Ira Cheifetz, MD

Professor of Pediatrics

Division Chief, Pediatric Critical Care Medicine

Department:
Pediatrics

Division:
Critical Care Medicine

Mailing Address:
DUMC 3046 Durham, NC 27710

Office Telephone:
919-681-5872

Fax:
919-681-8357

Training:
MD, Yale University School of Medicine (Connecticut), 1989

Fellowship:
Pediatric Critical Care, Duke University Medical Center, 1993-1996

Residency:
Pediatrics, Duke University Medical Center, 1989-1993

Clinical Interests:
Pediatric critical care medicine, acute lung injury, high-frequency ventilation, cardiopulmonary interactions, cardiopulmonary resuscitation, ECMO, congenital heart disease, mechanical ventilation

Research Interests:
Respiratory mechanics monitoring / Airway graphics
Capnography:  time-based and volumetric
Cardiorespiratory interactions
Acute lung injury and acute respiratory distress syndrome
Conventional mechanical ventilation
High-frequency oscillatory and jet ventilation
Right ventricular injury and inotrope administration
Extracorporeal membrane oxygenation (ECMO)
Noninvasive ventilation
   

Publications:
Nishisaki A, Hales R, Biagas K, Cheifetz I, Corriveau C, Garber N, Hunt E, Jarrah R, McCloskey J, Morrison W, Nelson K, Niles D, Smith S, Thomas S, Tuttle S, Helfaer M, Nadkarni V. A multi-institutional high-fidelity simulation "boot camp" orientation and training program for first year pediatric critical care fellows. Pediatr Crit Care Med. 2009 Mar;10(2):157-62.

Wratney AT, Benjamin DK Jr, Slonim AD, He J, Hamel DS, Cheifetz IM. The endotracheal tube air leak test does not predict extubation outcome in critically ill pediatric patients. Pediatr Crit Care Med. 2008 Sep;9(5):490-6.

Hurford WE, Cheifetz IM. Should heliox be used for mechanically ventilated patients? Respir Care. 2007 May;52(5):582-94.

Cheifetz IM, Myers TR. Should Every Mechanically Ventilated Patient Be Monitored With Capnography From Intubation to Extubation? Respir Care. 2007 Apr;52(4):423-442.

Cheifetz IM, Macintyre NR. Respiratory Controversies in the Critical Care Setting. Respir Care. 2007 May;52(5):636-644.

Cheifetz IM, Macintyre NR. Respiratory Controversies in the Critical Care Setting. Respir Care. 2007 Apr;52(4):406-407.

Bass AL, Gentile MA, Heinz JP, Craig DM, Hamel DS, Cheifetz IM. Setting positive end-expiratory pressure during jet ventilation to replicate the mean airway pressure of oscillatory ventilation. Respir Care. 2007 Jan;52(1):50-5.

Wratney AT, Cheifetz IM. Extubation criteria in infants and children. Respir Care Clin N Am. 2006 Sep;12(3):469-81.

Hamel DS, Cheifetz IM. Do all Mechanically Ventilated Pediatric Patients Require Continuous Capnography? Respir Care Clin N Am. 2006 Sep;12(3):501-13.

Cheifetz IM, Hamel DS. Is permissive hypoxemia a beneficial strategy for pediatric acute lung injury? Respir Care Clin N Am. 2006 Sep;12(3):359-69.

Cheifetz IM, Gentile MA. Preface. Respir Care Clin N Am. 2006 Sep;12(3):xv-xvi.

Cheifetz I. Intraoral treatment of Eagle's syndrome. J Oral Maxillofac Surg. 2006 Apr;64(4):749.

Alexander PJ, Lawson DS, Cornell J, Craig DM, Cheifetz IM. Insensible Water Loss From the Medtronic Minimax Oxygenator: An In Vitro Study. ASAIO J. 2006 March/April;52(2):206-210.

Randolph AG, Forbes PW, Gedeit RG, Arnold JH, Wetzel RC, Luckett PM, O'neil ME, Venkataraman ST, Meert KL, Cheifetz IM, Cox PN, Hanson JH, . Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children* Pediatr Crit Care Med. 2005 Nov;6(6):642-647.

