| Grant Title | Funding Source | Principal Investigator |
| Leukocyte Chemokine Blockade to Preserve Lung Development | (NIH-5R501 HL067021-04) | Richard Auten, M.D. |
| Oxidative Stress and Inflammation Impaired Postnatal Lung Development | (NIH HL-067021) | Richard Auten, M.D. |
| Bronchopulmonary Dysplasia Drug Therapy | (HL- 072614) |
Dean Maeda, Ph.D. |
| S-nitrosothiol Regulation of Postnatal Lung Development | (Nitrox, LLC) | Richard Auten, M.D. |
| Pre- and Post-natal Multiple Air Pollutant Exposure and Abnormal Airway Development | (Environmental Protection Agency) | Richard Auten, M.D. |
| Mechanisms of Auto-Rhythmicity in Heart Development | (NIH RO1 HL071015-04) | Tony Creazzo, Ph.D. |
| Development of the Heart: Role of Neural Crest | (NIH PO1 HL-36059-18) | Margaret Kirby, Ph.D. |
| Characterization of Secondary Heart Field | (NIH 5R01HL070140-03) | Margaret Kirby, Ph.D. |
| Neural Crest Modulates FGF Signaling in the Pharynx | (NIH 3R01HL083240-01A1S1) | Margaret Kirby, Ph.D. |
| Modeling Conotruncal Malformations in Zebrafish Embryos | (1R01HL084413-01) | Margaret Kirby, Ph.D. |
| Molecular Genetics of Neural Tube Defects in Mouse Transgenic Models | John Klingensmith, Ph.D. |
| Project | Fellow | Mentor |
| Neural Crest Modulates Fgf Signaling in the Pharynx | Kelly Nembhard, Ph.D. Candidate | Margaret Kirby, Ph.D. |
| Cardiac Neural Crest Modulates Fgf Signaling | Asako Sato, Ph.D. | Margaret Kirby, Ph.D. |
| Predoc Development of the Arterial Pole of the Zebrafish | Adrian Grimes, Ph.D. | Margaret Kirby, Ph.D. |
| Role of Mast Cell Influx/Degranulation on Newborn Airway Hyperreactivity, Airway Remodeling | Eric Schultz, D.O. | Richard Auten, M.D. |
| Grant Title | Funding Source | Principal Investigator |
|
Cooperative Multicenter Neonatal
Research Network | (NIH RFA 5U10-HD40492) | Ronald Goldberg, M.D. |
|
Grant Title | Funding Source | Principal Investigator |
| Multidisciplinary Neonatal Training Grant | (NIH 1 T32 HD043728-01A2) | Ronald Goldberg, M.D. |
| Project | Principal Investigator |
| Acquired Candida Infection in Neonates: Evaluation of Early Diagnostic Strategies | Danny Benjamin, M.D., Ph.D., and C. Michael Cotten, M.D. |
| Survey of Morbidity and Mortality Among VLBW Infants (401-1500 g) | Ronald Goldberg, M.D. |
| SUPPORT (Surfactant Positive Airway Pressure Pulse Oximetry Trial) in ELBWs | C. Michael Cotten, M.D. |
| Neuroimaging and Neurodevelopmental Outcome: A Secondary to SUPPORT | Ricki F. Goldstein, M.D. |
| NICHD SUPPORT Protocol: Breathing Outcomes Study | Ricki F. Goldstein, M.D. |
| Study of Immunogenicity of Heptavalent Pneumoccal Conjugate Vaccine in VLBWs | C. Michael Cotten, M.D. |
| Early-Onset Sepsis: An NICHD/CDC Surveillance Study | C. Michael Cotten, M.D. |
| Generic Database Follow-up Study for ELBW Infants (401 - 1000 grams) | Ricki F. Goldstein, M.D. |
| Neurodiagnostic Evaluations to Predict Adverse Outcomes Following Acute Perinatal Asphyxia | C. Michael Cotten, M.D. |
| Grant Title | Funding Source | Principal Investigator |
| A Multicenter, Randomized, Open Label, Single and Multiple Dose Study of the Pharmacokinetics and Pharmacodynamic of 2 Dose Levels of Pantoprazole Sodium Enteric-coated Spheroid Suspension In Infants Aged 1 Through 11 Months With Presumed GERD | Clinical Industry Trial [3001B3-333-US] | C. Michael Cotten, M.D. |
| A Multicenter, Open Label Pharmacokinetic, Pharmacodynamic, and Safety Study of Pantoprazole for Injection in Neonates and Preterm Infants with a Clinical Diagnosis of Gastroesophageal Reflux Disease (GERD) | Clinical Industry Trial [PROTOCOL NO. 3001K3-331] | C. Michael Cotten, M.D. |
| A Prospective, Non-Interventional Study to Evaluate the Incidence of Hospitalizations and Medically-Attended Lower Respiratory Tract Infection (MALR) in Premature Infants 32 to 35 Weeks Gestational Age Who Are Not Recommended to Receive Prophylaxis for RSV | Clinical Industry Trial | C. Michael Cotten, M.D. |
| Diagnosis of Gastroesophageal Reflux Disease in Very Low Birthweight Infants | Clinical Industry Trial (Gerber Grant) | William F. Malcolm, M.D. |
| Treatment of Gastroesophageal Reflux Disease in Very Low Birthweight Infants | Clinical Industry Trial (Gerber Grant) | William F. Malcolm, M.D. |
