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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Fouda, G, Amos, J, Wilks, A, Chand, A, Montefiori, D, Haynes, B, Letvin, N, Pickup, D, Liao, H, and Permar, S. "Vaccine-elicited systemic and mucosal humoral responses of lactating rhesus monkeys vaccinated with the transmitted/founder HIV Envelope 1086C." Retrovirology 9, no. Suppl 2 (2012): O20-O20.

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Ehlinger, EP, Webster, EM, Kang, HH, Cangialose, A, Simmons, AC, Barbas, KH, Burchett, SK, Gregory, ML, Puopolo, KM, and Permar, SR. "Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants." J Infect Dis 204, no. 11 (December 1, 2011): 1672-1682.

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Wilks, AB, Perry, JR, Ehlinger, EP, Zahn, RC, White, R, Gauduin, M-C, Carville, A, Seaman, MS, Schmitz, JE, and Permar, SR. "High cell-free virus load and robust autologous humoral immune responses in breast milk of simian immunodeficiency virus-infected african green monkeys." J Virol 85, no. 18 (September 2011): 9517-9526.

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Fouda, GG, Yates, NL, Pollara, J, Shen, X, Overman, GR, Mahlokozera, T, Wilks, AB, Kang, HH, Salazar-Gonzalez, JF, Salazar, MG, Kalilani, L, Meshnick, SR, Hahn, BH, Shaw, GM, Lovingood, RV, Denny, TN, Haynes, B, Letvin, NL, Ferrari, G, Montefiori, DC, Tomaras, GD, Permar, SR, and Center for HIV/AIDS Vaccine Immunology, . "HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies." J Virol 85, no. 18 (September 2011): 9555-9567.

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Sun, Y, Asmal, M, Lane, S, Permar, SR, Schmidt, SD, Mascola, JR, and Letvin, NL. "Antibody-dependent cell-mediated cytotoxicity in simian immunodeficiency virus-infected rhesus monkeys." J Virol 85, no. 14 (July 2011): 6906-6912.

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Salazar-Gonzalez, JF, Salazar, MG, Learn, GH, Fouda, GG, Kang, HH, Mahlokozera, T, Wilks, AB, Lovingood, RV, Stacey, A, Kalilani, L, Meshnick, SR, Borrow, P, Montefiori, DC, Denny, TN, Letvin, NL, Shaw, GM, Hahn, BH, Permar, SR, and Center for HIV/AIDS Vaccine Immunology A0167854, . "Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencing." Journal of virology 85, no. 6 (March 2011): 2751-2763.

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Mahlokozera, T, Kang, HH, Goonetilleke, N, Stacey, AR, Lovingood, RV, Denny, TN, Kalilani, L, Bunn, JEG, Meshnick, SR, Borrow, P, Letvin, NL, Permar, SR, and Center for HIV/AIDS Vaccine Immunology, . "The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk." PLoS One 6, no. 8 (2011): e23735-.

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Wilks, AB, Christian, EC, Seaman, MS, Sircar, P, Carville, A, Gomez, CE, Esteban, M, Pantaleo, G, Barouch, DH, Letvin, NL, and Permar, SR. "Robust vaccine-elicited cellular immune responses in breast milk following systemic simian immunodeficiency virus DNA prime and live virus vector boost vaccination of lactating rhesus monkeys." J Immunol 185, no. 11 (December 1, 2010): 7097-7106.

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Salazar-Gonzalez, JF, Salazar, MG, Learn, GH, Kang, HH, Mahlokozera, T, Kalilani, L, Meshnick, SR, Lovingood, RV, Denny, TN, Letvin, NL, Shaw, GM, Hahn, BH, and Permar, SR. "Local production of HIV variants in breast milk of chronically HIV-infected, lactating women." October 2010.

Scholars@Duke

Permar, SR, Wilks, AB, Ehlinger, EP, Kang, HH, Mahlokozera, T, Coffey, RT, Carville, A, Letvin, NL, and Seaman, MS. "Limited contribution of mucosal IgA to Simian immunodeficiency virus (SIV)-specific neutralizing antibody response and virus envelope evolution in breast milk of SIV-infected, lactating rhesus monkeys." J Virol 84, no. 16 (August 2010): 8209-8218.

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