P. Brian Smith, MD, MHS, MPH



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Professor of Pediatrics
Chief, Division of Quantitative Sciences, Pediatrics
Department / Division:
Pediatrics / Pediatrics-Neonatology
Duke Clinical Research Institute
P.O. Box 17969
Durham, NC 27715
Office Telephone:
  • MD, Mercer University School of Medicine (Georgia), 2001
  • Pediatrics, Duke University Medical Center, 2001-2004
  • Neonatology, Duke University School of Medicine, 2004-2007
Other Training:
  • MHS, Clinical Research, Duke University, 2006
  • MPH, University of North Carolina–Chapel Hill, 2009
Clinical Interests:
Nosocomial infections in preterm neonates, drug safety and efficacy in neonates
Research Interests:

Dr. Smith completed his residency in pediatrics and a fellowship in neonatal medicine at Duke University Medical Center in 2004 and 2007, respectively. He completed an MHS in clinical research from Duke University in 2006 and an MPH in biostatistics from the University of North Carolina at Chapel Hill in 2009. He research is focused on pediatric drug safety, neonatal pharmacology, and the epidemiology of neonatal infections. He is the chief of the Division of Quantitative Sciences in the Department of Pediatrics at Duke University Medical Center. Dr. Smith is or has been the protocol chair for more than 10 studies of drugs in infants. He is a steering committee member of the NICHD-funded Pediatric Trials Network (PTN).

Representative Publications:
  • Smith, PB; Walsh, TJ; Hope, W; Arrieta, A; Takada, A; Kovanda, LL; Kearns, GL; Kaufman, D; Sawamoto, T; Buell, DN; Benjamin, DK. Pharmacokinetics of an elevated dosage of micafungin in premature neonates. Pediatric Infectious Disease Journal. 2009;28:412-415.  Abstract
  • Benjamin, DK; Smith, PB; Jadhav, P; Gobburu, JV; Murphy, MD; Hasselblad, V; Baker-Smith, C; Califf, RM; Li, JS. Pediatric antihypertensive trial failures: analysis of end points and dose range. Hypertension. 2008;51:834-840.  Abstract
  • Smith, PB; Benjamin, DK; Murphy, MD; Johann-Liang, R; Iyasu, S; Gould, B; Califf, RM; Li, JS; Rodriguez, W. Safety monitoring of drugs receiving pediatric marketing exclusivity. Pediatrics. 2008;122:e628-e633.  Abstract
  • Smith, PB; Li, JS; Murphy, MD; Califf, RM; Benjamin, DK. Safety of placebo controls in pediatric hypertension trials. Hypertension. 2008;51:829-833.  Abstract
  • Smith, PB; Morgan, J; Benjamin, JD; Fridkin, SK; Sanza, LT; Harrison, LH; Sofair, AN; Huie-White, S; Benjamin, DK. Excess costs of hospital care associated with neonatal candidemia. Pediatric Infectious Disease Journal. 2007;26:197-200.  Abstract
  • Benjamin, DK; Smith, PB; Murphy, MD; Roberts, R; Mathis, L; Avant, D; Califf, RM; Li, JS. Peer-reviewed publication of clinical trials completed for pediatric exclusivity. JAMA : the journal of the American Medical Association. 2006;296:1266-1273.  Abstract
  • Garges, HP; Moody, MA; Cotten, CM; Smith, PB; Tiffany, KF; Lenfestey, R; Li, JS; Fowler, VG; Benjamin, DK. Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters?. Pediatrics. 2006;117:1094-1100.  Abstract