Mohamad A. Mikati, MD

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Professor of Pediatrics
Professor of Neurobiology
Division Chief, Pediatric Neurology
Department / Division:
Pediatrics / Pediatrics-Neurology
Address:
DUMC 3936
Durham, NC 27710
Appointment Telephone:
919-668-0477
Office Telephone:
919-668-0477
Fax:
919-681-8943
Training:
  • MD, American University of Beirut Faculty of Medicine (Lebanon), 1980
Residency:
  • Pediatrics, American University of Beirut Medical Center (Lebanon), 1979-1982
  • Pediatric Neurology, Massachusetts General Hospital, 1982-1985
Fellowship:
  • Pediatric Medical Genetics, Johns Hopkins Hospital (Maryland), 1980
  • Neurophysiology, Children's Hospital Boston (Massachusetts), 1985-1986
  • Pharmacology (Research), Children's Hospital Boston and Boston VA Medical Center (Massachusetts), 1986-1987
Clinical Interests:
Intractable epilepsy and epileptic encephalopathies, presurgical evaluation for epilepsy surgery, development and testing of new antiepileptic drugs, application of new MRI techniques in epilepsy, general pediatric neurology
Research Interests:
Mohamad A.  Mikati M.D., is the Wilburt C. Davison Professor of Pediatrics, Professor of Neurobiology, and Chief of the Division of Pediatric Neurology. Dr. Mikati’s clinical research has centered on characterization and therapy of pediatric epilepsy and neurology syndromes, describing several new pediatric neurological entities with two carrying his name (POSSUM syndromes # 3708 and 4468), developing novel therapeutic strategies for epilepsy and related disorders particularly Alternating Hemiplegia of Childhood, and applying cutting edge genetic and Magnetic Resonance Imaging techniques to drug resistant pediatric epilepsy.  In the laboratory he has elucidated mechanisms of seizure related neuronal injury, particularly those related to the ceramide pathway, and demonstrated neuroprotective effects of several agents including erythropoietin. Most recently he has concentrated his laboratory research on the pathophysiology of ATP1A3 dysfunction in the brain as model for epilepsy and of Alternating Hemiplegia of Childhood. He has more than 210 peer reviewed publications, 300 abstracts 40 chapters one book and two booklets. He also has more than 5,590 citations in the literature with an h-index of 44 and an i-10index of 118. Dr. Mikati has written chapters on epilepsy and related disorders in the major textbooks of Pediatrics and Pediatric Neurology including Swaiman’s Pediatric Neurology and Nelson’s Pediatrics. Before joining Duke in 2008 he had completed his M.D. and Pediatric training at the American University of Beirut, his Neurology at the Massachusetts General Hospital, his Neurophysiology at Boston Children’s Hospital and had been on the Faculty at Harvard as Director of Research in the Epilepsy Program at Boston Children’s Hospital and then as Professor and Chairman, Department of Pediatrics, Founder and Director of the Adult and Pediatric Epilepsy Program at the American University of Beirut. Dr. Mikati has had several international leadership roles including being President of the Union of the Middle Eastern and Mediterranean Pediatric Societies, on the Standing Committee of the International Pediatric Association, Officer of the International Child Neurology Association, Consultant to UNICEF, WHO, and the American Board of Pediatrics, and being one of only two Pediatric Neurologists, initially chosen worldwide, on the WHO advisory committee for the International Classification of Disease. He has received several national and international honors including, among others, Merritt Putnam American Epilepsy Society Fellowship Award, Harvard Community Health Plan Peer recognition Award, Debs Research Award, Hamdan Award for contributions to Medicine, Hans Zellweger Award for contributions to Pediatric Neurology, Patient Choice Award and the Michael Frank Award for research and lifetime contributions to the field of Pediatric Neurology.
Representative Publications:
  • Heinzen, EL; Depondt, C; Cavalleri, GL; Ruzzo, EK; Walley, NM; Need, AC; Ge, D; He, M; Cirulli, ET; Zhao, Q; Cronin, KD; Gumbs, CE; Campbell, CR; Hong, LK; Maia, JM; Shianna, KV; McCormack, M; Radtke, RA; O'Conner, GD; Mikati, MA; Gallentine, WB; Husain, AM; Sinha, SR; Chinthapalli, K; Puranam, RS; McNamara, JO; Ottman, R; Sisodiya, SM; Delanty, N; Goldstein, DB. Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy. The American Journal of Human Genetics. 2012;91:293-302.  Abstract
  • Heinzen, EL; Swoboda, KJ; Hitomi, Y; Gurrieri, F; Nicole, S; de Vries, B; Tiziano, FD; Fontaine, B; Walley, NM; Heavin, S; Panagiotakaki, E; European Alternating Hemiplegia of Childhood (AHC) Genetics Consortium, ; Biobanca e Registro Clinico per l'Emiplegia Alternante (I.B.AHC) Consortium, ; European Network for Research on Alternating Hemiplegia (ENRAH) for Small and Medium-sized Enterpriese (SMEs) Consortium, ; Fiori, S; Abiusi, E; Di Pietro, L; Sweney, MT; Newcomb, TM; Viollet, L; Huff, C et al.. De novo mutations in ATP1A3 cause alternating hemiplegia of childhood. Nature Genetics. 2012;44:1030-1034.  Abstract
