Blythe Hazlehurst Devlin, PhD

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Associate Professor in Pediatrics
Department / Division:
Pediatrics / Pediatrics-Allergy/Immunology
Address:
T0903 Childrens Hlth Ctr
Box 3352
Durham, NC 27710
Office Telephone:
(919) 668-1546
Training:
  • PhD, University of Virginia, 1978
Research Interests:
My research interests focus on the mechanisms of thymus engraftment after transplantation of cultured, allogeneic, postnatal thymus in infants born with athymia (complete DiGeorge Syndrome). I am interested in the signals that attract progenitor cells from the host bone marrow to the transplanted thymus and the differentiation of the transplanted thymus tissue into functional, but HLA mismatched, mature thymus. My research interests also include the diversification of the T cell receptor repertoire in the peripheral blood after thymus transplantation and the mechanisms that control T cell homeostasis.
Representative Publications:
  • Ciupe, SM; Devlin, BH; Markert, ML; Kepler, TB. The dynamics of T-cell receptor repertoire diversity following thymus transplantation for DiGeorge anomaly. PLoS computational biology. 2009;5:e1000396.  Abstract
  • Li, B; Li, J; Hsieh, CS; Hale, LP; Li, YJ; Devlin, BH; Markert, ML. Characterization of cultured thymus tissue used for transplantation with emphasis on promiscuous expression of thyroid tissue-specific genes. Immunologic Research. 2009;44:71-83.  Abstract
  • Markert, ML; Devlin, BH; Chinn, IK; McCarthy, EA. Thymus transplantation in complete DiGeorge anomaly. Immunologic Research. 2009;44:61-70.  Abstract
  • Chinn, IK; Devlin, BH; Li, YJ; Markert, ML. Long-term tolerance to allogeneic thymus transplants in complete DiGeorge anomaly. Clinical Immunology. 2008;126:277-281.  Abstract
  • Markert, ML; Devlin, BH; Chinn, IK; McCarthy, EA; Li, YJ. Factors affecting success of thymus transplantation for complete DiGeorge anomaly. American Journal of Transplantation. 2008;8:1729-1736.  Abstract
  • Markert, ML; Li, J; Devlin, BH; Hoehner, JC; Rice, HE; Skinner, MA; Li, YJ; Hale, LP. Use of allograft biopsies to assess thymopoiesis after thymus transplantation. Journal of immunology (Baltimore, Md. : 1950). 2008;180:6354-6364.  Abstract
  • Hudson, LL; Louise Markert, M; Devlin, BH; Haynes, BF; Sempowski, GD. Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection. Seminars in Immunology. 2007;19:297-309.  Abstract
  • Markert, ML; Devlin, BH; Alexieff, MJ; Li, J; McCarthy, EA; Gupton, SE; Chinn, IK; Hale, LP; Kepler, TB; He, M; Sarzotti, M; Skinner, MA; Rice, HE; Hoehner, JC. Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants. Blood. 2007;109:4539-4547.  Abstract
  • He, M; Tomfohr, JK; Devlin, BH; Sarzotti, M; Markert, ML; Kepler, TB. SpA: web-accessible spectratype analysis: data management, statistical analysis and visualization. Bioinformatics. 2005;21:3697-3699.  Abstract
  • Kepler, TB; He, M; Tomfohr, JK; Devlin, BH; Sarzotti, M; Markert, ML. Statistical analysis of antigen receptor spectratype data. Bioinformatics. 2005;21:3394-3400.  Abstract
  • Markert, ML; Alexieff, MJ; Li, J; Sarzotti, M; Ozaki, DA; Devlin, BH; Sedlak, DA; Sempowski, GD; Hale, LP; Rice, HE; Mahaffey, SM; Skinner, MA. Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome. Blood. 2004;104:2574-2581.  Abstract
  • Markert, ML; Alexieff, MJ; Li, J; Sarzotti, M; Ozaki, DA; Devlin, BH; Sempowski, GD; Rhein, ME; Szabolcs, P; Hale, LP; Buckley, RH; Coyne, KE; Rice, HE; Mahaffey, SM; Skinner, MA. Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases. Journal of Allergy and Clinical Immunology. 2004;113:734-741.  Abstract