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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Dennis, M, Eudailey, J, Pollara, J, McMillan, AS, Cronin, KD, Saha, PT, Curtis, AD, Hudgens, MG, Fouda, GG, Ferrari, G, Alam, M, Van Rompay, KKA, De Paris, K, Permar, S, and Shen, X. "Coadministration of CH31 Broadly Neutralizing Antibody Does Not Affect Development of Vaccine-Induced Anti-HIV-1 Envelope Antibody Responses in Infant Rhesus Macaques." Journal of Virology 93, no. 5 (March 2019).

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Burghuber, CK, Manook, M, Ezekian, B, Gibby, AC, Leopardi, FV, Song, M, Jenks, J, Saccoccio, F, Permar, S, Farris, AB, Iwakoshi, NN, Kwun, J, and Knechtle, SJ. "Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 19, no. 3 (March 2019): 724-736.

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Nelson, CS, Vera Cruz, D, Su, M, Xie, G, Vandergrift, N, Pass, RF, Forman, M, Diener-West, M, Koelle, K, Arav-Boger, R, and Permar, SR. "Intrahost Dynamics of Human Cytomegalovirus Variants Acquired by Seronegative Glycoprotein B Vaccinees." Journal of Virology 93, no. 5 (March 2019).

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Wyatt, L, Permar, SR, Ortiz, E, Berky, A, Woods, CW, Amouou, GF, Itell, H, Hsu-Kim, H, and Pan, W. "Mercury Exposure and Poor Nutritional Status Reduce Response to Six Expanded Program on Immunization Vaccines in Children: An Observational Cohort Study of Communities Affected by Gold Mining in the Peruvian Amazon." International Journal of Environmental Research and Public Health 16, no. 4 (February 21, 2019).

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Tay, MZ, Kunz, EL, Deal, A, Zhang, L, Seaton, KE, Rountree, W, Eudailey, JA, Heptinstall, J, McRaven, MD, Matias, E, McGuire, E, Yates, NL, Perez, LG, Montefiori, DC, Overman, RG, Hope, TJ, Shen, X, Kalilani, L, Fouda, GG, Tomaras, GD, and Permar, SR. "Rare Detection of Antiviral Functions of Polyclonal IgA Isolated from Plasma and Breast Milk Compartments in HIV-1 Chronically Infected Women." Journal of Virology (January 30, 2019).

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Shah, SV, Manickam, C, Ram, DR, Kroll, K, Itell, H, Permar, SR, Barouch, DH, Klatt, NR, and Reeves, RK. "CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques." Cell Reports 25, no. 10 (December 2018): 2766-2774.e3.

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Himes, JE, Goswami, R, Mangan, RJ, Kumar, A, Jeffries, TL, Eudailey, JA, Heimsath, H, Nguyen, QN, Pollara, J, LaBranche, C, Chen, M, Vandergrift, NA, Peacock, JW, Schiro, F, Midkiff, C, Ferrari, G, Montefiori, DC, Hernandez, XA, Aye, PP, and Permar, SR. "Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys." Mucosal Immunology 11, no. 6 (November 2018): 1716-1726.

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Lantos, PM, Maradiaga-Panayotti, G, Barber, X, Raynor, E, Tucci, D, Hoffman, K, Permar, SR, Jackson, P, Hughes, BL, Kind, A, and Swamy, GK. "Geographic and Racial Disparities in Infant Hearing Loss." Otolaryngology Head and Neck Surgery : Official Journal of American Academy of Otolaryngology Head and Neck Surgery (October 9, 2018): 194599818803305-null.

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Phillips, B, Van Rompay, KKA, Rodriguez-Nieves, J, Lorin, C, Koutsoukos, M, Tomai, M, Fox, CB, Eudailey, J, Dennis, M, Alam, SM, Hudgens, M, Fouda, G, Pollara, J, Moody, A, Shen, X, Ferrari, G, Permar, S, and De Paris, K. "Adjuvant-Dependent Enhancement of HIV Env-Specific Antibody Responses in Infant Rhesus Macaques." Journal of Virology 92, no. 20 (October 2018).

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Pollara, J, Jones, DI, Huffman, T, Dennis, M, Li, G, Goodman, D, Edwards, RW, Kumar, A, LaBranche, CC, Montefiori, DC, Fouda, GG, Tomaras, GD, Ferrari, G, Staats, HF, and Permar, SR. "Bridging Vaccine-induced Antibody Responses in Rabbit and Rhesus Macaque Animal Models." HIV Research for Prevention Meeting (HIVR4P) - AIDS Vaccine, Microbicide and ARV-Based Prevention Science. Madrid, SPAIN. October 21, 2018 - October 25, 2018.: MARY ANN LIEBERT, INC, October 1, 2018.

Scholars@Duke

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