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Chay Titus Kuo, PhD, MD

Associate Professor of Cell Biology
Associate Professor in Neurobiology
Faculty Network Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Affiliate of the Regeneration Next Initiative
Campus mail: 308 Nanaline Duke Bldg Box 3709, Department of Cell Biology, Durham, NC 27710
Phone: (919) 684-4612

We are interested in the regulation of postnatal/adult neural stem cells and how they modify brain homeostasis in health and disease. Throughout embryonic and postnatal development, neural stem cells give rise to differentiated neurons, astrocytes, and oligodendrocytes which modulate function of the adult nervous system. While during embryogenesis these progenitor cells are relatively abundant and help to construct the overall CNS architecture, during postnatal and adult periods they become restricted to specialized regions in the brain and produce progeny that participate in the modification of neural circuits and brain homeostasis. The work in my laboratory centers around understanding cellular pathways regulating postnatal/adult neural stem cells, using the rodent brain as a model system. Our current focus deals with how specialized environments in the brain (also called “niches”) sustain production of new neurons in vivo; how these microenvironments are changed in response to circuit-level inputs; and how injury modifies neural stem cell proliferation/differentiation. A better understanding of these processes may lead to future therapies for patients suffering from pre/postnatal brain injuries.

Education and Training

  • M.D., University of Chicago, 2002
  • Ph.D., University of Chicago, 1997

Publications

Abdi, Khadar, Gabriel Neves, Joon Pyun, Emre Kiziltug, Angelica Ahrens, and Chay T. Kuo. “EGFR Signaling Termination via Numb Trafficking in Ependymal Progenitors Controls Postnatal Neurogenic Niche Differentiation..” Cell Rep 28, no. 8 (August 20, 2019): 2012-2022.e4. https://doi.org/10.1016/j.celrep.2019.07.056.

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Dumm, Rebekah E., Jessica K. Fiege, Barbara M. Waring, Chay T. Kuo, Ryan A. Langlois, and Nicholas S. Heaton. “Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function..” Nat Commun 10, no. 1 (February 15, 2019). https://doi.org/10.1038/s41467-019-08617-z.

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Káradóttir, Ragnhildur T., and Chay T. Kuo. “Neuronal Activity-Dependent Control of Postnatal Neurogenesis and Gliogenesis..” Annu Rev Neurosci 41 (July 8, 2018): 139–61. https://doi.org/10.1146/annurev-neuro-072116-031054.

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Abdi, Khadar, and Chay T. Kuo. “Laminating the mammalian cortex during development: cell polarity protein function and Hippo signaling..” Genes Dev 32, no. 11–12 (June 1, 2018): 740–41. https://doi.org/10.1101/gad.316711.118.

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Abdi, Khadar, Chun-Hsiang Lai, Patricia Paez-Gonzalez, Mark Lay, Joon Pyun, and Chay T. Kuo. “Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus..” Nat Commun 9, no. 1 (April 25, 2018). https://doi.org/10.1038/s41467-018-03812-w.

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Chaboub, Lesley S., Jeanne M. Manalo, Hyun Kyoung Lee, Stacey M. Glasgow, Fengju Chen, Yoshihiro Kawasaki, Tetsu Akiyama, et al. “Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury..” J Neurosci 36, no. 47 (November 23, 2016): 11904–17. https://doi.org/10.1523/JNEUROSCI.1658-16.2016.

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Dieni, Cristina V., Roberto Panichi, James B. Aimone, Chay T. Kuo, Jacques I. Wadiche, and Linda Overstreet-Wadiche. “Low excitatory innervation balances high intrinsic excitability of immature dentate neurons..” Nat Commun 7 (April 20, 2016). https://doi.org/10.1038/ncomms11313.

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Asrican, Brent, Patricia Paez-Gonzalez, Joshua Erb, and Chay T. Kuo. “Cholinergic Circuit Control of Postnatal Neurogenesis..” Neurogenesis (Austin) 3, no. 1 (2016). https://doi.org/10.1080/23262133.2015.1127310.

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Adlaf, Elena W., Aaron Mitchell-Dick, and Chay T. Kuo. “Discerning Neurogenic vs. Non-Neurogenic Postnatal Lateral Ventricular Astrocytes via Activity-Dependent Input..” Front Neurosci 10 (2016). https://doi.org/10.3389/fnins.2016.00111.

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Paez-Gonzalez, Patricia, Brent Asrican, Erica Rodriguez, and Chay T. Kuo. “Identification of distinct ChAT⁺ neurons and activity-dependent control of postnatal SVZ neurogenesis..” Nat Neurosci 17, no. 7 (July 2014): 934–42. https://doi.org/10.1038/nn.3734.

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