Jennifer S. Li, MD



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Professor of Pediatrics
Professor of Medicine
Division Chief, Pediatric Cardiology
Department / Division:
Pediatrics / Pediatrics-Cardiology
DUMC 3090
Durham, NC 27710
Appointment Telephone:
Office Telephone:
  • MD, Duke University School of Medicine, 1987
  • Pediatrics, Children's Hospital of Philadelphia (Pennsylvania), 1987-1989
  • Pediatrics, Duke University Medical Center, 1989-1990
  • Pediatric Cardiology, Duke University Medical Center, 1990-1993
Clinical Interests:
Pediatric cardiology, echocardiography, hypertension, hyperlipidemia
Research Interests:
1. Pediatric hypertension and hyperlipidemia
2. Clinical trials in children with heart disease
3. Thrombosis in patients with congenital heart disease
4. Enzyme replacement in Pompe disease
5. Infective endocarditis
Representative Publications:
  • Baker-Smith, CM; Benjamin, DK; Califf, RM; Murphy, MD; Li, JS; Smith, PB. Cough in pediatric patients receiving angiotensin-converting enzyme inhibitor therapy or angiotensin receptor blocker therapy in randomized controlled trials. Clinical Pharmacology & Therapeutics (Nature). 2010;87:668-671.  Abstract
  • Barker, GM; O'Brien, SM; Welke, KF; Jacobs, ML; Jacobs, JP; Benjamin, DK; Peterson, ED; Jaggers, J; Li, JS. Major infection after pediatric cardiac surgery: a risk estimation model. Annals of Thoracic Surgery. 2010;89:843-850.  Abstract
  • Li, JS; Flynn, JT; Portman, R; Davis, I; Ogawa, M; Shi, H; Pressler, ML. The efficacy and safety of the novel aldosterone antagonist eplerenone in children with hypertension: a randomized, double-blind, dose-response study. The Journal of Pediatrics. 2010;157:282-287.  Abstract
  • Li, JS; Newburger, JW. Antiplatelet therapy in pediatric cardiovascular patients. Pediatric Cardiology. 2010;31:454-461.  Abstract
  • Benjamin, DK; Smith, PB; Sun, MJ; Murphy, MD; Avant, D; Mathis, L; Rodriguez, W; Califf, RM; Li, JS. Safety and transparency of pediatric drug trials. Archives of Pediatrics and Adolescent Medicine. 2009;163:1080-1086.  Abstract
  • Hsu, DT; Mital, S; Ravishankar, C; Margossian, R; Li, JS; Sleeper, LA; Williams, RV; Levine, JC; McCrindle, BW; Atz, AM; Servedio, D; Mahony, L; Pediatric Heart Network Investigators. Rationale and design of a trial of angiotensin-converting enzyme inhibition in infants with single ventricle. American Heart Journal. 2009;157:37-45.  Abstract
  • Baker-Smith, CM; Benjamin, DK; Grabowski, HG; Reid, ED; Mangum, B; Goldsmith, JV; Murphy, MD; Edwards, R; Eisenstein, EL; Sun, J; Califf, RM; Li, JS. The economic returns of pediatric clinical trials of antihypertensive drugs. American Heart Journal. 2008;156:682-688.  Abstract
  • Benjamin, DK; Smith, PB; Jadhav, P; Gobburu, JV; Murphy, MD; Hasselblad, V; Baker-Smith, C; Califf, RM; Li, JS. Pediatric antihypertensive trial failures: analysis of end points and dose range. Hypertension. 2008;51:834-840.  Abstract
  • Levine, JC; Kishnani, PS; Chen, YT; Herlong, JR; Li, JS. Cardiac remodeling after enzyme replacement therapy with acid alpha-glucosidase for infants with Pompe disease. Pediatric Cardiology. 2008;29:1033-1042.  Abstract
  • Li, JS; Baker-Smith, CM; Smith, PB; Hasselblad, V; Murphy, MD; Califf, RM; Benjamin, DK. Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis. Clinical Pharmacology & Therapeutics (Nature). 2008;84:315-319.  Abstract
  • Li, JS; Yow, E; Berezny, KY; Bokesch, PM; Takahashi, M; Graham, TP; Sanders, SP; Sidi, D; Bonnet, D; Ewert, P; Jennings, LK; Michelson, AD; PICOLO Investigators. Dosing of clopidogrel for platelet inhibition in infants and young children: primary results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) trial. Circulation. 2008;117:553-559.  Abstract
  • McDowell, R; Li, JS; Benjamin, DK; Morgan, C; Becker, A; Kishnani, PS; Kanter, RJ. Arrhythmias in patients receiving enzyme replacement therapy for infantile Pompe disease. Genetics in Medicine. 2008;10:758-762.  Abstract
  • Smith, PB; Benjamin, DK; Murphy, MD; Johann-Liang, R; Iyasu, S; Gould, B; Califf, RM; Li, JS; Rodriguez, W. Safety monitoring of drugs receiving pediatric marketing exclusivity. Pediatrics. 2008;122:e628-e633.  Abstract
  • Smith, PB; Li, JS; Murphy, MD; Califf, RM; Benjamin, DK. Safety of placebo controls in pediatric hypertension trials. Hypertension. 2008;51:829-833.  Abstract
  • Li, JS; Eisenstein, EL; Grabowski, HG; Reid, ED; Mangum, B; Schulman, KA; Goldsmith, JV; Murphy, MD; Califf, RM; Benjamin, DK. Economic return of clinical trials performed under the pediatric exclusivity program. JAMA : the journal of the American Medical Association. 2007;297:480-488.  Abstract
