Coleen K. Cunningham, MD

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Professor of Pediatrics
Professor of Pathology
Chief, Division of Pediatric Infectious Diseases
Chief, Division of Pediatric Global Health
Department / Division:
Pediatrics / Pediatrics-Infectious Diseases
Address:
DUMC 3499
Durham, NC 27710
Appointment Telephone:
919-668-4000
Office Telephone:
919-684-6335
Fax:
919-668-4859
Training:
  • MD, State University of New York Upstate Medical University College of Medicine, 1985
Residency:
  • Pediatrics, State University of New York Health Science Center–Syracuse, 1985-1988
Fellowship:
  • Pediatric Infectious Disease, State University of New York Health Science Center–Syracuse, 1988-1991
Clinical Interests:
Infections, unexplained fevers, meningitis, pneumonia, bone and joint infections, viral disease, pediatric HIV
Research Interests:
Pediatric HIV treatment
Prevention of perinatal transmission of HIV
Care of HIV infected children in the International setting
HIV vaccine in children and adolescents
Respiratory viral infections and vaccine
Ebola virus disease
Representative Publications:
  • Pilakka-Kanthikeel, S; Huang, S; Fenton, T; Borkowsky, W; Cunningham, CK; Pahwa, S. Increased gut microbial translocation in HIV-infected children persists in virologic responders and virologic failures after antiretroviral therapy. Pediatric Infectious Disease Journal. 2012;31:583-591.  Abstract
  • Crump, JA; Ramadhani, HO; Morrissey, AB; Msuya, LJ; Yang, LY; Chow, SC; Morpeth, SC; Reyburn, H; Njau, BN; Shaw, AV; Diefenthal, HC; Bartlett, JA; Shao, JF; Schimana, W; Cunningham, CK; Kinabo, GD. Invasive bacterial and fungal infections among hospitalized HIV-infected and HIV-uninfected children and infants in northern Tanzania. Tropical Medicine and International Health. 2011;16:830-837.  Abstract
  • Flynn, PM; Cunningham, CK; Rudy, B; Wilson, CM; Kapogiannis, B; Worrell, C; Bethel, J; Monte, D; Bojan, K; Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN). Hepatitis B vaccination in HIV-infected youth: a randomized trial of three regimens. JAIDS: Journal of Acquired Immune Deficiency Syndromes. 2011;56:325-332.  Abstract
  • Persaud, D; Luzuriaga, K; Ziemniak, C; Muresan, P; Greenough, T; Fenton, T; Blackford, A; Ferguson, K; Neu, N; Cunningham, CK. Effect of therapeutic HIV recombinant poxvirus vaccines on the size of the resting CD4+ T-cell latent HIV reservoir. AIDS. 2011;25:2227-2234.  Abstract
  • Watts, DH; Huang, S; Culnane, M; Kaiser, KA; Scheuerle, A; Mofenson, L; Stanley, K; Newell, ML; Mandelbrot, L; Delfraissy, JF; Cunningham, CK. Birth defects among a cohort of infants born to HIV-infected women on antiretroviral medication. Journal of Perinatal Medicine: official journal of the World Association of Perinatal Medicine. 2011;39:163-170.  Abstract
  • Buchanan, AM; Muro, FJ; Gratz, J; Crump, JA; Musyoka, AM; Sichangi, MW; Morrissey, AB; M'rimberia, JK; Njau, BN; Msuya, LJ; Bartlett, JA; Cunningham, CK. Establishment of haematological and immunological reference values for healthy Tanzanian children in Kilimanjaro Region. Tropical Medicine and International Health. 2010;15:1011-1021.  Abstract
