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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Professor of Pathology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital, Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital, Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Aliota, Matthew T., Dawn M. Dudley, Christina M. Newman, Emma L. Mohr, Dane D. Gellerup, Meghan E. Breitbach, Connor R. Buechler, et al. “Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques..” Plos Negl Trop Dis 10, no. 12 (December 2016). https://doi.org/10.1371/journal.pntd.0005168.

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Nguyen, Quang N., Jonathon E. Himes, David R. Martinez, and Sallie R. Permar. “The Impact of the Gut Microbiota on Humoral Immunity to Pathogens and Vaccination in Early Infancy..” Plos Pathog 12, no. 12 (December 2016). https://doi.org/10.1371/journal.ppat.1005997.

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Himes, Jonathon E., Carrie Ho, Quang N. Nguyen, Joshua D. Amos, Haolin Xu, Cliburn Chan, Shein-Chung Chow, et al. “Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized in Plasma and Milk in Chronically Infected African Green Monkeys..” J Virol 90, no. 19 (October 1, 2016): 8795–8808. https://doi.org/10.1128/JVI.00701-16.

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Martinez, David R., Erin McGuire, Sallie R. Permar, and Genevieve G. Fouda. “Variable IgG Transplacental Transfer in the Setting of Maternal HIV Infection.” In Aids Research and Human Retroviruses, 32:92–92. MARY ANN LIEBERT, INC, 2016.

Scholars@Duke

Zhang, Ruijun, S Munir Alam, Jae-Sung Yu, Richard Scearce, Bradley Lockwood, Kwan-Ki Hwang, Robert Parks, et al. “Novel Monoclonal Antibodies for Studies of Human and Rhesus Macaque Secretory Component and Human J-Chain..” Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 35, no. 4 (August 2016): 217–26. https://doi.org/10.1089/mab.2016.0014.

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Zhang, Ruijun, David R. Martinez, Quang N. Nguyen, Justin Pollara, Trina Arifin, Christina Stolarchuk, Andrew Foulger, et al. “Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus..” Nat Commun 7 (July 6, 2016). https://doi.org/10.1038/ncomms12131.

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Mukhopadhyay, Sagori, Sarah A. Meyer, Sallie R. Permar, and Karen M. Puopolo. “Symptomatic Postnatal Cytomegalovirus Testing among Very Low-Birth-Weight Infants: Indications and Outcomes..” Am J Perinatol 33, no. 9 (July 2016): 894–902. https://doi.org/10.1055/s-0036-1581080.

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Dudley, Dawn M., Matthew T. Aliota, Emma L. Mohr, Andrea M. Weiler, Gabrielle Lehrer-Brey, Kim L. Weisgrau, Mariel S. Mohns, et al. “A rhesus macaque model of Asian-lineage Zika virus infection..” Nat Commun 7 (June 28, 2016). https://doi.org/10.1038/ncomms12204.

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Nelson, Cody S., Justin Pollara, Erika L. Kunz, Thomas L. Jeffries, Ryan Duffy, Charles Beck, Lisa Stamper, et al. “Combined HIV-1 Envelope Systemic and Mucosal Immunization of Lactating Rhesus Monkeys Induces a Robust Immunoglobulin A Isotype B Cell Response in Breast Milk..” J Virol 90, no. 10 (May 15, 2016): 4951–65. https://doi.org/10.1128/JVI.00335-16.

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Jeffries, T. L., C. R. Sacha, J. Pollara, J. Himes, F. H. Jaeger, S. M. Dennison, E. McGuire, et al. “The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells..” Mucosal Immunol 9, no. 2 (March 2016): 414–27. https://doi.org/10.1038/mi.2015.70.

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