  • Li, JS; Yow, E; Berezny, KY; Rhodes, JF; Bokesch, PM; Charpie, JR; Forbus, GA; Mahony, L; Boshkov, L; Lambert, V; Bonnet, D; Michel-Behnke, I; Graham, TP; Takahashi, M; Jaggers, J; Califf, RM; Rakhit, A; Fontecave, S; Sanders, SP. Clinical outcomes of palliative surgery including a systemic-to-pulmonary artery shunt in infants with cyanotic congenital heart disease: does aspirin make a difference?. Circulation. 2007;116:293-297.  Abstract
  • McCrindle, BW; Li, JS; Minich, LL; Colan, SD; Atz, AM; Takahashi, M; Vetter, VL; Gersony, WM; Mitchell, PD; Newburger, JW; Pediatric Heart Network Investigators. Coronary artery involvement in children with Kawasaki disease: risk factors from analysis of serial normalized measurements. Circulation. 2007;116:174-179.  Abstract
  • Minich, LL; Sleeper, LA; Atz, AM; McCrindle, BW; Lu, M; Colan, SD; Printz, BF; Klein, GL; Sundel, RP; Takahashi, M; Li, JS; Vetter, VL; Newburger, JW; Pediatric Heart Network Investigators. Delayed diagnosis of Kawasaki disease: what are the risk factors?. Pediatrics. 2007;120:e1434-e1440.  Abstract
  • Newburger, JW; Sleeper, LA; McCrindle, BW; Minich, LL; Gersony, W; Vetter, VL; Atz, AM; Li, JS; Takahashi, M; Baker, AL; Colan, SD; Mitchell, PD; Klein, GL; Sundel, RP; Pediatric Heart Network Investigators. Randomized trial of pulsed corticosteroid therapy for primary treatment of Kawasaki disease. The New England journal of medicine. 2007;356:663-675.  Abstract
  • Ansong, AK; Li, JS; Nozik-Grayck, E; Ing, R; Kravitz, RM; Idriss, SF; Kanter, RJ; Rice, H; Chen, YT; Kishnani, PS. Electrocardiographic response to enzyme replacement therapy for Pompe disease. Genetics in Medicine. 2006;8:297-301.  Abstract
  • Benjamin, DK; Smith, PB; Murphy, MD; Roberts, R; Mathis, L; Avant, D; Califf, RM; Li, JS. Peer-reviewed publication of clinical trials completed for pediatric exclusivity. JAMA : the journal of the American Medical Association. 2006;296:1266-1273.  Abstract
  • Cook, AL; Kishnani, PS; Carboni, MP; Kanter, RJ; Chen, YT; Ansong, AK; Kravitz, RM; Rice, H; Li, JS. Ambulatory electrocardiogram analysis in infants treated with recombinant human acid alpha-glucosidase enzyme replacement therapy for Pompe disease. Genetics in Medicine. 2006;8:313-317.  Abstract
  • Li, JS; Jaggers, J; Anderson, PA. The use of TP10, soluble complement receptor 1, in cardiopulmonary bypass. Expert Review of Cardiovascular Therapy. 2006;4:649-654.  Abstract
  • McCrindle, BW; Williams, RV; Mitchell, PD; Hsu, DT; Paridon, SM; Atz, AM; Li, JS; Newburger, JW; Pediatric Heart Network Investigators. Relationship of patient and medical characteristics to health status in children and adolescents after the Fontan procedure. Circulation. 2006;113:1123-1129.  Abstract
  • Menon, S; Berezny, KY; Kilaru, R; Benjamin, DK; Kay, JD; Hazan, L; Portman, R; Hogg, R; Deitchman, D; Califf, RM; Li, JS. Racial differences are seen in blood pressure response to fosinopril in hypertensive children. American Heart Journal. 2006;152:394-399.  Abstract
  • Valente, AM; Jain, R; Scheurer, M; Fowler, VG; Corey, GR; Bengur, AR; Sanders, S; Li, JS. Frequency of infective endocarditis among infants and children with Staphylococcus aureus bacteremia. Pediatrics. 2005;115:e15-e19.  Abstract
  • Li, JS; Berezny, K; Kilaru, R; Hazan, L; Portman, R; Hogg, R; Jenkins, RD; Kanani, P; Cottrill, CM; Mattoo, TK; Zharkova, L; Kozlova, L; Weisman, I; Deitchman, D; Califf, RM. Is the extrapolated adult dose of fosinopril safe and effective in treating hypertensive children?. Hypertension. 2004;44:289-293.  Abstract
  • Li, JS; Sanders, SP; Perry, AE; Stinnett, SS; Jaggers, J; Bokesch, P; Reynolds, L; Nassar, R; Anderson, PA. Pharmacokinetics and safety of TP10, soluble complement receptor 1, in infants undergoing cardiopulmonary bypass. American Heart Journal. 2004;147:173-180.  Abstract
  • Milazzo, AS; Herlong, JR; Li, JS; Sanders, SP; Barrington, M; Bengur, AR. Real-time transmission of pediatric echocardiograms using a single ISDN line. Computers in Biology and Medicine. 2002;32:379-388.  Abstract
  • Pasquali, SK; Sanders, SP; Li, JS. Oral antihypertensive trial design and analysis under the pediatric exclusivity provision. American Heart Journal. 2002;144:608-614.  Abstract
  • Milazzo, AS; Li, JS. Bacterial endocarditis in infants and children. Pediatric Infectious Disease Journal. 2001;20:799-801.  Abstract
  • Li, JS; Sexton, DJ; Mick, N; Nettles, R; Fowler, VG; Ryan, T; Bashore, T; Corey, GR. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clinical Infectious Diseases. 2000;30:633-638.  Abstract