Michael M. Frank, MD



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Professor of Pediatrics
Professor of Immunology
Professor of Medicine
Department / Division:
Pediatrics / Pediatrics-Allergy/Immunology
DUMC 2611
Durham, NC 27710
Office Telephone:
  • MD, Harvard Medical School (Massachusetts), 1960
  • Internal Medicine, Boston City Hospital (Massachusetts), 1960-1961
  • Allergy/Immunology (Clinical Associate), National Institutes of Health, 1962-1964
  • Pediatrics, Johns Hopkins Hospital (Maryland), 1961-1962, 1964-1965
  • Allergy/Immunology, National Institutes of Health (Maryland), 1966-1968
Clinical Interests:
Defects in host defenses (complement), allergic and immunologic diseases, autoimmune diseases, hereditary angioedema
Research Interests:
The research of Dr. Frank's laboratory revolves around effector mechanisms of immune damage. Specifically, the laboratory is interested in understanding how antibody and complement contribute to the damage of tissues and micro-organisms. Overlapping areas of interest include the role of mediators in inflammation and the functions of antibody and complement in the production of autoimmune disease. Specific interests of the group in the last year have included studies of the mechanism by which infusion of intravenous immunoglobulin into animals and man down regulates immunologic damage. A second area of interest concerns the role of complement and antibody in the pathogenesis of HIV and in prevention of HIV infection. A third area concerns the role of complement in the generation of an immune response. A long term interest has been in the clinical signs and appropriate treatment of patients with hereditary angioedema.
Representative Publications:
  • Frank, MM. 8. Hereditary angioedema. Journal of Allergy and Clinical Immunology. 2008;121:S398-S401.  Abstract
  • Frank, MM; Jiang, H. New therapies for hereditary angioedema: disease outlook changes dramatically. Journal of Allergy and Clinical Immunology. 2008;121:272-280.  Abstract
  • Atkinson, JP; Frank, MM. Bypassing complement: evolutionary lessons and future implications. Journal of Clinical Investigation. 2006;116:1215-1218.  Abstract
  • Frank, MM; Atkinson, JP. Homozygous C1 inhibitor deficiency: The conclusion of a long search. Journal of Allergy and Clinical Immunology. 2006;118:1327-1329.  Abstract
  • Cunnion, KM; Benjamin, DK; Hester, CG; Frank, MM. Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia. Journal of Laboratory and Clinical Medicine. 2004;143:358-365.  Abstract
  • Frank, MM. Hereditary angioedema: a half century of progress. Journal of Allergy and Clinical Immunology. 2004;114:626-628.  Abstract
  • Jiang, H; Wang, Z; Serra, D; Frank, MM; Amalfitano, A. Recombinant adenovirus vectors activate the alternative complement pathway, leading to the binding of human complement protein C3 independent of anti-ad antibodies. Molecular Therapy. 2004;10:1140-1142.  Abstract
  • Cunnion, KM; Frank, MM. Complement activation influences Staphylococcus aureus adherence to endothelial cells. Infection and immunity. 2003;71:1321-1327.  Abstract
  • Cunnion, KM; Zhang, HM; Frank, MM. Availability of complement bound to Staphylococcus aureus to interact with membrane complement receptors influences efficiency of phagocytosis. Infection and immunity. 2003;71:656-662.  Abstract
  • Frank, MM. The "neurotic" edema: the parent disease and its offspring. The American Journal of Medicine. 2002;113:249-251.  Abstract
  • McCann, WA; Frank, MM; Cox, F; Ownby, DR. Haemophilus influenzae type b meningitis in a fully immunized 2-year-old. Annals of Allergy, Asthma & Immunology. 2002;88:551-555.  Abstract
  • Watford, WT; Smithers, MB; Frank, MM; Wright, JR. Surfactant protein A enhances the phagocytosis of C1q-coated particles by alveolar macrophages. American journal of physiology. Lung cellular and molecular physiology. 2002;283:L1011-L1022.  Abstract
  • Cunnion, KM; Lee, JC; Frank, MM. Capsule production and growth phase influence binding of complement to Staphylococcus aureus. Infection and immunity. 2001;69:6796-6803.  Abstract
  • Frank, MM. Annihilating host defense. Nature Medicine. 2001;7:1285-1286.  Abstract
  • Jiang, H; Wagner, E; Zhang, H; Frank, MM. Complement 1 inhibitor is a regulator of the alternative complement pathway. The Journal of Experimental Medicine. 2001;194:1609-1616.  Abstract
  • Wagner, E; Frank, MM; Smialowicz, RJ. 2,3,7,8-tetrachlorodibenzo-p-dioxin and natural immunity: lack of an effect on the complement system in a guinea pig model. TOXICOLOGY. 2001;159:107-113.  Abstract
  • Watford, WT; Wright, JR; Hester, CG; Jiang, H; Frank, MM. Surfactant protein A regulates complement activation. Journal of immunology (Baltimore, Md. : 1950). 2001;167:6593-6600.  Abstract
  • Frank, MM. Complement deficiencies. Pediatric Clinics of North America. 2000;47:1339-1354.  Abstract
  • Frank, MM; Miletic, VD; Jiang, H. Immunoglobulin in the control of complement action. Immunologic Research. 2000;22:137-146.  Abstract
  • Wagner, E; Platt, JL; Howell, DN; Marsh, HC; Frank, MM. IgG and complement-mediated tissue damage in the absence of C2: evidence of a functionally active C2-bypass pathway in a guinea pig model. Journal of immunology (Baltimore, Md. : 1950). 1999;163:3549-3558.  Abstract
  • Daggett, CW; Yeatman, M; Lodge, AJ; Chen, EP; Linn, SS; Gullotto, C; Frank, MM; Platt, JL; Davis, RD. Total respiratory support from swine lungs in primate recipients. Journal of Thoracic and Cardiovascular Surgery. 1998;115:19-27.  Abstract