Coleen K. Cunningham, MD



email this

Professor of Pediatrics
Research Professor of Global Health
Professor of Pathology
Chief, Division of Pediatric Infectious Diseases
Chief, Division of Pediatric Global Health
Department / Division:
Pediatrics / Pediatrics-Infectious Diseases
DUMC 3499
Durham, NC 27710
Appointment Telephone:
Office Telephone:
  • MD, State University of New York Upstate Medical University College of Medicine, 1985
  • Pediatrics, State University of New York Health Science Center–Syracuse, 1985-1988
  • Pediatric Infectious Disease, State University of New York Health Science Center–Syracuse, 1988-1991
Clinical Interests:
Infections, unexplained fevers, meningitis, pneumonia, bone and joint infections, viral disease, pediatric HIV
Research Interests:
Dr. Cunningham is a pediatric infectious diseases physician who has focused her research on the prevention and treatment of HIV infection in children.  She has also played important roles in evaluation of vaccines for other infectious diseases and recently has worked on Ebola virus treatment studies.  She is currently working on studies of active and passive immunization to prevent HIV transmission in neonates born to HIV infected women.
Representative Publications:
  • Berry, SM; Petzold, EA; Dull, P; Thielman, NM; Cunningham, CK; Corey, GR; McClain, MT; Hoover, DL; Russell, J; Griffiss, JM; Woods, CW. A response adaptive randomization platform trial for efficient evaluation of Ebola virus treatments: A model for pandemic response. Clinical Trials. 2016;13:22-30.  Abstract
  • Dow, DE; Turner, EL; Shayo, AM; Mmbaga, B; Cunningham, CK; O'Donnell, K. Evaluating mental health difficulties and associated outcomes among HIV-positive adolescents in Tanzania. AIDS Care. 2016;1-9.  Abstract
  • Thielman, NM; Cunningham, CK; Woods, C; Petzold, E; Sprenz, M; Russell, J. Ebola clinical trials: Five lessons learned and a way forward. Clinical Trials. 2016;13:83-86.  Abstract
  • Fouda, GG; Cunningham, CK; McFarland, EJ; Borkowsky, W; Muresan, P; Pollara, J; Song, LY; Liebl, BE; Whitaker, K; Shen, X; Vandergrift, NA; Overman, RG; Yates, NL; Moody, MA; Fry, C; Kim, JH; Michael, NL; Robb, M; Pitisuttithum, P; Kaewkungwal, J; Nitayaphan, S; Rerks-Ngarm, S; Liao, HX; Haynes, BF; Montefiori, DC; Ferrari, G; Tomaras, GD; Permar, SR. Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses. Journal of Infectious Diseases. 2015;211:508-517.  Abstract
  • Fouda, GG; Cunningham, CK; Permar, SR. Infant HIV-1 vaccines: supplementing strategies to reduce maternal-child transmission. JAMA : the journal of the American Medical Association. 2015;313:1513-1514.  Abstract
  • Kelly, MS; Smieja, M; Luinstra, K; Wirth, KE; Goldfarb, DM; Steenhoff, AP; Arscott-Mills, T; Cunningham, CK; Boiditswe, S; Sethomo, W; Shah, SS; Finalle, R; Feemster, KA. Association of respiratory viruses with outcomes of severe childhood pneumonia in Botswana. PloS one. 2015;10:e0126593.  Abstract
  • Kelly, MS; Wirth, KE; Madrigano, J; Feemster, KA; Cunningham, CK; Arscott-Mills, T; Boiditswe, S; Shah, SS; Finalle, R; Steenhoff, AP. The effect of exposure to wood smoke on outcomes of childhood pneumonia in Botswana. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 2015;19:349-355.  Abstract
  • Kelly, MS; Wirth, KE; Steenhoff, AP; Cunningham, CK; Arscott-Mills, T; Boiditswe, SC; Patel, MZ; Shah, SS; Finalle, R; Makone, I; Feemster, KA. Treatment Failures and Excess Mortality Among HIV-Exposed, Uninfected Children With Pneumonia. Journal of the Pediatric Infectious Diseases Society. 2015;4:e117-e126.  Abstract
  • Rehder, KJ; Wilson, EA; Zimmerman, KO; Cunningham, CK; Turner, DA. Detection of Multiple Respiratory Viruses Associated With Mortality and Severity of Illness in Children. Pediatric Critical Care Medicine. 2015;16:e201-e206.  Abstract
  • Fouda, GG; Cunningham, CK; McFarland, EJ; Borkowsky, W; Muresan, P; Liebl, BE; Liao, H; Haynes, BF; Overman, R; Yates, NL; Tomaras, GD; Permar, SR. HIV-1 gp120 Vaccination Elicits a Robust and Durable Anti-V1/V2 IgG Response and Yet No HIV-1 Env-Specific IgA Response in HIV-Exposed Infants. AIDS Research and Human Retroviruses. A13-A14.  