  • Mikati, MA; Ataya, N; El-Ferezli, J; Shamseddine, A; Rahi, A; Herlopian, A; Kurdi, R; Bhar, S; Hani, A; Comair, YG. Epilepsy surgery in a developing country (Lebanon): ten years experience and predictors of outcome. Epileptic Disorders. 2012;14:267-274.  Abstract
  • Mikati, MA; Nabulsi Khalil, M; Steele, SU. Principles of drug treatment in children. Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn. 2012;108:699-722.  Abstract
  • Puri, PK; Reddi, DM; Spencer-Manzon, M; Deak, K; Steele, SU; Mikati, MA. Banding pattern on polarized hair microscopic examination and unilateral polymicrogyria in a patient with steroid sulfatase deficiency. Archives of Dermatology. 2012;148:73-78.  Abstract
  • Steele, SU; Cheah, SM; Veerapandiyan, A; Gallentine, W; Smith, EC; Mikati, MA. Electroencephalographic and seizure manifestations in two patients with folate receptor autoimmune antibody-mediated primary cerebral folate deficiency. Epilepsy & Behavior. 2012;24:507-512.  Abstract
  • Veerapandiyan, A; Singh, P; Mikati, MA. Possible induction of West syndrome by oxcarbazepine therapy in a patient with complex partial seizures. Epileptic Disorders. 2012;14:99-103.  Abstract
  • Holt, RL; Mikati, MA. Care for child development: basic science rationale and effects of interventions. Pediatric Neurology. 2011;44:239-253.  Abstract
  • Holt, RL; Provenzale, JM; Veerapandiyan, A; Moon, WJ; De Bellis, MD; Leonard, S; Gallentine, WB; Grant, GA; Egger, H; Song, AW; Mikati, MA. Structural connectivity of the frontal lobe in children with drug-resistant partial epilepsy. Epilepsy & Behavior. 2011;21:65-70.  Abstract
  • Karam, PE; Daher, RT; Moller, LB; Mikati, MA. Experience with hyperphenylalaninemia in a developing country: unusual clinical manifestations and a novel gene mutation. Journal of Child Neurology. 2011;26:142-146.  Abstract
  • Mikati, MA; Daderian, R; Zeinieh, M; Leonard, AS; Azzam, D; Kurdi, R. Potential neuroprotective effects of continuous topiramate therapy in the developing brain. Epilepsy & Behavior. 2011;20:597-601.  Abstract
  • Muwakkit, SA; Majdalani, M; Hourani, R; Mahfouz, RA; Otrock, ZK; Bilalian, C; Chan, AK; Abboud, M; Mikati, MA. Inherited thrombophilia in childhood arterial stroke: data from Lebanon. Pediatric Neurology. 2011;45:155-158.  Abstract
  • Shah, R; Veerapandiyan, A; Winchester, S; Gallentine, W; Mikati, MA. Two patients with an anti-N-methyl-D-aspartate receptor antibody syndrome-like presentation and negative results of testing for autoantibodies. Pediatric Neurology. 2011;45:412-416.  Abstract
  • Veerapandiyan, A; Gallentine, WB; Winchester, SA; Baker, J; Kansagra, SM; Mikati, MA. Oculogyric crises secondary to lamotrigine overdosage. Epilepsia. 2011;52:e4-e6.  Abstract
  • Veerapandiyan, A; Winchester, SA; Gallentine, WB; Smith, EC; Kansagra, S; Hyland, K; Mikati, MA. Electroencephalographic and seizure manifestations of pyridoxal 5'-phosphate-dependent epilepsy. Epilepsy & Behavior. 2011;20:494-501.  Abstract
  • Farra, C; Yunis, K; Mikati, M; Yazbeck, N; Majdalani, M; Awwad, J. Goldenhar syndrome associated with prenatal maternal Fluoxetine ingestion: Cause or coincidence?. Birth Defects Research Part A: Clinical and Molecular Teratology. 2010;88:582-585.  Abstract
  • Heinzen, EL; Radtke, RA; Urban, TJ; Cavalleri, GL; Depondt, C; Need, AC; Walley, NM; Nicoletti, P; Ge, D; Catarino, CB; Duncan, JS; Kasperavici¿te, D; Tate, SK; Caboclo, LO; Sander, JW; Clayton, L; Linney, KN; Shianna, KV; Gumbs, CE; Smith, J; Cronin, KD; Maia, JM; Doherty, CP; Pandolfo, M; Leppert, D; Middleton, LT; Gibson, RA; Johnson, MR; Matthews, PM; Hosford, D; Kälviäinen, R; Eriksson, K; Kantanen, AM; Dorn, T; Hansen, J; Krämer, G; Steinhoff, BJ; Wieser, HG; Zumsteg, D; Ortega, M et al.. Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes. The American Journal of Human Genetics. 2010;86:707-718.  Abstract
  • Kansagra, S; Ataya, N; Lewis, D; Gallentine, W; Mikati, MA. The effect of vagus nerve stimulation therapy on body mass index in children. Epilepsy & Behavior. 2010;19:50-51.  Abstract
  • Kasperavici¿te, D; Catarino, CB; Heinzen, EL; Depondt, C; Cavalleri, GL; Caboclo, LO; Tate, SK; Jamnadas-Khoda, J; Chinthapalli, K; Clayton, LM; Shianna, KV; Radtke, RA; Mikati, MA; Gallentine, WB; Husain, AM; Alhusaini, S; Leppert, D; Middleton, LT; Gibson, RA; Johnson, MR; Matthews, PM; Hosford, D; Heuser, K; Amos, L; Ortega, M; Zumsteg, D; Wieser, HG; Steinhoff, BJ; Krämer, G; Hansen, J; Dorn, T; Kantanen, AM; Gjerstad, L; Peuralinna, T; Hernandez, DG; Eriksson, KJ; Kälviäinen, RK et al.. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. Brain. 2010;133:2136-2147.  Abstract
  • Leonard, AS; Mikati, MA. What is their fate after magnesium sulfate?. Neonatology. 2010;98:206-207.  Abstract
