Sallie R. Permar, MD, PhD

AddThis

Print

email this


Associate Professor of Pediatrics
Assistant Professor in Immunology
Assistant Professor in Molecular Genetics and Microbiology
Department / Division:
Pediatrics / Pediatrics-Infectious Diseases
Address:
DUMC 103020
Durham, NC 27710
Appointment Telephone:
919-684-6335
Office Telephone:
919-684-6335
Fax:
919-668-4859
Training:
  • MD, Harvard Medical School (Massachusetts), 2004
Residency:
  • Pediatrics, Children's Hospital Boston (Massachusetts), 2007
Fellowship:
  • Pediatric Infectious Diseases, Children's Hospital Boston (Massachusetts), 2009
Other Training:
  • PhD, Microbiology and Immunology, Johns Hopkins University (Maryland), 2004
Clinical Interests:
Prevention and treatment of neonatal viral infections; prevention and treatment of infectious diseases in immunosuppressed pediatric patients
Research Interests:
Dr. Permar's work focuses on maternal correlates of immune protection against vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS, Simian Immunodeficiency Virus (SIV) infection of rhesus monkeys, to characterize the virus-specific immune responses and virus evolution in breast milk. Furthermore, the Permar lab is characterizing HIV/SIV vaccine-elicited immune responses in breast milk of vaccinated rhesus monkeys, as a platform for developing a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Finally, Dr. Permar has established studies of maternal cytomegalovirus-specific immune responses that may protect against symptomatic congenital cytomegalovirus and postnatal transmission in preterm infants.
Representative Publications:
  • Chahroudi, A; Cartwright, E; Lee, ST; Mavigner, M; Carnathan, DG; Lawson, B; Carnathan, PM; Hashempoor, T; Murphy, MK; Meeker, T; Ehnert, S; Souder, C; Else, JG; Cohen, J; Collman, RG; Vanderford, TH; Permar, SR; Derdeyn, CA; Villinger, F; Silvestri, G. Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques. PLoS Pathogens. 2014;10:e1003958.  Abstract
  • Fouda, GG; Cunningham, CK; McFarland, EJ; Borkowsky, W; Muresan, P; Pollara, J; Song, LY; Liebl, BE; Whitaker, K; Shen, X; Vandergrift, NA; Overman, RG; Yates, NL; Moody, MA; Fry, C; Kim, JH; Michael, NL; Robb, M; Pitisuttithum, P; Kaewkungwal, J; Nitayaphan, S; Rerks-Ngarm, S; Liao, HX; Haynes, BF; Montefiori, DC; Ferrari, G; Tomaras, GD; Permar, SR. Infant HIV-1 gp120 vaccination elicits robust and durable anti-V1V2 IgG responses and only rare Envelope-specific IgA responses. Journal of Infectious Diseases. 2014;  Abstract
  • Fouda, GG; Permar, SR. Immune-based interventions to prevent postnatal HIV-1 transmission. Trends in Microbiology. 2014;22:425-427.  Abstract
  • Madani, N; Princiotto, AM; Schön, A; LaLonde, J; Feng, Y; Freire, E; Park, J; Courter, JR; Jones, DM; Robinson, J; Liao, HX; Moody, MA; Permar, S; Haynes, B; Smith, AB; Wyatt, R; Sodroski, J. CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies. Journal of Virology. 2014;88:6542-6555.  Abstract
  • Meyer, SA; Westreich, DJ; Patel, E; Ehlinger, EP; Kalilani, L; Lovingood, RV; Denny, TN; Swamy, GK; Permar, SR. Postnatal cytomegalovirus exposure in infants of antiretroviral-treated and untreated HIV-infected mothers. Infectious Diseases in Obstetrics and Gynecology. 2014;2014:989721.  Abstract
  • Permar, SR; Staats, HF. Which comes first: the antigen or the adjuvant?. Journal of Clinical Investigation. 2014;124:2364-2365.  Abstract
  • Sacha, CR; Vandergrift, N; Jeffries, TL; McGuire, E; Fouda, GG; Liebl, B; Marshall, DJ; Gurley, TC; Stiegel, L; Whitesides, JF; Friedman, J; Badiabo, A; Foulger, A; Yates, NL; Tomaras, GD; Kepler, TB; Liao, HX; Haynes, BF; Moody, MA; Permar, SR. Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women. Mucosal Immunology. 2014;  Abstract
  • Amos, JD; Wilks, AB; Fouda, GG; Smith, SD; Colvin, L; Mahlokozera, T; Ho, C; Beck, K; Overman, RG; DeMarco, CT; Hodge, TL; LaBranche, CC; Montefiori, DC; Denny, TN; Liao, HX; Tomaras, GD; Moody, MA; Permar, SR. Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys. Journal of Virology. 2013;87:11121-11134.  Abstract
  • Fouda, GG; Amos, JD; Wilks, AB; Pollara, J; Ray, CA; Chand, A; Kunz, EL; Liebl, BE; Whitaker, K; Carville, A; Smith, S; Colvin, L; Pickup, DJ; Staats, HF; Overman, G; Eutsey-Lloyd, K; Parks, R; Chen, H; Labranche, C; Barnett, S; Tomaras, GD; Ferrari, G; Montefiori, DC; Liao, HX; Letvin, NL; Haynes, BF; Permar, SR. Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milk. Journal of Virology. 2013;87:6986-6999.  Abstract
  • Fouda, GG; Cunningham, CK; McFarland, EJ; Borkowsky, W; Muresan, P; Liebl, BE; Liao, H; Haynes, BF; Overman, R; Yates, NL; Tomaras, GD; Permar, SR. HIV-1 gp120 Vaccination Elicits a Robust and Durable Anti-V1/V2 IgG Response and Yet No HIV-1 Env-Specific IgA Response in HIV-Exposed Infants. AIDS Research and Human Retroviruses. A13-A14.  
