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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Professor of Pathology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital, Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital, Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Martinez, David R., Sallie R. Permar, and Genevieve G. Fouda. “Contrasting Adult and Infant Immune Responses to HIV Infection and Vaccination..” Clin Vaccine Immunol 23, no. 2 (February 2016): 84–94. https://doi.org/10.1128/CVI.00565-15.

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Bialas, Kristy M., and Sallie R. Permar. “The March towards a Vaccine for Congenital CMV: Rationale and Models..” Plos Pathog 12, no. 2 (February 2016). https://doi.org/10.1371/journal.ppat.1005355.

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Mansour, Robin G., Lisa Stamper, Frederick Jaeger, Erin McGuire, Genevieve Fouda, Joshua Amos, Kimberly Barbas, et al. “The Presence and Anti-HIV-1 Function of Tenascin C in Breast Milk and Genital Fluids..” Plos One 11, no. 5 (2016). https://doi.org/10.1371/journal.pone.0155261.

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Kelly, Matthew S., Daniel K. Benjamin, Karen M. Puopolo, Matthew M. Laughon, Reese H. Clark, Sagori Mukhopadhyay, P Brian Smith, and Sallie R. Permar. “Postnatal Cytomegalovirus Infection and the Risk for Bronchopulmonary Dysplasia..” Jama Pediatr 169, no. 12 (December 2015). https://doi.org/10.1001/jamapediatrics.2015.3785.

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Lantos, Paul M., Sallie R. Permar, Kate Hoffman, and Geeta K. Swamy. “The Excess Burden of Cytomegalovirus in African American Communities: A Geospatial Analysis..” Open Forum Infect Dis 2, no. 4 (December 2015). https://doi.org/10.1093/ofid/ofv180.

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Bialas, Kristy M., Takayuki Tanaka, Dollnovan Tran, Valerie Varner, Eduardo Cisneros De La Rosa, Flavia Chiuppesi, Felix Wussow, et al. “Maternal CD4+ T cells protect against severe congenital cytomegalovirus disease in a novel nonhuman primate model of placental cytomegalovirus transmission..” Proc Natl Acad Sci U S A 112, no. 44 (November 3, 2015): 13645–50. https://doi.org/10.1073/pnas.1511526112.

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Wahl, Angela, Caroline Baker, Rae Ann Spagnuolo, Lisa W. Stamper, Genevieve G. Fouda, Sallie R. Permar, Katie Hinde, et al. “Breast Milk of HIV-Positive Mothers Has Potent and Species-Specific In Vivo HIV-Inhibitory Activity..” J Virol 89, no. 21 (November 2015): 10868–78. https://doi.org/10.1128/JVI.01702-15.

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Pollara, Justin, Erin McGuire, Genevieve G. Fouda, Wes Rountree, Josh Eudailey, R Glenn Overman, Kelly E. Seaton, et al. “Association of HIV-1 Envelope-Specific Breast Milk IgA Responses with Reduced Risk of Postnatal Mother-to-Child Transmission of HIV-1..” J Virol 89, no. 19 (October 2015): 9952–61. https://doi.org/10.1128/JVI.01560-15.

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Amos, Joshua D., Jonathon E. Himes, Lawrence Armand, Thaddeus C. Gurley, David R. Martinez, Lisa Colvin, Krista Beck, et al. “Rapid Development of gp120-Focused Neutralizing B Cell Responses during Acute Simian Immunodeficiency Virus Infection of African Green Monkeys..” J Virol 89, no. 18 (September 2015): 9485–98. https://doi.org/10.1128/JVI.01564-15.

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Shen, Xiaoying, Ryan Duffy, Robert Howington, Alethea Cope, Shanmugalakshmi Sadagopal, Haesun Park, Ranajit Pal, et al. “Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates..” J Virol 89, no. 16 (August 2015): 8643–50. https://doi.org/10.1128/JVI.03635-14.

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