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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Professor of Pathology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital, Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital, Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Goswami, Ria, Ashley N. Nelson, Joshua J. Tu, Maria Dennis, Liqi Feng, Amit Kumar, Jesse Mangold, et al. “Analytical Treatment Interruption after Short-Term Antiretroviral Therapy in a Postnatally Simian-Human Immunodeficiency Virus-Infected Infant Rhesus Macaque Model..” Mbio 10, no. 5 (September 5, 2019). https://doi.org/10.1128/mBio.01971-19.

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Hurst, Jillian H., Katherine J. Barrett, Matthew S. Kelly, Betty B. Staples, Kathleen A. McGann, Coleen K. Cunningham, Ann M. Reed, Rasheed A. Gbadegesin, and Sallie R. Permar. “Cultivating Research Skills During Clinical Training to Promote Pediatric-Scientist Development..” Pediatrics 144, no. 2 (August 2019). https://doi.org/10.1542/peds.2019-0745.

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Breitbach, Meghan E., Christina M. Newman, Dawn M. Dudley, Laurel M. Stewart, Matthew T. Aliota, Michelle R. Koenig, Phoenix M. Shepherd, et al. “Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques..” Plos Pathog 15, no. 8 (August 2019). https://doi.org/10.1371/journal.ppat.1007766.

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Nelson, Ashley N., Ria Goswami, Maria Dennis, Joshua Tu, Riley J. Mangan, Pooja T. Saha, Derek W. Cain, et al. “Simian-Human Immunodeficiency Virus SHIV.CH505-Infected Infant and Adult Rhesus Macaques Exhibit Similar Env-Specific Antibody Kinetics, despite Distinct T-Follicular Helper and Germinal Center B Cell Landscapes..” J Virol 93, no. 15 (August 1, 2019). https://doi.org/10.1128/JVI.00168-19.

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Saccoccio, Frances M., Jennifer A. Jenks, Hannah L. Itell, Shuk Hang Li, Madison Berry, Justin Pollara, Corey Casper, Soren Gantt, and Sallie R. Permar. “Humoral Immune Correlates for Prevention of Postnatal Cytomegalovirus Acquisition..” J Infect Dis 220, no. 5 (July 31, 2019): 772–80. https://doi.org/10.1093/infdis/jiz192.

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Singh, Anjali, Sallie Permar, Tobias R. Kollmann, Ofer Levy, Mary Marovich, and Kristina De Paris. “AIDS Vaccine Research Subcommittee (AVRS) Consultation: Early-Life Immunization Strategies against HIV Acquisition..” Msphere 4, no. 4 (July 17, 2019). https://doi.org/10.1128/mSphere.00320-19.

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Jones, Dorothy I., Justin J. Pollara, Brandi T. Johnson-Weaver, Celia C. LaBranche, David C. Montefiori, David J. Pickup, Sallie R. Permar, et al. “Optimized Mucosal Modified Vaccinia Virus Ankara Prime/Soluble gp120 Boost HIV Vaccination Regimen Induces Antibody Responses Similar to Those of an Intramuscular Regimen..” J Virol 93, no. 14 (July 15, 2019). https://doi.org/10.1128/JVI.00475-19.

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Mangan, Riley J., Lisa Stamper, Tomoo Ohashi, Joshua A. Eudailey, Eden P. Go, Frederick H. Jaeger, Hannah L. Itell, et al. “Determinants of Tenascin-C and HIV-1 envelope binding and neutralization..” Mucosal Immunol 12, no. 4 (July 2019): 1004–12. https://doi.org/10.1038/s41385-019-0164-2.

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Martinez, David R., Youyi Fong, Shuk Hang Li, Fang Yang, Madeleine F. Jennewein, Joshua A. Weiner, Erin A. Harrell, et al. “Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women..” Cell 178, no. 1 (June 27, 2019): 190-201.e11. https://doi.org/10.1016/j.cell.2019.05.046.

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Pollara, Justin, Dorothy I. Jones, Tori Huffman, R Whitney Edwards, Maria Dennis, Shuk Hang Li, Shalini Jha, et al. “Bridging Vaccine-Induced HIV-1 Neutralizing and Effector Antibody Responses in Rabbit and Rhesus Macaque Animal Models..” J Virol 93, no. 10 (May 15, 2019). https://doi.org/10.1128/JVI.02119-18.

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