Pulmonary and Sleep Medicine

Duke Center for Pediatric Lung Disease

About the Center

The Duke Center for Pediatric Lung Disease is a unique resource within the Department of Pediatrics at the Duke University School of Medicine, offering exceptional opportunities for collaborations between clinicians, scientists, epidemiologists, and research staff. Under the leadership of Judith A. Voynow, MD, the goals of the Center are to increase knowledge of the causes and mechanisms of pediatric lung diseases, to develop innovative approaches to the diagnosis and treatment of these diseases, and to provide an outstanding training environment for medical and graduate students, residents, and fellows. Areas of pediatric lung research currently include cystic fibrosis, bronchopulmonary dysplasia, asthma, and the pulmonary complications of environmental pollutants.

Work in the Center focuses on the full spectrum of discovery from basic science and molecular research, to translation into animal models of disease, to first-in-human trials of new therapies. The research programs are multidisciplinary and traverse traditional clinical and basic science departmental boundaries. Center faculty span the Department of Pediatrics (Divisions of Pulmonary and Sleep Medicine and Neonatology); the Department of Medicine (Divisions of Gastroenterology and Pulmonary, Allergy and Critical Care Medicine); and the Department of Cell Biology.

To further foster the success of its investigators, the Duke Center for Pediatric Lung Disease capitalizes on collaborations with the Institute of Genome Science Policy, the Jean and George Brumley, Jr. Neonatal- Perinatal Research Institute, the Asthma, Allergy, Airway Center, the Asthma Clinical Research Center, the Fitzpatrick Institute of Photonics, the National Institute of Environmental Health Sciences in Research Triangle Park, and the Environmental Protection Agency as well as membership in the NIH Prematurity and Respiratory Outcomes Program Network and participation in the Cystic Fibrosis Foundation-funded Therapeutic Development Network.

The research endeavors of the faculty have led to an outstanding record for attaining peer-reviewed, external research funding, and the Center is currently supporting a major multi-center National Institutes of Health (NIH)-funded project to study biomarkers of bronchopulmonary dysplasia severity and an NIH-funded project to study host factors and mechanisms of pulmonary susceptibility to air pollutants.

Core Centers

The following core centers have been established to provide high quality services, expertise, education and resources to support the Center’s research:

Clinical Research Core/CFF-funded Therapeutic Development Network Site
Principal Investigator: Judith A. Voynow, MD
Co-Director: Deanna Green, MD, MHS
Clinical Research Coordinator: Kathy Auten

Infant Pulmonary Function Core Laboratory/Biological Sampling Laboratory

Director: Judith A. Voynow, MD

Co-Director: Stacey L. Peterson-Carmichael, MD

Primary Lung Cell Isolation and Culture Core
Director: Bernard Fischer, DVM, PhD

Animal Physiology Core
Director: W. Michael Foster, PhD

Research Faculty

Name
Judith A. Voynow, MD, Director
Richard Auten, MD
Michel Bagnat, PhD
Gregory Crawford, PhD
Jonathan Cohn, MD
C. Michael Cotten, MD, MHS
Tuan Vo Dinh, PhD
Bernard Fischer, DVM, PhD
Matthew Foster, PhD
W. Michael Foster, PhD
Deanna Green, MD, MHS
John W. Hollingsworth, MD
Monica Kraft, MD
Madan M. Kwatra, PhD
M. Arthur Moseley, PhD
Thomas M. Murphy, MD
Scott Palmer, MD
Stacey L. Peterson-Carmichael, MD
Barry Stripp, PhD
Shuo Zheng, PhD