  • Mikati, MA; Ataya, N; Ferzli, J; Kurdi, R; El-Banna, D; Rahi, A; Shamseddine, A; Sinno, D; Comair, Y. Quality of life after surgery for intractable partial epilepsy in children: a cohort study with controls. Epilepsy Research. 2010;90:207-213.  Abstract
  • Mikati, MA; Cornett, KM. Therapy of infantile spasms: new opportunities and emerging challenges. Epilepsy & Behavior. 2010;17:571-573.  Abstract
  • Mikati, MA; Kurdi, R; El-Khoury, Z; Rahi, A; Raad, W. Intravenous immunoglobulin therapy in intractable childhood epilepsy: open-label study and review of the literature. Epilepsy & Behavior. 2010;17:90-94.  Abstract
  • Zeinieh, MP; Talhouk, RS; El-Sabban, ME; Mikati, MA. Differential expression of hippocampal connexins after acute hypoxia in the developing brain. Brain and Development. 2010;32:810-817.  Abstract
  • Gallentine, WB; Mikati, MA. Intraoperative electrocorticography and cortical stimulation in children. Journal of Clinical Neurophysiology. 2009;26:95-108.  Abstract
  • Karam, PE; Farra, C; Shamseddine, A; Mikati, MA. Two new familial severe infantile spasm syndromes in males. Epilepsy & Behavior. 2009;14:696-700.  Abstract
  • Mikati, MA; Ataya, N; El-Hajj Fuleihan, G. Re: Epilepsy-associated bone mineral density loss should be prevented. Neurology. 2009;72:943.  Abstract
  • Mikati, MA; Ataya, NF; El-Ferezli, JC; Baghdadi, TS; Turkmani, AH; Comair, YG; Kansagra, S; Najjar, MW. Quality of life after vagal nerve stimulator insertion. Epileptic Disorders. 2009;11:67-74.  Abstract
  • Mikati, MA; El-Bitar, MK; Najjar, MW; Rbeiz, JJ; Barada, WH; Najjar, VF; Yaktin, U; Tourjuman, O. A child with refractory complex partial seizures, right temporal ganglioglioma, contralateral continuous electrical status epilepticus, and a secondary Landau-Kleffner autistic syndrome. Epilepsy & Behavior. 2009;14:411-417.  Abstract
  • Mikati, MA; Mohler Cornett, KM. Letter: Antiepileptogenic and neuroprotective effects of erythropoietin: recent data. Epilepsia. 2009;50:1654-1655.  Abstract
  • Mikati, MA; Naasan, G; Tarabay, H; El Yamen, S; Baydoun, A; Comair, YG. Intracarotid propofol testing: a comparative study with amobarbital. Epilepsy & Behavior. 2009;14:503-507.  Abstract
  • Mikati, MA; Yehya, A; Darwish, H; Karam, P; Comair, Y. Deep brain stimulation as a mode of treatment of early onset pantothenate kinase-associated neurodegeneration. European Journal of Paediatric Neurology. 2009;13:61-64.  Abstract
  • Naasan, G; Yabroudi, M; Rahi, A; Mikati, MA. Electroencephalographic changes in pyridoxine-dependant epilepsy: new observations. Epileptic Disorders. 2009;11:293-300.  Abstract
  • Obeid, M; Wyllie, E; Rahi, AC; Mikati, MA. Approach to pediatric epilepsy surgery: State of the art, Part I: General principles and presurgical workup. European Journal of Paediatric Neurology. 2009;13:102-114.  Abstract
  • Obeid, M; Wyllie, E; Rahi, AC; Mikati, MA. Approach to pediatric epilepsy surgery: State of the art, Part II: Approach to specific epilepsy syndromes and etiologies. European Journal of Paediatric Neurology. 2009;13:115-127.  Abstract
  • Barada, W; Muwakkit, S; Hourani, R; Bitar, M; Mikati, M. Cerebral sinus thrombosis in a patient with humoral immunodeficiency on intravenous immunoglobulin therapy: a case report. Neuropediatrics. 2008;39:131-133.  Abstract
  • El-Hajj Fuleihan, G; Dib, L; Yamout, B; Sawaya, R; Mikati, MA. Predictors of bone density in ambulatory patients on antiepileptic drugs. BONE. 2008;43:149-155.  Abstract
  • El-Hajj, TI; Karam, PE; Mikati, MA. Biotin-responsive basal ganglia disease: case report and review of the literature. Neuropediatrics. 2008;39:268-271.  Abstract
  • Mikati, M; Holmes, GL. Guideline and algorithms for treatment of pediatric epilepsy in the West: how about the individual patient and the rest of the world?. Epileptic Disorders. 2008;10:69-71.  Abstract
  • Mikati, MA; El Banna, D; Sinno, D; Mroueh, S. Response of infantile spasms to levetiracetam. Neurology. 2008;70:574-575.  Abstract
  • Mikati, MA; Rahi, AC; Shamseddine, A; Mroueh, S; Shoeib, H; Comair, Y. Marked benefits in physical activity and well-being, but not in functioning domains, 2 years after successful epilepsy surgery in children. Epilepsy & Behavior. 2008;12:145-149.  Abstract
  • Mikati, MA; Rizk, E; El Dada, S; Zeinieh, M; Kurdi, R; El Hokayem, J; Rahmeh, A; Koubeissi, M; Azzam, D; Usta, J; El Sabban, M; Dbaibo, G. Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms. Brain & Development. 2008;30:513-519.  Abstract
  • Mikati, MA; Zeinieh, M; Habib, RA; El Hokayem, J; Rahmeh, A; El Sabban, M; Usta, J; Dbaibo, G. Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus. Epilepsy Research. 2008;81:161-166.  Abstract
  • Muwakkit, S; Nuwayhid, I; Nabulsi, M; al Hajj, R; Khoury, R; Mikati, M; Abboud, MR. Iron deficiency in young Lebanese children: association with elevated blood lead levels. Journal of Pediatric Hematology/Oncology. 2008;30:382-386.  Abstract
  • Piña-Garza, JE; Elterman, RD; Ayala, R; Corral, M; Mikati, MA; Piña-Garza, MJ; Warnock, CR; Conklin, HS; Messenheimer, JA. Long-term tolerability and efficacy of lamotrigine in infants 1 to 24 months old. Journal of Child Neurology. 2008;23:853-861.  Abstract
