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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Professor of Pathology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital, Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital, Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Jenks, Jennifer A., Matthew L. Goodwin, and Sallie R. Permar. “The Roles of Host and Viral Antibody Fc Receptors in Herpes Simplex Virus (HSV) and Human Cytomegalovirus (HCMV) Infections and Immunity..” Front Immunol 10 (2019). https://doi.org/10.3389/fimmu.2019.02110.

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Shah, Spandan V., Cordelia Manickam, Daniel R. Ram, Kyle Kroll, Hannah Itell, Sallie R. Permar, Dan H. Barouch, Nichole R. Klatt, and R Keith Reeves. “CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques..” Cell Rep 25, no. 10 (December 4, 2018): 2766-2774.e3. https://doi.org/10.1016/j.celrep.2018.11.020.

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Himes, Jonathon E., Ria Goswami, Riley J. Mangan, Amit Kumar, Thomas L. Jeffries, Joshua A. Eudailey, Holly Heimsath, et al. “Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys..” Mucosal Immunol 11, no. 6 (November 2018): 1716–26. https://doi.org/10.1038/s41385-018-0067-7.

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Phillips, Bonnie, Koen K. A. Van Rompay, Jennifer Rodriguez-Nieves, Clarisse Lorin, Marguerite Koutsoukos, Mark Tomai, Christopher B. Fox, et al. “Adjuvant-Dependent Enhancement of HIV Env-Specific Antibody Responses in Infant Rhesus Macaques..” J Virol 92, no. 20 (October 15, 2018). https://doi.org/10.1128/JVI.01051-18.

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Lantos, Paul M., Gabriela Maradiaga-Panayotti, Xavier Barber, Eileen Raynor, Debara Tucci, Kate Hoffman, Sallie R. Permar, et al. “Geographic and Racial Disparities in Infant Hearing Loss..” Otolaryngol Head Neck Surg, October 9, 2018. https://doi.org/10.1177/0194599818803305.

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Pollara, Justin, Dorothy I. Jones, Tori Huffman, Maria Dennis, Grace Li, Derrick Goodman, R Whitney Edwards, et al. “Bridging Vaccine-induced Antibody Responses in Rabbit and Rhesus Macaque Animal Models.” In Aids Research and Human Retroviruses, 34:129–129. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Martinez, David R., David Martinez, Riley J. Mangan, Elena Georgi, Juilin Chen, Michael Mengual, Jesse Mangold, et al. “Characterizing Env-specific Monoclonal Antibodies Isolated From US and Malawian HIV-infected Non-transmitting and Transmitting Women.” In Aids Research and Human Retroviruses, 34:390–390. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Martinez, David R., Youyi Fong, Grace Li, Erin A. Harrell, Madeleine Jennewein, Joshua A. Weiner, Galit Alter, et al. “Determinants of Transplacental Transfer of Protective Maternal IgG in HIV-infected Women.” In Aids Research and Human Retroviruses, 34:339–339. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Nelson, Ashley N., Ria Goswami, Maria Dennis, Riley J. Mangan, George M. Shaw, Katharine J. Bar, Kristina De Paris, Koen K. A. Van Rompay, and Sallie R. Permar. “Development of Neutralizing Antibody Responses in SHIV CH505-infected Adult and Infant Rhesus Macaques.” In Aids Research and Human Retroviruses, 34:250–250. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Permar, Sallie, Ofer Levy, Tobias R. Kollman, Anjali Singh, and Kristina De Paris. “Early Life HIV-1 Immunization: Providing a Window for Protection Before Sexual Debut..” Aids Res Hum Retroviruses 34, no. 10 (October 2018): 823–27. https://doi.org/10.1089/AID.2018.0018.

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