  • Lee, S; Kapogiannis, BG; Flynn, PM; Rudy, BJ; Bethel, J; Ahmad, S; Tucker, D; Abdalian, SE; Hoffman, D; Wilson, CM; Cunningham, CK. Comprehension of a simplified assent form in a vaccine trial for adolescents. Journal of medical ethics. 2013;39:410-412.  
  • Pilakka-Kanthikeel, S; Huang, S; Fenton, T; Borkowsky, W; Cunningham, CK; Pahwa, S. Increased gut microbial translocation in HIV-infected children persists in virologic responders and virologic failures after antiretroviral therapy. Pediatric Infectious Disease Journal. 2012;31:583-591.  Abstract
  • Crump, JA; Ramadhani, HO; Morrissey, AB; Msuya, LJ; Yang, LY; Chow, SC; Morpeth, SC; Reyburn, H; Njau, BN; Shaw, AV; Diefenthal, HC; Bartlett, JA; Shao, JF; Schimana, W; Cunningham, CK; Kinabo, GD. Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected children and infants in northern Tanzania. Tropical Medicine & International Health. 2011;16:830-837.  Abstract
  • Flynn, PM; Cunningham, CK; Rudy, B; Wilson, CM; Kapogiannis, B; Worrell, C; Bethel, J; Monte, D; Bojan, K; Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN). Hepatitis B vaccination in HIV-infected youth: a randomized trial of three regimens. Journal of Acquired Immune Deficiency Syndromes. 2011;56:325-332.  Abstract
  • Persaud, D; Luzuriaga, K; Ziemniak, C; Muresan, P; Greenough, T; Fenton, T; Blackford, A; Ferguson, K; Neu, N; Cunningham, CK. Effect of therapeutic HIV recombinant poxvirus vaccines on the size of the resting CD4+ T-cell latent HIV reservoir. AIDS. 2011;25:2227-2234.  Abstract
  • Watts, DH; Huang, S; Culnane, M; Kaiser, KA; Scheuerle, A; Mofenson, L; Stanley, K; Newell, ML; Mandelbrot, L; Delfraissy, JF; Cunningham, CK. Birth defects among a cohort of infants born to HIV-infected women on antiretroviral medication. Journal of Perinatal Medicine. 2011;39:163-170.  Abstract
  • Buchanan, AM; Muro, FJ; Gratz, J; Crump, JA; Musyoka, AM; Sichangi, MW; Morrissey, AB; M'rimberia, JK; Njau, BN; Msuya, LJ; Bartlett, JA; Cunningham, CK. Establishment of haematological and immunological reference values for healthy Tanzanian children in Kilimanjaro Region. Tropical Medicine & International Health. 2010;15:1011-1021.  Abstract
  • Cunningham, CK; Rudy, BJ; Xu, J; Bethel, J; Kapogiannis, BG; Ahmad, S; Wilson, CM; Flynn, PM; Adolescent Medicine Trials Network for HIV/AIDS Interventions. Randomized trial to determine safety and immunogenicity of two strategies for hepatitis B vaccination in healthy urban adolescents in the United States. Pediatric Infectious Disease Journal. 2010;29:530-534.  Abstract
  • Emmett, SD; Cunningham, CK; Mmbaga, BT; Kinabo, GD; Schimana, W; Swai, ME; Bartlett, JA; Crump, JA; Reddy, EA. Predicting virologic failure among HIV-1-infected children receiving antiretroviral therapy in Tanzania: a cross-sectional study. Journal of Acquired Immune Deficiency Syndromes. 2010;54:368-375.  Abstract
  • Buchanan, AM; Cunningham, CK. Advances and failures in preventing perinatal human immunodeficiency virus infection. Clinical microbiology reviews. 2009;22:493-507.  Abstract
