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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Professor of Pathology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital, Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital, Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Schleiss, Mark R., Sallie R. Permar, and Stanley A. Plotkin. “Progress toward Development of a Vaccine against Congenital Cytomegalovirus Infection..” Clin Vaccine Immunol 24, no. 12 (December 2017). https://doi.org/10.1128/CVI.00268-17.

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Voronin, Yegor, Ilesh Jani, Barney S. Graham, Coleen K. Cunningham, Lynne M. Mofenson, Philippa M. Musoke, Sallie R. Permar, and Gabriella Scarlatti. “Recent progress in immune-based interventions to prevent HIV-1 transmission to children..” J Int Aids Soc 20, no. 4 (December 2017). https://doi.org/10.1002/jia2.25038.

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Mohr, Emma L., Dawn M. Dudley, Matthew T. Aliota, Andrea Weiler, Gabrielle Lehrer-Brey, Kim L. Weisgrau, Mariel S. Mohns, et al. “DEVELOPMENT OF A NONHUMAN PRIMATE MODEL OF ZIKA VIRUS INFECTION IN PREGNANT AND NON-PREGNANT RHESUS MACAQUES.” In American Journal of Tropical Medicine and Hygiene, 95:570–570. AMER SOC TROP MED & HYGIENE, 2017.

Scholars@Duke

Han, Qifeng, Wilton B. Williams, Kevin O. Saunders, Kelly E. Seaton, Kevin J. Wiehe, Nathan Vandergrift, Tarra A. Von Holle, et al. “HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques..” J Virol 91, no. 21 (November 1, 2017). https://doi.org/10.1128/JVI.00923-17.

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Fong, Youyi, Ying Huang, Peter B. Gilbert, and Sallie R. Permar. “chngpt: threshold regression model estimation and inference..” Bmc Bioinformatics 18, no. 1 (October 16, 2017). https://doi.org/10.1186/s12859-017-1863-x.

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Lantos, Paul M., Kate Hoffman, Sallie R. Permar, Pearce Jackson, Brenna L. Hughes, and Geeta K. Swamy. “Geographic Disparities in Cytomegalovirus Infection During Pregnancy..” J Pediatric Infect Dis Soc 6, no. 3 (September 1, 2017): e55–61. https://doi.org/10.1093/jpids/piw088.

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Goswami, Ria, Jonathon E. Himes, Thomas L. Jeffries, Riley Mangan, Joshua Eudailey, Holly Jakubowski, Quang N. Nguyen, Pyone Aye, and Sallie R. Permar. “Effects of breast milk-derived non-broadly neutralizing antibodies on oral SHIV infection in infant rhesus monkeys.” In Journal of Medical Primatology, 46:189–189. WILEY, 2017.

Scholars@Duke

Mutucumarana, Charmaine P., Joshua Eudailey, Erin P. McGuire, Nathan Vandergrift, Gerald Tegha, Charles Chasela, Sascha Ellington, et al. “Maternal Humoral Immune Correlates of Peripartum Transmission of Clade C HIV-1 in the Setting of Peripartum Antiretrovirals..” Clin Vaccine Immunol 24, no. 8 (August 2017). https://doi.org/10.1128/CVI.00062-17.

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Kaur, Amitinder, Cody Nelson, Dollnovan Tran, Kristy M. Bialas, Robert Blair, Margaret Gilbert, Peter Barry, and Sallie R. Permar. “Pre-inoculation infusion with hyperimmune globulin protects against vertical transmission in the rhesus macaque model of congenital CMV infection.” In Journal of Medical Primatology, 46:183–183. WILEY, 2017.

Scholars@Duke

Itell, Hannah L., Amitinder Kaur, Jesse D. Deere, Peter A. Barry, and Sallie R. Permar. “Rhesus monkeys for a nonhuman primate model of cytomegalovirus infections..” Curr Opin Virol 25 (August 2017): 126–33. https://doi.org/10.1016/j.coviro.2017.08.005.

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