Skip to main content

Kevin Michael Watt, MD, PhD

Associate Professor of Pediatrics
Member in the Duke Clinical Research Institute
Campus mail: 300 West Morgan Street, Dumc#3850, Durham, NC 27701
Phone: (919) 668-8556
Email address: kevin.watt@duke.edu

Dr. Watt’s career goal is to advance public health by integrating physiology and pharmacology into approaches for designing and conducting early-phase trials in critically ill children. His current efforts focus on the use of physiologically-based pharmacokinetic modeling and simulation to understand drug disposition in children on extracorporeal life support. His research is supported by the NICHD-sponsored Pediatric Critical Care Scientist Development Program and a NICHD-sponsored Career Development Award. In addition, he is a principal investigator in the NICHD-sponsored Pediatric Trials Network where he leads multiple trials investigating the pharmacokinetics, safety, and efficacy of drugs in children.

Education and Training

  • ClinicalResearch Fellowship, Duke Clinical Research Institute, Duke University School of Medicine, 2010 - 2012
  • Pediatric Critical Care Fellowship, Pediatrics, Duke University School of Medicine, 2009 - 2012
  • Pediatric Internship and Residency, Pediatrics, Duke University School of Medicine, 2006 - 2009
  • Ph.D., University of North Carolina at Chapel Hill, 2016
  • M.D., University of North Carolina at Chapel Hill, 2006

Publications

Ku, LC, Hornik, CP, Beechinor, RJ, Chamberlain, JM, Guptill, JT, Harper, B, Capparelli, EV, Martz, K, Anand, R, Cohen-Wolkowiez, M, Gonzalez, D, and Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee, . "Population Pharmacokinetics and Exploratory Exposure-Response Relationships of Diazepam in Children Treated for Status Epilepticus." Cpt: Pharmacometrics & Systems Pharmacology 7, no. 11 (November 2018): 718-727.

Full Text

Watt, KM, Cohen-Wolkowiez, M, Barrett, JS, Sevestre, M, Zhao, P, Brouwer, KLR, and Edginton, AN. "Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO." Cpt: Pharmacometrics & Systems Pharmacology 7, no. 10 (October 2018): 629-637.

Full Text

Sherwin, J, Thompson, E, Hill, KD, Watt, K, Lodge, AJ, Gonzalez, D, and Hornik, CP. "Clinical pharmacology considerations for children supported with ventricular assist devices." Cardiology in the Young 28, no. 9 (September 2018): 1082-1090. (Review)

Full Text

Watt, KM, Avant, D, Sherwin, J, Benjamin, DK, Hornik, C, Benjamin, DK, Li, JS, and Smith, PB. "Effect of renal function on antihypertensive drug safety and efficacy in children." Pediatric nephrology (Berlin, Germany) 33, no. 1 (January 2018): 139-146.

Full Text

Salerno, SN, Edginton, A, Cohen-Wolkowiez, M, Hornik, CP, Watt, KM, Jamieson, BD, and Gonzalez, D. "Development of an Adult Physiologically Based Pharmacokinetic Model of Solithromycin in Plasma and Epithelial Lining Fluid." Cpt: Pharmacometrics & Systems Pharmacology 6, no. 12 (December 2017): 814-822.

Full Text

Hornik, CP, Wu, H, Edginton, AN, Watt, K, Cohen-Wolkowiez, M, and Gonzalez, D. "Development of a Pediatric Physiologically-Based Pharmacokinetic Model of Clindamycin Using Opportunistic Pharmacokinetic Data." Clinical Pharmacokinetics 56, no. 11 (November 2017): 1343-1353.

Full Text

Watt, KM, Cohen-Wolkowiez, M, Williams, DC, Bonadonna, DK, Cheifetz, IM, Thakker, D, Benjamin, DK, and Brouwer, KLR. "Antifungal Extraction by the Extracorporeal Membrane Oxygenation Circuit." The journal of extra-corporeal technology 49, no. 3 (September 2017): 150-159.

Scholars@Duke

Gonzalez, D, Bradley, JS, Blumer, J, Yogev, R, Watt, KM, James, LP, Palazzi, DL, Bhatt-Mehta, V, Sullivan, JE, Zhang, L, Murphy, J, Ussery, XT, Puttagunta, S, Dunne, MW, and Cohen-Wolkowiez, M. "Dalbavancin Pharmacokinetics and Safety in Children 3 Months to 11 Years of Age." The Pediatric Infectious Disease Journal 36, no. 7 (July 2017): 645-653.

Full Text

Smith, MJ, Gonzalez, D, Goldman, JL, Yogev, R, Sullivan, JE, Reed, MD, Anand, R, Martz, K, Berezny, K, Benjamin, DK, Smith, PB, Cohen-Wolkowiez, M, Watt, K, and Best Pharmaceuticals for Children Act—Pediatric Trials Network Steering Committee, . "Pharmacokinetics of Clindamycin in Obese and Nonobese Children." Antimicrobial Agents and Chemotherapy 61, no. 4 (April 2017).

Full Text

Autmizguine, J, Hornik, CP, Jr, BDK, Brouwer, KLR, Hupp, SR, Cohen-Wolkowiez, M, and Watt, KM. "Pharmacokinetics and Safety of Micafungin in Infants Supported With Extracorporeal Membrane Oxygenation." PEDIATRIC INFECTIOUS DISEASE JOURNAL 35, no. 11 (November 2016): 1204-1210.

Full Text

Pages