  • Johnson, OO; Benjamin, DK; Benjamin, DK; Schimana, W; Tillekeratne, LG; Crump, JA; Landman, KZ; Kinabo, GD; Mmbaga, B; Msuya, LJ; Shao, JF; Swai, ME; Cunningham, CK. Total lymphocyte count and World Health Organization pediatric clinical stage as markers to assess need to initiate antiretroviral therapy among human immunodeficiency virus-infected children in Moshi, Northern Tanzania. Pediatric Infectious Disease Journal. 2009;28:493-497.  Abstract
  • Rudy, BJ; Sleasman, J; Kapogiannis, B; Wilson, CM; Bethel, J; Serchuck, L; Ahmad, S; Cunningham, CK; Adolescent Trials Network for HIV/AIDS Interventions. Short-cycle therapy in adolescents after continuous therapy with established viral suppression: the impact on viral load suppression. AIDS Research and Human Retroviruses. 2009;25:555-561.  Abstract
  • Shiu, C; Cunningham, CK; Greenough, T; Muresan, P; Sanchez-Merino, V; Carey, V; Jackson, JB; Ziemniak, C; Fox, L; Belzer, M; Ray, SC; Luzuriaga, K; Persaud, D; Pediatric AIDS Clinical Trials Group P1059 Team. Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy. Journal of virology. 2009;83:9731-9742.  Abstract
  • Greenough, TC; Cunningham, CK; Muresan, P; McManus, M; Persaud, D; Fenton, T; Barker, P; Gaur, A; Panicali, D; Sullivan, JL; Luzuriaga, K; Pediatric AIDS Clinical Trials Group P1059 Team. Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy. Vaccine. 2008;26:6883-6893.  Abstract
  • Jaspan, HB; Cunningham, CK; Tucker, TJ; Wright, PF; Self, SG; Sheets, RL; Rogers, AS; Bekker, LG; Wilson, CM; Duerr, A; Wasserheit, JN; HIV Vaccine Adolescent Trials Working Group. Inclusion of adolescents in preventive HIV vaccine trials: public health policy and research design at a crossroads. Journal of Acquired Immune Deficiency Syndromes. 2008;47:86-92.  Abstract
  • Kiser, JJ; Fletcher, CV; Flynn, PM; Cunningham, CK; Wilson, CM; Kapogiannis, BG; Major-Wilson, H; Viani, RM; Liu, NX; Muenz, LR; Harris, DR; Havens, PL; Adolescent Trials Network for HIV/AIDS Interventions. Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection. Antimicrobial agents and chemotherapy. 2008;52:631-637.  Abstract
  • Dixon, TC; Cunningham, CK. Treatment of children with HIV infection. Current HIV/AIDS Reports. 2007;4:93-99.  Abstract
  • Ku, CL; von Bernuth, H; Picard, C; Zhang, SY; Chang, HH; Yang, K; Chrabieh, M; Issekutz, AC; Cunningham, CK; Gallin, J; Holland, SM; Roifman, C; Ehl, S; Smart, J; Tang, M; Barrat, FJ; Levy, O; McDonald, D; Day-Good, NK; Miller, R; Takada, H; Hara, T; Al-Hajjar, S; Al-Ghonaium, A; Speert, D; Sanlaville, D; Li, X; Geissmann, F; Vivier, E; Maródi, L; Garty, BZ; Chapel, H; Rodriguez-Gallego, C; Bossuyt, X; Abel, L; Puel, A; Casanova, JL. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. The Journal of Experimental Medicine. 2007;204:2407-2422.  Abstract
