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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Professor of Pathology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital, Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital, Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Permar, S. R., W. J. Moss, J. J. Ryon, M. Monze, F. Cutts, T. C. Quinn, and D. E. Griffin. “Prolonged measles virus shedding in human immunodeficiency virus-infected children, detected by reverse transcriptase-polymerase chain reaction..” J Infect Dis 183, no. 4 (February 15, 2001): 532–38. https://doi.org/10.1086/318533.

Full Text

Polack, F. P., S. H. Lee, S. Permar, E. Manyara, H. G. Nousari, Y. Jeng, F. Mustafa, et al. “Successful DNA immunization against measles: neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles..” Nat Med 6, no. 7 (July 2000): 776–81. https://doi.org/10.1038/77506.

Full Text

Polack, FP, Lee, SH, Permar, S, Manyara, E, Nousari, HG, Jeng, Y, Mustafa, F, Valsamakis, A, Adams, RJ, Robinson, HL, and Griffin, DE. "Erratum: Successful DNA immunization against measles: Neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles (Nature Medicine (2000) 6 (776-781))." Nature Medicine 6, no. 9 (2000): 1062--.

Full Text

Cromartie, J. D., S. M. Mercer, S. R. Permar, and A. M. Campbell. “Development of the sarcoplasmic reticulum as a calcium pool in early embryonic chicken hearts.” Molecular Biology of the Cell 7 (December 1, 1996): 775–775.

Scholars@Duke

Pages