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Coleen Kathryn Cunningham, MD

Professor of Pediatrics
Chief, Division of Global Health, Pediatrics
Vice Chair of Research in the Department of Pediatrics
Research Professor of Global Health
Professor of Pathology
Campus mail: Box 3352 Med Ctr, Durham, NC 27710
Phone: (919) 684-6335
Email address: coleen.cunningham@duke.edu

Dr. Cunningham is a pediatric infectious diseases physician who has focused her research on the prevention and treatment of HIV infection in children.  She has also played important roles in evaluation of vaccines for other infectious diseases and recently has worked on Ebola virus treatment studies.  She is currently working on studies of active and passive immunization to prevent HIV transmission in neonates born to HIV infected women.

Education and Training

  • Fellow, Pediatric Infectious Diseases, Pediatrics, SUNY Upstate Medical University, 1988 - 1991
  • Residency, Pediatrics, SUNY Upstate Medical University, 1985 - 1988
  • M.D., SUNY Upstate Medical University, 1985

Selected Grants and Awards

Publications

Church, Joseph A., Michael Hughes, Jie Chen, Paul Palumbo, Lynne M. Mofenson, Patricia Delora, Elizabeth Smith, et al. “Long term tolerability and safety of enfuvirtide for human immunodeficiency virus 1-infected children.” Pediatr Infect Dis J 23, no. 8 (August 2004): 713–18. https://doi.org/10.1097/01.inf.0000133045.45316.6a.

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Cunningham, Coleen K., Rajalakshmi Balasubramanian, Isaac Delke, Robert Maupin, Lynne Mofenson, Alex Dorenbaum, John L. Sullivan, et al. “The impact of race/ethnicity on mother-to-child HIV transmission in the United States in Pediatric AIDS Clinical Trials Group Protocol 316.” J Acquir Immune Defic Syndr 36, no. 3 (July 1, 2004): 800–807. https://doi.org/10.1097/00126334-200407010-00006.

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Watts, D Heather, Rajalakshmi Balasubramanian, Robert T. Maupin, Isaac Delke, Alejandro Dorenbaum, Simone Fiore, Marie-Louise Newell, et al. “Maternal toxicity and pregnancy complications in human immunodeficiency virus-infected women receiving antiretroviral therapy: PACTG 316.” Am J Obstet Gynecol 190, no. 2 (February 2004): 506–16. https://doi.org/10.1016/j.ajog.2003.07.018.

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McKinney, Ross E., and Coleen K. Cunningham. “Newer treatments for HIV in children.” Curr Opin Pediatr 16, no. 1 (February 2004): 76–79. https://doi.org/10.1097/00008480-200402000-00014.

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Soy, Dolors, Francesca T. Aweeka, Joseph A. Church, Coleen K. Cunningham, Paul Palumbo, Bradley W. Kosel, Lewis B. Sheiner, and Lewis B. Pediatric AIDS Clinical Trial Group (PACTG) Study P1005 Investigators. “Population pharmacokinetics of enfuvirtide in pediatric patients with human immunodeficiency virus: searching for exposure-response relationships.” Clin Pharmacol Ther 74, no. 6 (December 2003): 569–80. https://doi.org/10.1016/j.clpt.2003.09.002.

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Mirochnick, Mark, Alejandro Dorenbaum, Suzette Blanchard, Coleen K. Cunningham, Richard D. Gelber, Lynne Mofenson, Mary Culnane, and John L. Sullivan. “Predose infant nevirapine concentration with the two-dose intrapartum neonatal nevirapine regimen: association with timing of maternal intrapartum nevirapine dose.” J Acquir Immune Defic Syndr 33, no. 2 (June 1, 2003): 153–56. https://doi.org/10.1097/00126334-200306010-00006.

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Capparelli, Edmund V., Mark Mirochnick, Wayne M. Dankner, Suzette Blanchard, Lynne Mofenson, George D. McSherry, Hannah Gay, et al. “Pharmacokinetics and tolerance of zidovudine in preterm infants.” J Pediatr 142, no. 1 (January 2003): 47–52. https://doi.org/10.1067/mpd.2003.mpd0335.

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Mirochnick, Mark, Alex Dorenbaum, Diane Holland, Bethann Cunningham-Schrader, Colleen Cunningham, Richard Gelber, Lynne Mofenson, Mary Culnane, James Connor, and John L. Sullivan. “Concentrations of protease inhibitors in cord blood after in utero exposure.” Pediatr Infect Dis J 21, no. 9 (September 2002): 835–38. https://doi.org/10.1097/00006454-200209000-00010.

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Cunningham, Coleen K., Marie-Laure Chaix, Claire Rekacewicz, Paula Britto, Christine Rouzioux, Richard D. Gelber, Alejandro Dorenbaum, et al. “Development of resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus type 1 transmission: a substudy of pediatric AIDS clinical trials group protocol 316.” J Infect Dis 186, no. 2 (July 15, 2002): 181–88. https://doi.org/10.1086/341300.

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Dorenbaum, Alejandro, Coleen K. Cunningham, Richard D. Gelber, Mary Culnane, Lynne Mofenson, Paula Britto, Claire Rekacewicz, et al. “Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trial.” Jama 288, no. 2 (July 10, 2002): 189–98. https://doi.org/10.1001/jama.288.2.189.

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