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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Chahroudi, A, Permar, S, and Pandrea, I. "SIV Transmission in Natural Hosts." (July 10, 2014): 257-268. (Chapter)

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Madani, N, Princiotto, AM, Schön, A, LaLonde, J, Feng, Y, Freire, E, Park, J, Courter, JR, Jones, DM, Robinson, J, Liao, H-X, Moody, MA, Permar, S, Haynes, B, Smith, AB, Wyatt, R, and Sodroski, J. "CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies." Journal of virology 88, no. 12 (June 2014): 6542-6555.

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Permar, SR, and Staats, HF. "Which comes first: the antigen or the adjuvant?." The Journal of clinical investigation 124, no. 6 (June 2014): 2364-2365.

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Chahroudi, A, Cartwright, E, Lee, ST, Mavigner, M, Carnathan, DG, Lawson, B, Carnathan, PM, Hashempoor, T, Murphy, MK, Meeker, T, Ehnert, S, Souder, C, Else, JG, Cohen, J, Collman, RG, Vanderford, TH, Permar, SR, Derdeyn, CA, Villinger, F, and Silvestri, G. "Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques." PLoS Pathogens 10, no. 3 (March 6, 2014): e1003958-.

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Meyer, SA, Westreich, DJ, Patel, E, Ehlinger, EP, Kalilani, L, Lovingood, RV, Denny, TN, Swamy, GK, and Permar, SR. "Postnatal cytomegalovirus exposure in infants of antiretroviral-treated and untreated HIV-infected mothers." Infectious Diseases in Obstetrics and Gynecology 2014 (January 2014): 989721-.

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Kunz, E, Fouda, G, Ho, C, Amos, J, Colvin, L, Montefiori, D, Martelli, A, Allen, A, Aramand, L, Marshall, DJ, Letvin, NL, Staats, H, Pickup, D, Barnett, SC, Moody, MA, Haynes, BF, Liao, H, and Permar, SR. "Combined Mucosal and Systemic C.1086 Envelope Immunization of Lactating Monkeys Induces Potent IgA and Functional IgG Antibody Responses in Milk." November 1, 2013.

Scholars@Duke

Sacha, CR, Vandergrift, N, Marshall, DJ, Gurley, TC, Stiegel, L, Whitesides, JF, Friedman, J, Fouda, GG, Liebl, B, McGuire, E, Foulger, A, Kepler, TB, Liao, H, Haynes, BF, Moody, MA, and Permar, SR. "Distinct VH Gene Usage and HIV Envelope Specificity of Colostrum and Peripheral B Cell Monoclonal Antibodies of HIV-Infected, Lactating African Women." November 1, 2013.

Scholars@Duke

Fouda, GG, Cunningham, CK, McFarland, EJ, Borkowsky, W, Muresan, P, Liebl, BE, Liao, H, Haynes, BF, Overman, R, Yates, NL, Tomaras, GD, and Permar, SR. "HIV-1 gp120 Vaccination Elicits a Robust and Durable Anti-V1/V2 IgG Response and Yet No HIV-1 Env-Specific IgA Response in HIV-Exposed Infants." November 1, 2013.

Scholars@Duke

Fouda, GG, Jaeger, FH, Amos, JD, Ho, C, Kunz, EL, Anasti, K, Stamper, LW, Liebl, BE, Barbas, KH, Ohashi, T, Moseley, MA, Liao, H-X, Erickson, HP, Alam, SM, and Permar, SR. "Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk." Proceedings of the National Academy of Sciences of the United States of America 110, no. 45 (November 2013): 18220-18225.

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Amos, JD, Wilks, AB, Fouda, GG, Smith, SD, Colvin, L, Mahlokozera, T, Ho, C, Beck, K, Overman, RG, DeMarco, CT, Hodge, TL, LaBranche, CC, Montefiori, DC, Denny, TN, Liao, H-X, Tomaras, GD, Moody, MA, and Permar, SR. "Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys." J Virol 87, no. 20 (October 2013): 11121-11134.

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