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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Bialas, KM, Westreich, D, Cisneros de la Rosa, E, Nelson, CS, Kauvar, LM, Fu, T-M, and Permar, SR. "Maternal Antibody Responses and Nonprimary Congenital Cytomegalovirus Infection of HIV-1-Exposed Infants." The Journal of infectious diseases 214, no. 12 (December 2016): 1916-1923.

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Himes, JE, Ho, C, Nguyen, QN, Amos, JD, Xu, H, Chan, C, Chow, S-C, Ochsenbauer, C, Kaidarova, Z, Keating, SM, Fouda, GG, and Permar, SR. "Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized in Plasma and Milk in Chronically Infected African Green Monkeys." Journal of virology 90, no. 19 (October 2016): 8795-8808.

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Martinez, DR, McGuire, E, Permar, SR, and Fouda, GG. "Variable IgG Transplacental Transfer in the Setting of Maternal HIV Infection." October 2016.

Scholars@Duke

Zhang, R, Alam, SM, Yu, J-S, Scearce, R, Lockwood, B, Hwang, K-K, Parks, R, Permar, S, Brandtzaeg, P, Haynes, BF, and Liao, H-X. "Novel Monoclonal Antibodies for Studies of Human and Rhesus Macaque Secretory Component and Human J-Chain." Monoclonal antibodies in immunodiagnosis and immunotherapy 35, no. 4 (August 2016): 217-226.

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Zhang, R, Martinez, DR, Nguyen, QN, Pollara, J, Arifin, T, Stolarchuk, C, Foulger, A, Amos, JD, Parks, R, Himes, JE, Wang, M, Edwards, RW, Trama, AM, Vandergrift, N, Colvin, L, Dewar, K, Juretic, N, Wasserscheid, J, Ferrari, G, Liao, H-X, and Permar, SR. "Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus." Nature communications 7 (July 6, 2016): 12131-.

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Mukhopadhyay, S, Meyer, SA, Permar, SR, and Puopolo, KM. "Symptomatic Postnatal Cytomegalovirus Testing among Very Low-Birth-Weight Infants: Indications and Outcomes." American journal of perinatology 33, no. 9 (July 2016): 894-902.

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Dudley, DM, Aliota, MT, Mohr, EL, Weiler, AM, Lehrer-Brey, G, Weisgrau, KL, Mohns, MS, Breitbach, ME, Rasheed, MN, Newman, CM, Gellerup, DD, Moncla, LH, Post, J, Schultz-Darken, N, Schotzko, ML, Hayes, JM, Eudailey, JA, Moody, MA, Permar, SR, O'Connor, SL, Rakasz, EG, Simmons, HA, Capuano, S, Golos, TG, Osorio, JE, Friedrich, TC, and O'Connor, DH. "A rhesus macaque model of Asian-lineage Zika virus infection." Nature communications 7 (June 28, 2016): 12204-.

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Nelson, CS, Pollara, J, Kunz, EL, Jeffries, TL, Duffy, R, Beck, C, Stamper, L, Wang, M, Shen, X, Pickup, DJ, Staats, HF, Hudgens, MG, Kepler, TB, Montefiori, DC, Moody, MA, Tomaras, GD, Liao, H-X, Haynes, BF, Ferrari, G, Fouda, GGA, and Permar, SR. "Combined HIV-1 Envelope Systemic and Mucosal Immunization of Lactating Rhesus Monkeys Induces a Robust Immunoglobulin A Isotype B Cell Response in Breast Milk." Journal of virology 90, no. 10 (May 2016): 4951-4965.

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Jeffries, TL, Sacha, CR, Pollara, J, Himes, J, Jaeger, FH, Dennison, SM, McGuire, E, Kunz, E, Eudailey, JA, Trama, AM, LaBranche, C, Fouda, GG, Wiehe, K, Montefiori, DC, Haynes, BF, Liao, H-X, Ferrari, G, Alam, SM, Moody, MA, and Permar, SR. "The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells." Mucosal immunology 9, no. 2 (March 2016): 414-427.

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Bialas, KM, and Permar, SR. "The March towards a Vaccine for Congenital CMV: Rationale and Models." PLoS pathogens 12, no. 2 (February 11, 2016): e1005355-.

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