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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Nguyen, QN, Martinez, DR, Himes, JE, Whitney Edwards, R, Han, Q, Kumar, A, Mangan, R, Nicely, NI, Xie, G, Vandergrift, N, Shen, X, Pollara, J, and Permar, SR. "Predominant envelope variable loop 2-specific and gp120-specific antibody-dependent cellular cytotoxicity antibody responses in acutely SIV-infected African green monkeys." Retrovirology 15, no. 1 (March 9, 2018): 24-.

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Premkumar, L, Collins, M, Graham, S, Liou, G-JA, Lopez, CA, Jadi, R, Balmaseda, A, Brackbill, JA, Dietze, R, Camacho, E, De Silva, AD, Giuberti, C, Dos Reis, HL, Singh, T, Heimsath, H, Weiskopf, D, Sette, A, Osorio, JE, Permar, SR, Miley, MJ, Lazear, HM, Harris, E, and de Silva, AM. "Development of Envelope Protein Antigens To Serologically Differentiate Zika Virus Infection from Dengue Virus Infection." Journal of clinical microbiology 56, no. 3 (March 2018).

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Eudailey, JA, Dennis, ML, Parker, ME, Phillips, BL, Huffman, TN, Bay, CP, Hudgens, MG, Wiseman, RW, Pollara, JJ, Fouda, GG, Ferrari, G, Pickup, DJ, Kozlowski, PA, Van Rompay, KKA, De Paris, K, and Permar, SR. "Maternal HIV-1 Env Vaccination for Systemic and Breast Milk Immunity To Prevent Oral SHIV Acquisition in Infant Macaques." Msphere 3, no. 1 (January 10, 2018).

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McGuire, EP, Fong, Y, Toote, C, Cunningham, CK, McFarland, EJ, Borkowsky, W, Barnett, S, Itell, HL, Kumar, A, Gray, G, McElrath, MJ, Tomaras, GD, Permar, SR, and Fouda, GG. "HIV-Exposed Infants Vaccinated with an MF59/Recombinant gp120 Vaccine Have Higher-Magnitude Anti-V1V2 IgG Responses than Adults Immunized with the Same Vaccine." Journal of virology 92, no. 1 (January 2018).

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Fouda, GG, Martinez, DR, Swamy, GK, and Permar, SR. "The Impact of IgG transplacental transfer on early life immunity." Immunohorizons 2, no. 1 (January 2018): 14-25.

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Schleiss, MR, Permar, SR, and Plotkin, SA. "Progress toward Development of a Vaccine against Congenital Cytomegalovirus Infection." Clinical and Vaccine Immunology : Cvi 24, no. 12 (December 5, 2017). (Review)

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Itell, HL, Nelson, CS, Martinez, DR, and Permar, SR. "Maternal immune correlates of protection against placental transmission of cytomegalovirus." Placenta 60 Suppl 1 (December 2017): S73-S79.

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Voronin, Y, Jani, I, Graham, BS, Cunningham, CK, Mofenson, LM, Musoke, PM, Permar, SR, and Scarlatti, G. "Recent progress in immune-based interventions to prevent HIV-1 transmission to children." Journal of the International Aids Society 20, no. 4 (December 2017).

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Mohr, EL, Dudley, DM, Aliota, MT, Weiler, A, Lehrer-Brey, G, Weisgrau, KL, Mohns, MS, Breitbach, ME, Rasheed, MN, Gellerup, DD, Moncla, LH, Post, J, Schultz-Darken, N, Schotkzo, ML, Hayes, JM, Eudailey, JA, Moody, MA, Permar, SR, O'Connor, SL, Rakasz, EG, Simmons, HA, III, CS, Golos, TG, Osorio, JE, Friedrich, TC, and O'Connor, DH. "DEVELOPMENT OF A NONHUMAN PRIMATE MODEL OF ZIKA VIRUS INFECTION IN PREGNANT AND NON-PREGNANT RHESUS MACAQUES." November 2017.

Scholars@Duke

Han, Q, Williams, WB, Saunders, KO, Seaton, KE, Wiehe, KJ, Vandergrift, N, Von Holle, TA, Trama, AM, Parks, RJ, Luo, K, Gurley, TC, Kepler, TB, Marshall, DJ, Montefiori, DC, Sutherland, LL, Alam, MS, Whitesides, JF, Bowman, CM, Permar, SR, Graham, BS, Mascola, JR, Seed, PC, Van Rompay, KKA, Tomaras, GD, Moody, MA, and Haynes, BF. "HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques." Journal of Virology 91, no. 21 (November 2017).

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