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Mary Redmond Hutson, PhD

Assistant Professor in Pediatrics
Campus mail: 403 Jones Bldg, Durham, NC 27710
Phone: (919) 668-2309
Email address: mhutson@duke.edu

My laboratory is interested in understanding how congenital heart defects occur. In particular I am focused on defects of the conotruncus (or arterial pole) which include persistent truncus arteriosus, double outlet right ventricle, and tetralogy of Fallot. During early stages of heart development the secondary heart field, a population of cardiac stem cells, forms the smooth muscle and myocardial junction of the arterial pole. Another cell population important for arterial pole formation are the cardiac neural crest. These cells migrate into the arterial pole and form a septum to divide the systemic and pulmonary circulations. Disruption of secondary heart field or cardiac neural crest development results in conotruncal defects. My research focuses on the understanding the integration of the cell signaling mechanisms that influence the secondary heart field progenitor cells and cardiac neural crest to form the arterial pole. We have shown that modulation of fibroblast growth factor 8 (FGF8) signaling by cardiac neural crest in the pharynx is required for normal heart development and that too much or too little FGF8 signaling results in secondary heart field defects that lead to arterial pole defects. Current work in the lab focuses on the integration of FGF8 signaling with other signaling pathways including retinoic acid, sonic hedgehog (Shh), and BMP to effect normal arterial pole development. We want to understand how these signals balance to maintain a pool of undifferentiated secondary heart field progenitors and the coordinated differentiation of myocardial and vascular smooth muscle cells.

Education and Training

  • Ph.D., Medical College of Georgia School of Medicine, 1995

Publications

Hutson, MR, Keyte, AL, Hernández-Morales, M, Gibbs, E, Kupchinsky, ZA, Argyridis, I, Erwin, KN, Pegram, K, Kneifel, M, Rosenberg, PB, Matak, P, Xie, L, Grandl, J, Davis, EE, Katsanis, N, Liu, C, and Benner, EJ. "Temperature-activated ion channels in neural crest cells confer maternal fever-associated birth defects." Science signaling 10, no. 500 (October 10, 2017).

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Andersen, ND, Ramachandran, KV, Bao, MM, Kirby, ML, Pitt, GS, and Hutson, MR. "Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow." Journal of molecular and cellular cardiology 80 (March 2015): 1-9.

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Sinha, T, Li, D, Théveniau-Ruissy, M, Hutson, MR, Kelly, RG, and Wang, J. "Loss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndrome." Human molecular genetics 24, no. 6 (March 2015): 1704-1716.

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Billmyre, KK, Hutson, M, and Klingensmith, J. "One shall become two: Separation of the esophagus and trachea from the common foregut tube." Developmental dynamics : an official publication of the American Association of Anatomists 244, no. 3 (March 2015): 277-288. (Review)

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Thattaliyath, B, and Hutson, M. "Neural crest." In Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways, 41-54. January 1, 2015.

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Keyte, AL, Alonzo-Johnsen, M, and Hutson, MR. "Evolutionary and developmental origins of the cardiac neural crest: building a divided outflow tract." Birth defects research. Part C, Embryo today : reviews 102, no. 3 (September 16, 2014): 309-323. (Review)

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Leddy, HA, McNulty, AL, Lee, SH, Rothfusz, NE, Gloss, B, Kirby, ML, Hutson, MR, Cohn, DH, Guilak, F, and Liedtke, W. "Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28, no. 6 (June 2014): 2525-2537.

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Andersen, ND, Ramachandran, K, Bao, MM, Thattaliyath, B, Pitt, GS, Kirby, ML, and Hutson, MR. "Ca2+Signaling is Required for Cardiomyocyte Hypertrophy During Chamber Development Independent of Contraction or Blood Flow." November 26, 2013.

Scholars@Duke

Keyte, A, and Hutson, MR. "The neural crest in cardiac congenital anomalies." Differentiation 84, no. 1 (July 2012): 25-40. (Review)

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Muller-Borer, B, Esch, G, Aldina, R, Woon, W, Fox, R, Bursac, N, Hiller, S, Maeda, N, Shepherd, N, Jin, JP, Hutson, M, Anderson, P, Kirby, ML, and Malouf, NN. "Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage." PLoS One 7, no. 6 (2012): e38454-.

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