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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Mwila, K, Chilengi, R, Simuyandi, M, Permar, SR, and Becker-Dreps, S. "Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries." Clinical and vaccine immunology : CVI 24, no. 1 (January 2017). (Review)

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Mwila-Kazimbaya, K, Garcia, MP, Bosomprah, S, Laban, NM, Chisenga, CC, Permar, SR, Simuyandi, M, Munsaka, S, and Chilengi, R. "Effect of innate antiviral glycoproteins in breast milk on seroconversion to rotavirus vaccine (Rotarix) in children in Lusaka, Zambia." PloS one 12, no. 12 (January 2017): e0189351-.

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Fouda, GG, Eudailey, J, Kunz, EL, Amos, JD, Liebl, BE, Himes, J, Boakye-Agyeman, F, Beck, K, Michaels, AJ, Cohen-Wolkowiez, M, Haynes, BF, Reimann, KA, and Permar, SR. "Systemic administration of an HIV-1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization." Mucosal immunology 10, no. 1 (January 2017): 228-237.

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Douglas, AO, Martinez, DR, and Permar, SR. "The Role of Maternal HIV Envelope-Specific Antibodies and Mother-to-Child Transmission Risk." Frontiers in Immunology 8 (January 2017): 1091-. (Review)

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Nguyen, QN, Himes, JE, Martinez, DR, and Permar, SR. "The Impact of the Gut Microbiota on Humoral Immunity to Pathogens and Vaccination in Early Infancy." PLoS pathogens 12, no. 12 (December 22, 2016): e1005997-. (Review)

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Aliota, MT, Dudley, DM, Newman, CM, Mohr, EL, Gellerup, DD, Breitbach, ME, Buechler, CR, Rasheed, MN, Mohns, MS, Weiler, AM, Barry, GL, Weisgrau, KL, Eudailey, JA, Rakasz, EG, Vosler, LJ, Post, J, Capuano, S, Golos, TG, Permar, SR, Osorio, JE, Friedrich, TC, O'Connor, SL, and O'Connor, DH. "Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques." PLoS neglected tropical diseases 10, no. 12 (December 2, 2016): e0005168-.

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Bialas, KM, Westreich, D, Cisneros de la Rosa, E, Nelson, CS, Kauvar, LM, Fu, T-M, and Permar, SR. "Maternal Antibody Responses and Nonprimary Congenital Cytomegalovirus Infection of HIV-1-Exposed Infants." The Journal of infectious diseases 214, no. 12 (December 2016): 1916-1923.

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Himes, JE, Ho, C, Nguyen, QN, Amos, JD, Xu, H, Chan, C, Chow, S-C, Ochsenbauer, C, Kaidarova, Z, Keating, SM, Fouda, GG, and Permar, SR. "Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized in Plasma and Milk in Chronically Infected African Green Monkeys." Journal of virology 90, no. 19 (October 2016): 8795-8808.

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Martinez, DR, McGuire, E, Permar, SR, and Fouda, GG. "Variable IgG Transplacental Transfer in the Setting of Maternal HIV Infection." October 2016.

Scholars@Duke

Zhang, R, Alam, SM, Yu, J-S, Scearce, R, Lockwood, B, Hwang, K-K, Parks, R, Permar, S, Brandtzaeg, P, Haynes, BF, and Liao, H-X. "Novel Monoclonal Antibodies for Studies of Human and Rhesus Macaque Secretory Component and Human J-Chain." Monoclonal antibodies in immunodiagnosis and immunotherapy 35, no. 4 (August 2016): 217-226.

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