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Darrell Vincent Lewis, MD

Professor of Pediatrics
Campus mail: 125 Bell Bldg, Durham, NC 27710
Phone: (919) 668-0477
Email address: lewis013@mc.duke.edu

Current Research Efforts:
Explore the relationship between prolonged febrile convulsions, temporal lobe epilepsy and hippocampal sclerosis; The hypothesis that prolonged febrile convulsions cause hippocampal injury that evolves to sclerosis and then to temporal lobe epilepsy has been promulgated for decades since the advent of surgical treatment of temporal lobe epilepsy. However, this concept has never been addressed with a prospective clinical study. With the availability of magnetic resonance imaging techniques capable of discerning hippocampal edema and measuring hippocampal volume, patients suffering from these seizures can now be studied acutely and chronically to determine if hippocampal injury does occur during them and under what clinical circumstances. We are conducting a longterm study of this phenomenon in cooperation with 5 other medical centers which will prospectively enroll 200 infants presenting with febrile status epilepticus and follow these infants for 10 - 15 years with sequential neuroimaging, electroencephalographic and developmental testing to determine the long term consequences of these infantile seizures.

Education and Training

  • M.D., University of Minnesota, Twin Cities, 1969

Publications

Gallentine, William B., Shlomo Shinnar, Dale C. Hesdorffer, Leon Epstein, Douglas R. Nordli, Darrell V. Lewis, L Matthew Frank, et al. “Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury..” Epilepsia 58, no. 6 (June 2017): 1102–11. https://doi.org/10.1111/epi.13750.

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McClelland, A. C., W. A. Gomes, S. Shinnar, D. C. Hesdorffer, E. Bagiella, D. V. Lewis, J. A. Bello, et al. “Quantitative Evaluation of Medial Temporal Lobe Morphology in Children with Febrile Status Epilepticus: Results of the FEBSTAT Study..” Ajnr Am J Neuroradiol 37, no. 12 (December 2016): 2356–62. https://doi.org/10.3174/ajnr.A4919.

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Hesdorffer, Dale C., Shlomo Shinnar, Daniel N. Lax, John M. Pellock, Douglas R. Nordli, Syndi Seinfeld, William Gallentine, et al. “Risk factors for subsequent febrile seizures in the FEBSTAT study..” Epilepsia 57, no. 7 (July 2016): 1042–47. https://doi.org/10.1111/epi.13418.

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Chan, Stephen, Jacqueline A. Bello, Shlomo Shinnar, Dale C. Hesdorffer, Darrell V. Lewis, James MacFall, Ruth C. Shinnar, et al. “Hippocampal Malrotation Is Associated With Prolonged Febrile Seizures: Results of the FEBSTAT Study..” Ajr Am J Roentgenol 205, no. 5 (November 2015): 1068–74. https://doi.org/10.2214/AJR.14.13330.

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Puranam, Ram S., Xiao Ping He, Lijun Yao, Tri Le, Wonjo Jang, Catherine W. Rehder, Darrell V. Lewis, and James O. McNamara. “Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus..” J Neurosci 35, no. 23 (June 10, 2015): 8866–81. https://doi.org/10.1523/JNEUROSCI.3470-14.2015.

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Lewis, Darrell, Dale Hesdorffer, Solomon L. Moshé, Shlomo Shinnar, and Shlomo FEBSTAT Study Team. “Reply: To PMID 24318290..” Ann Neurol 76, no. 2 (August 2014): 316–17. https://doi.org/10.1002/ana.24206.

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Lewis, Darrell V., Shlomo Shinnar, Dale C. Hesdorffer, Emilia Bagiella, Jacqueline A. Bello, Stephen Chan, Yuan Xu, et al. “Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study..” Ann Neurol 75, no. 2 (February 2014): 178–85. https://doi.org/10.1002/ana.24081.

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Hesdorffer, Dale C., Shlomo Shinnar, Darrell V. Lewis, Douglas R. Nordli, John M. Pellock, Solomon L. Moshé, Ruth C. Shinnar, et al. “Risk factors for febrile status epilepticus: a case-control study..” J Pediatr 163, no. 4 (October 2013): 1147-51.e1. https://doi.org/10.1016/j.jpeds.2013.05.038.

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Frank, L Matthew, Shlomo Shinnar, Dale C. Hesdorffer, Ruth C. Shinnar, John M. Pellock, William Gallentine, Douglas R. Nordli, et al. “Cerebrospinal fluid findings in children with fever-associated status epilepticus: results of the consequences of prolonged febrile seizures (FEBSTAT) study..” J Pediatr 161, no. 6 (December 2012): 1169–71. https://doi.org/10.1016/j.jpeds.2012.08.008.

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Nordli, Douglas R., Solomon L. Moshé, Shlomo Shinnar, Dale C. Hesdorffer, Yoshimi Sogawa, John M. Pellock, Darrell V. Lewis, et al. “Acute EEG findings in children with febrile status epilepticus: results of the FEBSTAT study..” Neurology 79, no. 22 (November 27, 2012): 2180–86. https://doi.org/10.1212/WNL.0b013e3182759766.

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