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Sallie Robey Permar, MD, PhD

Professor of Pediatrics
Professor of Molecular Genetics and Microbiology
Professor in Immunology
Affiliate, Duke Global Health Institute
Associate of the Duke Initiative for Science & Society
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Human Vaccine Institute
Campus mail: 103020, 2 Genome Ct MSRBII, Durham, NC 27710
Phone: (919) 684-2515
Email address: sallie.permar@duke.edu

Dr. Permar's work focuses on the development of vaccines to prevent vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS to characterize the virus-specific immune responses and virus evolution in breast milk and develop a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Importantly, Dr. Permar has established a nonhuman primate model of congenital CMV infection adn is using this model to establish the maternal immune responses that are necessary for protection against placental virus transmission. Finally, Dr. Permar is studying the impact and prevention of postnatal CMV transmission in preterm infants.

Education and Training

  • Fellowship in Pediatric Infectious Diseases, Pediatrics, Children's Hospital Boston, 2007 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital Boston, 2004 - 2007
  • Ph.D., Johns Hopkins University, 2004
  • M.D., Harvard Medical School, 2004

Selected Grants and Awards

Publications

Phillips, B, Van Rompay, KKA, Rodriguez-Nieves, J, Lorin, C, Koutsoukos, M, Tomai, M, Fox, CB, Eudailey, J, Dennis, M, Alam, SM, Hudgens, M, Fouda, G, Pollara, J, Moody, A, Shen, X, Ferrari, G, Permar, S, and De Paris, K. "Adjuvant-Dependent Enhancement of HIV Env-Specific Antibody Responses in Infant Rhesus Macaques." Journal of Virology 92, no. 20 (October 2018).

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Itell, HL, McGuire, EP, Muresan, P, Cunningham, CK, McFarland, EJ, Borkowsky, W, Permar, SR, and Fouda, GG. "Development and application of a multiplex assay for the simultaneous measurement of antibody responses elicited by common childhood vaccines." Vaccine 36, no. 37 (September 2018): 5600-5608.

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Martinez, DR, Fouda, GG, Peng, X, Ackerman, ME, and Permar, SR. "Noncanonical placental Fc receptors: What is their role in modulating transplacental transfer of maternal IgG?." Plos Pathogens 14, no. 8 (August 30, 2018): e1007161-null.

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Himes, JE, Goswami, R, Mangan, RJ, Kumar, A, Jeffries, TL, Eudailey, JA, Heimsath, H, Nguyen, QN, Pollara, J, LaBranche, C, Chen, M, Vandergrift, NA, Peacock, JW, Schiro, F, Midkiff, C, Ferrari, G, Montefiori, DC, Hernandez, XA, Aye, PP, and Permar, SR. "Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys." Mucosal Immunology (August 16, 2018).

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Burghuber, CK, Manook, M, Ezekian, B, Gibby, AC, Leopardi, FV, Song, M, Jenks, J, Saccoccio, F, Permar, S, Farris, AB, Iwakoshi, NN, Kwun, J, and Knechtle, SJ. "Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons (August 13, 2018).

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Lantos, PM, Hoffman, K, Permar, SR, Jackson, P, Hughes, BL, Kind, A, and Swamy, G. "Neighborhood Disadvantage is Associated with High Cytomegalovirus Seroprevalence in Pregnancy." Journal of Racial and Ethnic Health Disparities 5, no. 4 (August 2018): 782-786.

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Permar, SR, Schleiss, MR, and Plotkin, SA. "Reply to Gantt et al., "Higher Expectations for a Vaccine To Prevent Congenital Cytomegalovirus Infection"." Journal of Virology 92, no. 15 (August 2018).

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Permar, S, Levy, O, Kollman, TR, Singh, A, and De Paris, K. "Early Life HIV-1 Immunization: Providing a Window for Protection Before Sexual Debut." Aids Research and Human Retroviruses (July 3, 2018).

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Coffey, LL, Keesler, RI, Pesavento, PA, Woolard, K, Singapuri, A, Watanabe, J, Cruzen, C, Christe, KL, Usachenko, J, Yee, J, Heng, VA, Bliss-Moreau, E, Reader, JR, von Morgenland, W, Gibbons, AM, Jackson, K, Ardeshir, A, Heimsath, H, Permar, S, Senthamaraikannan, P, Presicce, P, Kallapur, SG, Linnen, JM, Gao, K, Orr, R, MacGill, T, McClure, M, McFarland, R, Morrison, JH, and Van Rompay, KKA. "Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease." Nature Communications 9, no. 1 (June 20, 2018): 2414-null.

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Nelson, CS, Huffman, T, Jenks, JA, Cisneros de la Rosa, E, Xie, G, Vandergrift, N, Pass, RF, Pollara, J, and Permar, SR. "HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions." Proceedings of the National Academy of Sciences of the United States of America 115, no. 24 (June 2018): 6267-6272.

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