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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Professor of Pathology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital, Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital, Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Nelson, Cody S., Diana Vera Cruz, Dollnovan Tran, Kristy M. Bialas, Lisa Stamper, Huali Wu, Margaret Gilbert, et al. “Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys..” Jci Insight 2, no. 13 (July 6, 2017). https://doi.org/10.1172/jci.insight.94002.

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Nguyen, Sydney M., Kathleen M. Antony, Dawn M. Dudley, Sarah Kohn, Heather A. Simmons, Bryce Wolfe, M Shahriar Salamat, et al. “Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques..” Plos Pathog 13, no. 5 (May 2017). https://doi.org/10.1371/journal.ppat.1006378.

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Martinez, David R., Nathan Vandergrift, Ayooluwa O. Douglas, Erin McGuire, John Bainbridge, Nathan I. Nicely, David C. Montefiori, Georgia D. Tomaras, Genevieve G. Fouda, and Sallie R. Permar. “Maternal Binding and Neutralizing IgG Responses Targeting the C-Terminal Region of the V3 Loop Are Predictive of Reduced Peripartum HIV-1 Transmission Risk..” J Virol 91, no. 9 (May 1, 2017). https://doi.org/10.1128/JVI.02422-16.

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Fan, Qihua, Cody S. Nelson, Kristy M. Bialas, Flavia Chiuppesi, Joshua Amos, Thaddeus C. Gurley, Dawn Jones Marshall, et al. “Plasmablast Response to Primary Rhesus Cytomegalovirus (CMV) Infection in a Monkey Model of Congenital CMV Transmission..” Clin Vaccine Immunol 24, no. 5 (May 2017). https://doi.org/10.1128/CVI.00510-16.

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Becker-Dreps, Sylvia, Wan Suk Choi, Lisa Stamper, Samuel Vilchez, Daniel E. Velasquez, Sung-Sil Moon, Michael G. Hudgens, Baoming Jiang, and Sallie R. Permar. “Innate Immune Factors in Mothers' Breast Milk and Their Lack of Association With Rotavirus Vaccine Immunogenicity in Nicaraguan Infants..” J Pediatric Infect Dis Soc 6, no. 1 (March 1, 2017): 87–90. https://doi.org/10.1093/jpids/piv076.

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Mwila, Katayi, Roma Chilengi, Michelo Simuyandi, Sallie R. Permar, and Sylvia Becker-Dreps. “Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries..” Clin Vaccine Immunol 24, no. 1 (January 2017). https://doi.org/10.1128/CVI.00405-16.

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Mwila-Kazimbaya, Katayi, Miguel Pugliese Garcia, Samuel Bosomprah, Natasha Makabilo Laban, Caroline Cleopatra Chisenga, Sallie Robey Permar, Michelo Simuyandi, Sody Munsaka, and Roma Chilengi. “Effect of innate antiviral glycoproteins in breast milk on seroconversion to rotavirus vaccine (Rotarix) in children in Lusaka, Zambia..” Plos One 12, no. 12 (2017). https://doi.org/10.1371/journal.pone.0189351.

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Fouda, Genevieve G., Joshua Eudailey, Erika L. Kunz, Joshua D. Amos, Brooke E. Liebl, Jonathan Himes, Felix Boakye-Agyeman, et al. “Systemic administration of an HIV-1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization..” Mucosal Immunol 10, no. 1 (January 2017): 228–37. https://doi.org/10.1038/mi.2016.32.

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Douglas, Ayooluwa O., David R. Martinez, and Sallie R. Permar. “The Role of Maternal HIV Envelope-Specific Antibodies and Mother-to-Child Transmission Risk..” Front Immunol 8 (2017). https://doi.org/10.3389/fimmu.2017.01091.

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Bialas, Kristy M., Daniel Westreich, Eduardo Cisneros de la Rosa, Cody S. Nelson, Lawrence M. Kauvar, Tong-Ming Fu, and Sallie R. Permar. “Maternal Antibody Responses and Nonprimary Congenital Cytomegalovirus Infection of HIV-1-Exposed Infants..” J Infect Dis 214, no. 12 (December 15, 2016): 1916–23. https://doi.org/10.1093/infdis/jiw487.

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