Skip to main content

Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Kunz, E, Fouda, G, Ho, C, Amos, J, Colvin, L, Montefiori, D, Martelli, A, Allen, A, Aramand, L, Marshall, DJ, Letvin, NL, Staats, H, Pickup, D, Barnett, SC, Moody, MA, Haynes, BF, Liao, H, and Permar, SR. "Combined Mucosal and Systemic C.1086 Envelope Immunization of Lactating Monkeys Induces Potent IgA and Functional IgG Antibody Responses in Milk." November 1, 2013.

Scholars@Duke

Sacha, CR, Vandergrift, N, Marshall, DJ, Gurley, TC, Stiegel, L, Whitesides, JF, Friedman, J, Fouda, GG, Liebl, B, McGuire, E, Foulger, A, Kepler, TB, Liao, H, Haynes, BF, Moody, MA, and Permar, SR. "Distinct VH Gene Usage and HIV Envelope Specificity of Colostrum and Peripheral B Cell Monoclonal Antibodies of HIV-Infected, Lactating African Women." November 1, 2013.

Scholars@Duke

Fouda, GG, Cunningham, CK, McFarland, EJ, Borkowsky, W, Muresan, P, Liebl, BE, Liao, H, Haynes, BF, Overman, R, Yates, NL, Tomaras, GD, and Permar, SR. "HIV-1 gp120 Vaccination Elicits a Robust and Durable Anti-V1/V2 IgG Response and Yet No HIV-1 Env-Specific IgA Response in HIV-Exposed Infants." November 1, 2013.

Scholars@Duke

Amos, JD, Wilks, AB, Fouda, GG, Smith, SD, Colvin, L, Mahlokozera, T, Ho, C, Beck, K, Overman, RG, DeMarco, CT, Hodge, TL, LaBranche, CC, Montefiori, DC, Denny, TN, Liao, H-X, Tomaras, GD, Moody, MA, and Permar, SR. "Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys." J Virol 87, no. 20 (October 2013): 11121-11134.

Full Text

Ho, C, Wu, S, Amos, JD, Colvin, L, Smith, SD, Wilks, AB, Demarco, CT, Brinkley, C, Denny, TN, Schmitz, JE, Rodrigo, AG, and Permar, SR. "Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys." J Virol 87, no. 20 (October 2013): 11292-11299.

Full Text

Permar, SR, Salazar, MG, Gao, F, Cai, F, Learn, GH, Kalilani, L, Hahn, BH, Shaw, GM, and Salazar-Gonzalez, JF. "Clonal amplification and maternal-infant transmission of nevirapine-resistant HIV-1 variants in breast milk following single-dose nevirapine prophylaxis. (Published online)" Retrovirology 10 (August 14, 2013): 88-.

Full Text

Fouda, GGA, Amos, JD, Wilks, AB, Pollara, J, Ray, CA, Chand, A, Kunz, EL, Liebl, BE, Whitaker, K, Carville, A, Smith, S, Colvin, L, Pickup, DJ, Staats, HF, Overman, G, Eutsey-Lloyd, K, Parks, R, Chen, H, Labranche, C, Barnett, S, Tomaras, GD, Ferrari, G, Montefiori, DC, Liao, H-X, Letvin, NL, Haynes, BF, and Permar, SR. "Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milk." J Virol 87, no. 12 (June 2013): 6986-6999.

Full Text

Fouda, GG, Mahlokozera, T, Salazar-Gonzalez, JF, Salazar, MG, Learn, G, Kumar, SB, Dennison, SM, Russell, E, Rizzolo, K, Jaeger, F, Cai, F, Vandergrift, NA, Gao, F, Hahn, B, Shaw, GM, Ochsenbauer, C, Swanstrom, R, Meshnick, S, Mwapasa, V, Kalilani, L, Fiscus, S, Montefiori, D, Haynes, B, Kwiek, J, Alam, SM, and Permar, SR. "Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants. (Published online)" Retrovirology 10 (January 10, 2013): 3-.

Full Text

Handley, SA, Thackray, LB, Zhao, G, Presti, R, Miller, AD, Droit, L, Abbink, P, Maxfield, LF, Kambal, A, Duan, E, Stanley, K, Kramer, J, Macri, SC, Permar, SR, Schmitz, JE, Mansfield, K, Brenchley, JM, Veazey, RS, Stappenbeck, TS, Wang, D, Barouch, DH, and Virgin, HW. "Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome." Cell 151, no. 2 (October 12, 2012): 253-266.

Full Text

Russell, ES, Ojeda, S, Fouda, G, Meshnick, SR, Montefiori, D, Permar, SR, and Swanstrom, R. "HIV-1 subtype C variants transmitted through the bottleneck of breastfeeding are sensitive to new generation broadly-neutralizing antibodies directed against quaternary and CD4-binding site epitopes." AIDS research and human retroviruses (October 2012). (Academic Article)

Full Text

Pages