pediatrics.duke.edu  
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Division of Neurology

Clinical Trials

Clinical trials projects being conducted in the Division of Pediatric Neurology:
 
  • An Open-Label, Multicenter Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Three Dosing Regimens of Oral AT2220 in Patients with Pompe Disease.  PI: Priya Kishnani, MD. Co-Investigator: Edward Smith, MD. 
  • Is Autologous Umbilical Cord Blood Infusion Beneficial in Children with Cerebral Palsy: A Randomized, Blinded, Placebo-Controlled, Crossover Study.  PI:  Joanne Kurtzberg, MD. Co-Investigator: Mohamad Mikati, MD.

  • A placebo-controlled, escalating dose, multiple dose study to evaluate the safety, tolerability, and pharmacokinetics of Pregabalin in pediatric patients with partial onset seizures.  PI:  Mohamad Mikati, MD. Co-Investigators:  William Gallentine, DO; Edward Smith, MD.

  • A 12-month open label extension study evaluating the safety and tolerability of flexible doses of Pregabalin in pediatric patients with partial onset seizures.  PI:  Mohamad Mikati, MD. Co-Investigators: William Gallentine, DO; Edward Smith, MD.

  • A Multicenter, Open-Label Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Lacosamide (LCM) Oral Solution (Syrup) as Adjunctive Therapy in Children with Partial-Onset Seizures.  PI:  Mohamad Mikati, MD. Co-Investigators: William Gallentine, DO; Edward Smith, MD.

  • An Open-Label Extension Study to Determine Safety, Tolerability, and Efficacy of Long-Term Oral Lacosamide (LCM) as Adjunctive Therapy in Children with Partial-Onset Seizures.  PI: Mohamad Mikati, MD. Co-Investigators: William Gallentine, DO; Edward Smith, MD.       

  • Possible role of Costamere integrity and Ankyrins in muscular dystrophy.  PI: Edward Smith, MD.

  • Phase I/II Trial of Valproic Acid and Carnitine in Infants with Spinal Muscular Atrophy Type I (CARNI-VAL Type I).  PI: Swoboda. Co-Investigator: Edward Smith, MD.

  • A Phase 2b Efficacy and Safety Study of PTC124 in Subjects with Nonsense-Mutation-Mediated Duchenne and Becker Muscular Dystrophy. PI: Stephanie Wechsler, MD. Co-Investigator: Edward Smith, MD.
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Contact Information
Division offices 
T0913 Children's Health Center
DUMC Box 3936
Durham, NC 27710
919-668-0477
919-681-8943 fax
Other numbers 
New and return appointments: 919-668-0477
 
Prescription refills: 919-668-0477
 
Pediatric neurology resident on call evenings/weekends/holidays:  919-684-8111

Physician consultations and referrals: 888-MED-DUKE
Links
Child Neurology Society at www.childneurologysociety.org

American Academy of Neurology at www.aan.com

Epilepsy Foundation at www.epilepsyfoundation.org

Tourette Syndrome Association at www.tsa-usa.org

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