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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Professor of Pathology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital, Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital, Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Fouda, Genevieve G., Kristina De Paris, Ofer Levy, Arnaud Marchant, Glenda Gray, Sallie Permar, Mary Marovich, and Anjali Singh. “Immunological mechanisms of inducing HIV immunity in infants..” Vaccine 38, no. 3 (January 16, 2020): 411–15. https://doi.org/10.1016/j.vaccine.2019.11.011.

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Weimer, Kristin E. D., Matthew S. Kelly, Sallie R. Permar, Reese H. Clark, and Rachel G. Greenberg. “Association of Adverse Hearing, Growth, and Discharge Age Outcomes With Postnatal Cytomegalovirus Infection in Infants With Very Low Birth Weight..” Jama Pediatr, December 2, 2019. https://doi.org/10.1001/jamapediatrics.2019.4532.

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Ezekian, Brian, Paul M. Schroder, Michael S. Mulvihill, Andrew Barbas, Bradley Collins, Kyle Freischlag, Janghoon Yoon, et al. “Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients..” J Am Soc Nephrol 30, no. 12 (December 2019): 2399–2411. https://doi.org/10.1681/ASN.2019030304.

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Hompe, Eliza D., Denise L. Jacobson, Joshua A. Eudailey, Kevin Butler, Whitney Edwards, Justin Pollara, Sean S. Brummel, et al. “Maternal Humoral Immune Responses Do Not Predict Postnatal HIV-1 Transmission Risk in Antiretroviral-Treated Mothers from the IMPAACT PROMISE Study..” Msphere 4, no. 5 (October 23, 2019). https://doi.org/10.1128/mSphere.00716-19.

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Coppola, Tiziana, Jesse F. Mangold, Sarah Cantrell, and Sallie R. Permar. “Impact of Maternal Immunity on Congenital Cytomegalovirus Birth Prevalence and Infant Outcomes: A Systematic Review..” Vaccines (Basel) 7, no. 4 (September 26, 2019). https://doi.org/10.3390/vaccines7040129.

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Goswami, Ria, Ashley N. Nelson, Joshua J. Tu, Maria Dennis, Liqi Feng, Amit Kumar, Jesse Mangold, et al. “Analytical Treatment Interruption after Short-Term Antiretroviral Therapy in a Postnatally Simian-Human Immunodeficiency Virus-Infected Infant Rhesus Macaque Model..” Mbio 10, no. 5 (September 5, 2019). https://doi.org/10.1128/mBio.01971-19.

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Maness, Nicholas J., Blake Schouest, Anil Singapuri, Maria Dennis, Margaret H. Gilbert, Rudolf P. Bohm, Faith Schiro, et al. “Postnatal Zika virus infection of nonhuman primate infants born to mothers infected with homologous Brazilian Zika virus..” Sci Rep 9, no. 1 (September 5, 2019). https://doi.org/10.1038/s41598-019-49209-7.

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Hurst, Jillian H., Katherine J. Barrett, Matthew S. Kelly, Betty B. Staples, Kathleen A. McGann, Coleen K. Cunningham, Ann M. Reed, Rasheed A. Gbadegesin, and Sallie R. Permar. “Cultivating Research Skills During Clinical Training to Promote Pediatric-Scientist Development..” Pediatrics 144, no. 2 (August 2019). https://doi.org/10.1542/peds.2019-0745.

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Singh, Tulika, Cesar A. Lopez, Camila Giuberti, Maria L. Dennis, Hannah L. Itell, Holly J. Heimsath, Helen S. Webster, et al. “Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy..” Plos Negl Trop Dis 13, no. 8 (August 2019). https://doi.org/10.1371/journal.pntd.0007648.

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Breitbach, Meghan E., Christina M. Newman, Dawn M. Dudley, Laurel M. Stewart, Matthew T. Aliota, Michelle R. Koenig, Phoenix M. Shepherd, et al. “Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques..” Plos Pathog 15, no. 8 (August 2019). https://doi.org/10.1371/journal.ppat.1007766.

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