  • Fouda, GG; Jaeger, FH; Amos, JD; Ho, C; Kunz, EL; Anasti, K; Stamper, LW; Liebl, BE; Barbas, KH; Ohashi, T; Moseley, MA; Liao, HX; Erickson, HP; Alam, SM; Permar, SR. Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk. Proceedings of the National Academy of Sciences of USA. 2013;110:18220-18225.  Abstract
  • Fouda, GG; Mahlokozera, T; Salazar-Gonzalez, JF; Salazar, MG; Learn, G; Kumar, SB; Dennison, SM; Russell, E; Rizzolo, K; Jaeger, F; Cai, F; Vandergrift, NA; Gao, F; Hahn, B; Shaw, GM; Ochsenbauer, C; Swanstrom, R; Meshnick, S; Mwapasa, V; Kalilani, L; Fiscus, S; Montefiori, D; Haynes, B; Kwiek, J; Alam, SM; Permar, SR. Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants. Retrovirology. 2013;10:3.  Abstract
  • Ho, C; Wu, S; Amos, JD; Colvin, L; Smith, SD; Wilks, AB; Demarco, CT; Brinkley, C; Denny, TN; Schmitz, JE; Rodrigo, AG; Permar, SR. Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys. Journal of Virology. 2013;87:11292-11299.  Abstract
  • Kunz, E; Fouda, G; Ho, C; Amos, J; Colvin, L; Montefiori, D; Martelli, A; Allen, A; Aramand, L; Marshall, DJ; Letvin, NL; Staats, H; Pickup, D; Barnett, SC; Moody, MA; Haynes, BF; Liao, H; Permar, SR. Combined Mucosal and Systemic C.1086 Envelope Immunization of Lactating Monkeys Induces Potent IgA and Functional IgG Antibody Responses in Milk. AIDS Research and Human Retroviruses. A180-A180.  
  • Permar, SR; Salazar, MG; Gao, F; Cai, F; Learn, GH; Kalilani, L; Hahn, BH; Shaw, GM; Salazar-Gonzalez, JF. Clonal amplification and maternal-infant transmission of nevirapine-resistant HIV-1 variants in breast milk following single-dose nevirapine prophylaxis. Retrovirology. 2013;10:88.  Abstract
  • Russell, ES; Ojeda, S; Fouda, GG; Meshnick, SR; Montefiori, D; Permar, SR; Swanstrom, R. Short communication: HIV type 1 subtype C variants transmitted through the bottleneck of breastfeeding are sensitive to new generation broadly neutralizing antibodies directed against quaternary and CD4-binding site epitopes. AIDS Research and Human Retroviruses. 2013;29:511-515.  Abstract
  • Sacha, CR; Vandergrift, N; Marshall, DJ; Gurley, TC; Stiegel, L; Whitesides, JF; Friedman, J; Fouda, GG; Liebl, B; McGuire, E; Foulger, A; Kepler, TB; Liao, H; Haynes, BF; Moody, MA; Permar, SR. Distinct VH Gene Usage and HIV Envelope Specificity of Colostrum and Peripheral B Cell Monoclonal Antibodies of HIV-Infected, Lactating African Women. AIDS Research and Human Retroviruses. A169-A170.  
  • Amos, JD; Wilks, AB; Fouda, GG; Smith, SD; Overman, GR; Beck, K; Moody, MA; Tomaras, GD; Permar, SR. Strong SIV gp120-specific IgG/IgA responses in milk of African green monkeys may contribute to the rarity of postnatal transmission in this species. Retrovirology. 2012;9.  
