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Michael Scott Freemark, MD

Robert C. Atkins, M.D. and Veronica Atkins Professor of Pediatrics, in the School of Medicine
Professor of Pediatrics
Chief, Divison of Pediatric Endocrinology
Affiliate, Duke Global Health Institute
Member of Sarah W. Stedman Nutrition and Metabolism Center
Campus mail: Box 102820 Med Ctr, Durham, NC 27710
Phone: (919) 684-8350
Email address: freem001@mc.duke.edu

The primary objective of my basic research has been to elucidate the roles of placental and fetal hormones in the regulation of maternal metabolism and fetal growth. My work has focused on the lactogenic hormones produced by the pituitary gland and placenta. In recent studies we have used targeted knockout mice to explore the molecular mechanisms by which prolactin and placental lactogen regulate pancreatic beta cell mass and insulin production during pregnancy and postnatal life.
I also have a clinical research interest in the pathogenesis and treatment of obesity and hyperlipidemia and the prevention of type 2 diabetes. In previous studies we showed that the drug metformin reduces fat stores and blood glucose and insulin levels in obese adolescents and may reduce the risk of progression to diabetes in selected patients. We have also examined the unique metabolic characteristics of Prader Willi syndrome, a genetic obesity disorder. Finally, we have recently completed a detailed study of metabolism in malnourished children in Uganda and characterized the effects of concurrent HIV infection on nutritional recovery.

Education and Training

  • M.D., Duke University, 1976
  • B.A., Brandeis University, 1972

Selected Grants and Awards

Publications

Brooks, Elizabeth Drake, Dianne Little, Ramamani Arumugam, Baodong Sun, Sarah Curtis, Amanda Demaster, Michael Maranzano, et al. “Pathogenesis of growth failure and partial reversal with gene therapy in murine and canine Glycogen Storage Disease type Ia..” Mol Genet Metab 109, no. 2 (June 2013): 161–70. https://doi.org/10.1016/j.ymgme.2013.03.018.

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Brooks, Elizabeth J., Dianne Little, Ramamani Arumugam, Baodong Sun, Sarah Curtis, Amanda DeMaster, Michael Maranzano, et al. “Pathogenesis of Growth Failure in Murine and Canine Glycogen Storage Disease-Ia and Partial Reversal of Growth Failure Using Adeno-Associated Viral Vector Therapy.” In Molecular Therapy, 21:S105–6. NATURE PUBLISHING GROUP, 2013.

Scholars@Duke

Bartz, Sarah, and Michael Freemark. “Pathogenesis and prevention of type 2 diabetes: parental determinants, breastfeeding, and early childhood nutrition..” Curr Diab Rep 12, no. 1 (February 2012): 82–87. https://doi.org/10.1007/s11892-011-0246-3.

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Newbern, Dorothee, and Michael Freemark. “Placental hormones and the control of maternal metabolism and fetal growth..” Curr Opin Endocrinol Diabetes Obes 18, no. 6 (December 2011): 409–16. https://doi.org/10.1097/MED.0b013e32834c800d.

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Freemark, Michael. “Management of adolescents with polycystic ovary syndrome..” J Clin Endocrinol Metab 96, no. 11 (November 2011): 3354–56. https://doi.org/10.1210/jc.2011-2520.

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Arumugam, Ramamani, Donald Fleenor, Danhong Lu, and Michael Freemark. “Differential and complementary effects of glucose and prolactin on islet DNA synthesis and gene expression..” Endocrinology 152, no. 3 (March 2011): 856–68. https://doi.org/10.1210/en.2010-1258.

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Haqq, Andrea M., Michael J. Muehlbauer, Christopher B. Newgard, Steven Grambow, and Michael Freemark. “The metabolic phenotype of Prader-Willi syndrome (PWS) in childhood: heightened insulin sensitivity relative to body mass index..” J Clin Endocrinol Metab 96, no. 1 (January 2011): E225–32. https://doi.org/10.1210/jc.2010-1733.

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Brown, W Virgil, Don P. Wilson, Michael Freemark, and Peter O. Kwiterovich. “The use of lipid-lowering drugs in children..” J Clin Lipidol 4, no. 6 (November 2010): 449–61. https://doi.org/10.1016/j.jacl.2010.10.003.

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Arumugam, Ramamani, Eric Horowitz, Robert C. Noland, Danhong Lu, Donald Fleenor, and Michael Freemark. “Regulation of islet beta-cell pyruvate metabolism: interactions of prolactin, glucose, and dexamethasone..” Endocrinology 151, no. 7 (July 2010): 3074–83. https://doi.org/10.1210/en.2010-0049.

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Freemark, M. “Childhood Obesity,” June 20, 2010, 530–58. https://doi.org/10.1002/9781444316728.ch20.

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