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Patricia Lynn Ashley, PhD, MD

Associate Professor of Pediatrics
Campus mail: 2424 Erwin Road, Suite 504, Durham, NC 27705
Phone: (919) 681-3501
Email address: ashle022@mc.duke.edu

My current clinical time is divided between inpatient and outpatient care of infants who graduate from the ICN or TCN.  In addition, I am a provider in our Transitions program for the most medically fragile and complex infants that we care for.
My research interests center on how Nutrition influences growth and development, primarily in infants born extremely premature.  Through a combination of clinical research and basic science involving study of the microbiome and metabolome, we are seeking new answers regarding how to optimize growth, development, and eventual long term outcomes for these infants.
I also have taken on administrative and regulatory roles involving research over the last three years when I became a member of the IRB.  More recently I have taken on the role of Director for the Children's Clinical Research Unit.

Education and Training

  • Resident, Pediatrics, University of Texas at Dallas, 1991 - 1994
  • M.D., University of Texas at Dallas, 1991
  • Ph.D., University of Texas at Dallas, 1984

Publications

Younge, Noelle E., Christopher B. Newgard, C Michael Cotten, Ronald N. Goldberg, Michael J. Muehlbauer, James R. Bain, Robert D. Stevens, et al. “Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure..” Sci Rep 9, no. 1 (June 3, 2019). https://doi.org/10.1038/s41598-019-44547-y.

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Meyers, J. M., S. Tan, E. F. Bell, A. F. Duncan, R. Guillet, B. J. Stoll, C. T. D’Angio, and C. T. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. “Neurodevelopmental outcomes among extremely premature infants with linear growth restriction..” J Perinatol 39, no. 2 (February 2019): 193–202. https://doi.org/10.1038/s41372-018-0259-8.

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Khan, Tahir N., Kamal Khan, Azita Sadeghpour, Hannah Reynolds, Yezmin Perilla, Marie T. McDonald, William B. Gallentine, et al. “Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies..” Am J Hum Genet 104, no. 1 (January 3, 2019): 94–111. https://doi.org/10.1016/j.ajhg.2018.11.017.

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Duncan, Andrea F., Carla M. Bann, Allison Dempsey, Myriam Peralta-Carcelen, Susan Hintz, and Susan Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network. “Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm..” J Pediatr 204 (January 2019): 148-156.e4. https://doi.org/10.1016/j.jpeds.2018.08.059.

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Lowe, Jean R., Janell F. Fuller, Barbara T. Do, Betty R. Vohr, Abhik Das, Susan R. Hintz, Kristi L. Watterberg, Rosemary D. Higgins, Rosemary D. Eunice Kennedy Shriver National Institute of Child Health, and Rosemary D. Human Development Neonatal Research Network. “Behavioral problems are associated with cognitive and language scores in toddlers born extremely preterm..” Early Hum Dev 128 (January 2019): 48–54. https://doi.org/10.1016/j.earlhumdev.2018.11.007.

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Vohr, Betty R., Roy Heyne, Carla M. Bann, Abhik Das, Rosemary D. Higgins, Susan R. Hintz, and Susan R. Eunice Kennedy Shriver National Institute of Child Health, and Development Neonatal Research Network. “Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort..” J Pediatr 200 (September 2018): 132-139.e3. https://doi.org/10.1016/j.jpeds.2018.04.073.

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Hintz, Susan R., Betty R. Vohr, Carla M. Bann, H Gerry Taylor, Abhik Das, Kathryn E. Gustafson, Kimberly Yolton, et al. “Preterm Neuroimaging and School-Age Cognitive Outcomes..” Pediatrics 142, no. 1 (July 2018). https://doi.org/10.1542/peds.2017-4058.

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Adams-Chapman, Ira, Roy J. Heyne, Sara B. DeMauro, Andrea F. Duncan, Susan R. Hintz, Athina Pappas, Betty R. Vohr, et al. “Neurodevelopmental Impairment Among Extremely Preterm Infants in the Neonatal Research Network..” Pediatrics 141, no. 5 (May 2018). https://doi.org/10.1542/peds.2017-3091.

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Sarkar, Subrata, Seetha Shankaran, John Barks, Barbara T. Do, Abbot R. Laptook, Abhik Das, Namasivayam Ambalavanan, et al. “Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age..” J Pediatr 195 (April 2018): 59-65.e3. https://doi.org/10.1016/j.jpeds.2017.12.010.

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Pappas, Athina, Ira Adams-Chapman, Seetha Shankaran, Scott A. McDonald, Barbara J. Stoll, Abbot R. Laptook, Waldemar A. Carlo, et al. “Neurodevelopmental and Behavioral Outcomes in Extremely Premature Neonates With Ventriculomegaly in the Absence of Periventricular-Intraventricular Hemorrhage..” Jama Pediatr 172, no. 1 (January 1, 2018): 32–42. https://doi.org/10.1001/jamapediatrics.2017.3545.

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