Oden J, Cheifetz IM. Neonatal thyrotoxicosis and persistent pulmonary hypertension necessitating extracorporeal life support. Pediatrics. 2005 Jan;115(1):e105-8.

Lawson DS, Ing R, Cheifetz IM, Walczak R, Craig D, Schulman S, Kern F, Shearer IR, Lodge A, Jaggers J. Hemolytic characteristics of three commercially available centrifugal blood pumps. Pediatr Crit Care Med. 2005 Sep;6(5):573-577.

Hamel DS, Katz AL, Craig DM, Davies JD, Cheifetz IM. Carbon dioxide elimination and gas displacement vary with piston position during high-frequency oscillatory ventilation. Respir Care. 2005 Mar;50(3):361-6.

Gupta VK, Cheifetz IM. Heliox administration in the pediatric intensive care unit: An evidence-based review. Pediatr Crit Care Med. 2005 Mar;6(2):204-11.

Wratney AT, Gentile MA, Hamel DS, Cheifetz IM. Successful treatment of acute chest syndrome with high-frequency oscillatory ventilation in pediatric patients. Respir Care. 2004 Mar;49(3):263-9.

Venkataraman S, Randolph A, Hanson J, Forbes P, Cheifetz I, Gedeit R, Luckett P. All roses are flowers, but not all flowers are roses. Am J Respir Crit Care Med. 2004 Apr 15;169(8):969.

Turi JL, Cheifetz IM. Does improved oxygenation really imply increased benefit? Crit Care Med. 2004 Apr;32(4):1089-91.

Hubble CL, Cheifetz IM, Craig DM, Quick G, Meliones JN, Clark RH. Inhaled nitric oxide results in deteriorating hemodynamics when administered during cardiopulmonary bypass in neonatal swine. Pediatr Crit Care Med. 2004 Mar;5(2):157-62.

Gupta VK, Grayck EN, Cheifetz IM. Heliox administration during high-frequency jet ventilation augments carbon dioxide clearance. Respir Care. 2004 Sep;49(9):1038-44.

Gentile MA, Cheifetz IM. Optimal positive end-expiratory pressure: The search for the Holy Grail continues. Crit Care Med. 2004 12;32(12):2553-2554.

Randolph AG, Meert KL, O'Neil ME, Hanson JH, Luckett PM, Arnold JH, Gedeit RG, Cox PN, Roberts JS, Venkataraman ST, Forbes PW, Cheifetz IM, . The feasibility of conducting clinical trials in infants and children with acute respiratory failure. Am J Respir Crit Care Med. 2003 May 15;167(10):1334-40.

Katz AL, Gentile MA, Craig DM, Quick G, Cheifetz IM. Heliox does not affect gas exchange during high-frequency oscillatory ventilation if tidal volume is held constant. Crit Care Med. 2003 Jul;31(7):2006-9.

Hagen SA, Craig DM, Martin PL, Plumer DD, Gentile MA, Schulman SR, Cheifetz IM. Mechanically ventilated pediatric stem cell transplant recipients: effect of cord blood transplant and organ dysfunction on outcome. Pediatr Crit Care Med. 2003 Apr;4(2):206-13.

Cheifetz IM. Invasive and noninvasive pediatric mechanical ventilation. Respir Care. 2003 Apr;48(4):442-58.

Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert KL, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial. JAMA. 2002 Nov 27;288(20):2561-8.

Hamel DS, Cheifetz IM.  Measuring Pediatric Tidal Volumes.  Respiratory Times   June/July, 2002.  pp. 40-42.

Erb TO, Craig DM, Gaskin PM, Cheifetz IM, Resai Bengur A, Sanders SP. Preload recruitable stroke work relationship in the right ventricle: simultaneous assessment using conductance catheter and sonomicrometry. Crit Care Med. 2002 Nov;30(11):2535-41.

