Vinod K. Prasad, MD

Assistant Professor of Pediatrics

Department:
Pediatrics

Division:
Blood and Marrow Transplantation

Mailing Address:
DUMC 3350 Durham, NC 27710

Appointment Telephone:
919-668-1100

Office Telephone:
919-668-0442

Fax:
919-668-1180

Training:
MD (Pediatrics), University of Delhi (India), 1986

Fellowship:
Memorial Sloan-Kettering Cancer Center and Cornell University Medical Center (New York), 1994-1997

Residency:
Member, Royal College of Physicians (United Kingdom), 1990

Clinical Interests:
Cord-blood, stem-cell, and bone-marrow transplant for childhood cancers; inherited metabolic disorders; immunodeficiency; hemoglobinopathies and other serious diseases; histocompatibility (tissue typing) and other determinants of alloreactivity, with a focus on identifying the best-matched donors by using cutting-edge molecular techniques; post-transplant viral infections, with a focus on early detection and treatment

Research Interests:
1. Expanding the role of umbilical cord blood transplants for inherited metabolic disorders.
2. Impact of histocompatibility and other determinants of alloreactivity on clinical outcomes of unrelated cord blood transplants.
3. Studies to analyse the impact of Killer Immunoglobulin receptors on the outcomes of hematopoietic stem cell transplantation utilizing haploidentical, CD34 selected, familial grafts.
4. Propective longitudinal study of serial monitoring of adenovirus in allogenic transpants(SMAART)patients.
5. Use of mesenchymal stem cells for the treatment of GVHD

Publications:
Prasad VK, Mendizabal A, Gill P et al. Unrelated Umbilical Cord Blood Transplantation from a Single 4/6 Matched Unit is an Effective Therapy for Children with Malignant and Non-Malignant Diagnoses: Good Survival, Low Graft Failure and Graft-vs-Host Disease in a Single Center Analysis of 314 Patients. Biology of Blood and Marrow Transplantation, Feb. 2009 (Vol. 15, Issue 2, Page 27). Oral presentation at ASBMT Annual Meeting Tampa FL, 2009.

Parikh SH, Mendizabal A, Martin PL, Prasad VK, Szabolcs P, Driscoll TA, Kurtzberg J. Unrelated donor umbilical cord blood transplantation in pediatric myelodysplastic syndrome: a single-center experience. Biol Blood Marrow Transplant. 2009 Aug;15(8):948-55.

Hwang E, Camitta MGW, Vinesett R, Mendizabal A, Wood S, Semmel D, Page K, Driscoll TA, Parikh SH, Szabolcs P, Martin PL, Kurtzberg J, and Prasad, VK. Pericardial Effusion Following Unrelated Umbilical Cord Blood Transplantation: Analysis in a Cohort Of 423 Pediatric Patients Transplanted at a Single Center. Biology of Blood and Marrow Transplantation, Feb. 2009 (Vol. 15, Issue 2, Pages 73-74). Poster presentation at ASBMT Annual Meeting Tampa FL, 2009

Boelens JJ, Rocha V, Aldenhoven M, Wynn R, O'Meara A, Michel G, Ionescu I, Parikh S, Prasad VK, Szabolcs P, Escolar M, Gluckman E, Cavazzana-Calvo M, Kurtzberg J, . Risk factor analysis of outcomes after unrelated cord blood transplantation in patients with hurler syndrome. Biol Blood Marrow Transplant. 2009 May;15(5):618-25.

Prasad VK, Mendizabal A, Parikh SH, Szabolcs P, Driscoll TA, Page K, Lakshminarayanan S, Allison J, Wood S, Semmel D, Escolar ML, Martin PL, Carter S, Kurtzberg J. Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single center: influence of cellular composition of the graft on transplant outcomes. Blood. 2008 Jun 27.

Prasad VK, Kurtzberg J. Emerging trends in transplantation of inherited metabolic diseases. Bone Marrow Transplant. 2008 Jan;41(2):99-108.

Prasad VK, Chen D-F, Broadwater G, Reinsmoen NL, Clark A, Chao NJ, and Rizzieri DA: Impact of Inhibitory and Activating KIR and HLA Ligands in Non-Myeloablative Haplo Hematopoietic Transplants in Patients with High-Risk Lymphoid Malignancy. 15th International Histocompatibility and Immunogenetics Workshop and Conference, 2008.

Page KM, Mendizabal AM, Prasad VK, Martin PL, Parikh S, Wood S, Sempowski GD, Szabolcs P, Kurtzberg J. Posttransplant autoimmune hemolytic anemia and other autoimmune cytopenias are increased in very young infants undergoing unrelated donor umbilical cord blood transplantation. Biol Blood Marrow Transplant. 2008 Oct;14(10):1108-17.

Kurtzberg J, Prasad VK, Carter SL, Wagner JE, Baxter-Lowe LA, Wall D, Kapoor N, Guinan EC, Feig SA, Wagner EL, Kernan NA, . Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood. 2008 Nov 15;112(10):4318-27.

Hollingsworth CL, Frush DP, Kurtzburg J, Prasad VK. Pediatric hematopoietic stem cell transplantation and the role of imaging. Radiology. 2008 Aug;248(2):348-65.

