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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Permar, SR, Schleiss, MR, and Plotkin, SA. "Reply to Gantt et al., "Higher Expectations for a Vaccine To Prevent Congenital Cytomegalovirus Infection"." Journal of Virology 92, no. 15 (August 2018).

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Coffey, LL, Keesler, RI, Pesavento, PA, Woolard, K, Singapuri, A, Watanabe, J, Cruzen, C, Christe, KL, Usachenko, J, Yee, J, Heng, VA, Bliss-Moreau, E, Reader, JR, von Morgenland, W, Gibbons, AM, Jackson, K, Ardeshir, A, Heimsath, H, Permar, S, Senthamaraikannan, P, Presicce, P, Kallapur, SG, Linnen, JM, Gao, K, Orr, R, MacGill, T, McClure, M, McFarland, R, Morrison, JH, and Van Rompay, KKA. "Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease." Nature Communications 9, no. 1 (June 20, 2018): 2414-null.

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Nelson, CS, Huffman, T, Jenks, JA, Cisneros de la Rosa, E, Xie, G, Vandergrift, N, Pass, RF, Pollara, J, and Permar, SR. "HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions." Proceedings of the National Academy of Sciences of the United States of America 115, no. 24 (June 2018): 6267-6272.

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Ram, DR, Manickam, C, Hueber, B, Itell, HL, Permar, SR, Varner, V, and Reeves, RK. "Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques." Plos Pathogens 14, no. 5 (May 31, 2018): e1007104-null.

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Jegaskanda, S, Mason, RD, Andrews, SF, Wheatley, AK, Zhang, R, Reynoso, GV, Ambrozak, DR, Santos, CP, Luke, CJ, Matsuoka, Y, Brenchley, JM, Hickman, HD, Talaat, KR, Permar, SR, Liao, H-X, Yewdell, JW, Koup, RA, Roederer, M, McDermott, AB, and Subbarao, K. "Intranasal Live Influenza Vaccine Priming Elicits Localized B Cell Responses in Mediastinal Lymph Nodes." Journal of Virology 92, no. 9 (May 2018).

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Kumar, A, Smith, CEP, Giorgi, EE, Eudailey, J, Martinez, DR, Yusim, K, Douglas, AO, Stamper, L, McGuire, E, LaBranche, CC, Montefiori, DC, Fouda, GG, Gao, F, and Permar, SR. "Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma." Plos Pathogens 14, no. 4 (April 19, 2018): e1006944-null.

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Permar, SR, Schleiss, MR, and Plotkin, SA. "Advancing Our Understanding of Protective Maternal Immunity as a Guide for Development of Vaccines To Reduce Congenital Cytomegalovirus Infections." Journal of Virology 92, no. 7 (April 2018). (Review)

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Nguyen, QN, Martinez, DR, Himes, JE, Whitney Edwards, R, Han, Q, Kumar, A, Mangan, R, Nicely, NI, Xie, G, Vandergrift, N, Shen, X, Pollara, J, and Permar, SR. "Predominant envelope variable loop 2-specific and gp120-specific antibody-dependent cellular cytotoxicity antibody responses in acutely SIV-infected African green monkeys." Retrovirology 15, no. 1 (March 9, 2018): 24-null.

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Premkumar, L, Collins, M, Graham, S, Liou, G-JA, Lopez, CA, Jadi, R, Balmaseda, A, Brackbill, JA, Dietze, R, Camacho, E, De Silva, AD, Giuberti, C, Dos Reis, HL, Singh, T, Heimsath, H, Weiskopf, D, Sette, A, Osorio, JE, Permar, SR, Miley, MJ, Lazear, HM, Harris, E, and de Silva, AM. "Development of Envelope Protein Antigens To Serologically Differentiate Zika Virus Infection from Dengue Virus Infection." Journal of Clinical Microbiology 56, no. 3 (March 2018).

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Eudailey, JA, Dennis, ML, Parker, ME, Phillips, BL, Huffman, TN, Bay, CP, Hudgens, MG, Wiseman, RW, Pollara, JJ, Fouda, GG, Ferrari, G, Pickup, DJ, Kozlowski, PA, Van Rompay, KKA, De Paris, K, and Permar, SR. "Maternal HIV-1 Env Vaccination for Systemic and Breast Milk Immunity To Prevent Oral SHIV Acquisition in Infant Macaques." Msphere 3, no. 1 (January 10, 2018).

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