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Kevin Michael Watt, MD, PhD

Associate Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 300 West Morgan Street, Dumc#3850, Durham, NC 27701
Phone: (919) 668-8556
Email address: kevin.watt@duke.edu

Dr. Watt’s career goal is to advance public health by integrating physiology and pharmacology into approaches for designing and conducting early-phase trials in critically ill children. His current efforts focus on the use of physiologically-based pharmacokinetic modeling and simulation to understand drug disposition in children on extracorporeal life support. His research is supported by the NICHD-sponsored Pediatric Critical Care Scientist Development Program and a NICHD-sponsored Career Development Award. In addition, he is a principal investigator in the NICHD-sponsored Pediatric Trials Network where he leads multiple trials investigating the pharmacokinetics, safety, and efficacy of drugs in children.

Education and Training

  • ClinicalResearch Fellowship, Duke Clinical Research Institute, Duke University School of Medicine, 2010 - 2012
  • Pediatric Critical Care Fellowship, Pediatrics, Duke University School of Medicine, 2009 - 2012
  • Pediatric Internship and Residency, Pediatrics, Duke University School of Medicine, 2006 - 2009
  • Ph.D., University of North Carolina at Chapel Hill, 2016
  • M.D., University of North Carolina at Chapel Hill, 2006

Publications

Hornik, Christoph P., Ram Yogev, Peter M. Mourani, Kevin M. Watt, Janice E. Sullivan, Andrew M. Atz, David Speicher, et al. “Population Pharmacokinetics of Milrinone in Infants, Children, and Adolescents..” J Clin Pharmacol, July 17, 2019. https://doi.org/10.1002/jcph.1499.

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Gerhart, Jacqueline G., Kevin M. Watt, Andrea Edginton, Kelly C. Wade, Sara N. Salerno, Daniel K. Benjamin, P Brian Smith, et al. “Physiologically-Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants..” In Cpt Pharmacometrics Syst Pharmacol, 8:500–510, 2019. https://doi.org/10.1002/psp4.12414.

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Watt, Kevin M., Christoph P. Hornik, Stephen J. Balevic, Gratias Mundakel, C Michael Cotten, Barrie Harper, Daniel K. Benjamin, et al. “Pharmacokinetics of ticarcillin-clavulanate in premature infants..” Br J Clin Pharmacol 85, no. 5 (May 2019): 1021–27. https://doi.org/10.1111/bcp.13882.

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Ku, Lawrence C., Christoph P. Hornik, Ryan J. Beechinor, James M. Chamberlain, Jeffrey T. Guptill, Barrie Harper, Edmund V. Capparelli, et al. “Population Pharmacokinetics and Exploratory Exposure-Response Relationships of Diazepam in Children Treated for Status Epilepticus..” Cpt Pharmacometrics Syst Pharmacol 7, no. 11 (November 2018): 718–27. https://doi.org/10.1002/psp4.12349.

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Watt, Kevin M., Michael Cohen-Wolkowiez, Jeffrey S. Barrett, Michael Sevestre, Ping Zhao, Kim L. R. Brouwer, and Andrea N. Edginton. “Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO..” Cpt Pharmacometrics Syst Pharmacol 7, no. 10 (October 2018): 629–37. https://doi.org/10.1002/psp4.12338.

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Sherwin, Jennifer, Elizabeth Thompson, Kevin D. Hill, Kevin Watt, Andrew J. Lodge, Daniel Gonzalez, and Christoph P. Hornik. “Clinical pharmacology considerations for children supported with ventricular assist devices..” Cardiol Young 28, no. 9 (September 2018): 1082–90. https://doi.org/10.1017/S1047951118001075.

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Zimmerman, Kanecia O., Huali Wu, Matthew Laughon, Rachel G. Greenberg, Richard Walczak, Scott R. Schulman, P Brian Smith, Christoph P. Hornik, Michael Cohen-Wolkowiez, and Kevin M. Watt. “Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass..” Anesth Analg, August 22, 2018. https://doi.org/10.1213/ANE.0000000000003700.

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Watt, Kevin M., Debbie Avant, Jennifer Sherwin, Daniel K. Benjamin, Christoph Hornik, Jennifer S. Li, and P Brian Smith. “Effect of renal function on antihypertensive drug safety and efficacy in children..” Pediatr Nephrol 33, no. 1 (January 2018): 139–46. https://doi.org/10.1007/s00467-017-3763-8.

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Salerno, Sara N., Andrea Edginton, Michael Cohen-Wolkowiez, Christoph P. Hornik, Kevin M. Watt, Brian D. Jamieson, and Daniel Gonzalez. “Development of an Adult Physiologically Based Pharmacokinetic Model of Solithromycin in Plasma and Epithelial Lining Fluid..” Cpt Pharmacometrics Syst Pharmacol 6, no. 12 (December 2017): 814–22. https://doi.org/10.1002/psp4.12252.

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Hornik, Christoph P., Huali Wu, Andrea N. Edginton, Kevin Watt, Michael Cohen-Wolkowiez, and Daniel Gonzalez. “Development of a Pediatric Physiologically-Based Pharmacokinetic Model of Clindamycin Using Opportunistic Pharmacokinetic Data..” Clin Pharmacokinet 56, no. 11 (November 2017): 1343–53. https://doi.org/10.1007/s40262-017-0525-5.

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