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Bernard Mathey-Prevot, PhD

Research Professor of Pharmacology & Cancer Biology
Professor in Pediatrics
Affiliate of the Regeneration Next Initiative
Campus mail: Duke Box 3813, Durham, NC 27710
Phone: (919) 684-8043
Email address: bernard.mathey-prevot@duke.edu

The central focus of the lab is to understand how signaling pathway architecture and integration result in specific cell fates and how these properties have been hijacked in cancer cells. In particular, we are interested in assessing the extent to which cell-to-cell heterogeneity can affect the temporal dynamics and regulation of signaling pathways. We are focusing on the E2F/Rb network and have established a platform to follow in real time the activation and expression of E2F1 at the single cell level. In collaboration with the You lab (Duke Biomedical Engineering), which has developed mathematical approaches to model the behavior of the Rb/E2F network, we wish to identify functional characteristics in the signaling dynamics that may underlie disparate cell fates in response to a given external cue. Ultimately, our goal is to build an integrative understanding of the logic and structure in aberrant signaling network(s) known to drive tumor development and metastasis. 

Education and Training

  • Research Fellow in Biology, Biology, Massachusetts Institute of Technology, 1983 - 1987
  • Ph.D., Rockefeller University, 1983

Publications

Chen, Po-Han, Jianli Wu, Chien-Kuang Cornelia Ding, Chao-Chieh Lin, Samuel Pan, Nathan Bossa, Yitong Xu, Wen-Hsuan Yang, Bernard Mathey-Prevot, and Jen-Tsan Chi. “Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism.” Cell Death Differ 27, no. 3 (March 2020): 1008–22. https://doi.org/10.1038/s41418-019-0393-7.

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Mathey-Prevot, Bernard, Bao-Tran Parker, Carolyn Im, Cierra Hong, Peng Dong, Guang Yao, and Lingchong You. “Quantifying E2F1 protein dynamics in single cells.” Quant Biol 8, no. 1 (March 2020): 20–30. https://doi.org/10.1007/s40484-019-0193-6.

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Dong, Peng, Manoj V. Maddali, Jaydeep K. Srimani, François Thélot, Joseph R. Nevins, Bernard Mathey-Prevot, and Lingchong You. “Author Correction: Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control.” Nat Commun 9, no. 1 (November 13, 2018): 4766. https://doi.org/10.1038/s41467-018-07169-y.

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Lin, Chao-Chieh, Mayumi Kitagawa, Xiaohu Tang, Ming-Hsin Hou, Jianli Wu, Dan Chen Qu, Vinayaka Srinivas, et al. “CoA synthase regulates mitotic fidelity via CBP-mediated acetylation.” In Nat Commun, 9:1039, 2018. https://doi.org/10.1038/s41467-018-03422-6.

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Dong, Peng, Carolyn Zhang, Bao-Tran Parker, Lingchong You, and Bernard Mathey-Prevot. “Cyclin D/CDK4/6 activity controls G1 length in mammalian cells.” Plos One 13, no. 1 (2018): e0185637. https://doi.org/10.1371/journal.pone.0185637.

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Dong, Peng, Manoj V. Maddali, Jaydeep K. Srimani, François Thélot, Joseph R. Nevins, Bernard Mathey-Prevot, and Lingchong You. “Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control.” Nat Commun 5 (September 1, 2014): 4750. https://doi.org/10.1038/ncomms5750.

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Lin, Shu-Hong, Lauren Beane, Dawn Chasse, Kevin W. Zhu, Bernard Mathey-Prevot, and Jeffrey T. Chang. “Cross-platform prediction of gene expression signatures.” Plos One 8, no. 11 (2013): e79228. https://doi.org/10.1371/journal.pone.0079228.

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Flockhart, Ian T., Matthew Booker, Yanhui Hu, Benjamin McElvany, Quentin Gilly, Bernard Mathey-Prevot, Norbert Perrimon, and Stephanie E. Mohr. “FlyRNAi.org--the database of the Drosophila RNAi screening center: 2012 update.” Nucleic Acids Res 40, no. Database issue (January 2012): D715–19. https://doi.org/10.1093/nar/gkr953.

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Wong, Jeffrey V., Peng Dong, Joseph R. Nevins, Bernard Mathey-Prevot, and Lingchong You. “Network calisthenics: control of E2F dynamics in cell cycle entry.” Cell Cycle 10, no. 18 (September 15, 2011): 3086–94. https://doi.org/10.4161/cc.10.18.17350.

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Gatza, Michael L., Joseph E. Lucas, William T. Barry, Jong Wook Kim, Quanli Wang, Matthew D. Crawford, Michael B. Datto, et al. “A pathway-based classification of human breast cancer.” Proc Natl Acad Sci U S A 107, no. 15 (April 13, 2010): 6994–99. https://doi.org/10.1073/pnas.0912708107.

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