  • Piña-Garza, JE; Levisohn, P; Gucuyener, K; Mikati, MA; Warnock, CR; Conklin, HS; Messenheimer, J. Adjunctive lamotrigine for partial seizures in patients aged 1 to 24 months. Neurology. 2008;70:2099-2108.  Abstract
  • Sinno, DD; Darras, BT; Yamout, BI; Rebeiz, JG; Mikati, MA. Motor variant of chronic inflammatory demyelinating polyneuropathy in a child. Pediatric Neurology. 2008;38:426-429.  Abstract
  • Talhouk, RS; Zeinieh, MP; Mikati, MA; El-Sabban, ME. Gap junctional intercellular communication in hypoxia-ischemia-induced neuronal injury. Progress in Neurobiology. 2008;84:57-76.  Abstract
  • Azzam, DJ; Usta, JA; Mouneimne, Y; El Hokayem, JA; Mikati, MA. High-performance liquid chromatography method for quantifying sphingomyelin in rat brain. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 2007;859:131-136.  Abstract
  • Chamoun, RB; Mikati, MA; Comair, YG. Functional recovery following resection of an epileptogenic focus in the motor hand area. Epilepsy & Behavior. 2007;11:384-388.  Abstract
  • El Yaman, SH; Mroueh, SM; Sinno, DD; Mikati, MA. Long-term patterns of weight changes during topiramate therapy: an observational study. Neurology. 2007;69:310-311.  Abstract
  • Habib, Z; Mourani, C; Naasan, G; Hourani-Rizk, R; Mikati, MA. Venous sinus thrombosis in a renal transplant patient. Transplantation. 2007;83:825-827.  Abstract
  • Lohi, H; Turnbull, J; Zhao, XC; Pullenayegum, S; Ianzano, L; Yahyaoui, M; Mikati, MA; Quinn, NP; Franceschetti, S; Zara, F; Minassian, BA. Genetic diagnosis in Lafora disease: genotype-phenotype correlations and diagnostic pitfalls. Neurology. 2007;68:996-1001.  Abstract
  • Mikati, MA. Arthrogryposis, renal tubular acidosis and cholestasis syndrome: spectrum of the clinical manifestations. Clinical Dysmorphology. 2007;16:71.  Abstract
  • Mikati, MA; Chaaban, HR; Karam, PE; Krishnamoorthy, KS. Brain malformation and infantile spasms in a SCAD deficiency patient. Pediatric Neurology. 2007;36:48-50.  Abstract
  • Mikati, MA; El Hokayem, JA; El Sabban, ME. Effects of a single dose of erythropoietin on subsequent seizure susceptibility in rats exposed to acute hypoxia at P10. Epilepsia. 2007;48:175-181.  Abstract
  • Mikati, MA; Tarabay, H; Khalil, A; Rahi, AC; El Banna, D; Najjar, S. Risk factors for development of subclinical hypothyroidism during valproic acid therapy. The Journal of Pediatrics. 2007;151:178-181.  Abstract
  • Obeid, M; Mikati, MA. Expanding spectrum of paroxysmal events in children: potential mimickers of epilepsy. Pediatric Neurology. 2007;37:309-316.  Abstract
  • Weiss, N; Tadmouri, A; Mikati, M; Ronjat, M; De Waard, M. Importance of voltage-dependent inactivation in N-type calcium channel regulation by G-proteins. Pflügers Archiv. 2007;454:115-129.  Abstract
  • Zahed, L; Pramparo, T; Farra, C; Mikati, M; Zuffardi, O. A patient with duplication (7)(p22.1pter) characterized by array-CGH. American Journal of Medical Genetics Part A. 2007;143A:168-171.  Abstract
  • Boisseau, S; Mabrouk, K; Ram, N; Garmy, N; Collin, V; Tadmouri, A; Mikati, M; Sabatier, JM; Ronjat, M; Fantini, J; De Waard, M. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 2006;1758:308-319.  Abstract
  • Chahine, LM; Mikati, MA. Benign pediatric localization-related epilepsies. Epileptic Disorders. 2006;8:243-258.  Abstract
  • Chahine, LM; Mikati, MA. Benign pediatric localization-related epilepsies. Part I. Syndromes in infancy. Epileptic Disorders. 2006;8:169-183.  Abstract
  • Mikati, MA; Comair, YG; Rahi, A. Normalization of quality of life three years after temporal lobectomy: a controlled study. Epilepsia. 2006;47:928-933.  Abstract
  • Mikati, MA; Dib, L; Yamout, B; Sawaya, R; Rahi, AC; Fuleihan, GELH. Two randomized vitamin D trials in ambulatory patients on anticonvulsants: impact on bone. Neurology. 2006;67:2005-2014.  Abstract
  • Mikati, MA; Injibar, H; Kurdi, RM; El Hokayem, J; Abou Rialy, S; Lteif, L; Abdul Jawad, M; Francis, E; Geha, G; Farhat, F. Effects of magnesium sulfate in kainic acid-induced status epilepticus. Le Journal medical libanais. The Lebanese medical journal. 2006;54:200-204.  Abstract
  • Mikati, MA; Zalloua, P; Karam, P; Habbal, MZ; Rahi, AC. Novel mutation causing partial biotinidase deficiency in a Syrian boy with infantile spasms and retardation. Journal of Child Neurology. 2006;21:978-981.  Abstract
  • Nabulsi, MM; Tamim, H; Mahfoud, Z; Itani, M; Sabra, R; Chamseddine, F; Mikati, M. Alternating ibuprofen and acetaminophen in the treatment of febrile children: a pilot study [ISRCTN30487061]. BMC Medicine. 2006;4:4.  Abstract
  • Sinno, D; Al-Amin, H; Comair, Y; Mikati, MA. Exacerbation of vocal tics after temporal lobectomy. Epilepsy & Behavior. 2006;9:211-213.  Abstract
  • Mikati, MA; Comair, YG; Shamseddine, AN. Pattern-induced partial seizures with repetitive affectionate kissing: an unusual manifestation of right temporal lobe epilepsy. Epilepsy & Behavior. 2005;6:447-451.  Abstract