Prasad VK, Lucas KG, Kleiner GI, Talano JM, Jacobsohn D, Szabolcs P, Monroy R, and Kurtzberg J. Use of Mesenchymal Stem Cells to Treat Pediatric Patients with Severe (Grade III-IV) acute Graft versus Host Disease refractory to steroid and other agents on a Compassionate Use Basis. American Society of Hematology Annual meeting, 2007

Parikh SH, Szabolcs P, Prasad VK, Lakshminarayanan S, Martin PL, Driscoll TA, Kurtzberg J. Correction of chronic granulomatous disease after second unrelated-donor umbilical cord blood transplantation. Pediatr Blood Cancer. 2007 Dec;49(7):982-4.

Beam D, Poe MD, Provenzale JM, Szabolcs P, Martin PL, Prasad V, Parikh S, Driscoll T, Mukundan S, Kurtzberg J, Escolar ML. Outcomes of unrelated umbilical cord blood transplantation for X-linked adrenoleukodystrophy. Biol Blood Marrow Transplant. 2007 Jun;13(6):665-74.

Ten Allele High-Resolution DNA Typing has a Direct Impact on the Disease Free Survival (DFS) In Pediatric Recipients of T-cell depleted (TCD) Unrelated Donor (URD) Hematopoietic Stem Cell Transplant (HCT). VK Prasad, A. Selvakumar, H Dastigir, F. Boulad, S Prockop,  T.N. Small,  R.J. O'Reilly B. Dupont, NA Kernan. Presented at American Society of Bone Marrow Transplantation annual meeting at Orlando, 2004; Biology of Blood & Marrow Transplantation, 2004 Vol 10(2) supp1:abstr #146.


High-Resolution DNA Typing for HLA-A, -B, and -DRB1 Has Direct Impact on the Survival in the Recipients of Unrelated Donor (URD) Hematopoietic Stem Cell Transplant (HSCT). Vinod K. Prasad, N.A. Kernan, G. Heller, F. Boulad, H. Castro-Malaspina, A. Jakubowski, E. Papadopoulos, M. Perales, T.N. Small, M. VanDen Brink, J. Young, A. Selvakumar, B. Dupont, R.J. O'Reilly.   Poster Presentation Annual Meeting of American Society of Hematology, Philadelphia, December 2002. Blood Vol 100(11):641a

Seo SK, Regan A, Cihlar T, Lin DC, Boulad F, George D, Prasad VK, Kiehn TE, Polsky B. Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance. Clin Infect Dis. 2001 Nov 1;33(9):e105-8.

Boulad F, Gillio A, Small TN, George D, Prasad V, Torok-Castanza J, Regan AD, Collins N, Auerbach AD, Kernan NA, O'Reilly RJ. Stem cell transplantation for the treatment of Fanconi anaemia using a fludarabine-based cytoreductive regimen and T-cell-depleted related HLA-mismatched peripheral blood stem cell grafts. Br J Haematol. 2000 Dec;111(4):1153-7.

Antunes NL, Boulad F, Prasad V, Rosenblum M, Lis E, Souweidane M. Rolandic encephalopathy and epilepsia partialis continua following bone marrow transplant. Bone Marrow Transplant. 2000 Oct;26(8):917-9.

Prasad VK, Kernan NA, Heller G, O'Reilly RJ, Yang SY. HLA-C disparity between patients and unrelated donors matched for HLA-A, -B, and -DRB1 alleles: impact of serological vs. DNA typing for HLA-A and -B loci. Biol Blood Marrow Transplant. 1999;5(2):77-85.

Prasad VK, Kernan NA, Heller G, O'Reilly RJ, Yang SY. DNA typing for HLA-A and HLA-B identifies disparities between patients and unrelated donors matched by HLA-A and HLA-B serology and HLA-DRB1. Blood. 1999 Jan 1;93(1):399-409.

Prasad VK, Heller G, Kernan NA, O'Reilly RJ, Yang SY. The probability of HLA-C matching between patient and unrelated donor at the molecular level: estimations based on the linkage disequilibrium between DNA typed HLA-B and HLA-C alleles. Transplantation. 1999 Oct 15;68(7):1044-50.

Prasad VK, Yang SY. Allele assignment for HLA-A, -B, and -C genes to the Tenth International Histocompatibility Workshop cell lines. Tissue Antigens. 1996 Jun;47(6):538-46.

Prasad VK, Lewis IJ, Aparicio SR, Heney D, Hale JP, Bailey CC, Kinsey SE. Progressive glomerular toxicity of ifosfamide in children. Med Pediatr Oncol. 1996 Sep;27(3):149-55.

Prasad VK, Kim IK, Farrington K, Bussel JB. TTP following ITP in an HIV-positive boy. J Pediatr Hematol Oncol. 1996 Nov;18(4):384-6.

Prasad VK, Aronson DC, Gerald WL, Meyers PA, La Quaglia MP. Hepatic focal nodular hyperplasia in infant antenatally exposed to steroids. Lancet. 1995 Aug 5;346(8971):371.

Prasad VK, Corlett SA, Abaasi K, Heney D, Lewis I, Chrystyn H. Ifosfamide enantiomers: pharmacokinetics in children. Cancer Chemother Pharmacol. 1994;34(5):447-9.

McClure RJ, Prasad VK, Brocklebank JT. Treatment of hyperkalaemia using intravenous and nebulised salbutamol. Arch Dis Child. 1994 Feb;70(2):126-8.

Kumar H, Aneja S, Prasad VK, Arora SK, Mullick DN. Tetanus neonatorum: clinico-epidemiological profile. Indian Pediatr. 1988 Nov;25(11):1054-7.