  • Fouda, G; Amos, J; Wilks, AB; Chand, A; Montefiori, D; Haynes, B; Letvin, N; Pickup, D; Liao, H; Permar, SR. Vaccine-elicited systemic and mucosal humoral responses of lactating rhesus monkeys vaccinated with the transmitted/founder HIV Envelope 1086C. Retrovirology. 2012;9:O20-O20.  
  • Friedman, J; Alam, SM; Shen, X; Xia, SM; Stewart, S; Anasti, K; Pollara, J; Fouda, GG; Yang, G; Kelsoe, G; Ferrari, G; Tomaras, GD; Haynes, BF; Liao, HX; Moody, MA; Permar, SR. Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum. PLoS One. 2012;7:e37648.  Abstract
  • Handley, SA; Thackray, LB; Zhao, G; Presti, R; Miller, AD; Droit, L; Abbink, P; Maxfield, LF; Kambal, A; Duan, E; Stanley, K; Kramer, J; Macri, SC; Permar, SR; Schmitz, JE; Mansfield, K; Brenchley, JM; Veazey, RS; Stappenbeck, TS; Wang, D; Barouch, DH; Virgin, HW. Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome. Cell. 2012;151:253-266.  Abstract
  • Parrish, NF; Wilen, CB; Banks, LB; Iyer, SS; Pfaff, JM; Salazar-Gonzalez, JF; Salazar, MG; Decker, JM; Parrish, EH; Berg, A; Hopper, J; Hora, B; Kumar, A; Mahlokozera, T; Yuan, S; Coleman, C; Vermeulen, M; Ding, H; Ochsenbauer, C; Tilton, JC; Permar, SR; Kappes, JC; Betts, MR; Busch, MP; Gao, F; Montefiori, D; Haynes, BF; Shaw, GM; Hahn, BH; Doms, RW. Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin ¿4ß7. PLoS Pathogens. 2012;8:e1002686.  Abstract
  • Schmitz, JE; Ma, ZM; Hagan, EA; Wilks, AB; Furr, KL; Linde, CH; Zahn, RC; Brenchley, JM; Miller, CJ; Permar, SR. Memory CD4(+) T lymphocytes in the gastrointestinal tract are a major source of cell-associated simian immunodeficiency virus in chronic nonpathogenic infection of African green monkeys. Journal of Virology. 2012;86:11380-11385.  Abstract
  • Ehlinger, EP; Webster, EM; Kang, HH; Cangialose, A; Simmons, AC; Barbas, KH; Burchett, SK; Gregory, ML; Puopolo, KM; Permar, SR. Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants. Journal of Infectious Diseases. 2011;204:1672-1682.  Abstract
  • Fouda, GG; Yates, NL; Pollara, J; Shen, X; Overman, GR; Mahlokozera, T; Wilks, AB; Kang, HH; Salazar-Gonzalez, JF; Salazar, MG; Kalilani, L; Meshnick, SR; Hahn, BH; Shaw, GM; Lovingood, RV; Denny, TN; Haynes, B; Letvin, NL; Ferrari, G; Montefiori, DC; Tomaras, GD; Permar, SR; Center for HIV/AIDS Vaccine Immunology. HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies. Journal of Virology. 2011;85:9555-9567.  Abstract
  • Mahlokozera, T; Kang, HH; Goonetilleke, N; Stacey, AR; Lovingood, RV; Denny, TN; Kalilani, L; Bunn, JE; Meshnick, SR; Borrow, P; Letvin, NL; Permar, SR; Center for HIV/AIDS Vaccine Immunology. The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk. PLoS One. 2011;6:e23735.  Abstract
  • Salazar-Gonzalez, JF; Salazar, MG; Learn, GH; Fouda, GG; Kang, HH; Mahlokozera, T; Wilks, AB; Lovingood, RV; Stacey, A; Kalilani, L; Meshnick, SR; Borrow, P; Montefiori, DC; Denny, TN; Letvin, NL; Shaw, GM; Hahn, BH; Permar, SR; Center for HIV/AIDS Vaccine Immunology A0167854. Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencing. Journal of Virology. 2011;85:2751-2763.  Abstract
  • Sun, Y; Asmal, M; Lane, S; Permar, SR; Schmidt, SD; Mascola, JR; Letvin, NL. Antibody-dependent cell-mediated cytotoxicity in simian immunodeficiency virus-infected rhesus monkeys. Journal of Virology. 2011;85:6906-6912.  Abstract
  • Wilks, AB; Perry, JR; Ehlinger, EP; Zahn, RC; White, R; Gauduin, MC; Carville, A; Seaman, MS; Schmitz, JE; Permar, SR. High cell-free virus load and robust autologous humoral immune responses in breast milk of simian immunodeficiency virus-infected african green monkeys. Journal of Virology. 2011;85:9517-9526.  Abstract
  • Permar, SR; Kang, HH; Carville, A; Wilks, AB; Mansfield, KG; Rao, SS; Letvin, NL. Preservation of memory CD4(+) T lymphocytes in breast milk of lactating rhesus monkeys during acute simian immunodeficiency virus infection. Journal of Infectious Diseases. 2010;201:302-310.  Abstract
  • Permar, SR; Kang, HH; Wilks, AB; Mach, LV; Carville, A; Mansfield, KG; Learn, GH; Hahn, BH; Letvin, NL. Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys. Retrovirology. 2010;7.  