  • Cunningham, CK; Rudy, BJ; Xu, J; Bethel, J; Kapogiannis, BG; Ahmad, S; Wilson, CM; Flynn, PM; Adolescent Medicine Trials Network for HIV/AIDS Interventions. Randomized trial to determine safety and immunogenicity of two strategies for hepatitis B vaccination in healthy urban adolescents in the United States. Pediatric Infectious Disease Journal. 2010;29:530-534.  Abstract
  • Emmett, SD; Cunningham, CK; Mmbaga, BT; Kinabo, GD; Schimana, W; Swai, ME; Bartlett, JA; Crump, JA; Reddy, EA. Predicting virologic failure among HIV-1-infected children receiving antiretroviral therapy in Tanzania: a cross-sectional study. JAIDS: Journal of Acquired Immune Deficiency Syndromes. 2010;54:368-375.  Abstract
  • Buchanan, AM; Cunningham, CK. Advances and failures in preventing perinatal human immunodeficiency virus infection. Clinical Microbiology Reviews. 2009;22:493-507.  Abstract
  • Johnson, OO; Benjamin, DK; Benjamin, DK; Schimana, W; Tillekeratne, LG; Crump, JA; Landman, KZ; Kinabo, GD; Mmbaga, B; Msuya, LJ; Shao, JF; Swai, ME; Cunningham, CK. Total lymphocyte count and World Health Organization pediatric clinical stage as markers to assess need to initiate antiretroviral therapy among human immunodeficiency virus-infected children in Moshi, Northern Tanzania. Pediatric Infectious Disease Journal. 2009;28:493-497.  Abstract
  • Rudy, BJ; Sleasman, J; Kapogiannis, B; Wilson, CM; Bethel, J; Serchuck, L; Ahmad, S; Cunningham, CK; Adolescent Trials Network for HIV/AIDS Interventions. Short-cycle therapy in adolescents after continuous therapy with established viral suppression: the impact on viral load suppression. AIDS Research and Human Retroviruses. 2009;25:555-561.  Abstract
  • Shiu, C; Cunningham, CK; Greenough, T; Muresan, P; Sanchez-Merino, V; Carey, V; Jackson, JB; Ziemniak, C; Fox, L; Belzer, M; Ray, SC; Luzuriaga, K; Persaud, D; Pediatric AIDS Clinical Trials Group P1059 Team. Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy. Journal of Virology. 2009;83:9731-9742.  Abstract
  • Greenough, TC; Cunningham, CK; Muresan, P; McManus, M; Persaud, D; Fenton, T; Barker, P; Gaur, A; Panicali, D; Sullivan, JL; Luzuriaga, K; Pediatric AIDS Clinical Trials Group P1059 Team. Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy. Vaccine. 2008;26:6883-6893.  Abstract
  • Jaspan, HB; Cunningham, CK; Tucker, TJ; Wright, PF; Self, SG; Sheets, RL; Rogers, AS; Bekker, LG; Wilson, CM; Duerr, A; Wasserheit, JN; HIV Vaccine Adolescent Trials Working Group. Inclusion of adolescents in preventive HIV vaccine trials: public health policy and research design at a crossroads. JAIDS: Journal of Acquired Immune Deficiency Syndromes. 2008;47:86-92.  Abstract
  • Kiser, JJ; Fletcher, CV; Flynn, PM; Cunningham, CK; Wilson, CM; Kapogiannis, BG; Major-Wilson, H; Viani, RM; Liu, NX; Muenz, LR; Harris, DR; Havens, PL; Adolescent Trials Network for HIV/AIDS Interventions. Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection. Antimicrobial Agents and Chemotherapy. 2008;52:631-637.  Abstract
  • Dixon, TC; Cunningham, CK. Treatment of children with HIV infection. Current HIV/AIDS Reports. 2007;4:93-99.  Abstract
  • Ku, CL; von Bernuth, H; Picard, C; Zhang, SY; Chang, HH; Yang, K; Chrabieh, M; Issekutz, AC; Cunningham, CK; Gallin, J; Holland, SM; Roifman, C; Ehl, S; Smart, J; Tang, M; Barrat, FJ; Levy, O; McDonald, D; Day-Good, NK; Miller, R; Takada, H; Hara, T; Al-Hajjar, S; Al-Ghonaium, A; Speert, D; Sanlaville, D; Li, X; Geissmann, F; Vivier, E; Maródi, L; Garty, BZ; Chapel, H; Rodriguez-Gallego, C; Bossuyt, X; Abel, L; Puel, A; Casanova, JL. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. Journal of Experimental Medicine. 2007;204:2407-2422.  Abstract