  • Mikati, MA; Rahi, AC. Febrile seizures. From molecular biology to clinical practice. Neurosciences (Riyadh, Saudi Arabia). 2005;10:14-22.  Abstract
  • Mikati, MA; Shamseddine, AN. Management of Landau-Kleffner syndrome. Paediatric drugs. 2005;7:377-389.  Abstract
  • Mikati, MA; Shamseddine, AN. Refractory calculation-induced idiopathic generalized epilepsy: a case report and review of the literature. Epilepsia. 2005;46 Suppl 10:48-50.  Abstract
  • Mikati, MA; Zeinieh, MP; Kurdi, RM; Harb, SA; El Hokayem, JA; Daderian, RH; Shamseddine, A; Obeid, M; Bitar, FF; El Sabban, M. Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain. Developmental Brain Research. 2005;157:98-102.  Abstract
  • Nabulsi, M; Tamim, H; Sabra, R; Mahfoud, Z; Malaeb, S; Fakih, H; Mikati, M. Equal antipyretic effectiveness of oral and rectal acetaminophen: a randomized controlled trial [ISRCTN11886401]. BMC Pediatrics. 2005;5:35.  Abstract
  • Neill, JC; Liu, Z; Mikati, M; Holmes, GL. Pilocarpine seizures cause age-dependent impairment in auditory location discrimination. Journal of the experimental analysis of behavior. 2005;84:357-370.  Abstract
  • Rizk, EB; El-Bitar, MA; Matae, GM; Saad, K; Mikati, MA. Facial nerve palsy with acute otitis media during the first 2 weeks of life. Journal of Child Neurology. 2005;20:452-454.  Abstract
  • Ziad, ELK; Rahi, AC; Hamdan, SA; Mikati, MA. Age, dose, and environmental temperature are risk factors for topiramate-related hyperthermia. Neurology. 2005;65:1139-1140.  Abstract
  • Mikati, M. Neuronal cell death in a rat model of mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures. Epilepsia. 2004;45:296.  Abstract
  • Mikati, MA; Comair, Y; Ismail, R; Faour, R; Rahi, AC. Effects of epilepsy surgery on quality of life: a controlled study in a Middle Eastern population. Epilepsy & Behavior. 2004;5:72-80.  Abstract
  • Mikati, MA; Holmes, GL; Werner, S; Bakkar, N; Carmant, L; Liu, Z; Stafstrom, CE. Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats. Epilepsy & Behavior. 2004;5:168-174.  Abstract
  • Mikati, MA; Kurdit, RM; Rahmeh, AA; Farhat, F; Abu Rialy, S; Lteif, L; Francis, E; Geha, G; Maraashli, W. Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats. Brain Injury. 2004;18:1229-1241.  Abstract
  • Ferzli, GT; El-Tal, AELK; Kibbi, AG; Mikati, MA. Localized morphea: a rare adverse effect of valproic acid. Pediatric Neurology. 2003;29:253-255.  Abstract
  • Mikati, M; Wakim, RH; Fayad, M. Symptomatic antiepileptic drug associated vitamin D deficiency in noninstitutionalized patients: an under-diagnosed disorder. Le Journal medical libanais. The Lebanese medical journal. 2003;51:71-73.  Abstract
  • Mikati, MA; Abi-Habib, RJ; El Sabban, ME; Dbaibo, GS; Kurdi, RM; Kobeissi, M; Farhat, F; Asaad, W. Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms. Epilepsia. 2003;44:282-291.  Abstract
  • Mikati, MA; Werner, S; Shalak, L; Shamseddine, A; Simaan, E; Liu, Z; Tarif, S; Stafstrom, C; Holmes, G. Stages of status epilepticus in the developing brain. Epilepsy Research. 2003;55:9-19.  Abstract
  • Nuwayhid, I; Nabulsi, M; Muwakkit, S; Kouzi, S; Salem, G; Mikati, M; Ariss, M. Blood lead concentrations in 1-3 year old Lebanese children: a cross-sectional study. Environmental Health. 2003;2:5.  Abstract
  • Bitar, FF; el Sabban, M; Bitar, H; Diab, K; Mroueh, S; Nasser, M; Mikati, M; Dbaibo, GS. Lack of apoptosis in the hypoxic brain of a rat model mimicking cyanotic heart disease. Brain Injury. 2002;16:891-900.  Abstract
  • Farhat, G; Yamout, B; Mikati, MA; Demirjian, S; Sawaya, R; El-Hajj Fuleihan, G. Effect of antiepileptic drugs on bone density in ambulatory patients. Neurology. 2002;58:1348-1353.  Abstract
  • Mikati, MA; Fayad, M; Koleilat, M; Mounla, N; Hussein, R; Kazma, A; Yunis, K. Efficacy, tolerability, and kinetics of lamotrigine in infants. The Journal of Pediatrics. 2002;141:31-35.  Abstract
  • Mikati, MA; Lepejian, GA; Holmes, GL. Medical treatment of patients with infantile spasms. Clinical Neuropharmacology. 2002;25:61-70.  Abstract
  • Mikati, MA; Saab, R; Fayad, MN; Choueiri, RN. Efficacy of intravenous immunoglobulin in Landau-Kleffner syndrome. Pediatric Neurology. 2002;26:298-300.  Abstract
  • Muwakkit, S; Al-Ajam, M; Arayssi, T; Hasbini, D; Masri, AF; Mikati, M. Isolated digital gangrene complicating hepatitis a infection in a child. Journal of Clinical Rheumatology. 2002;8:223-227.  Abstract
  • Choueiri, RN; Fayad, MN; Farah, A; Mikati, MA. Classification of epilepsy syndromes and role of genetic factors. Pediatric Neurology. 2001;24:37-43.  Abstract
  • Cilio, MR; Bolanos, AR; Liu, Z; Schmid, R; Yang, Y; Stafstrom, CE; Mikati, MA; Holmes, GL. Anticonvulsant action and long-term effects of gabapentin in the immature brain. Neuropharmacology. 2001;40:139-147.  Abstract
  • Diab, KA; Richani, R; Al Kutoubi, A; Mikati, M; Dbaibo, GS; Bitar, FF. Cerebral mycotic aneurysm in a child with Down's syndrome: a unique association. Journal of Child Neurology. 2001;16:868-870.  Abstract
