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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Nguyen, SM, Antony, KM, Dudley, DM, Kohn, S, Simmons, HA, Wolfe, B, Salamat, MS, Teixeira, LBC, Wiepz, GJ, Thoong, TH, Aliota, MT, Weiler, AM, Barry, GL, Weisgrau, KL, Vosler, LJ, Mohns, MS, Breitbach, ME, Stewart, LM, Rasheed, MN, Newman, CM, Graham, ME, Wieben, OE, Turski, PA, Johnson, KM, Post, J, Hayes, JM, Schultz-Darken, N, Schotzko, ML, Eudailey, JA, Permar, SR, Rakasz, EG, Mohr, EL, Capuano, S, Tarantal, AF, Osorio, JE, O'Connor, SL, Friedrich, TC, O'Connor, DH, and Golos, TG. "Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques." PLoS pathogens 13, no. 5 (May 25, 2017): e1006378-.

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Martinez, DR, Vandergrift, N, Douglas, AO, McGuire, E, Bainbridge, J, Nicely, NI, Montefiori, DC, Tomaras, GD, Fouda, GG, and Permar, SR. "Maternal Binding and Neutralizing IgG Responses Targeting the C-Terminal Region of the V3 Loop Are Predictive of Reduced Peripartum HIV-1 Transmission Risk." Journal of virology 91, no. 9 (May 2017).

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Fan, Q, Nelson, CS, Bialas, KM, Chiuppesi, F, Amos, J, Gurley, TC, Marshall, DJ, Eudailey, J, Heimsath, H, Himes, J, Deshpande, A, Walter, MR, Wussow, F, Diamond, DJ, Barry, PA, Moody, MA, Kaur, A, and Permar, SR. "Plasmablast Response to Primary Rhesus Cytomegalovirus (CMV) Infection in a Monkey Model of Congenital CMV Transmission." Clinical and vaccine immunology : CVI 24, no. 5 (May 2017).

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Becker-Dreps, S, Choi, WS, Stamper, L, Vilchez, S, Velasquez, DE, Moon, S-S, Hudgens, MG, Jiang, B, and Permar, SR. "Innate Immune Factors in Mothers' Breast Milk and Their Lack of Association With Rotavirus Vaccine Immunogenicity in Nicaraguan Infants." Journal of the Pediatric Infectious Diseases Society 6, no. 1 (March 2017): 87-90.

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Mwila, K, Chilengi, R, Simuyandi, M, Permar, SR, and Becker-Dreps, S. "Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries." Clinical and vaccine immunology : CVI 24, no. 1 (January 2017). (Review)

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Mwila-Kazimbaya, K, Garcia, MP, Bosomprah, S, Laban, NM, Chisenga, CC, Permar, SR, Simuyandi, M, Munsaka, S, and Chilengi, R. "Effect of innate antiviral glycoproteins in breast milk on seroconversion to rotavirus vaccine (Rotarix) in children in Lusaka, Zambia." PloS one 12, no. 12 (January 2017): e0189351-.

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Fouda, GG, Eudailey, J, Kunz, EL, Amos, JD, Liebl, BE, Himes, J, Boakye-Agyeman, F, Beck, K, Michaels, AJ, Cohen-Wolkowiez, M, Haynes, BF, Reimann, KA, and Permar, SR. "Systemic administration of an HIV-1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization." Mucosal immunology 10, no. 1 (January 2017): 228-237.

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Douglas, AO, Martinez, DR, and Permar, SR. "The Role of Maternal HIV Envelope-Specific Antibodies and Mother-to-Child Transmission Risk." Frontiers in immunology 8 (January 2017): 1091-. (Review)

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Nguyen, QN, Himes, JE, Martinez, DR, and Permar, SR. "The Impact of the Gut Microbiota on Humoral Immunity to Pathogens and Vaccination in Early Infancy." PLoS pathogens 12, no. 12 (December 22, 2016): e1005997-. (Review)

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Aliota, MT, Dudley, DM, Newman, CM, Mohr, EL, Gellerup, DD, Breitbach, ME, Buechler, CR, Rasheed, MN, Mohns, MS, Weiler, AM, Barry, GL, Weisgrau, KL, Eudailey, JA, Rakasz, EG, Vosler, LJ, Post, J, Capuano, S, Golos, TG, Permar, SR, Osorio, JE, Friedrich, TC, O'Connor, SL, and O'Connor, DH. "Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques." PLoS neglected tropical diseases 10, no. 12 (December 2, 2016): e0005168-.

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