Skip to main content

Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Zhang, R, Alam, SM, Yu, J-S, Scearce, R, Lockwood, B, Hwang, K-K, Parks, R, Permar, S, Brandtzaeg, P, Haynes, BF, and Liao, H-X. "Novel Monoclonal Antibodies for Studies of Human and Rhesus Macaque Secretory Component and Human J-Chain." Monoclonal antibodies in immunodiagnosis and immunotherapy 35, no. 4 (August 2016): 217-226.

Full Text

Zhang, R, Martinez, DR, Nguyen, QN, Pollara, J, Arifin, T, Stolarchuk, C, Foulger, A, Amos, JD, Parks, R, Himes, JE, Wang, M, Edwards, RW, Trama, AM, Vandergrift, N, Colvin, L, Dewar, K, Juretic, N, Wasserscheid, J, Ferrari, G, Liao, H-X, and Permar, SR. "Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus." Nature communications 7 (July 6, 2016): 12131-.

Full Text

Mukhopadhyay, S, Meyer, SA, Permar, SR, and Puopolo, KM. "Symptomatic Postnatal Cytomegalovirus Testing among Very Low-Birth-Weight Infants: Indications and Outcomes." American journal of perinatology 33, no. 9 (July 2016): 894-902.

Full Text

Dudley, DM, Aliota, MT, Mohr, EL, Weiler, AM, Lehrer-Brey, G, Weisgrau, KL, Mohns, MS, Breitbach, ME, Rasheed, MN, Newman, CM, Gellerup, DD, Moncla, LH, Post, J, Schultz-Darken, N, Schotzko, ML, Hayes, JM, Eudailey, JA, Moody, MA, Permar, SR, O'Connor, SL, Rakasz, EG, Simmons, HA, Capuano, S, Golos, TG, Osorio, JE, Friedrich, TC, and O'Connor, DH. "A rhesus macaque model of Asian-lineage Zika virus infection." Nature communications 7 (June 28, 2016): 12204-.

Full Text

Nelson, CS, Pollara, J, Kunz, EL, Jeffries, TL, Duffy, R, Beck, C, Stamper, L, Wang, M, Shen, X, Pickup, DJ, Staats, HF, Hudgens, MG, Kepler, TB, Montefiori, DC, Moody, MA, Tomaras, GD, Liao, H-X, Haynes, BF, Ferrari, G, Fouda, GGA, and Permar, SR. "Combined HIV-1 Envelope Systemic and Mucosal Immunization of Lactating Rhesus Monkeys Induces a Robust Immunoglobulin A Isotype B Cell Response in Breast Milk." Journal of Virology 90, no. 10 (May 2016): 4951-4965.

Full Text

Jeffries, TL, Sacha, CR, Pollara, J, Himes, J, Jaeger, FH, Dennison, SM, McGuire, E, Kunz, E, Eudailey, JA, Trama, AM, LaBranche, C, Fouda, GG, Wiehe, K, Montefiori, DC, Haynes, BF, Liao, H-X, Ferrari, G, Alam, SM, Moody, MA, and Permar, SR. "The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells." Mucosal Immunology 9, no. 2 (March 2016): 414-427.

Full Text

Bialas, KM, and Permar, SR. "The March towards a Vaccine for Congenital CMV: Rationale and Models." Plos Pathogens 12, no. 2 (February 11, 2016): e1005355-null.

Full Text

Martinez, DR, Permar, SR, and Fouda, GG. "Contrasting Adult and Infant Immune Responses to HIV Infection and Vaccination." Clinical and vaccine immunology : CVI 23, no. 2 (February 2016): 84-94. (Review)

Full Text

Mansour, RG, Stamper, L, Jaeger, F, McGuire, E, Fouda, G, Amos, J, Barbas, K, Ohashi, T, Alam, SM, Erickson, H, and Permar, SR. "The Presence and Anti-HIV-1 Function of Tenascin C in Breast Milk and Genital Fluids." Plos One 11, no. 5 (January 2016): e0155261-null.

Full Text

Kelly, MS, Benjamin, DK, Puopolo, KM, Laughon, MM, Clark, RH, Mukhopadhyay, S, Benjamin, DK, Smith, PB, and Permar, SR. "Postnatal Cytomegalovirus Infection and the Risk for Bronchopulmonary Dysplasia." JAMA pediatrics 169, no. 12 (December 7, 2015): e153785-.

Full Text

Pages