  • Hasbini, DA; Mikati, MA; Habbal, ZM. Isolated adipic aciduria. Pediatric Neurology. 2001;24:77-78.  Abstract
  • Mikati, MA; Tarif, S; Lteif, L; Jawad, MA. Time sequence and types of memory deficits after experimental status epilepticus. Epilepsy Research. 2001;43:97-101.  Abstract
  • Bitar, FF; Hayek, P; Obeid, M; Gharzeddine, W; Mikati, M; Dbaibo, GS. Rheumatic fever in children: a 15-year experience in a developing country. Pediatric Cardiology. 2000;21:119-122.  Abstract
  • Fayad, M; Choueiri, R; Mikati, M. Fatality from hepatitis A in a child taking valproate. Journal of Child Neurology. 2000;15:135-136.  Abstract
  • Fayad, M; Choueiri, R; Mikati, M. Potential hepatotoxicity of lamotrigine. Pediatric Neurology. 2000;22:49-52.  Abstract
  • Mikati, MA; Kramer, U; Zupanc, ML; Shanahan, RJ. Alternating hemiplegia of childhood: clinical manifestations and long-term outcome. Pediatric Neurology. 2000;23:134-141.  Abstract
  • Mikati, MA; Saab, R. Successful use of intravenous immunoglobulin as initial monotherapy in Landau-Kleffner syndrome. Epilepsia. 2000;41:880-886.  Abstract
  • Mikati, M. Alternating hemiplegia of childhood. Pediatric Neurology. 1999;21:764.  Abstract
  • Mikati, MA; Werner, S; Gatt, A; Liu, Z; Rahmeh, AA; Rachid, RA; Stafstrom, CE; Holmes, GL. Consequences of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor blockade during status epilepticus in the developing brain. Developmental Brain Research. 1999;113:139-142.  Abstract
  • Sawaya, RA; Mourad, FH; Najjar, S; Mikati, M; Raymond, GV. Adrenoleukodystrophy associated with vitiligo and ulcerative colitis. European neurology. 1999;42:169-172.  Abstract
  • Simaan, EM; Mikati, MA; Touma, EH; Rötig, A. Unusual presentation of Kearns-Sayre syndrome in early childhood. Pediatric Neurology. 1999;21:830-831.  Abstract
  • Yunis, KA; Bitar, FF; Hayek, P; Mroueh, SM; Mikati, M. Transient hypertrophic cardiomyopathy in the newborn following multiple doses of antenatal corticosteroids. American Journal of Perinatology. 1999;16:17-21.  Abstract
  • Bolanos, AR; Sarkisian, M; Yang, Y; Hori, A; Helmers, SL; Mikati, M; Tandon, P; Stafstrom, CE; Holmes, GL. Comparison of valproate and phenobarbital treatment after status epilepticus in rats. Neurology. 1998;51:41-48.  Abstract
  • Itani, MH; Mikati, MA. Early onset neonatal spontaneous pneumopericardium. Le Journal medical libanais. The Lebanese medical journal. 1998;46:165-167.  Abstract
  • Kramer, U; Carmant, L; Mikati, MA. Electroencephalographic discharges of temporal lobe seizures in children and young adults. Electroencephalography and Clinical Neurophysiology. 1998;107:353-360.  Abstract
  • Mikati, M; Fayad, M; Choueri, R. IVIG in Landau-Kleffner syndrome. Pediatric Neurology. 1998;19:399-400.  Abstract
  • Mikati, MA; Choueri, R; Khurana, DS; Riviello, J; Helmers, S; Holmes, G. Gabapentin in the treatment of refractory partial epilepsy in children with intellectual disability. Journal of Intellectual Disability Research. 1998;42 Suppl 1:57-62.  Abstract
  • Dangond, F; Garada, B; Murawski, BJ; Rey-Casserly, C; Holman, BL; Mikati, MA. Focal brain dysfunction in a 41-year old man with familial alternating hemiplegia. European Archives of Psychiatry and Clinical Neuroscience. 1997;247:35-41.  Abstract
  • Fayad, MN; Choueiri, R; Mikati, M. Landau-Kleffner syndrome: consistent response to repeated intravenous gamma-globulin doses: a case report. Epilepsia. 1997;38:489-494.  Abstract
  • Kramer, U; Sue, WC; Mikati, MA. Focal features in West syndrome indicating candidacy for surgery. Pediatric Neurology. 1997;16:213-217.  Abstract
  • Kramer, U; Sue, WC; Mikati, MA. Hypsarrhythmia: frequency of variant patterns and correlation with etiology and outcome. Neurology. 1997;48:197-203.  Abstract
  • Mikati, MA; Holmes, GL. Lamotrigine in absence and primary generalized epilepsies. Journal of Child Neurology. 1997;12 Suppl 1:S29-S37.  Abstract
  • Stafstrom, CE; Tandon, P; Hori, A; Liu, Z; Mikati, MA; Holmes, GL. Acute effects of MK801 on kainic acid-induced seizures in neonatal rats. Epilepsy Research. 1997;26:335-344.  Abstract
  • Carmant, L; Carrazana, E; Kramer, U; Helmers, SL; Holmes, GL; Black, PM; Mikati, MA. Pharyngeal dysesthesia as an aura in temporal lobe epilepsy. Epilepsia. 1996;37:911-913.  Abstract
  • Carmant, L; Kramer, U; Holmes, GL; Mikati, MA; Riviello, JJ; Helmers, SL. Differential diagnosis of staring spells in children: a video-EEG study. Pediatric Neurology. 1996;14:199-202.  Abstract
  • Khurana, DS; Riviello, J; Helmers, S; Holmes, G; Anderson, J; Mikati, MA. Efficacy of gabapentin therapy in children with refractory partial seizures. The Journal of Pediatrics. 1996;128:829-833.  Abstract
  • Lee, DO; Steingard, RJ; Cesena, M; Helmers, SL; Riviello, JJ; Mikati, MA. Behavioral side effects of gabapentin in children. Epilepsia. 1996;37:87-90.  Abstract