  • McKinney, RE; Rodman, J; Hu, C; Britto, P; Hughes, M; Smith, ME; Serchuck, LK; Kraimer, J; Ortiz, AA; Flynn, P; Yogev, R; Spector, S; Draper, L; Tran, P; Scites, M; Dickover, R; Weinberg, A; Cunningham, C; Abrams, E; Blum, MR; Chittick, GE; Reynolds, L; Rathore, M; Pediatric AIDS Clinical Trials Group Protocol P1021 Study Team. Long-term safety and efficacy of a once-daily regimen of emtricitabine, didanosine, and efavirenz in HIV-infected, therapy-naive children and adolescents: Pediatric AIDS Clinical Trials Group Protocol P1021. Pediatrics. 2007;120:e416-e423.  Abstract
  • Newell, ML; Huang, S; Fiore, S; Thorne, C; Mandelbrot, L; Sullivan, JL; Maupin, R; Delke, I; Watts, DH; Gelber, RD; Cunningham, CK; PACTG 316 Study Team. Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA. BMC Infectious Diseases. 2007;7:60.  Abstract
  • Witt, KL; Cunningham, CK; Patterson, KB; Kissling, GE; Dertinger, SD; Livingston, E; Bishop, JB. Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV. Environmental and Molecular Mutagenesis. 2007;48:322-329.  Abstract
  • Church, JA; Hughes, M; Chen, J; Palumbo, P; Mofenson, LM; Delora, P; Smith, E; Wiznia, A; Hawkins, E; Sista, P; Cunningham, CK; Pediatric AIDS Clinical Trials Group P1005 Study Team. Long term tolerability and safety of enfuvirtide for human immunodeficiency virus 1-infected children. Pediatric Infectious Disease Journal. 2004;23:713-718.  Abstract
  • Cunningham, CK; Balasubramanian, R; Delke, I; Maupin, R; Mofenson, L; Dorenbaum, A; Sullivan, JL; Gonzalez-Garcia, A; Thorpe, E; Rathore, M; Gelber, RD. The impact of race/ethnicity on mother-to-child HIV transmission in the United States in Pediatric AIDS Clinical Trials Group Protocol 316. Journal of Acquired Immune Deficiency Syndromes. 2004;36:800-807.  Abstract
  • Watts, DH; Balasubramanian, R; Maupin, RT; Delke, I; Dorenbaum, A; Fiore, S; Newell, ML; Delfraissy, JF; Gelber, RD; Mofenson, LM; Culnane, M; Cunningham, CK; PACTG 316 Study Team. Maternal toxicity and pregnancy complications in human immunodeficiency virus-infected women receiving antiretroviral therapy: PACTG 316. American Journal of Obstetrics & Gynecology. 2004;190:506-516.  Abstract
  • Church, JA; Cunningham, C; Hughes, M; Palumbo, P; Mofenson, LM; Delora, P; Smith, E; Wiznia, A; Purdue, L; Hawkins, E; Sista, P; PACTG P1005 Study Team. Pediatric AIDS Clinical Trials Group. Safety and antiretroviral activity of chronic subcutaneous administration of T-20 in human immunodeficiency virus 1-infected children. Pediatric Infectious Disease Journal. 2002;21:653-659.  Abstract
  • Cunningham, CK; Chaix, ML; Rekacewicz, C; Britto, P; Rouzioux, C; Gelber, RD; Dorenbaum, A; Delfraissy, JF; Bazin, B; Mofenson, L; Sullivan, JL. Development of resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus type 1 transmission: a substudy of pediatric AIDS clinical trials group protocol 316. Journal of Infectious Diseases. 2002;186:181-188.  Abstract
  • Dorenbaum, A; Cunningham, CK; Gelber, RD; Culnane, M; Mofenson, L; Britto, P; Rekacewicz, C; Newell, ML; Delfraissy, JF; Cunningham-Schrader, B; Mirochnick, M; Sullivan, JL; International PACTG 316 Team. Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trial. JAMA : the journal of the American Medical Association. 2002;288:189-198.  Abstract
