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Michael M. Frank, MD

Samuel L. Katz Professor Emeritus of Pediatrics, in the School of Medicine
Professor Emeritus of Pediatrics
Campus mail: 131 MSRB, Durham, NC 27710
Phone: (919) 684-2922
Email address: frank007@mc.duke.edu

The research of Dr. Frank's laboratory revolves around effector mechanisms of immune damage. Specifically, the laboratory is interested in understanding how antibody and complement contribute to the damage of tissues and micro-organisms. Overlapping areas of interest include the role of mediators in inflammation and the functions of antibody and complement in the production of autoimmune disease. Specific interests of the group in the last year have included studies of the mechanism by which infusion of intravenous immunoglobulin into animals and man down regulates immunologic damage. A second area of interest concerns the role of complement and antibody in the pathogenesis of HIV and in prevention of HIV infection. A third area concerns the role of complement in the generation of an immune response. A long term interest has been in the clinical signs and appropriate treatment of patients with hereditary angioedema.

Education and Training

  • M.D., Harvard University, 1960

Publications

Ali, HA, Pavlisko, EN, Snyder, LD, Frank, M, and Palmer, SM. "Complement system in Lung Transplantation." Clinical transplantation (January 23, 2018). (Review)

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Busse, P, Baker, J, Martinez-Saguer, I, Bernstein, JA, Craig, T, Magerl, M, Riedl, M, Shapiro, R, Frank, M, Lumry, W, Rosch, J, Edelman, J, Williams-Herman, D, Feuersenger, H, Rojavin, M, and Berinert Registry Investigators, . "Safety of C1-inhibitor concentrate use for hereditary angioedema in pediatric patients." The journal of allergy and clinical immunology. In practice 5, no. 4 (July 2017): 1142-1145.

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Farkas, H, Martinez-Saguer, I, Bork, K, Bowen, T, Craig, T, Frank, M, Germenis, AE, Grumach, AS, Luczay, A, Varga, L, Zanichelli, A, and HAWK, . "International consensus on the diagnosis and management of pediatric patients with hereditary angioedema with C1 inhibitor deficiency." Allergy 72, no. 2 (February 2017): 300-313.

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Magerl, M, Frank, M, Lumry, W, Bernstein, J, Busse, P, Craig, T, Martinez-Saguer, I, Riedl, MA, Shapiro, R, Edelman, J, Williams-Herman, D, Wood, DN, Feuersenger, H, Rojavin, M, and Berinert Registry Investigators, . "Short-term prophylactic use of C1-inhibitor concentrate in hereditary angioedema: Findings from an international patient registry." Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 118, no. 1 (January 2017): 110-112.

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Frank, MM, Zuraw, B, Banerji, A, Bernstein, JA, Craig, T, Busse, P, Christiansen, S, Davis-Lorton, M, Li, HH, Lumry, WR, Riedl, M, and US Hereditary Angioedema Association Medical Advisory Board, . "Management of Children With Hereditary Angioedema Due to C1 Inhibitor Deficiency." Pediatrics 138, no. 5 (November 2016).

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Khandelwal, S, Lee, GM, Hester, CG, Poncz, M, McKenzie, SE, Sachais, BS, Rauova, L, Kelsoe, G, Cines, DB, Frank, M, and Arepally, GM. "The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21)." Blood 128, no. 14 (October 2016): 1789-1799.

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Riedl, MA, Bygum, A, Lumry, W, Magerl, M, Bernstein, JA, Busse, P, Craig, T, Frank, MM, Edelman, J, Williams-Herman, D, Feuersenger, H, Rojavin, M, and Berinert Registry investigators, . "Safety and Usage of C1-Inhibitor in Hereditary Angioedema: Berinert Registry Data." The journal of allergy and clinical immunology. In practice 4, no. 5 (September 2016): 963-971.

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Bonilla, FA, Khan, DA, Ballas, ZK, Chinen, J, Frank, MM, Hsu, JT, Keller, M, Kobrynski, LJ, Komarow, HD, Mazer, B, Nelson, RP, Orange, JS, Routes, JM, Shearer, WT, Sorensen, RU, Verbsky, JW, Bernstein, DI, Blessing-Moore, J, Lang, D, Nicklas, RA, Oppenheimer, J, Portnoy, JM, Randolph, CR, Schuller, D, Spector, SL, Tilles, S, Wallace, D, Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology, and the American College of Allergy, Asthma & Immunology et al. "Practice parameter for the diagnosis and management of primary immunodeficiency." The Journal of allergy and clinical immunology 136, no. 5 (November 2015): 1186-205.e1-78-.

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Banerji, A, Busse, P, Christiansen, SC, Li, H, Lumry, W, Davis-Lorton, M, Bernstein, JA, Frank, M, Castaldo, A, Long, JF, Zuraw, BL, and Riedl, M. "Current state of hereditary angioedema management: a patient survey." Allergy and asthma proceedings 36, no. 3 (May 2015): 213-217.

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Christiansen, SC, Bygum, A, Banerji, A, Busse, P, Li, H, Lumry, W, Davis-Lorton, M, Bernstein, JA, Frank, MM, Castaldo, A, Long, JF, Riedl, M, and Zuraw, BL. "Before and after, the impact of available on-demand treatment for HAE." Allergy and asthma proceedings 36, no. 2 (March 2015): 145-150.

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