  • Tandon, P; Liu, Z; Stafstrom, CE; Sarkisian, M; Werner, SJ; Mikati, M; Yang, Y; Holmes, GL. Long-term effects of excitatory amino acid antagonists NBQX and MK-801 on the developing brain. Developmental Brain Research. 1996;95:256-262.  Abstract
  • Adelson, PD; Black, PM; Madsen, JR; Kramer, U; Rockoff, MA; Riviello, JJ; Helmers, SL; Mikati, M; Holmes, GL. Use of subdural grids and strip electrodes to identify a seizure focus in children. Pediatric neurosurgery. 1995;22:174-180.  Abstract
  • Carmant, L; Kramer, U; Mikati, MA; Riviello, JJ; Helmers, SL; Holmes, GL. Pseudoseizure manifestations in two preschool age children. Seizure - European Journal of Epilepsy. 1995;4:147-149.  Abstract
  • Carmant, L; Kramer, U; Riviello, JJ; Helmers, SL; Mikati, MA; Madsen, JR; Black, PM; Lombroso, CT; Holmes, GL. EEG prior to hemispherectomy: correlation with outcome and pathology. Electroencephalography and Clinical Neurophysiology. 1995;94:265-270.  Abstract
  • Carmant, L; Liu, Z; Werner, SJ; Mikati, MA; Holmes, GL. Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals. Developmental Brain Research. 1995;89:67-72.  Abstract
  • Kramer, U; Carmant, L; Riviello, JJ; Stauffer, A; Helmers, SL; Mikati, MA; Holmes, GL. Psychogenic seizures: video telemetry observations in 27 patients. Pediatric Neurology. 1995;12:39-41.  Abstract
  • Liu, Z; Mikati, M; Holmes, GL. Mesial temporal sclerosis: pathogenesis and significance. Pediatric Neurology. 1995;12:5-16.  Abstract
  • Lynch, BJ; O'Tuama, LA; Treves, ST; Mikati, M; Holmes, GL. Correlation of 99mTc-HMPAO SPECT with EEG monitoring: prognostic value for outcome of epilepsy surgery in children. Brain & Development. 1995;17:409-417.  Abstract
  • Rifai, N; Sakamoto, M; Law, T; Platt, O; Mikati, M; Armsby, CC; Brugnara, C. HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent. Clinical chemistry. 1995;41:387-391.  Abstract
  • Riviello, JJ; Helmers, SL; Mikati, M; Holmes, GL. The preoperative evaluation of the child with epilepsy. Neurosurgery Clinics of North America. 1995;6:431-442.  Abstract
  • Carmant, L; Holmes, GL; Sawyer, S; Rifai, N; Anderson, J; Mikati, MA. Efficacy of felbamate in therapy for partial epilepsy in children. The Journal of Pediatrics. 1994;125:481-486.  Abstract
  • Carmant, L; O'Tuama, LA; Roach, PJ; Kramer, U; Mikati, MA; Riviello, JJ; Helmers, SL; Madsen, JR; Black, PM; Lombroso, CT. Technetium-99m HmPAO brain SPECT and outcome of hemispherectomy for intractable seizures. Pediatric Neurology. 1994;11:203-207.  Abstract
  • Liu, Z; Gatt, A; Werner, SJ; Mikati, MA; Holmes, GL. Long-term behavioral deficits following pilocarpine seizures in immature rats. Epilepsy Research. 1994;19:191-204.  Abstract
  • Malow, BA; Lynch, B; Blaxton, TA; Mikati, MA. Relationship of carbamazepine reduction rate to seizure frequency during inpatient telemetry. Epilepsia. 1994;35:1160-1164.  Abstract
  • Mikati, MA; Holmes, GL; Chronopoulos, A; Hyde, P; Thurber, S; Gatt, A; Liu, Z; Werner, S; Stafstrom, CE. Phenobarbital modifies seizure-related brain injury in the developing brain. Annals of Neurology. 1994;36:425-433.  Abstract
  • Pledger, GW; Sackellares, JC; Treiman, DM; Pellock, JM; Wright, FS; Mikati, M; Sahlroot, JT; Tsay, JY; Drake, ME; Olson, L. Flunarizine for treatment of partial seizures: results of a concentration-controlled trial. Neurology. 1994;44:1830-1836.  Abstract
  • Rifai, N; Fuller, D; Law, T; Mikati, M. Measurement of felbamate by wide-bore capillary gas chromatography and flame ionization detection. Clinical chemistry. 1994;40:745-748.  Abstract
  • Thurber, SJ; Mikati, MA; Stafstrom, CE; Jensen, FE; Holmes, GL. Quisqualic acid-induced seizures during development: a behavioral and EEG study. Epilepsia. 1994;35:868-875.  Abstract
  • Carrazana, EJ; Lombroso, CT; Mikati, M; Helmers, S; Holmes, GL. Facilitation of infantile spasms by partial seizures. Epilepsia. 1993;34:97-109.  Abstract
  • Chronopoulos, A; Stafstrom, C; Thurber, S; Hyde, P; Mikati, M; Holmes, GL. Neuroprotective effect of felbamate after kainic acid-induced status epilepticus. Epilepsia. 1993;34:359-366.  Abstract
  • Holmes, GL; Chronopoulos, A; Stafstrom, CE; Mikati, MA; Thurber, SJ; Hyde, PA; Thompson, JL. Effects of kindling on subsequent learning, memory, behavior, and seizure susceptibility. Developmental Brain Research. 1993;73:71-77.  Abstract
  • Holmes, GL; Thurber, SJ; Liu, Z; Stafstrom, CE; Gatt, A; Mikati, MA. Effects of quisqualic acid and glutamate on subsequent learning, emotionality, and seizure susceptibility in the immature and mature animal. Brain Research. 1993;623:325-328.  Abstract
  • Liu, Z; D'Amore, PA; Mikati, M; Gatt, A; Holmes, GL. Neuroprotective effect of chronic infusion of basic fibroblast growth factor on seizure-associated hippocampal damage. Brain Research. 1993;626:335-338.  Abstract
  • Liu, Z; Gatt, A; Mikati, M; Holmes, GL. Effect of temperature on kainic acid-induced seizures. Brain Research. 1993;631:51-58.  Abstract
  • Browne, TR; Feldman, RG; Mikati, MA; Burdette, D; Otis, J. A nineteen-year-old man with altered mental status. Journal of Clinical Pharmacology. 1992;32:511-519.  Abstract
