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Joseph Linton Roberts, MD, PhD

Professor of Pediatrics
Campus mail: Box 2898 Med Ctr, Durham, NC 27710
Phone: (919) 684-6534
Email address: rober060@mc.duke.edu

My overall research interests are studying T cell development and defining the molecular bases of inherited immunodeficiency diseases. We are using standard candidate gene analysis approaches as well as new high throughput genome-wide sequencing, bioinformatics and functional screening in zebrafish and murine models in our work. Using these strategies we have recently reported a new molecular etiology of severe combined immunodeficiency (SCID), CD3 zeta chain deficiency. In collaboration with Dr. Wesley Burks we are also examining changes in T cell transcription patterns following treatment for peanut allergy using genome wide oligonucleotide microarrays.

Education and Training

  • Research Associate, Immunology, Duke University, 1994 - 1996
  • Fellow, Experimental Immunology Branch, Cancer Institute, National Institutes of Health, 1988 - 1994
  • Fellow, Pediatric Allergy/Immunology, Pediatrics, Duke University, 1984 - 1988
  • Internship/Residency, Pediatrics, Yale University, 1981 - 1984
  • Ph.D., Duke University, 1992
  • M.D., Emory University, 1981

Publications

Petrovski, S, Parrott, RE, Roberts, JL, Huang, H, Yang, J, Gorentla, B, Mousallem, T, Wang, E, Armstrong, M, McHale, D, MacIver, NJ, Goldstein, DB, Zhong, X-P, and Buckley, RH. "Dominant Splice Site Mutations in PIK3R1 Cause Hyper IgM Syndrome, Lymphadenopathy and Short Stature." Journal of clinical immunology 36, no. 5 (July 2016): 462-471.

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Mousallem, T, Urban, TJ, McSweeney, KM, Kleinstein, SE, Zhu, M, Adeli, M, Parrott, RE, Roberts, JL, Krueger, B, Buckley, RH, and Goldstein, DB. "Clinical application of whole-genome sequencing in patients with primary immunodeficiency." The Journal of allergy and clinical immunology 136, no. 2 (August 2015): 476-9.e6. (Letter)

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Mousallem, T, Yang, J, Urban, TJ, Wang, H, Adeli, M, Parrott, RE, Roberts, JL, Goldstein, DB, Buckley, RH, and Zhong, X-P. "A nonsense mutation in IKBKB causes combined immunodeficiency." Blood 124, no. 13 (September 2014): 2046-2050.

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Roberts, JL, Buckley, RH, Luo, B, Pei, J, Lapidus, A, Peri, S, Wei, Q, Shin, J, Parrott, RE, Dunbrack, RL, Testa, JR, Zhong, X-P, and Wiest, DL. "CD45-deficient severe combined immunodeficiency caused by uniparental disomy." Proc Natl Acad Sci U S A 109, no. 26 (June 26, 2012): 10456-10461.

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Tracy, ET, Haas, KM, Gentry, T, Danko, M, Roberts, JL, Kurtzberg, J, and Rice, HE. "Partial splenectomy but not total splenectomy preserves immunoglobulin M memory B cells in mice." J Pediatr Surg 46, no. 9 (September 2011): 1706-1710.

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Yu, GP, Nadeau, KC, Berk, DR, Basile, GDS, Lambert, N, Knapnougel, P, Roberts, J, Kavanau, K, Dunn, E, Stiehm, ER, Lewis, DB, Umetsu, DT, Puck, JM, and Cowan, MJ. "Genotype, phenotype, and outcomes of nine patients with T-B+NK+ SCID." Pediatric Transplantation 15, no. 7 (2011): 733-741.

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Sarzotti-Kelsoe, M, Win, CM, Parrott, RE, Cooney, M, Moser, BK, Roberts, JL, Sempowski, GD, and Buckley, RH. "Thymic output, T-cell diversity, and T-cell function in long-term human SCID chimeras." Blood 114, no. 7 (August 13, 2009): 1445-1453.

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Jones, SM, Pons, L, Roberts, JL, Scurlock, AM, Perry, TT, Kulis, M, Shreffler, WG, Steele, P, Henry, KA, Adair, M, Francis, JM, Durham, S, Vickery, BP, Zhong, X, and Burks, AW. "Clinical efficacy and immune regulation with peanut oral immunotherapy." J Allergy Clin Immunol 124, no. 2 (August 2009): 292-300.97.

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Blanco, BD, Roberts, JL, Zamarreño, N, Balmelle-Devaux, N, and Hernández-Munain, C. "Flexible stereospecific interactions and composition within nucleoprotein complexes assembled on the TCRα gene enhancer." Journal of Immunology 183, no. 3 (2009): 1871-1883.

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Palmer, K, Green, TD, Roberts, JL, Sajaroff, E, Cooney, M, Parrott, R, Chen, D-F, Reinsmoen, NL, and Buckley, RH. "Unusual clinical and immunologic manifestations of transplacentally acquired maternal T cells in severe combined immunodeficiency." J Allergy Clin Immunol 120, no. 2 (August 2007): 423-428.

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