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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Fong, Y, Huang, Y, Gilbert, PB, and Permar, SR. "chngpt: threshold regression model estimation and inference." BMC bioinformatics 18, no. 1 (October 16, 2017): 454-.

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Lantos, PM, Hoffman, K, Permar, SR, Jackson, P, Hughes, BL, and Swamy, GK. "Geographic Disparities in Cytomegalovirus Infection During Pregnancy." Journal of the Pediatric Infectious Diseases Society 6, no. 3 (September 2017): e55-e61.

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Mutucumarana, CP, Eudailey, J, McGuire, EP, Vandergrift, N, Tegha, G, Chasela, C, Ellington, S, van der Horst, C, Kourtis, AP, Permar, SR, and Fouda, GG. "Maternal Humoral Immune Correlates of Peripartum Transmission of Clade C HIV-1 in the Setting of Peripartum Antiretrovirals." Clinical and Vaccine Immunology : Cvi 24, no. 8 (August 4, 2017).

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Goswami, R, Himes, JE, Jeffries, TL, Mangan, R, Eudailey, J, Jakubowski, H, Nguyen, QN, Aye, P, and Permar, SR. "Effects of breast milk-derived non-broadly neutralizing antibodies on oral SHIV infection in infant rhesus monkeys." August 2017.

Scholars@Duke

Kaur, A, Nelson, C, Tran, D, Bialas, KM, Blair, R, Gilbert, M, Barry, P, and Permar, SR. "Pre-inoculation infusion with hyperimmune globulin protects against vertical transmission in the rhesus macaque model of congenital CMV infection." August 2017.

Scholars@Duke

Itell, HL, Kaur, A, Deere, JD, Barry, PA, and Permar, SR. "Rhesus monkeys for a nonhuman primate model of cytomegalovirus infections." Current opinion in virology 25 (August 2017): 126-133. (Review)

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Nelson, CS, Cruz, DV, Tran, D, Bialas, KM, Stamper, L, Wu, H, Gilbert, M, Blair, R, Alvarez, X, Itell, H, Chen, M, Deshpande, A, Chiuppesi, F, Wussow, F, Diamond, DJ, Vandergrift, N, Walter, MR, Barry, PA, Cohen-Wolkowiez, M, Koelle, K, Kaur, A, and Permar, SR. "Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys." JCI insight 2, no. 13 (July 6, 2017).

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Nguyen, SM, Antony, KM, Dudley, DM, Kohn, S, Simmons, HA, Wolfe, B, Salamat, MS, Teixeira, LBC, Wiepz, GJ, Thoong, TH, Aliota, MT, Weiler, AM, Barry, GL, Weisgrau, KL, Vosler, LJ, Mohns, MS, Breitbach, ME, Stewart, LM, Rasheed, MN, Newman, CM, Graham, ME, Wieben, OE, Turski, PA, Johnson, KM, Post, J, Hayes, JM, Schultz-Darken, N, Schotzko, ML, Eudailey, JA, Permar, SR, Rakasz, EG, Mohr, EL, Capuano, S, Tarantal, AF, Osorio, JE, O'Connor, SL, Friedrich, TC, O'Connor, DH, and Golos, TG. "Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques." Plos Pathogens 13, no. 5 (May 25, 2017): e1006378-null.

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Martinez, DR, Vandergrift, N, Douglas, AO, McGuire, E, Bainbridge, J, Nicely, NI, Montefiori, DC, Tomaras, GD, Fouda, GG, and Permar, SR. "Maternal Binding and Neutralizing IgG Responses Targeting the C-Terminal Region of the V3 Loop Are Predictive of Reduced Peripartum HIV-1 Transmission Risk." Journal of virology 91, no. 9 (May 2017).

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Fan, Q, Nelson, CS, Bialas, KM, Chiuppesi, F, Amos, J, Gurley, TC, Marshall, DJ, Eudailey, J, Heimsath, H, Himes, J, Deshpande, A, Walter, MR, Wussow, F, Diamond, DJ, Barry, PA, Moody, MA, Kaur, A, and Permar, SR. "Plasmablast Response to Primary Rhesus Cytomegalovirus (CMV) Infection in a Monkey Model of Congenital CMV Transmission." Clinical and vaccine immunology : CVI 24, no. 5 (May 2017).

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