  • Finberg, RW; Newburger, JW; Mikati, MA; Heller, AH; Burns, JC. Effect of high doses of intravenously administered immune globulin on natural killer cell activity in peripheral blood. The Journal of Pediatrics. 1992;120:376-380.  Abstract
  • Mikati, M; Bassett, N; Schachter, S. Double-blind randomized study comparing brand-name and generic phenytoin monotherapy. Epilepsia. 1992;33:359-365.  Abstract
  • Mikati, MA; Maguire, H; Barlow, CF; Ozelius, L; Breakefield, XO; Klauck, SM; Korf, B; O'Tuama, SL; Dangond, F. A syndrome of autosomal dominant alternating hemiplegia: clinical presentation mimicking intractable epilepsy; chromosomal studies; and physiologic investigations. Neurology. 1992;42:2251-2257.  Abstract
  • Liu, GT; Carrazana, EJ; Macklis, JD; Mikati, MA. Delayed oculogyric crises associated with striatocapsular infarction. Journal of Clinical Neuro-Ophthalmology. 1991;11:198-201.  Abstract
  • Mikati, M. The newer antiepileptic drugs: carbamazepine and valproic acid. Pediatric annals. 1991;20:34-40.  Abstract
  • Mikati, MA; Trevathan, E; Krishnamoorthy, KS; Lombroso, CT. Pyridoxine-dependent epilepsy: EEG investigations and long-term follow-up. Electroencephalography and Clinical Neurophysiology. 1991;78:215-221.  Abstract
  • Mikati, M. Approach to epilepsy in children. The Indian Journal of Pediatrics. 1990;57:297-312.  Abstract
  • Mikati, MA; Feraru, E; Krishnamoorthy, K; Lombroso, CT. Neonatal herpes simplex meningoencephalitis: EEG investigations and clinical correlates. Neurology. 1990;40:1433-1437.  Abstract
  • Mikati, MA; Browne, TR; Collins, JF. Time course of carbamazepine autoinduction. The VA Cooperative Study No.118 Group. Neurology. 1989;39:592-594.  Abstract
  • Mikati, MA; Schachter, SC; Schomer, DL; Keally, M; Osborne-Shafer, P; Seaman, CA; Sheridan, PH; Ashworth, M; Kupferberg, H; Valakas, A. Long-term tolerability, pharmacokinetic and preliminary efficacy study of lamotrigine in patients with resistant partial seizures. Clinical Neuropharmacology. 1989;12:312-321.  Abstract
  • Browne, TR; Szabo, GK; Evans, J; Evans, BA; Greenblatt, DJ; Mikati, MA. Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics. Neurology. 1988;38:639-642.  Abstract
  • Browne, TR; Szabo, GK; Evans, JE; Evans, BA; Greenblatt, DJ; Mikati, MA. Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance. Neurology. 1988;38:1146-1150.  Abstract
  • Mikati, MA; Browne, TR. Comparative efficacy of antiepileptic drugs. Clinical Neuropharmacology. 1988;11:130-140.  Abstract
  • Mikati, MA; Szabo, GK; Pylilo, RJ; LeDuc, BW; Browne, TR; Greenblatt, DJ. Improved high-performance liquid chromatographic assay of antipyrine, hydroxymethylantipyrine, 4-hydroxyantipyrine and norantipyrine in urine. 1988;433:305-311.  Abstract
  • Mansour, AM; Laibson, PD; Reinecke, RD; Henkind, P; Mikati, M. Bilateral total corneal and conjunctival choristomas associated with epidermal nevus. Archives of Ophthalmology. 1986;104:245-248.  Abstract
  • Der Kaloustian, VM; Jarudi, NI; Khoury, MJ; Afifi, AK; Bahuth, NB; Deeb, ME; Shammas, J; Mikati, MA. Familial spinocerebellar degeneration with corneal dystrophy. American Journal of Medical Genetics Part A. 1985;20:325-339.  Abstract
  • Mikati, MA; DeLong, GR. Childhood Guillain-Barré syndrome masquerading as a protracted pain syndrome. Archives of Neurology. 1985;42:839.  Abstract
  • Mikati, MA; Krishnamoorthy, KS. Hypoglycorrhachia in neonatal herpes simplex virus meningoencephalitis. The Journal of Pediatrics. 1985;107:746-748.  Abstract
  • Mikati, MA; Lee, WL; DeLong, GR. Protracted epileptiform encephalopathy: an unusual form of partial complex status epilepticus. Epilepsia. 1985;26:563-571.  Abstract
  • Mikati, MA; Najjar, SS; Sahli, IF; Melhem, RE; Mansour, S; Der Kaloustian, VM. Microcephaly, hypergonadotropic hypogonadism, short stature, and minor anomalies: a new syndrome. American Journal of Medical Genetics Part A. 1985;22:599-608.  Abstract
  • Mikati, MA; Barakat, AY; Sulh, HB; Der Kaloustian, VM. Renal tubular insufficiency, cholestatic jaundice, and multiple congenital anomalies--a new multisystem syndrome. Helvetica Paediatrica Acta. 1984;39:463-471.  Abstract
  • Jaatoul, NY; Haddad, NE; Khoury, LA; Afifi, AK; Bahuth, NB; Deeb, ME; Mikati, MA; Der Kaloustian, VM. Brief clinical report and review: the Marden-Walker syndrome. American Journal of Medical Genetics Part A. 1982;11:259-271.  Abstract
  • Mardini, MK; Mikati, MA; Lifeso, R. Hypertension encephalopathy: rare complication after orthopedic manipulation. American Journal of Diseases of Children. 1982;136:1092-1094.  Abstract
  • Mikati, MA; Dudin, GE; Der Kaloustian, VM; Benson, PF; Fensom, AH. Maple syrup urine disease with increased intracranial pressure. American Journal of Diseases of Children. 1982;136:642-643.  Abstract
  • Mikati, MA; Melhem, RE; Najjar, SS. The syndrome of hyperostosis and hyperphosphatemia. The Journal of Pediatrics. 1981;99:900-904.  Abstract