Williams EA, Welty SE, Geske RS, Hubble CL, Craig DM, Quick G, Meliones JN, Cheifetz IM. Liquid lung ventilation reduces neutrophil sequestration in a neonatal swine model of cardiopulmonary bypass. Crit Care Med. 2001 Apr;29(4):789-95.

Moya MP, Gow AJ, McMahon TJ, Toone EJ, Cheifetz IM, Goldberg RN, Stamler JS. S-nitrosothiol repletion by an inhaled gas regulates pulmonary function. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5792-7.

Kern FH, Greeley WJ, Schulman SS, Cheifetz IM, Meliones JN.  Pediatric Intensive Care.  In:  Cardiac Anesthesia:  Principles and Clinical Practice.  Eds. Estafanous FG, Barash PG, Reves JG.  Second edition.  Lippincott Williams and Wilkins.  2001.  pp. 505-537.

Katz A, Gentile MA, Craig DM, Quick G, Meliones JN, Cheifetz IM. Heliox improves gas exchange during high-frequency ventilation in a pediatric model of acute lung injury. Am J Respir Crit Care Med. 2001 Jul 15;164(2):260-4.

McGovern JJ, Cheifetz IM, Craig DM, Bengur AR, Quick G, Ungerleider RM, Meliones JN. Right ventricular injury in young swine: effects of catecholamines on right ventricular function and pulmonary vascular mechanics. Pediatr Res. 2000 Dec;48(6):763-9.

Klonin H, Bowman B, Peters M, Raffeeq P, Durward A, Bohn DJ, Meliones JN, Cheifetz IM. Negative pressure ventilation via chest cuirass to decrease ventilator-associated complications in infants with acute respiratory failure: a case series. Respir Care. 2000 May;45(5):486-90.

Hubble CL, Gentile MA, Tripp DS, Craig DM, Meliones JN, Cheifetz IM. Deadspace to tidal volume ratio predicts successful extubation in infants and children. Crit Care Med. 2000 Jun;28(6):2034-40.

Gentile MA, Cheifetz IM.  Extracorporeal Techniques for Cardiopulmonary Support.   In:  Mechanical Ventilation.  Eds. MacIntyre NR, Branson R.  W.B. Saunders Company. 2000.  pp. 425-432.

Cheifetz IM. Inhaled nitric oxide: plenty of data, no consensus. Crit Care Med. 2000 Mar;28(3):902-3.

Cheifetz IM, Meliones JN. Hemodynamic effects of high-frequency oscillatory ventilation: a little volume goes a long way. Crit Care Med. 2000 Jan;28(1):282-4.

Cannon ML, Cornell J, Tripp-Hamel DS, Gentile MA, Hubble CL, Meliones JN, Cheifetz IM. Tidal volumes for ventilated infants should be determined with a pneumotachometer placed at the endotracheal tube. Am J Respir Crit Care Med. 2000 Dec;162(6):2109-12.

Arnold JH, Anas NG, Luckett P, Cheifetz IM, Reyes G, Newth CJ, Kocis KC, Heidemann SM, Hanson JH, Brogan TV, Bohn DJ. High-frequency oscillatory ventilation in pediatric respiratory failure: a multicenter experience. Crit Care Med. 2000 Dec;28(12):3913-9.

Gentile MA, Cheifetz IM, Davies JD.  High-frequency oscillatory ventilation in ARDS.  Respiratory Times   April/May, 1999. pp. 96-98.

Chai PJ, Williamson JA, Lodge AJ, Daggett CW, Scarborough JE, Meliones JN, Cheifetz IM, Jaggers JJ, Ungerleider RM. Effects of ischemia on pulmonary dysfunction after cardiopulmonary bypass. Ann Thorac Surg. 1999 Mar;67(3):731-5.

Cannon ML, Cheifetz IM, Craig DM, Hubble CL, Quick G, Ungerleider RM, Smith PK, Meliones JN. Optimizing liquid ventilation as a lung protection strategy for neonatal cardiopulmonary bypass: full functional residual capacity dosing is more effective than half functional residual capacity dosing. Crit Care Med. 1999 Jun;27(6):1140-6.