| Grant Title | Funding Source | Principal Investigator |
| Pharmacokinetics of Antimicrobials in Premature Infants | Pediatric Pharmacokinetics Research Network | C. Michael Cotten, M.D. |
| Dose-Ranging, Safety and Efficacy of Cathflo® Activase (Alteplase)T for the Treatment of Central Catheter Occlusion in Neonates and Infants; Phase I | Pediatric Pharmacokinetics Research Network | C. Michael Cotten, M.D. |
| A Multicenter, Open Label Pharmacokinetic Study of Fluconazole in Infants | Pediatric Pharmacokinetics Research Network | C. Michael Cotten, M.D. |
| An Open Label Study to Further Describe the Pharmacokinetics of Micafungin in Neonates | Astellas and Duke PI initiated | P. Brian Smith, M.D. |
| A Phase 1, Open Label Study to Further Describe the Pharmacokinetics of Micafungin in Neonates | Astellas and Duke PI initiated | P. Brian Smith, M.D. |
| A Phase 3, Randomized, Double-Blind, Multi-Center Study To Compare the Efficacy and Safety of Micafungin versus Amphotericin B Deoxycholate for the Treatment of Neonatal Candidiasis | Astellas and Duke PI initiated | P. Brian Smith, M.D. |
| Grant Title | Funding Source | Principal Investigator |
| Automated Adverse Drug Event Detection and Intervention | AHRQ (5UC1HS014882-03) | Jeffrey M. Ferranti, M.D, M.S. |
| ISO-11179 Based Meta-Data Standard for Use in the Codified Exchange of Clinical Research Data | Neonatal Perinatal Research Institute (NPRI) | Jeffrey M. Ferranti, M.D, M.S. |
| Project | Project Date | Fellow | Advisor |
| Design and Implementation of a Tablet PC-based Neonatal Rounding System | 07/2005 - 07/2006 | Jeffrey M. Ferranti, M.D. | W. Ed Hammond, Ph.D. |
| Creation of a Standards-based Neonatal Data Dictionary for use in Clinical Research Data Sharing | 07/2005 - 07/2006 | Jeffrey M. Ferranti, M.D. | W. Ed Hammond, Ph.D. |
| Project | Project Date | Fellow | Advisor |
| The Role of the Mast Cell in the Pathophysiology of Broncho-Pulmonary Dysplasia | 07/2005 - Present | Eric Schultz, D.O. | Richard Auten, M.D. |
| Preventing Methicillin Resistant S. Aureus (MRSA) Infections in the NICU | 09/2006 - Present | Eric Schultz, D.O. |
Ronald Goldberg, M.D.
Brian Smith, M.D.
Daniel K. Benjamin, M.D., Ph.D. |
| Peripherally Inserted Central Catheter Infection Rate in the NICU | 09/2006 - Present | Eric Schultz, D.O. | Daniel K. Benjamin, M.D., Ph.D. |
| Quantitative DNA PCR for Diagnosis of Candida | 7/2004-Present | Brian Smith, M.D. | Tom Mitchell, Ph.D., John Perfect, M.D. |
| Beta-glucan and Arabinitol Levels in Pediatric Patients | 7/2005-Present | Brian Smith, M.D. |
Daniel K. Benjamin Jr., M.D., Ph.D.
William Steinbach, M.D. |
| CSF Parameters for Neonatal Meningitis | 7/2004-Present | Brian Smith, M.D. |
Daniel K. Benjamin Jr., M.D., Ph.D.
C. Michael Cotten, M.D. |
| Micafungin Phase I Study | 7/2006-Present | Brian Smith, M.D. | Daniel K Benjamin Jr., M.D., Ph.D. |
| Micafungin Phase III Study | 7/2006-Present | Brian Smith, M.D. | Daniel K Benjamin Jr., M.D., Ph.D. |
| Meropenem for Neonatal Intra-abdominal Infections | 1/2006-Present | Brian Smith, M.D. | Daniel K Benjamin Jr., M.D., Ph.D. |
| Daptomycin for Treatment of Neonatal Staph aureus Infections | 7/2006-Present | Brian Smith, M.D. | Daniel K Benjamin Jr., M.D., Ph.D. |
| Contact Isolation for MRSA and Nosocomial Infection Rates | 7/2006-Present | Brian Smith, M.D. | Daniel K Benjamin Jr., M.D., Ph.D. |
| PICC Line Infection Rates in Neonates | 7/2006-Present | Brian Smith, M.D. |
Daniel K. Benjamin Jr., M.D., Ph.D.
Courtney Thornburg, M.D. |
| Neonatal UTIs | 7/2006-Present | Brian Smith, M.D. |
Daniel K Benjamin Jr., M.D., Ph.D.
Ronald Goldberg, M.D. |
| Placebo Group AE Rates | 7/2006-Present | Brian Smith, M.D. | Daniel K Benjamin Jr., M.D., Ph.D. |
| Candidemia Cost analysis - CDC | 7/2005-7/2006 | Brian Smith, M.D. | Daniel K Benjamin Jr., M.D., Ph.D. |
| Fluconazole for Candida Prophylaxis in Neonates <750g birthweight | 10/2006-Present | Brian Smith, M.D. |
Daniel K Benjamin Jr., M.D., Ph.D.
Ronald Goldberg, M.D. |
| Grant Title | Funding Source |
|
Preterm Infants: Light Effects on Health and Development
Debra Brandon | NIH-R01 NR08044-01A |
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