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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Ho, C, Wu, S, Amos, JD, Colvin, L, Smith, SD, Wilks, AB, Demarco, CT, Brinkley, C, Denny, TN, Schmitz, JE, Rodrigo, AG, and Permar, SR. "Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys." J Virol 87, no. 20 (October 2013): 11292-11299.

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Permar, SR, Salazar, MG, Gao, F, Cai, F, Learn, GH, Kalilani, L, Hahn, BH, Shaw, GM, and Salazar-Gonzalez, JF. "Clonal amplification and maternal-infant transmission of nevirapine-resistant HIV-1 variants in breast milk following single-dose nevirapine prophylaxis. (Published online)" Retrovirology 10 (August 14, 2013): 88-.

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Fouda, GGA, Amos, JD, Wilks, AB, Pollara, J, Ray, CA, Chand, A, Kunz, EL, Liebl, BE, Whitaker, K, Carville, A, Smith, S, Colvin, L, Pickup, DJ, Staats, HF, Overman, G, Eutsey-Lloyd, K, Parks, R, Chen, H, Labranche, C, Barnett, S, Tomaras, GD, Ferrari, G, Montefiori, DC, Liao, H-X, Letvin, NL, Haynes, BF, and Permar, SR. "Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milk." J Virol 87, no. 12 (June 2013): 6986-6999.

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Russell, ES, Ojeda, S, Fouda, GG, Meshnick, SR, Montefiori, D, Permar, SR, and Swanstrom, R. "Short communication: HIV type 1 subtype C variants transmitted through the bottleneck of breastfeeding are sensitive to new generation broadly neutralizing antibodies directed against quaternary and CD4-binding site epitopes." AIDS research and human retroviruses 29, no. 3 (March 2013): 511-515.

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Fouda, GG, Mahlokozera, T, Salazar-Gonzalez, JF, Salazar, MG, Learn, G, Kumar, SB, Dennison, SM, Russell, E, Rizzolo, K, Jaeger, F, Cai, F, Vandergrift, NA, Gao, F, Hahn, B, Shaw, GM, Ochsenbauer, C, Swanstrom, R, Meshnick, S, Mwapasa, V, Kalilani, L, Fiscus, S, Montefiori, D, Haynes, B, Kwiek, J, Alam, SM, and Permar, SR. "Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants. (Published online)" Retrovirology 10 (January 10, 2013): 3-.

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Handley, SA, Thackray, LB, Zhao, G, Presti, R, Miller, AD, Droit, L, Abbink, P, Maxfield, LF, Kambal, A, Duan, E, Stanley, K, Kramer, J, Macri, SC, Permar, SR, Schmitz, JE, Mansfield, K, Brenchley, JM, Veazey, RS, Stappenbeck, TS, Wang, D, Barouch, DH, and Virgin, HW. "Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome." Cell 151, no. 2 (October 12, 2012): 253-266.

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Schmitz, JE, Ma, Z-M, Hagan, EA, Wilks, AB, Furr, KL, Linde, CH, Zahn, RC, Brenchley, JM, Miller, CJ, and Permar, SR. "Memory CD4(+) T lymphocytes in the gastrointestinal tract are a major source of cell-associated simian immunodeficiency virus in chronic nonpathogenic infection of African green monkeys." J Virol 86, no. 20 (October 2012): 11380-11385.

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Amos, JD, Wilks, AB, Fouda, GG, Smith, SD, Overman, GR, Beck, K, Moody, MA, Tomaras, GD, and Permar, SR. "Strong SIV gp120-specific IgG/IgA responses in milk of African green monkeys may contribute to the rarity of postnatal transmission in this species." September 13, 2012.

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Friedman, J, Alam, SM, Shen, X, Xia, S-M, Stewart, S, Anasti, K, Pollara, J, Fouda, GG, Yang, G, Kelsoe, G, Ferrari, G, Tomaras, GD, Haynes, BF, Liao, H-X, Moody, MA, and Permar, SR. "Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum." PLoS One 7, no. 5 (2012): e37648-.

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Parrish, NF, Wilen, CB, Banks, LB, Iyer, SS, Pfaff, JM, Salazar-Gonzalez, JF, Salazar, MG, Decker, JM, Parrish, EH, Berg, A, Hopper, J, Hora, B, Kumar, A, Mahlokozera, T, Yuan, S, Coleman, C, Vermeulen, M, Ding, H, Ochsenbauer, C, Tilton, JC, Permar, SR, Kappes, JC, Betts, MR, Busch, MP, Gao, F, Montefiori, D, Haynes, BF, Shaw, GM, Hahn, BH, and Doms, RW. "Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7." PLoS Pathog 8, no. 5 (2012): e1002686-.

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