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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Professor of Pathology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital, Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital, Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Hompe, Eliza D., Amit Kumar, Elena E. Giorgi, Erin McGuire, Genevieve G. Fouda, Feng Gao, and Sallie R. Permar. “Induction of Neutralizing Antibodies Against Autologous Viruses in HIV-1 Infected Pregnant Women Immunized With a gp120/160 Vaccine.” In Aids Research and Human Retroviruses, 34:393–393. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Dudley, Dawn, Christina M. Newman, Emma L. Mohr, Matthew T. Aliota, Sydney M. Nguyen, Kathleen M. Antony, Sarah Kohn, et al. “Nonhuman primate models for Zika virus infection.” In Journal of Medical Primatology, 47:326–27. WILEY, 2018.

Scholars@Duke

Itell, Hannah L., Erin P. McGuire, Petronella Muresan, Coleen K. Cunningham, Elizabeth J. McFarland, William Borkowsky, Sallie R. Permar, and Genevieve G. Fouda. “Development and application of a multiplex assay for the simultaneous measurement of antibody responses elicited by common childhood vaccines..” Vaccine 36, no. 37 (September 5, 2018): 5600–5608. https://doi.org/10.1016/j.vaccine.2018.07.048.

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Lantos, Paul M., Kate Hoffman, Sallie R. Permar, Pearce Jackson, Brenna L. Hughes, Amy Kind, and Geeta Swamy. “Neighborhood Disadvantage is Associated with High Cytomegalovirus Seroprevalence in Pregnancy..” J Racial Ethn Health Disparities 5, no. 4 (August 2018): 782–86. https://doi.org/10.1007/s40615-017-0423-4.

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Martinez, David R., Genevieve G. Fouda, Xinxia Peng, Margaret E. Ackerman, and Sallie R. Permar. “Noncanonical placental Fc receptors: What is their role in modulating transplacental transfer of maternal IgG?.” Plos Pathog 14, no. 8 (August 2018). https://doi.org/10.1371/journal.ppat.1007161.

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Permar, Sallie R., Mark R. Schleiss, and Stanley A. Plotkin. “Reply to Gantt et al., "Higher Expectations for a Vaccine To Prevent Congenital Cytomegalovirus Infection"..” J Virol 92, no. 15 (August 1, 2018). https://doi.org/10.1128/JVI.00771-18.

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Coffey, Lark L., Rebekah I. Keesler, Patricia A. Pesavento, Kevin Woolard, Anil Singapuri, Jennifer Watanabe, Christina Cruzen, et al. “Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease..” Nat Commun 9, no. 1 (June 20, 2018). https://doi.org/10.1038/s41467-018-04777-6.

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Nelson, Cody S., Tori Huffman, Jennifer A. Jenks, Eduardo Cisneros de la Rosa, Guanhua Xie, Nathan Vandergrift, Robert F. Pass, Justin Pollara, and Sallie R. Permar. “HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions..” Proc Natl Acad Sci U S A 115, no. 24 (June 12, 2018): 6267–72. https://doi.org/10.1073/pnas.1800177115.

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Jegaskanda, Sinthujan, Rosemarie D. Mason, Sarah F. Andrews, Adam K. Wheatley, Ruijun Zhang, Glennys V. Reynoso, David R. Ambrozak, et al. “Intranasal Live Influenza Vaccine Priming Elicits Localized B Cell Responses in Mediastinal Lymph Nodes..” J Virol 92, no. 9 (May 1, 2018). https://doi.org/10.1128/JVI.01970-17.

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Ram, Daniel R., Cordelia Manickam, Brady Hueber, Hannah L. Itell, Sallie R. Permar, Valerie Varner, and R Keith Reeves. “Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques..” Plos Pathog 14, no. 5 (May 2018). https://doi.org/10.1371/journal.ppat.1007104.

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