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William J. Steinbach, MD

Professor of Pediatrics
Chief, Division of Pediatric Infectious Diseases
Professor in Molecular Genetics and Microbiology
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: Box 3499 Med Ctr, Durham, NC 27710
Phone: (919) 681-1504
Email address: bill.steinbach@duke.edu

My overall clinical and research focus is to improve the diagnosis, treatment, and outcomes of immunocompromised patients, specifically those with invasive fungal infections.  My research enterprise is divided between my laboratory focusing on the molecular pathogenesis of Aspergillus fumigatus and development of novel antifungal drugs and diagnostic assays, and numerous translational and clinical studies centered on several diagnostic and therapeutic aspects of invasive fungal infections.  

My laboratory (www.steinbachlab.org) work is very translational in nature by design – all of it is performed with the specific goal of directly improving our fundamental understanding of how and why Aspergillus fumigatus, a leading killer in patients with cancer or following transplantation, is so deadly and how to best prevent and treat it. Our laboratory uses molecular genetic tools to knock-out or mutate pathogenesis genes and proteins to analyze their function and role in disease, including various genomic, proteomic, and biochemical approaches. We also perform extensive in vitro and in vivo testing of antifungal compounds . Since we are focused on the pathogenesis, we utilize numerous different animal models specifically designed to mimic the immune system of a cancer patient or transplant recipient.

I am also the Chief of Pediatric Infectious Diseases and my clinical research includes my founding and directing the International Pediatric Fungal Network (www.ipfn.org), a 55-site multinational NIH-funded consortium dedicated to the epidemiology, diagnosis, treatment, and outcomes of pediatric invasive fungal infections.  This Network is the largest of its kind in the world and is currently leading two global clinical studies that will allow us to generate the first ever pediatric-specific international guidelines for these diseases.

I am the co-founder and continuing co-chair of the past eight Advances Against Aspergillosis international conferences, the leading forum for this deadly disease and most recently at www.AAA2018.org.  I am the co-editor of the largest textbook in the field, Aspergillus fumigatus and Aspergillosis, and have co-edited eight other pediatric infectious diseases textbooks, including Feigin & Cherry's Textbook of Pediatric Infectious Diseases (nearly 4,000 pages), and the American Academy of Pediatrics Nelson's Pediatric Antimicrobial Therapy textbook.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 2001 - 2004
  • Resident, Pediatrics, Stanford University, 1998 - 2001
  • M.D., University of North Carolina at Chapel Hill, 1998

Selected Grants and Awards

Publications

Hoy, MJ, Fox, D, Wheaton, J, Mutz, M, Steinbach, WJ, Ciofani, M, and Heitman, J. "Novel FK506 analog exhibits anti-fungal activity against Cryptococcus neoformans in vitro and in an animal model.": OXFORD UNIV PRESS, June 1, 2018.

Scholars@Duke

Danziger-Isakov, L, Steinbach, WJ, Paulsen, G, Munoz, FM, Sweet, LR, Green, M, Michaels, MG, Englund, JA, Murray, A, Halasa, N, Dulek, DE, Madan, RP, Herold, BC, and Fisher, BT. "A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection." Journal of the Pediatric Infectious Diseases Society (March 10, 2018).

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Moseley, MA, Hughes, CJ, Juvvadi, PR, Soderblom, EJ, Lennon, S, Perkins, SR, Thompson, JW, Steinbach, WJ, Geromanos, SJ, Wildgoose, J, Langridge, JI, Richardson, K, and Vissers, JPC. "Scanning Quadrupole Data-Independent Acquisition, Part A: Qualitative and Quantitative Characterization." Journal of proteome research 17, no. 2 (February 2018): 770-779.

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Juvvadi, PR, Moseley, MA, Hughes, CJ, Soderblom, EJ, Lennon, S, Perkins, SR, Thompson, JW, Geromanos, SJ, Wildgoose, J, Richardson, K, Langridge, JI, Vissers, JPC, and Steinbach, WJ. "Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs." Journal of Proteome Research 17, no. 2 (February 2018): 780-793.

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Renshaw, H, Vargas-Muñiz, JM, Juvvadi, PR, Richards, AD, Waitt, G, Soderblom, EJ, Moseley, MA, and Steinbach, WJ. "The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth." Journal of cell science 131, no. 3 (February 2018).

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Shwab, EK, Juvvadi, PR, Waitt, G, Soderblom, EJ, Moseley, MA, Nicely, NI, and Steinbach, WJ. "Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms." FEBS letters 591, no. 22 (November 2017): 3730-3744. (Letter)

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Wong, SSW, Rasid, O, Laskaris, P, Fekkar, A, Cavaillon, J-M, Steinbach, WJ, and Ibrahim-Granet, O. "Treatment of Cyclosporin A retains host defense against invasive pulmonary aspergillosis in a non-immunosuppressive murine model by preserving the myeloid cell population." Virulence 8, no. 8 (November 2017): 1744-1752.

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Moreno-Velásquez, SD, Seidel, C, Juvvadi, PR, Steinbach, WJ, and Read, ND. "Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus Involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in β-1,3-Glucan Synthase Localization." Antimicrobial Agents and Chemotherapy 61, no. 10 (October 2017).

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"Elimination of Perinatal Hepatitis B: Providing the First Vaccine Dose Within 24 Hours of Birth." Pediatrics 140, no. 3 (September 2017): e20171870-e20171870.

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Steinbach, WJ, and Fisher, BT. "International Collaborative on Contemporary Epidemiology and Diagnosis of Invasive Fungal Disease in Children." Journal of the Pediatric Infectious Diseases Society 6, no. suppl_1 (September 2017): S1-S2.

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