  • McKinney, RE; Rodman, J; Hu, C; Britto, P; Hughes, M; Smith, ME; Serchuck, LK; Kraimer, J; Ortiz, AA; Flynn, P; Yogev, R; Spector, S; Draper, L; Tran, P; Scites, M; Dickover, R; Weinberg, A; Cunningham, C; Abrams, E; Blum, MR; Chittick, GE; Reynolds, L; Rathore, M; Pediatric AIDS Clinical Trials Group Protocol P1021 Study Team. Long-term safety and efficacy of a once-daily regimen of emtricitabine, didanosine, and efavirenz in HIV-infected, therapy-naive children and adolescents: Pediatric AIDS Clinical Trials Group Protocol P1021. Pediatrics. 2007;120:e416-e423.  Abstract
  • Newell, ML; Huang, S; Fiore, S; Thorne, C; Mandelbrot, L; Sullivan, JL; Maupin, R; Delke, I; Watts, DH; Gelber, RD; Cunningham, CK; PACTG 316 Study Team. Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA. BMC Infectious Diseases. 2007;7:60.  Abstract
  • Witt, KL; Cunningham, CK; Patterson, KB; Kissling, GE; Dertinger, SD; Livingston, E; Bishop, JB. Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV. Environmental and Molecular Mutagenesis. 2007;48:322-329.  Abstract
  • Church, JA; Hughes, M; Chen, J; Palumbo, P; Mofenson, LM; Delora, P; Smith, E; Wiznia, A; Hawkins, E; Sista, P; Cunningham, CK; Pediatric AIDS Clinical Trials Group P1005 Study Team. Long term tolerability and safety of enfuvirtide for human immunodeficiency virus 1-infected children. Pediatric Infectious Disease Journal. 2004;23:713-718.  Abstract
  • Cunningham, CK; Balasubramanian, R; Delke, I; Maupin, R; Mofenson, L; Dorenbaum, A; Sullivan, JL; Gonzalez-Garcia, A; Thorpe, E; Rathore, M; Gelber, RD. The impact of race/ethnicity on mother-to-child HIV transmission in the United States in Pediatric AIDS Clinical Trials Group Protocol 316. JAIDS: Journal of Acquired Immune Deficiency Syndromes. 2004;36:800-807.  Abstract
  • Watts, DH; Balasubramanian, R; Maupin, RT; Delke, I; Dorenbaum, A; Fiore, S; Newell, ML; Delfraissy, JF; Gelber, RD; Mofenson, LM; Culnane, M; Cunningham, CK; PACTG 316 Study Team. Maternal toxicity and pregnancy complications in human immunodeficiency virus-infected women receiving antiretroviral therapy: PACTG 316. American Journal of Obstetrics and Gynecology. 2004;190:506-516.  Abstract
  • Church, JA; Cunningham, C; Hughes, M; Palumbo, P; Mofenson, LM; Delora, P; Smith, E; Wiznia, A; Purdue, L; Hawkins, E; Sista, P; PACTG P1005 Study Team. Pediatric AIDS Clinical Trials Group. Safety and antiretroviral activity of chronic subcutaneous administration of T-20 in human immunodeficiency virus 1-infected children. Pediatric Infectious Disease Journal. 2002;21:653-659.  Abstract
  • Cunningham, CK; Chaix, ML; Rekacewicz, C; Britto, P; Rouzioux, C; Gelber, RD; Dorenbaum, A; Delfraissy, JF; Bazin, B; Mofenson, L; Sullivan, JL. Development of resistance mutations in women receiving standard antiretroviral therapy who received intrapartum nevirapine to prevent perinatal human immunodeficiency virus type 1 transmission: a substudy of pediatric AIDS clinical trials group protocol 316. Journal of Infectious Diseases. 2002;186:181-188.  Abstract