  • Cunningham, CK; Wara, DW; Kang, M; Fenton, T; Hawkins, E; McNamara, J; Mofenson, L; Duliege, AM; Francis, D; McFarland, EJ; Borkowsky, W; Pediatric AIDS Clinical Trials Group 230 Collaborators. Safety of 2 recombinant human immunodeficiency virus type 1 (HIV-1) envelope vaccines in neonates born to HIV-1-infected women. Clinical Infectious Diseases. 2001;32:801-807.  Abstract
  • McFarland, EJ; Borkowsky, W; Fenton, T; Wara, D; McNamara, J; Samson, P; Kang, M; Mofenson, L; Cunningham, C; Duliege, AM; Sinangil, F; Spector, SA; Jimenez, E; Bryson, Y; Burchett, S; Frenkel, LM; Yogev, R; Gigliotti, F; Luzuriaga, K; Livingston, RA; AIDS Clinical Trials Group 230 Collaborators. Human immunodeficiency virus type 1 (HIV-1) gp120-specific antibodies in neonates receiving an HIV-1 recombinant gp120 vaccine. Journal of Infectious Diseases. 2001;184:1331-1335.  Abstract
  • Borkowsky, W; Wara, D; Fenton, T; McNamara, J; Kang, M; Mofenson, L; McFarland, E; Cunningham, C; Duliege, AM; Francis, D; Bryson, Y; Burchett, S; Spector, SA; Frenkel, LM; Starr, S; Van Dyke, R; Jimenez, E. Lymphoproliferative responses to recombinant HIV-1 envelope antigens in neonates and infants receiving gp120 vaccines. AIDS Clinical Trial Group 230 Collaborators. Journal of Infectious Diseases. 2000;181:890-896.  Abstract
  • Cunningham, CK; Bonville, CA; Ochs, HD; Seyama, K; John, PA; Rotbart, HA; Weiner, LB. Enteroviral meningoencephalitis as a complication of X-linked hyper IgM syndrome. The Journal of Pediatrics. 1999;134:584-588.  Abstract
  • Cunningham, CK; Charbonneau, TT; Song, K; Patterson, D; Sullivan, T; Cummins, T; Poiesz, B. Comparison of human immunodeficiency virus 1 DNA polymerase chain reaction and qualitative and quantitative RNA polymerase chain reaction in human immunodeficiency virus 1-exposed infants. Pediatric Infectious Disease Journal. 1999;18:30-35.  Abstract
  • Coplan, J; Contello, KA; Cunningham, CK; Weiner, LB; Dye, TD; Roberge, L; Wojtowycz, MA; Kirkwood, K. Early language development in children exposed to or infected with human immunodeficiency virus. Pediatrics. 1998;102:e8.  Abstract
  • Coplan, J; Dye, TD; Contello, KA; Cunningham, CK; Kirkwood, K; Weiner, LB. Failure to identify human immunodeficiency virus-seropositive newborns: epidemiology and enrollment patterns in a predominantly white, nonurban setting. Pediatrics. 1995;96:1083-1089.  Abstract
  • Flynn, PM; Cunningham, CK; Kerkering, T; San Jorge, AR; Peters, VB; Pitel, PA; Harris, J; Gilbert, G; Castagnaro, L; Robinson, P. Oropharyngeal candidiasis in immunocompromised children: a randomized, multicenter study of orally administered fluconazole suspension versus nystatin. The Multicenter Fluconazole Study Group. The Journal of Pediatrics. 1995;127:322-328.  Abstract
  • Cunningham, CK; McMillan, JA; Gross, SJ. Rehospitalization for respiratory illness in infants of less than 32 weeks' gestation. Pediatrics. 1991;88:527-532.  Abstract