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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Permar, SR, Kang, HH, Wilks, AB, Mach, LV, Carville, A, Mansfield, KG, Learn, GH, Hahn, BH, and Letvin, NL. "Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys." RETROVIROLOGY 7 (February 1, 2010).

Full Text

Permar, SR, Kang, HH, Wilks, AB, Mach, LV, Carville, A, Mansfield, KG, Learn, GH, Hahn, BH, and Letvin, NL. "Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys. (Published online)" Retrovirology 7 (February 1, 2010): 7-.

Full Text

Permar, SR, Kang, HH, Carville, A, Wilks, AB, Mansfield, KG, Rao, SS, and Letvin, NL. "Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection." J Infect Dis 201, no. 2 (January 15, 2010): 302-310.

Full Text

Permar, SR, Kang, HH, Carville, A, Mansfield, KG, Gelman, RS, Rao, SS, Whitney, JB, and Letvin, NL. "Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys." J Immunol 181, no. 5 (September 1, 2008): 3643-3650.

Scholars@Duke

Permar, SR, Rao, SS, Sun, Y, Bao, S, Buzby, AP, Kang, HH, and Letvin, NL. "Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys." J Infect Dis 196, no. 12 (December 15, 2007): 1784-1793.

Full Text

Sun, Y, Permar, SR, Buzby, AP, and Letvin, NL. "Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection." J Virol 81, no. 15 (August 2007): 8009-8015.

Full Text

Permar, SR, Griffin, DE, and Letvin, NL. "Immune containment and consequences of measles virus infection in healthy and immunocompromised individuals." CLINICAL AND VACCINE IMMUNOLOGY 13, no. 4 (April 2006): 437-443.

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Permar, SR, Griffin, DE, and Letvin, NL. "Immune containment and consequences of measles virus infection in healthy and immunocompromised individuals." Clin Vaccine Immunol 13, no. 4 (April 2006): 437-443. (Review)

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Permar, SR, Klumpp, SA, Mansfield, KG, Carville, AAL, Gorgone, DA, Lifton, MA, Schmitz, JE, Reimann, KA, Polack, FP, Griffin, DE, and Letvin, NL. "Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys." J Infect Dis 190, no. 5 (September 1, 2004): 998-1005.

Full Text

Permar, SR, Moss, WJ, Ryon, JJ, Douek, DC, Monze, M, and Griffin, DE. "Increased thymic output during acute measles virus infection." J Virol 77, no. 14 (July 2003): 7872-7879.

Scholars@Duke

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