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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Professor of Pathology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital, Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital, Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Jones, Dorothy I., Justin J. Pollara, Brandi T. Johnson-Weaver, Celia C. LaBranche, David C. Montefiori, David J. Pickup, Sallie R. Permar, et al. “Optimized Mucosal Modified Vaccinia Virus Ankara Prime/Soluble gp120 Boost HIV Vaccination Regimen Induces Antibody Responses Similar to Those of an Intramuscular Regimen..” J Virol 93, no. 14 (July 15, 2019). https://doi.org/10.1128/JVI.00475-19.

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Mangan, Riley J., Lisa Stamper, Tomoo Ohashi, Joshua A. Eudailey, Eden P. Go, Frederick H. Jaeger, Hannah L. Itell, et al. “Determinants of Tenascin-C and HIV-1 envelope binding and neutralization..” Mucosal Immunol 12, no. 4 (July 2019): 1004–12. https://doi.org/10.1038/s41385-019-0164-2.

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Martinez, David R., Youyi Fong, Shuk Hang Li, Fang Yang, Madeleine F. Jennewein, Joshua A. Weiner, Erin A. Harrell, et al. “Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women..” Cell 178, no. 1 (June 27, 2019): 190-201.e11. https://doi.org/10.1016/j.cell.2019.05.046.

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Pollara, Justin, Dorothy I. Jones, Tori Huffman, R Whitney Edwards, Maria Dennis, Shuk Hang Li, Shalini Jha, et al. “Bridging Vaccine-Induced HIV-1 Neutralizing and Effector Antibody Responses in Rabbit and Rhesus Macaque Animal Models..” J Virol 93, no. 10 (May 15, 2019). https://doi.org/10.1128/JVI.02119-18.

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Tay, Matthew Zirui, Erika L. Kunz, Aaron Deal, Lu Zhang, Kelly E. Seaton, Wes Rountree, Joshua A. Eudailey, et al. “Rare Detection of Antiviral Functions of Polyclonal IgA Isolated from Plasma and Breast Milk Compartments in Women Chronically Infected with HIV-1..” J Virol 93, no. 7 (April 1, 2019). https://doi.org/10.1128/JVI.02084-18.

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Dennis, Maria, Joshua Eudailey, Justin Pollara, Arthur S. McMillan, Kenneth D. Cronin, Pooja T. Saha, Alan D. Curtis, et al. “Coadministration of CH31 Broadly Neutralizing Antibody Does Not Affect Development of Vaccine-Induced Anti-HIV-1 Envelope Antibody Responses in Infant Rhesus Macaques..” J Virol 93, no. 5 (March 1, 2019). https://doi.org/10.1128/JVI.01783-18.

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Burghuber, Christopher K., Miriam Manook, Brian Ezekian, Adriana C. Gibby, Frank V. Leopardi, Minqing Song, Jennifer Jenks, et al. “Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients..” Am J Transplant 19, no. 3 (March 2019): 724–36. https://doi.org/10.1111/ajt.15067.

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Nelson, Cody S., Diana Vera Cruz, Melody Su, Guanhua Xie, Nathan Vandergrift, Robert F. Pass, Michael Forman, et al. “Intrahost Dynamics of Human Cytomegalovirus Variants Acquired by Seronegative Glycoprotein B Vaccinees..” J Virol 93, no. 5 (March 1, 2019). https://doi.org/10.1128/JVI.01695-18.

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Wyatt, Lauren, Sallie Robey Permar, Ernesto Ortiz, Axel Berky, Christopher W. Woods, Genevieve Fouda Amouou, Hannah Itell, Heileen Hsu-Kim, and William Pan. “Mercury Exposure and Poor Nutritional Status Reduce Response to Six Expanded Program on Immunization Vaccines in Children: An Observational Cohort Study of Communities Affected by Gold Mining in the Peruvian Amazon..” Int J Environ Res Public Health 16, no. 4 (February 21, 2019). https://doi.org/10.3390/ijerph16040638.

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Nelson, C. S., G. G. A. Fouda, and S. R. Permar. “Pediatric HIV-1 acquisition and lifelong consequences of infant infection.” Current Immunology Reviews 15, no. 1 (January 1, 2019): 131–38. https://doi.org/10.2174/1573395514666180531074047.

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