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Mary Louise Markert, PhD, MD

Professor of Pediatrics
Professor of Immunology
Member of the Duke Cancer Institute
Campus mail: Box 3068 Med Ctr, Durham, NC 27710
Phone: (919) 684-6263
Email address: marke001@mc.duke.edu

Dr. Markert is currently investigating thymus transplantation in complete DiGeorge syndrome. Complete DiGeorge syndrome is a fatal genetic disorder in which patients have heart defects, severe parathyroid hypoplasia and absence of the thymus. In a research protocol complete DiGeorge patients who have no T cells are transplanted with postnatal cultured human thymic epithelial tissue. The transplants are later biopsied to evaluate whether host stem cells have migrated to the tranplanted tissue and developed into T cells. Seventy nine infants with complete DiGeorge anomaly have been transplanted and 56 survive (71%). Her research to date has shown that the patient can develop new recipient T cells in the graft and normal T cell proliferative responses to mitogens and antigens. Thus, in infants born with no T cells because of DiGeorge syndrome, cultured donor postnatal thymic tissue is sufficient for the development of recipient T cells from recipient stem cells. Dr. Markert is now studying patients previously transplanted to learn how long the thymus functions and why the T cell numbers in her post thymus transplantation patients remain low for age - similar to the T cell numbers in patients with partial DiGeorge anomaly who do not need thymus transplantation. In 2012, Dr. Markert began studies in an animal model to use thymus transplantatin to induce tolerance to solid organ transplants. This work was funded by The Hartwell Foundation and is continuing under internal funding.

Education and Training

  • M.D., Duke University, 1982
  • Ph.D., Duke University, 1981

Selected Grants and Awards

Publications

Liu, N, Schoch, K, Luo, X, Pena, LDM, Bhavana, VH, Kukolich, MK, Stringer, S, Powis, Z, Radtke, K, Mroske, C, Deak, KL, McDonald, MT, McConkie-Rosell, A, Markert, ML, Kranz, PG, Stong, N, Need, AC, Bick, D, Amaral, MD, Worthey, EA, Levy, S, Undiagnosed Diseases Network (UDN), , Wangler, MF, Bellen, HJ, Shashi, V, and Yamamoto, S. "Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder." Human molecular genetics (May 2, 2018).

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Davies, EG, Cheung, M, Gilmour, K, Maimaris, J, Curry, J, Furmanski, A, Sebire, N, Halliday, N, Mengrelis, K, Adams, S, Bernatoniene, J, Bremner, R, Browning, M, Devlin, B, Erichsen, HC, Gaspar, HB, Hutchison, L, Ip, W, Ifversen, M, Leahy, TR, McCarthy, E, Moshous, D, Neuling, K, Pac, M, Papadopol, A, Parsley, KL, Poliani, L, Ricciardelli, I, Sansom, DM, Voor, T, Worth, A, Crompton, T, Markert, ML, and Thrasher, AJ. "Thymus transplantation for complete DiGeorge syndrome: European experience." The Journal of allergy and clinical immunology 140, no. 6 (December 2017): 1660-1670.e16.

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Stone, CA, Markert, ML, Abraham, RS, and Norton, A. "A case of atypical, complete DiGeorge syndrome without 22q11 mutation." Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 118, no. 5 (May 2017): 640-642.e2.

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Yin, SM, Ferdman, RM, Wang, L, Markert, ML, and Tam, JS. "Disseminated Mycobacterium kansasii disease in complete DiGeorge syndrome." Journal of clinical immunology 35, no. 5 (July 2015): 435-438.

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Agada, NO, Yin, SM, Tam, JS, Kelly, MS, and Markert, ML. "Disseminated Atypical Mycobacterial Infection in Three Patients with Complete Digeorge Anomaly." February 2015.

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Rendell, VR, Giamberardino, C, Li, J, Markert, ML, and Brennan, TV. "Complete thymectomy in adult rats with non-invasive endotracheal intubation." Journal of visualized experiments : JoVE, no. 94 (December 29, 2014).

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Lee, JH, Markert, ML, Hornik, CP, McCarthy, EA, Gupton, SE, Cheifetz, IM, and Turner, DA. "Clinical course and outcome predictors of critically ill infants with complete DiGeorge anomaly following thymus transplantation." Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 15, no. 7 (September 2014): e321-e326.

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Markert, ML. "Defects in Thymic Development: DiGeorge/CHARGE/Chromosome 22q11.2 Deletion." In Stiehm's Immune Deficiencies, 221-242. August 12, 2014.

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Louise Markert, M. "Thymus Transplantation." (August 12, 2014): 1059-1067. (Chapter)

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Yu, X, Almeida, J, Darko, S, van der Burg, M, DeRavin, SS, Malech, H, Gennery, A, Chinn, I, Markert, ML, Perales, M-A, Pamer, EG, Douek, DC, and Milner, JD. "Human Syndromes of Immune Deficiency and Dysregulation are Characterized by Distinct Defects in T-Cell Receptor Repertoire Development." April 2014.

Scholars@Duke

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