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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Richard, J, Veillette, M, Brassard, N, Iyer, SS, Roger, M, Martin, L, Pazgier, M, Schön, A, Freire, E, Routy, J-P, Smith, AB, Park, J, Jones, DM, Courter, JR, Melillo, BN, Kaufmann, DE, Hahn, BH, Permar, SR, Haynes, BF, Madani, N, Sodroski, JG, and Finzi, A. "CD4 mimetics sensitize HIV-1-infected cells to ADCC." Proceedings of the National Academy of Sciences of the United States of America 112, no. 20 (May 4, 2015): E2687-E2694.

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Fouda, GG, Moody, MA, and Permar, SR. "Antibodies for prevention of mother-to-child transmission of HIV-1." Current opinion in HIV and AIDS 10, no. 3 (May 2015): 177-182. (Review)

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Fong, Y, Di, C, and Permar, S. "Change point testing in logistic regression models with interaction term." Statistics in medicine 34, no. 9 (April 2015): 1483-1494.

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Fouda, GG, Cunningham, CK, and Permar, SR. "Infant HIV-1 vaccines: supplementing strategies to reduce maternal-child transmission." JAMA 313, no. 15 (April 2015): 1513-1514.

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Bialas, KM, Swamy, GK, and Permar, SR. "Perinatal Cytomegalovirus Infections: Epidemiology, Prevention, and Treatment." NeoReviews 16, no. 4 (April 1, 2015): e231-e235.

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Wright, CJ, and Permar, SR. "Preventing postnatal cytomegalovirus infection in the preterm infant: should it be done, can it be done, and at what cost?." The Journal of pediatrics 166, no. 4 (April 2015): 795-798.

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Bialas, KM, Swamy, GK, and Permar, SR. "Perinatal cytomegalovirus and varicella zoster virus infections: epidemiology, prevention, and treatment." Clinics in perinatology 42, no. 1 (March 2015): 61-viii. (Review)

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Sacha, CR, Vandergrift, N, Jeffries, TL, McGuire, E, Fouda, GG, Liebl, B, Marshall, DJ, Gurley, TC, Stiegel, L, Whitesides, JF, Friedman, J, Badiabo, A, Foulger, A, Yates, NL, Tomaras, GD, Kepler, TB, Liao, HX, Haynes, BF, Moody, MA, and Permar, SR. "Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women." Mucosal immunology 8, no. 2 (March 2015): 316-326.

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Fouda, GG, Cunningham, CK, McFarland, EJ, Borkowsky, W, Muresan, P, Pollara, J, Song, LY, Liebl, BE, Whitaker, K, Shen, X, Vandergrift, NA, Overman, RG, Yates, NL, Moody, MA, Fry, C, Kim, JH, Michael, NL, Robb, M, Pitisuttithum, P, Kaewkungwal, J, Nitayaphan, S, Rerks-Ngarm, S, Liao, H-X, Haynes, BF, Montefiori, DC, Ferrari, G, Tomaras, GD, and Permar, SR. "Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses." The Journal of infectious diseases 211, no. 4 (February 2015): 508-517.

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Smith, SD, Amos, JD, Beck, KN, Colvin, LM, Franke, KS, Liebl, BE, and Permar, SR. "Refinement of a protocol for the induction of lactation in nonpregnant nonhuman primates by using exogenous hormone treatment." Journal of the American Association for Laboratory Animal Science : JAALAS 53, no. 6 (November 2014): 700-707.

Scholars@Duke

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