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William J. Steinbach, MD

Samuel L. Katz Professor of Pediatrics
Professor of Pediatrics
Chief, Division of Pediatric Infectious Diseases
Professor in Molecular Genetics and Microbiology
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: Box 3499 Med Ctr, Durham, NC 27710
Phone: (919) 681-1504
Email address: bill.steinbach@duke.edu

My overall clinical and research focus is to improve the diagnosis, treatment, and outcomes of immunocompromised patients, specifically those with invasive fungal infections.  My research enterprise is divided between my laboratory focusing on the molecular pathogenesis of Aspergillus fumigatus and development of novel antifungal drugs and diagnostic assays, and numerous translational and clinical studies centered on several diagnostic and therapeutic aspects of invasive fungal infections.  

My laboratory (www.steinbachlab.org) work is very translational in nature by design – all of it is performed with the specific goal of directly improving our fundamental understanding of how and why Aspergillus fumigatus, a leading killer in patients with cancer or following transplantation, is so deadly and how to best prevent and treat it. Our laboratory uses molecular genetic tools to knock-out or mutate pathogenesis genes and proteins to analyze their function and role in disease, including various genomic, proteomic, and biochemical approaches. We also perform extensive in vitro and in vivo testing of antifungal compounds . Since we are focused on the pathogenesis, we utilize numerous different animal models specifically designed to mimic the immune system of a cancer patient or transplant recipient.

I am also the Chief of Pediatric Infectious Diseases and my clinical research includes my founding and directing the International Pediatric Fungal Network (www.ipfn.org), a 55-site multinational NIH-funded consortium dedicated to the epidemiology, diagnosis, treatment, and outcomes of pediatric invasive fungal infections.  This Network is the largest of its kind in the world and is currently leading two global clinical studies that will allow us to generate the first ever pediatric-specific international guidelines for these diseases.

I am the co-founder and continuing co-chair of the past eight Advances Against Aspergillosis international conferences, the leading forum for this deadly disease and most recently at www.AAA2018.org.  I am the co-editor of the largest textbook in the field, Aspergillus fumigatus and Aspergillosis, and have co-edited eight other pediatric infectious diseases textbooks, including Feigin & Cherry's Textbook of Pediatric Infectious Diseases (nearly 4,000 pages), and the American Academy of Pediatrics Nelson's Pediatric Antimicrobial Therapy textbook.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, Duke University, 2001 - 2004
  • Resident, Pediatrics, Stanford University, 1998 - 2001
  • M.D., University of North Carolina at Chapel Hill, 1998

Selected Grants and Awards

Publications

Lehrnbecher, Thomas, Brian T. Fisher, Bob Phillips, Sarah Alexander, Roland A. Ammann, Melissa Beauchemin, Fabianne Carlesse, et al. “Guideline for Antibacterial Prophylaxis Administration in Pediatric Cancer and Hematopoietic Stem Cell Transplantation..” Clin Infect Dis, November 2, 2019. https://doi.org/10.1093/cid/ciz1082.

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COMMITTEE ON INFECTIOUS DISEASES, Huseyin. “Recommendations for Prevention and Control of Influenza in Children, 2019-2020..” Pediatrics 144, no. 4 (October 2019). https://doi.org/10.1542/peds.2019-2478.

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Juvvadi, Praveen R., David Fox, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, et al. “Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents..” Nat Commun 10, no. 1 (September 19, 2019). https://doi.org/10.1038/s41467-019-12199-1.

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Danziger-Isakov, Lara, William J. Steinbach, Grant Paulsen, Flor M. Munoz, Leigh R. Sweet, Michael Green, Marian G. Michaels, et al. “A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection..” J Pediatric Infect Dis Soc 8, no. 3 (July 1, 2019): 197–204. https://doi.org/10.1093/jpids/piy024.

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Shwab, E Keats, Praveen R. Juvvadi, Greg Waitt, Erik J. Soderblom, Blake C. Barrington, Yohannes G. Asfaw, M Arthur Moseley, and William J. Steinbach. “Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus..” Mol Microbiol 112, no. 1 (July 2019): 62–80. https://doi.org/10.1111/mmi.14254.

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Spees, Lisa P., Paul L. Martin, Joanne Kurtzberg, Andre Stokhuyzen, Lauren McGill, Vinod K. Prasad, Timothy A. Driscoll, et al. “Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014)..” Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 25, no. 4 (April 2019): 756–63. https://doi.org/10.1016/j.bbmt.2018.11.018.

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COMMITTEE ON INFECTIOUS DISEASES, Amy L. “Recommended Childhood and Adolescent Immunization Schedules: United States, 2019..” Pediatrics 143, no. 3 (March 2019). https://doi.org/10.1542/peds.2019-0065.

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Fisher, Brian T., Lara Danziger-Isakov, Leigh R. Sweet, Flor M. Munoz, Gabriela Maron, Elaine Tuomanen, Alistair Murray, et al. “A Multicenter Consortium to Define the Epidemiology and Outcomes of Inpatient Respiratory Viral Infections in Pediatric Hematopoietic Stem Cell Transplant Recipients..” J Pediatric Infect Dis Soc 7, no. 4 (December 3, 2018): 275–82. https://doi.org/10.1093/jpids/pix051.

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Steinbach, William J., Daniel K. Benjamin, and John W. Sleasman. “Funding Pediatric Subspecialty Training: Are T32 Grants the Future?.” J Pediatr 202 (November 2018): 4-7.e1. https://doi.org/10.1016/j.jpeds.2018.08.035.

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COMMITTEE ON INFECTIOUS DISEASES, Timothy J. “Recommendations for Prevention and Control of Influenza in Children, 2018-2019..” Pediatrics 142, no. 4 (October 2018). https://doi.org/10.1542/peds.2018-2367.

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