Meliones JN, Cheifetz IM. Treatments for pulmonary artery hypertension: show me the outcome! Crit Care Med. 1998 Aug;26(8):1308-10.

Cheifetz IM. Acute Respiratory Failure in Infants and Children. In: Neonatal and Pediatric Respiratory Care Edited by Wilson BW. Third Edition. Mosby-Year Book, Inc. 1998

Cheifetz IM, Craig DM, Quick G, McGovern JJ, Cannon ML, Ungerleider RM, Smith PK, Meliones JN. Increasing tidal volumes and pulmonary overdistention adversely affect pulmonary vascular mechanics and cardiac output in a pediatric swine model. Crit Care Med. 1998 Apr;26(4):710-6.

Cheifetz IM, Cannon ML, Craig DM, Quick G, Kern FH, Smith PK, Ungerleider RM, Meliones JN. Liquid ventilation improves pulmonary function and cardiac output in a neonatal swine model of cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1998 Mar;115(3):528-35.

Meliones JN, Cheifetz IM.  Pulmonary Physiology and Heart Lung Interactions.   In:  The Science and Practice of Pediatric Cardiology.  Eds. Garson AG, Bricker JT, Fisher DJ, Neish SR.  Second edition.  Williams and Wilkins.  1997.  pp. 297-312.

Hillman ND, Cheifetz IM, Craig DM, Smith PK, Ungerleider RM, Meliones JN. Inhaled nitric oxide, right ventricular efficiency, and pulmonary vascular mechanics: selective vasodilation of small pulmonary vessels during hypoxic pulmonary vasoconstriction. J Thorac Cardiovasc Surg. 1997 Jun;113(6):1006-13.

Cheifetz IM, Kern FH, Schulman SR, Greeley WJ, Ungerleider RM, Meliones JN. Serum lactates correlate with mortality after operations for complex congenital heart disease. Ann Thorac Surg. 1997 Sep;64(3):735-8.

Trant CA, Casey JR, Hansell D, Cheifetz IM, Meliones JN, Ungerleider RM, Browning I, Greeley WJ. Successful use of extracorporeal membrance oxygenation in the treatment of acute chest syndrome in a child with severe sickle cell anemia. ASAIO Journal. 1996;42(3):236-239.

Trant CA Jr, Casey JR, Hansell D, Cheifetz I, Meliones JN, Ungerleider RM, Browning I, Greeley WJ. Successful use of extracorporeal membrane oxygenation in the treatment of acute chest syndrome in a child with severe sickle cell anemia. ASAIO J. 1996 May-Jun;42(3):236-9.

Meliones JN, Wilson BG, Cheifetz IM, Hayden WR, Greenberg RS.  Respiratory Monitoring.   In:  Textbook of Pediatric Intensive Care.  Eds. Rogers MC, Nichols DG, Ackerman AD, Dean JM, Greeley WJ, Fackler JC, Wetzel RC.  Third edition.  Williams and Wilkins.  1996.  pp. 331-366.

Cheifetz IM, Meliones JN, Wilson BG, Gaynor JW, Schulman SR. Severe cardiorespiratory dysfunction following cold water submersion: The successful use of extracorporeal membrane oxygenation. Respiratory Care 1996;41(3):226-231.

Cheifetz IM, Craig DM, Kern FH, Black DR, Hillman ND, Greeley WJ, Ungerleider RM, Smith PK, Meliones JN. Nitric oxide improves transpulmonary vascular mechanics but does not change intrinsic right ventricular contractility in an acute respiratory distress syndrome model with permissive hypercapnia. Crit Care Med. 1996 Sep;24(9):1554-61.

Hillman ND, Meliones JN, Black DR, Craig DM, Cheifetz IM, Smith PK. In acute lung injury, inhaled nitric oxide improves ventilation-perfusion matching, pulmonary vascular mechanics, and transpulmonary vascular efficiency. J Thorac Cardiovasc Surg. 1995 Sep;110(3):593-9; discussion 599-600.