  • Dorenbaum, A; Cunningham, CK; Gelber, RD; Culnane, M; Mofenson, L; Britto, P; Rekacewicz, C; Newell, ML; Delfraissy, JF; Cunningham-Schrader, B; Mirochnick, M; Sullivan, JL; International PACTG 316 Team. Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trial. JAMA: Journal of the American Medical Association. 2002;288:189-198.  Abstract
  • Cunningham, CK; Wara, DW; Kang, M; Fenton, T; Hawkins, E; McNamara, J; Mofenson, L; Duliege, AM; Francis, D; McFarland, EJ; Borkowsky, W; Pediatric AIDS Clinical Trials Group 230 Collaborators. Safety of 2 recombinant human immunodeficiency virus type 1 (HIV-1) envelope vaccines in neonates born to HIV-1-infected women. Clinical Infectious Diseases. 2001;32:801-807.  Abstract
  • McFarland, EJ; Borkowsky, W; Fenton, T; Wara, D; McNamara, J; Samson, P; Kang, M; Mofenson, L; Cunningham, C; Duliege, AM; Sinangil, F; Spector, SA; Jimenez, E; Bryson, Y; Burchett, S; Frenkel, LM; Yogev, R; Gigliotti, F; Luzuriaga, K; Livingston, RA; AIDS Clinical Trials Group 230 Collaborators. Human immunodeficiency virus type 1 (HIV-1) gp120-specific antibodies in neonates receiving an HIV-1 recombinant gp120 vaccine. Journal of Infectious Diseases. 2001;184:1331-1335.  Abstract
  • Borkowsky, W; Wara, D; Fenton, T; McNamara, J; Kang, M; Mofenson, L; McFarland, E; Cunningham, C; Duliege, AM; Francis, D; Bryson, Y; Burchett, S; Spector, SA; Frenkel, LM; Starr, S; Van Dyke, R; Jimenez, E. Lymphoproliferative responses to recombinant HIV-1 envelope antigens in neonates and infants receiving gp120 vaccines. AIDS Clinical Trial Group 230 Collaborators. Journal of Infectious Diseases. 2000;181:890-896.  Abstract
  • Cunningham, CK; Bonville, CA; Ochs, HD; Seyama, K; John, PA; Rotbart, HA; Weiner, LB. Enteroviral meningoencephalitis as a complication of X-linked hyper IgM syndrome. Journal of Pediatrics. 1999;134:584-588.  Abstract
  • Cunningham, CK; Charbonneau, TT; Song, K; Patterson, D; Sullivan, T; Cummins, T; Poiesz, B. Comparison of human immunodeficiency virus 1 DNA polymerase chain reaction and qualitative and quantitative RNA polymerase chain reaction in human immunodeficiency virus 1-exposed infants. Pediatric Infectious Disease Journal. 1999;18:30-35.  Abstract
  • Coplan, J; Contello, KA; Cunningham, CK; Weiner, LB; Dye, TD; Roberge, L; Wojtowycz, MA; Kirkwood, K. Early language development in children exposed to or infected with human immunodeficiency virus. Pediatrics. 1998;102:e8.  Abstract
  • Coplan, J; Dye, TD; Contello, KA; Cunningham, CK; Kirkwood, K; Weiner, LB. Failure to identify human immunodeficiency virus-seropositive newborns: epidemiology and enrollment patterns in a predominantly white, nonurban setting. Pediatrics. 1995;96:1083-1089.  Abstract
  • Flynn, PM; Cunningham, CK; Kerkering, T; San Jorge, AR; Peters, VB; Pitel, PA; Harris, J; Gilbert, G; Castagnaro, L; Robinson, P. Oropharyngeal candidiasis in immunocompromised children: a randomized, multicenter study of orally administered fluconazole suspension versus nystatin. The Multicenter Fluconazole Study Group. Journal of Pediatrics. 1995;127:322-328.  Abstract
  • Cunningham, CK; McMillan, JA; Gross, SJ. Rehospitalization for respiratory illness in infants of less than 32 weeks' gestation. Pediatrics. 1991;88:527-532.  Abstract