded global clinical studies that will allow us to generate the first ever pediatric-specific international guidelines for these diseases.
I am the co-founder and continuing co-chair of the past nine Advances Against Aspergillosis adn Mucormycosis international conferences, the leading forum for these deadly diseases and most recently at https://aaam2020.org. I have co-edited 12 infectious diseases textbooks, including as co-editor of the largest textbook in the field, Aspergillus fumigatus and Aspergillosis, Feigin & Cherry's Textbook of Pediatric Infectious Diseases (approx. 4,000 pages), the American Academy of Pediatrics Nelson's Pediatric Antimicrobial Therapy textbook, and most recently as the lead editor of the only textbook in the subfield Pediatric Transplant and Oncology Infectious Diseases.
I am the Basic Science Research Director for the Duke Transplant Center, and Medical Director of the Duke Children’s Clinical Research Unit overseeing 813 studies. I am a member of the American Academy of Pediatrics Red Book committee, and recently completed a Board of Directors tenure for the Pediatric Infectious Diseases Society, where I currently chair the Division Chief working group. I am a fellow of the American Association for the Advancement of Science and have been elected into the American Society for Clinical Investigation and the Association of American Physicians, for which I currently serve on the Council.
Education and Training
- Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 2001 - 2004
- Resident, Pediatrics, Stanford University, 1998 - 2001
- M.D., University of North Carolina - Chapel Hill, 1998
Selected Grants and Awards
- Genetic and Genomics Training Grant
- Unified Program for Therapeutics in Children
- Diagnosis and Outcomes of Pulmonary Invasive Mold Infections in Immunocompromised Children
- Duke Resident Physician-Scientist Program - NIAID
- Structural Biological Development of Fungal-Specific Calcineurin Inhibitors
- Research Training in Allergy and Clinical Immunology
- Molecular Mycology and Pathogenesis Training Program
- Development of non-toxic amphotericin B derivatives targeting invasive fungal infections
- Discovering novel antifungal agents via multi-species profiling of a structurally and stereochemically diverse, well-validated compound library
- Phosphoproteomic identification of Aspergillus fumigatus virulence-associated protein kinase A downstream effectors
- Genetics Training Grant
- Fungal biomarkers for diagnosis and response to therapy for pediatric candidemia
- Defining the Aspergillus fumigatus Calcineurin-Dependent Regulatory Network through Whole Phosphoproteome Analysis
- Multi-center studies to improve diagnosis and treatment of pediatric candidiasis
- Developing a novel antifungal targeting Gwt1 for the treatment of invasive aspergillosis and rare mold infections
- Structural Biological Development of Fungal-Specific Calcineurin Inhibitors
- The use of NExtGEn Genetics to determine gene function in genetically intractable but medically important microbes
- A study of the safety, tolerability and pharmacokinetics of Intravenous (IV) and Powder for Oral suspension formulations of Posaconazol (POS) in Immunocompromised Pediatric Subjects with Neutropenia
- Developing a New Therapeutic for the Treatment of Invasive Aspergillosis
- Institutional Training Grant in Pediatric Infectious Disease
- A novel antisense therapeutic for treatment of Aspergillus fumigatus infections
- ID Week 2014TM Trainee Travel Grant
- Developing a New Therapeutic for the Treatment of Invasive Aspergillosis
- NON-IMMUNOSUPPRESSIVE CYCLOSPORINE ANALOGS FOR NOVEL ANTIFUNGAL THERAPIES
- Iterative In Vitro and In Vivo Screening for Anti-Aspergillus Activity of Aureobasidin A Analogs
- Instrumentation for Quantitative Phosphoproteomics and Acetylomics
- Development of anti-Aspergillus single chain Abs as serum and imaging diagnostics
- ID Week 2014TM Trainee Travel Grant
- Identification of calcineurin-binding proteins in A. fumigatus septum formation
- Calcineurin Inhibition to Halt Aspergillus fumigatus Hyphae and Virulence
- Microfluidic PCR Platform to Detect Microbial DNA
- Calcineurin and Aspergillus fumigatus Pathogenesis