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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Professor of Pathology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital, Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital, Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Nelson, Cody S., Tori Huffman, Jennifer A. Jenks, Eduardo Cisneros de la Rosa, Guanhua Xie, Nathan Vandergrift, Robert F. Pass, Justin Pollara, and Sallie R. Permar. “HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions..” Proc Natl Acad Sci U S A 115, no. 24 (June 12, 2018): 6267–72. https://doi.org/10.1073/pnas.1800177115.

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Jegaskanda, Sinthujan, Rosemarie D. Mason, Sarah F. Andrews, Adam K. Wheatley, Ruijun Zhang, Glennys V. Reynoso, David R. Ambrozak, et al. “Intranasal Live Influenza Vaccine Priming Elicits Localized B Cell Responses in Mediastinal Lymph Nodes..” J Virol 92, no. 9 (May 1, 2018). https://doi.org/10.1128/JVI.01970-17.

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Ram, Daniel R., Cordelia Manickam, Brady Hueber, Hannah L. Itell, Sallie R. Permar, Valerie Varner, and R Keith Reeves. “Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques..” Plos Pathog 14, no. 5 (May 2018). https://doi.org/10.1371/journal.ppat.1007104.

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Permar, Sallie R., Mark R. Schleiss, and Stanley A. Plotkin. “Advancing Our Understanding of Protective Maternal Immunity as a Guide for Development of Vaccines To Reduce Congenital Cytomegalovirus Infections..” J Virol 92, no. 7 (April 1, 2018). https://doi.org/10.1128/JVI.00030-18.

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Kumar, Amit, Claire E. P. Smith, Elena E. Giorgi, Joshua Eudailey, David R. Martinez, Karina Yusim, Ayooluwa O. Douglas, et al. “Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma..” Plos Pathog 14, no. 4 (April 2018). https://doi.org/10.1371/journal.ppat.1006944.

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Nguyen, Quang N., David R. Martinez, Jonathon E. Himes, R. Whitney Edwards, Qifeng Han, Amit Kumar, Riley Mangan, et al. “Predominant envelope variable loop 2-specific and gp120-specific antibody-dependent cellular cytotoxicity antibody responses in acutely SIV-infected African green monkeys..” Retrovirology 15, no. 1 (March 9, 2018). https://doi.org/10.1186/s12977-018-0406-5.

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Premkumar, Lakshmanane, Matthew Collins, Stephen Graham, Guei-Jiun Alice Liou, Cesar A. Lopez, Ramesh Jadi, Angel Balmaseda, et al. “Development of Envelope Protein Antigens To Serologically Differentiate Zika Virus Infection from Dengue Virus Infection..” J Clin Microbiol 56, no. 3 (March 2018). https://doi.org/10.1128/JCM.01504-17.

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Nelson, Cody S., Betsy C. Herold, and Sallie R. Permar. “A new era in cytomegalovirus vaccinology: considerations for rational design of next-generation vaccines to prevent congenital cytomegalovirus infection..” Npj Vaccines 3 (2018). https://doi.org/10.1038/s41541-018-0074-4.

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McGuire, Erin P., Youyi Fong, Christopher Toote, Coleen K. Cunningham, Elizabeth J. McFarland, William Borkowsky, Susan Barnett, et al. “HIV-Exposed Infants Vaccinated with an MF59/Recombinant gp120 Vaccine Have Higher-Magnitude Anti-V1V2 IgG Responses than Adults Immunized with the Same Vaccine..” J Virol 92, no. 1 (January 1, 2018). https://doi.org/10.1128/JVI.01070-17.

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Eudailey, Joshua A., Maria L. Dennis, Morgan E. Parker, Bonnie L. Phillips, Tori N. Huffman, Camden P. Bay, Michael G. Hudgens, et al. “Maternal HIV-1 Env Vaccination for Systemic and Breast Milk Immunity To Prevent Oral SHIV Acquisition in Infant Macaques..” Msphere 3, no. 1 (January 2018). https://doi.org/10.1128/mSphere.00505-17.

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