For information about clinical trials in the Division of Blood and Marrow Transplantation, please contact:

 

Joanne Kurtzberg, M.D.

919-668-1100

Current Trials

Following are clinical trials currently being conducted in the Division of Blood and Marrow Transplantation.

 

Principal Investigator: Joanne Kurtzberg, M.D.

• A Pilot Study of Umbilical Cord Blood Transplantation in Children and Adults with Hematologic Malignancies
• A Pilot Study of Unrelated Umbilical Cord Blood Transplant in Adults and Children with Bone Marrow Failure Syndromes or Inherited Metabolic or Hematologic Diseases
• A Pilot Trail of unrelated Umbilical Cord Blood Transplantation (UCBT) Augmented with Cytokine-Primed Aldehyde Dehydrogenase-Bright (ALDH) Cells
• A Pilot Trial of Umbilical Cord Blood Transplantation Augmented with Cord Blood Cells Expanded Ex Vivo (Aastrom)
• A Prospective, Phase I/II Trail Determining the Efficacy and safety of Allogeneic Hematopoietic Stem Cell Transplantation using banked unrelated Umbilical Cord Blood Supplemented with Related, Haplo-Identical T-Cell Depleted Stem Cells in patients with High Risk Malignancies
• A Randomized Double-Blind Trial of Fluconazole Vs. Voriconazole for the Prevention of Invasive Fungal Infections in Allogeneic Blood and Marrow Transplant Patients
• A Randomized Trail of Conventional Vs T-Cell Depleted unrelated Donor Marrow Transplantation for the treatment of Leukemia, Myelodysplasia, and Lymphoblastic Lymphoma
• Filgrastim-Mobilized Peripheral Blood Stem Cells for Primary Allogeneic Transplantation with Unrelated Donors
• Fludarabine-based Conditioning for Allogeneic Marrow Transplantation from HLA-compatible Unrelated Donors in Server Aplastic Anemia
• Hepatitis B Virus (HBV) and west Nile Virus (WNV) Nucleic Acid Testing Program Through the Carolinas Cord Blood Bank on Behalf of the American Red Cross
• Initial Systemic Treatment of Acute GVHD: A Phase II Randomized Trail Evaluation Etanercept, Mycophenolate Mofetil (MMF), Denileukin Diftitox (Ontak) and Pentostatin in Addition to Corticosteroids
• International Severe Chronic Neutropenia Disease Registry Using Commercially Available G-CSF for the Long-Term Treatment of SCN Patients
• Multicenter Investigation of Sibling Donor Cord Blood Transplantation for Treatment of Symptomatic Sickle Cell Disease or B-Thalassemia Major
• Multi-Center, open Label, Randomized Trail Comparing Single Versus Double Umbilical Cord Blood (UCB) Transplantation in Pediatric Patients with High Risk Leukemia and Myelodysplasia
• Pilot Study of Sequential Myeloablative Stem Cell Transplantation and Reduced Intensity Allogeneic Stem Cell Transplantation Followed by Adoptive Cellular Immunotherapy in Patients with Recurrent/Refractory Non-Hodgkin’s Lymphoma and Hodgkin's Disease
• The Banking of Umbilical Cord Blood Stem Cells for Use in Clinical Research on Transplantation of Umbilical Cord Blood Stem and Progenitor Cells (COBLT)
• The National Marrow Donor Program Research Database and Research Sample Repository for Allogeneic Unrelated Hematopoietic Stem Cell Transplantation
• Transplantation of Banked Umbilical Cord Blood Stem Cells for use in Clinical Research on Transplantation of Umbilical Cord Blood Stem and Progenitor Cells (COBLT)

Principal Investigator: Paul L. Martin, M.D., Ph.D.

• Autologous or Allogeneic Bone Marrow Transplantation with Busulfan and Melphalan for Pediatric Patients with Acute Nonlymphocytic Leukemia or Myelodysplastic Syndrome
• Compassionate Use if IV Ribavirin in Immunocompromised Patients with Life-Threatening Viral Infections
• Critical Care in Pediatric Stem Cell Transplant Patients: A Retrospective Analysis
• Defibrotide For Hematopoietic Stem Cell Transplant Patients With Severe Hepatic Veno-Occlusive Disease (VOD): A Randomized Phase II Study To Determine The Effective Dose
• Defibrotide for the Treatment of Server Veno-Occlusive Disease (VOD) in Hematopoietic Stem Cell Transplant Patients: A Historically-Controlled, Multi-Center Phase III Study to Determine Safety and Efficacy
• Infections in Pediatric Stem Cell Transplant Patients: A Retrospective Analysis – Part 2
  
  

Principal Investigator: Suhag H. Parikh, M.D.

• Unrelated Donor Hematopoietic Cell Transplantation for Children with Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen
• A Pilot Study of Reduced Intensity Conditioning in Pediatric Patients <21 Years of Age with Non-malignant Disorders Undergoing Umbilical Cord Blood Transplantation
• Phase I/II Pilot Study of Mixed Chimerism to Treat Hemoglobinopathies
  

Principal Investigator: Paul Szabolcs, M.D.

• A Phase II Trail to Determine the Safety and Efficacy of Administration of Recombinant Human Growth Hormone (rh-GH) for Accelerating Immune Reconstitution in Pediatric and Adult Patients Undergoing Unrelated Cord Blood Transplantation
• A Pilot Study of High-Dose Immunosuppression Followed by Infusion of CD34 Selected Autologous Peripheral Blood Stem Cell for Treatment of Sever Crohn's Disease in Children and Young Adults
• Hematopoietic Graft Engineering:  Pre-Clinical Studies
• The Efficacy of DNA Hybrid Capture Monitoring of Cytomegalovirus Infection in Pediatric Stem Cell Transplant Patients: A Retrospective Study