  • Permar, SR; Kang, HH; Wilks, AB; Mach, LV; Carville, A; Mansfield, KG; Learn, GH; Hahn, BH; Letvin, NL. Local replication of simian immunodeficiency virus in the breast milk compartment of chronically-infected, lactating rhesus monkeys. Retrovirology. 2010;7:7.  Abstract
  • Permar, SR; Wilks, AB; Ehlinger, EP; Kang, HH; Mahlokozera, T; Coffey, RT; Carville, A; Letvin, NL; Seaman, MS. Limited contribution of mucosal IgA to Simian immunodeficiency virus (SIV)-specific neutralizing antibody response and virus envelope evolution in breast milk of SIV-infected, lactating rhesus monkeys. Journal of Virology. 2010;84:8209-8218.  Abstract
  • Salazar-Gonzalez, JF; Salazar, MG; Learn, GH; Kang, HH; Mahlokozera, T; Kalilani, L; Meshnick, SR; Lovingood, RV; Denny, TN; Letvin, NL; Shaw, GM; Hahn, BH; Permar, SR. Local production of HIV variants in breast milk of chronically HIV-infected, lactating women. AIDS Research and Human Retroviruses. A148-A148.  
  • Wilks, AB; Christian, EC; Seaman, MS; Sircar, P; Carville, A; Gomez, CE; Esteban, M; Pantaleo, G; Barouch, DH; Letvin, NL; Permar, SR. Robust vaccine-elicited cellular immune responses in breast milk following systemic simian immunodeficiency virus DNA prime and live virus vector boost vaccination of lactating rhesus monkeys. Journal of Immunology. 2010;185:7097-7106.  Abstract
  • Permar, SR; Kang, HH; Carville, A; Mansfield, KG; Gelman, RS; Rao, SS; Whitney, JB; Letvin, NL. Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys. Journal of Immunology. 2008;181:3643-3650.  Abstract
  • Permar, SR; Rao, SS; Sun, Y; Bao, S; Buzby, AP; Kang, HH; Letvin, NL. Clinical measles after measles virus challenge in simian immunodeficiency virus-infected measles virus-vaccinated rhesus monkeys. Journal of Infectious Diseases. 2007;196:1784-1793.  Abstract
  • Sun, Y; Permar, SR; Buzby, AP; Letvin, NL. Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection. Journal of Virology. 2007;81:8009-8015.  Abstract
  • Permar, SR; Griffin, DE; Letvin, NL. Immune containment and consequences of measles virus infection in healthy and immunocompromised individuals. Clinical and Vaccine Immunology. 2006;13:437-443.  
  • Permar, SR; Griffin, DE; Letvin, NL. Immune containment and consequences of measles virus infection in healthy and immunocompromised individuals. Clinical and Vaccine Immunology. 2006;13:437-443.  Abstract
  • Permar, SR; Klumpp, SA; Mansfield, KG; Carville, AA; Gorgone, DA; Lifton, MA; Schmitz, JE; Reimann, KA; Polack, FP; Griffin, DE; Letvin, NL. Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys. Journal of Infectious Diseases. 2004;190:998-1005.  Abstract
  • Permar, SR; Klumpp, SA; Mansfield, KG; Kim, WK; Gorgone, DA; Lifton, MA; Williams, KC; Schmitz, JE; Reimann, KA; Axthelm, MK; Polack, FP; Griffin, DE; Letvin, NL. Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys. Journal of Virology. 2003;77:4396-4400.  Abstract
  • Permar, SR; Moss, WJ; Ryon, JJ; Douek, DC; Monze, M; Griffin, DE. Increased thymic output during acute measles virus infection. Journal of Virology. 2003;77:7872-7879.  Abstract
  • Permar, SR; Moss, WJ; Ryon, JJ; Monze, M; Cutts, F; Quinn, TC; Griffin, DE. Prolonged measles virus shedding in human immunodeficiency virus-infected children, detected by reverse transcriptase-polymerase chain reaction. Journal of Infectious Diseases. 2001;183:532-538.  Abstract