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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Martinez, DR, Permar, SR, and Fouda, GG. "Contrasting Adult and Infant Immune Responses to HIV Infection and Vaccination." Clinical and vaccine immunology : CVI 23, no. 2 (February 2016): 84-94. (Review)

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Mansour, RG, Stamper, L, Jaeger, F, McGuire, E, Fouda, G, Amos, J, Barbas, K, Ohashi, T, Alam, SM, Erickson, H, and Permar, SR. "The Presence and Anti-HIV-1 Function of Tenascin C in Breast Milk and Genital Fluids." PLoS ONE 11, no. 5 (January 2016): e0155261-.

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Kelly, MS, Benjamin, DK, Puopolo, KM, Laughon, MM, Clark, RH, Mukhopadhyay, S, Benjamin, DK, Smith, PB, and Permar, SR. "Postnatal Cytomegalovirus Infection and the Risk for Bronchopulmonary Dysplasia." JAMA pediatrics 169, no. 12 (December 7, 2015): e153785-.

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Lantos, PM, Permar, SR, Hoffman, K, and Swamy, GK. "The Excess Burden of Cytomegalovirus in African American Communities: A Geospatial Analysis." Open forum infectious diseases 2, no. 4 (December 2015): ofv180-.

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Wahl, A, Baker, C, Spagnuolo, RA, Stamper, LW, Fouda, GG, Permar, SR, Hinde, K, Kuhn, L, Bode, L, Aldrovandi, GM, and Garcia, JV. "Breast Milk of HIV-Positive Mothers Has Potent and Species-Specific In Vivo HIV-Inhibitory Activity." Journal of virology 89, no. 21 (November 2015): 10868-10878.

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Bialas, KM, Tanaka, T, Tran, D, Varner, V, Cisneros De La Rosa, E, Chiuppesi, F, Wussow, F, Kattenhorn, L, Macri, S, Kunz, EL, Estroff, JA, Kirchherr, J, Yue, Y, Fan, Q, Lauck, M, O'Connor, DH, Hall, AHS, Xavier, A, Diamond, DJ, Barry, PA, Kaur, A, and Permar, SR. "Maternal CD4+ T cells protect against severe congenital cytomegalovirus disease in a novel nonhuman primate model of placental cytomegalovirus transmission." Proceedings of the National Academy of Sciences of the United States of America 112, no. 44 (November 2015): 13645-13650.

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Pollara, J, McGuire, E, Fouda, GG, Rountree, W, Eudailey, J, Overman, RG, Seaton, KE, Deal, A, Edwards, RW, Tegha, G, Kamwendo, D, Kumwenda, J, Nelson, JAE, Liao, H-X, Brinkley, C, Denny, TN, Ochsenbauer, C, Ellington, S, King, CC, Jamieson, DJ, van der Horst, C, Kourtis, AP, Tomaras, GD, Ferrari, G, and Permar, SR. "Association of HIV-1 Envelope-Specific Breast Milk IgA Responses with Reduced Risk of Postnatal Mother-to-Child Transmission of HIV-1." Journal of virology 89, no. 19 (October 2015): 9952-9961.

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Amos, JD, Himes, JE, Armand, L, Gurley, TC, Martinez, DR, Colvin, L, Beck, K, Overman, RG, Liao, H-X, Moody, MA, and Permar, SR. "Rapid Development of gp120-Focused Neutralizing B Cell Responses during Acute Simian Immunodeficiency Virus Infection of African Green Monkeys." Journal of virology 89, no. 18 (September 2015): 9485-9498.

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Shen, X, Duffy, R, Howington, R, Cope, A, Sadagopal, S, Park, H, Pal, R, Kwa, S, Ding, S, Yang, OO, Fouda, GG, Le Grand, R, Bolton, D, Esteban, M, Phogat, S, Roederer, M, Amara, RR, Picker, LJ, Seder, RA, McElrath, MJ, Barnett, S, Permar, SR, Shattock, R, DeVico, AL, Felber, BK, Pavlakis, GN, Pantaleo, G, Korber, BT, Montefiori, DC, and Tomaras, GD. "Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates." Journal of virology 89, no. 16 (August 2015): 8643-8650.

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Permar, SR, Fong, Y, Vandergrift, N, Fouda, GG, Gilbert, P, Parks, R, Jaeger, FH, Pollara, J, Martelli, A, Liebl, BE, Lloyd, K, Yates, NL, Overman, RG, Shen, X, Whitaker, K, Chen, H, Pritchett, J, Solomon, E, Friberg, E, Marshall, DJ, Whitesides, JF, Gurley, TC, Von Holle, T, Martinez, DR, Cai, F, Kumar, A, Xia, S-M, Lu, X, Louzao, R, Wilkes, S, Datta, S, Sarzotti-Kelsoe, M, Liao, H-X, Ferrari, G, Alam, SM, Montefiori, DC, Denny, TN, Moody, MA, Tomaras, GD, Gao, F, and Haynes, BF. "Maternal HIV-1 envelope-specific antibody responses and reduced risk of perinatal transmission." The Journal of clinical investigation 125, no. 7 (July 2015): 2702-2706.

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